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Category:natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 512.60 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 432.00 °F. TCC ( 222.30 °C. ) (est)
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| logP (o/w): | 7.730 (est) |
| Soluble in: |
| | water, 0.0007348 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | natural substances and extractives |
| Recommendation for umbelliprenin usage levels up to: | | | not for fragrance use.
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| Recommendation for umbelliprenin flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
| | 7-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienoxy]chromen-2-one |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 1781413 |
| Pubchem (sid): | 135159159 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | angelin | | 2H-1- | benzopyran-2-one, 7-[[(2E,6E)-3,7,11-trimethyl-2,6,10-dodecatrien-1-yl]oxy]- | | | coumarin, 7-((3,7,22-trimethyl-2,6,10-dodecatrienyl)oxy)- | | 7-[(2E,6E)-3,7,11- | trimethyldodeca-2,6,10-trienoxy]chromen-2-one |
Articles:
| PubMed:Mcl-1 Is Up Regulated by Prenylated Coumarin, Umbelliprenin in Jurkat Cells. |
| PubMed:Biological properties and molecular targets of umbelliprenin--a mini-review. |
| PubMed:Potent and selective inhibitors of class A β-lactamase: 7-prenyloxy coumarins. |
| PubMed:Relaxant effects of asafoetida extract and its constituent umbelliprenin on guinea-pig tracheal smooth muscle. |
| PubMed:Umbelliprenin induced production of IFN-γ and TNF-α, and reduced IL-10, IL-4, Foxp3 and TGF-β in a mouse model of lung cancer. |
| PubMed:Umbelliprenin from Ferula szowitsiana Activates both Intrinsic and Extrinsic Pathways of Apoptosis in Jurkat T-CLL cell line. |
| PubMed:Cytotoxic activities of phytochemicals from Ferula species. |
| PubMed:Umbelliprenin is cytotoxic against QU-DB large cell lung cancer cell line but anti-proliferative against A549 adenocarcinoma cells. |
| PubMed:Umbelliprenin Induces Apoptosis in CLL Cell Lines. |
| PubMed:Methyl galbanate, a novel inhibitor of nitric oxide production in mouse macrophage RAW264.7 cells. |
| PubMed:Identification of non-alkaloid acetylcholinesterase inhibitors from Ferulago campestris (Besser) Grecescu (Apiaceae). |
| PubMed:New sesquiterpene coumarins from the roots of Ferula flabelliloba. |
| PubMed:Galbanic acid, a cytotoxic sesquiterpene from the gum resin of Ferula asafoetida, blocks protein farnesyltransferase. |
| PubMed:Two new sesquiterpene derivatives from the Tunisian endemic Ferula tunetana Pom. |
| PubMed:Cancer chemopreventive activity of the prenylated coumarin, umbelliprenin, in vivo. |
| PubMed:Evaluation of antigenotoxicity effects of umbelliprenin on human peripheral lymphocytes exposed to oxidative stress. |
| PubMed:Cancer chemopreventive activity of terpenoid coumarins from Ferula species. |
| PubMed:Umbelliprenin from Ferula szowitsiana inhibits the growth of human M4Beu metastatic pigmented malignant melanoma cells through cell-cycle arrest in G1 and induction of caspase-dependent apoptosis. |
| PubMed:A novel cytotoxic lignan from Seseli annuum L. |
| PubMed:Sesquiterpene coumarins from Ferula szowitsiana and in vitro antileishmanial activity of 7-prenyloxycoumarins against promastigotes. |
| PubMed:Antibacterial and anticoagulant activities of coumarins isolated from the flowers of Magydaris tomentosa. |
| PubMed:Two matrix metalloproteinases inhibitors from Ferula persica var. persica. |
| PubMed:Bleaching of Serratia marcescens by some coumarins: a spectrophotometric study. |
| PubMed:Umbelliprenin from Ferula persica roots inhibits the red pigment production in Serratia marcescens. |
| PubMed:Farnesyloxycoumarins, a new class of squalene-hopene cyclase inhibitors. |
| PubMed:Constituents of Peucedanum zenkeri seeds and their antimicrobial effects. |
| PubMed:Natural coumarins. XII. Umbelliprenin, a constituent of ammi majus L. fruits. |
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3D/inchi