EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

alpha-ketoglutaric acid
2-oxopentanedioic acid

Supplier Sponsors

CAS Number: 328-50-7Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:206-330-3
FDA UNII:8ID597Z82X
Nikkaji Web:J11.847H
Beilstein Number:1705689
MDL:MFCD00004165
CoE Number:653
XlogP3-AA:-0.90 (est)
Molecular Weight:146.09882000
Formula:C5 H6 O5
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:flavoring agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
JECFA Food Flavoring:634 2-oxopentanedioic acid
DG SANTE Food Flavourings:08.037 2-oxo-glutaric acid
FEMA Number:3891 2-oxopentanedioic acid
FDA:No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF):328-50-7 ; 2-OXOPENTANEDIOIC ACID
 
Physical Properties:
Appearance:white to pale yellow crystals (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 114.00 to 116.00 °C. @ 760.00 mm Hg
Boiling Point: 323.00 °C. @ 760.00 mm Hg
Vapor Pressure:0.000010 mmHg @ 25.00 °C. (est)
Flash Point: 351.00 °F. TCC ( 177.00 °C. ) (est)
logP (o/w): -1.430
Shelf Life: 12.00 month(s) or longer if stored properly.
Storage:refrigerate in tightly sealed containers.
Soluble in:
 water, 1e+006 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor Description:odorless
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: deodorants
 
Suppliers:
AIDP
Alpha Keto Glutaric Acid (AKG) AKG 99% min
Alfa Biotechnology
For experimental / research use only.
2-Ketoglutaric acid 98%
American International Chemical, LLC.
Alpha-ketoglutaric Acid
BOC Sciences
For experimental / research use only.
a-ketoGlutaric Acid
Carbosynth
For experimental / research use only.
a-Ketoglutaric acid
Charkit Chemical
ALPHA KETOGLUTARIC ACID
Glentham Life Sciences
2-Ketoglutaric acid
Graham Chemical
alpha-ketoGlutaric Acid
Indis NV
For experimental / research use only.
Alpha-Ketoglutaric Acid / 2-Oxoglutaric Acid
Penta International
2-OXOPENTANEDIOIC ACID
Prinova
alpha-ketoGlutaric Acid
Santa Cruz Biotechnology
For experimental / research use only.
alpha-ketoGlutaric Acid ≥98%
Sigma-Aldrich
For experimental / research use only.
a-Ketoglutaric acid puriss., ≥99.0% (T)
TCI AMERICA
For experimental / research use only.
2-Oxoglutaric Acid >99.0%(T)
 
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
Xi - Irritant
R 37/38 - Irritating to respiratory system and skin.
R 41 - Risk of serious damage to eyes.
S 02 - Keep out of the reach of children.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36/39 - Wear suitable clothing and eye/face protection.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
flavoring agents
Recommendation for alpha-ketoglutaric acid usage levels up to:
 not for fragrance use.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): ND (μg/capita/day)
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 18
Click here to view publication 18
 average usual ppmaverage maximum ppm
baked goods: --
beverages(nonalcoholic): 0.100005.00000
beverages(alcoholic): --
breakfast cereal: --
cheese: 0.500005.00000
chewing gum: --
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: 0.400005.00000
fish products: --
frozen dairy: 1.000005.00000
fruit ices: --
gelatins / puddings: --
granulated sugar: --
gravies: --
hard candy: --
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: 0.500005.00000
nut products: --
other grains: --
poultry: --
processed fruits: 0.100001.00000
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: 0.100005.00000
sugar substitutes: --
sweet sauces: --
 
Safety References:
European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) on a request from the Commission related to - Flavouring Group Evaluation 10: Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30 - (Commission Regulation (EC) No 1565/2000 of 18 July 2000)
View page or View pdf

Flavouring Group Evaluation 10, Revision 1 (FGE10 Rev1)[1] - Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30 - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC)
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 10, Revision 2 (FGE.10Rev2): Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30
View page or View pdf

EPI System: View
ClinicalTrials.gov:search
Daily Med:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):328-50-7
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :51
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
2-oxopentanedioic acid
Chemidplus:0000328507
 
References:
 2-oxopentanedioic acid
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:328-50-7
Pubchem (cid):51
Pubchem (sid):134973455
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
CHEBI:View
CHEMBL:View
Golm Metabolome Database:Search
Metabolomics Database:Search
UM BBD:Search
KEGG (GenomeNet):C00026
HMDB (The Human Metabolome Database):HMDB00208
FooDB:FDB007242
YMDB (Yeast Metabolome Database):YMDB00153
Export Tariff Code:2918.30.9000
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
FAO:2-Oxopentanedioic acid
 
Potential Blenders and core components note
None Found
 
Potential Uses:
 deodorants
 
Occurrence (nature, food, other):note
 apple plant
Search Trop Picture
 banana leaf
Search Trop Picture
 barley
Search Trop Picture
 barley seed
Search Trop Picture
 carrot root
Search Trop Picture
 cheese
Search PMC Picture
 coffee
Search PMC Picture
 oat hull husk
Search Trop Picture
 peanut seed
Search Trop Picture
 potato plant
Search Trop Picture
 soybean seed
Search Trop Picture
 star fruit fruit
Search Trop Picture
 tamarind flower
Search Trop Picture
 tamarind fruit
Search Trop Picture
 tamarind leaf
Search Trop Picture
 tamarind seed
Search Trop Picture
 tomato fruit
Search Trop Picture
 
Synonyms:
bis(L-arginin)-2-oxoglutarate
bis(laevo-arginin)-2-oxoglutarate
2-ketoglutaric acid
2-oxoglutaric acid
2-oxo-glutaric acid
a-ketoglutaric acid
a-oxoglutaric acid
alpha-oxoglutaric acid
 glutaric acid, 2-oxo-
a- ketolutaric acid
2-oxopentane dioic acid
2-oxo-1,5-pentane dioic acid
2-oxopentanedioic acid
2-oxo-1,5-pentanedioic acid
a-oxopentanedioic acid
 pentanedioic acid, 2-oxo-
2-oxopentanedionic acid
 
 
Notes:
Flavouring ingredient Alpha-ketoglutaric acid is an important biological compound and is a key intermediate in the Krebs cycle. Alpha-ketoglutaric acid occurs naturally within cells. One of its functions is to combine with ammonia to form glutamic acid and then glutamine. Another function is to combine with nitrogen released in the cell, therefore preventing nitrogen overload. (wikipedia)
Please share your Comments.
Email Address:
Top of Page Home
Copyright © 1980-2021 The Good Scents Company (tgsc) ™ Disclaimer Privacy Policy