|
Category:natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
|
| Food Chemicals Codex Listed: | No |
| Boiling Point: | 528.00 to 529.00 °C. @ 760.00 mm Hg (est)
|
| Flash Point: | 404.00 °F. TCC ( 206.40 °C. ) (est)
|
| logP (o/w): | 2.339 (est) |
| Soluble in: |
| | water, 174.5 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
|
Not determined
|
| Dermal Toxicity: |
|
Not determined
|
| Inhalation Toxicity: |
|
Not determined
|
Safety in Use Information:
| Category: | | natural substances and extractives |
| Recommendation for hydrangenol usage levels up to: | | | not for fragrance use.
|
| |
| Recommendation for hydrangenol flavor usage levels up to: |
| | not for flavor use.
|
Safety References:
References:
| | 8-hydroxy-3-(4-hydroxyphenyl)-3,4-dihydroisochromen-1-one |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 119199 |
| Pubchem (sid): | 135073858 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 1H-2- | benzopyran-1-one, 3,4-dihydro-8-hydroxy-3-(4-hydroxyphenyl)- | | 3,4- | dihydro-8-hydroxy-3-(4-hydroxyphenyl)-1h-2-benzopyran-1-one | | 8- | hydroxy-3-(4-hydroxyphenyl)-3,4-dihydroisochromen-1-one |
Articles:
| PubMed:Search for new type of PPARĪ³ agonist-like anti-diabetic compounds from medicinal plants. |
| PubMed:[Chemical constituents from Hydrangea macrophylla]. |
| PubMed:Phenolic compounds from the roots of Jordanian viper's grass, Scorzonera judaica. |
| PubMed:Three new glycosides from the leaves of Hydrangea macrophylla subsp. serrata (THUNB.) MAKINO. |
| PubMed:New type of anti-diabetic compounds from the processed leaves of Hydrangea macrophylla var. thunbergii (Hydrangeae Dulcis Folium). |
| PubMed:Inhibitory effects of thunberginols A, B, and F on degranulations and releases of TNF-alpha and IL-4 in RBL-2H3 cells. |
| PubMed:Metabolic fate of orally administered phyllodulcin in rats. |
| PubMed:Stilbenecarboxylate biosynthesis: a new function in the family of chalcone synthase-related proteins. |
| PubMed:Allergic contact dermatitis from hydrangea--is it so rare? |
| PubMed:Effects of phyllodulcin, hydrangenol, and their 8-O-glucosides, and thunberginols A and F from Hydrangea macrophylla SERINGE var. thunbergii MAKINO on passive cutaneous anaphylaxis reaction in rats. |
| PubMed:Structure-requirements of isocoumarins, phthalides, and stilbenes from Hydrangeae Dulcis Folium for inhibitory activity on histamine release from rat peritoneal mast cells. |
| PubMed:Immunomodulatory activity of thunberginol A and related compounds isolated from Hydrangeae Dulcis Folium on splenocyte proliferation activated by mitogens. |
| PubMed:Development of bioactive functions in Hydrangeae Dulcis Folium. VII. Immunomodulatory activities of thunberginol A and related compounds on lymphocyte proliferation. |
| PubMed:Inhibitory effects of plumbagin and juglone on azoxymethane-induced intestinal carcinogenesis in rats. |
| PubMed:Development of bioactive functions in Hydrangeae dulcis folium. VI. Syntheses of thunberginols A and F and their 3'-deoxy-derivatives using regiospecific lactonization of stilbene carboxylic acid: structures and inhibitory activity on histamine release of hydramacrophyllols A and B. |
| PubMed:Development of bioactive functions in hydrangeae dulcis folium. V. On the antiallergic and antimicrobial principles of hydrangeae dulcis folium. (2). Thunberginols C, D, and E, thunberginol G 3'-O-glucoside, (-)-hydrangenol 4'-o-glucoside, and (+)-hydrangenol 4'-O-glucoside. |
| PubMed:Modifying effects of naturally occurring products on the development of colonic aberrant crypt foci induced by azoxymethane in F344 rats. |
| PubMed:Development of bioactive functions in hydrangeae dulcis folium. III. On the antiallergic and antimicrobial principles of hydrangeae dulcis folium. (1). Thunberginols A, B, and F. |
| PubMed:[Development of bioactive functions in hydrangeae dulcis folium. II. Antiulcer, antiallergy, and cholagoic effects of the extract from hydrangeae dulcis folium]. |
| PubMed:[Chemical constituents of Hydrangea macrophylla (Thunb.) Ser]. |
| PubMed:[Quantitative analysis of dihydroisocoumarin constituents of Hydrangeae Dulcis Folium by means of high performance liquid chromatography. Chemical characterization of the processing, distribution in plant, and seasonal fluctuation]. |
| PubMed:Thunberginols C, D, and E, new antiallergic and antimicrobial dihydroisocoumarins, and thunberginol G 3'-O-glucoside and (-)-hydrangenol 4'-O-glucoside, new dihydroisocoumarin glycosides, from Hydrangeae Dulcis Folium. |
| PubMed:Thunberginols A, B, and F, new antiallergic and antimicrobial principles from hydrangeae dulcis folium. |
| PubMed:Hydrangenol, a strong contact sensitizer found in hydrangea (Hydrangea sp.; Hydrangeaceae). |
| PubMed:Inhibitory effects of hydrangenol derivatives on the activation of hyaluronidase and their antiallergic activities. |
| PubMed:Allergic contact dermatitis to hydrangea. |
| PubMed:Antifungal activity of oosponol, oospolactone, phyllodulcin, hydrangenol, and some other related compounds. |
| PubMed:[High-speed liquid chromatographic analysis of drugs. IV. Speration analysis of phyllodulcin and hydrangenol in sweet hydrangea (author's transl)]. |
| PubMed:Studies of hydrangenol in Hydrangea macrophylla Ser. II. Biosynthesis of hydrangenol from C14-labelled compounds. |
| PubMed:Enhancement of Gibberellin Growth-Promoting Activity by Hydrangenol Isolated from Leaves of Hydrangea Macrophylla. |
| PubMed:Studies of hydrangenol in hydrangea macrophylla Ser. I. Isolation, identification, and biosynthesis from C 14-labelled compounds. |
|
3D/inchi