| Name: | (2R,3R,4S,5S,6R)-2-[[(8S,9S,10R,13R,14S)-17-[(2R,5R)-5-ethyl-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol |
| CAS Number: | 474-58-8 |  3D/inchi
|
| FDA UNII: | U45VN859W3 |
| Beilstein Number: | 4359450 |
| MDL: | MFCD01683621 |
| XlogP3-AA: | 7.70 (est) |
| Molecular Weight: | 576.85840000 |
| Formula: | C35 H60 O6 |
| NMR Predictor: | Predict (works with chrome, Edge or firefox) |
Category:pharmaceuticals / chemical synthisis
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
|
| Food Chemicals Codex Listed: | No |
| Boiling Point: | 673.60 °C. @ 760.00 mm Hg (est)
|
| Flash Point: | 682.00 °F. TCC ( 361.20 °C. ) (est)
|
| logP (o/w): | 8.615 (est) |
| Soluble in: |
| | water, 5.213e-005 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
| Alfa Biotechnology |
| For experimental / research use only. |
| Eleutheroside A 98%
|
| BOC Sciences |
| For experimental / research use only. |
| Eleutheroside A
|
| Carbosynth |
| For experimental / research use only. |
| b-Sitosterol b-D-glucoside
|
| Coompo |
| For experimental / research use only. |
| Daucosterol from Plants ≥96%
Odor: characteristic Use: We investigated immunomodulatory effect of daucosterol against disseminated candidiasis caused by Candida albicans. Results showed that direct interaction of daucosterol with C. albicans yeast cells resulted in no growth-inhibition by in vitro susceptibility analysis. In contrast, mice given daucosterol (DS) intraperitoneally before intravenous challenge with live C. albicans yeast cells survived longer than DS-untreated control mice against disseminated candidiasis (P<0.05). By assessment of the fungal CFU in kidneys, DS-treated mice before the challenge developed about 81% fewer kidney CFU than untreated controls. This protection was removable by pretreatment of mice with anti-CD4+ antibody before the DS-treatment and challenge with the yeast. ELISA analysis revealed there were predominant production of IFNgamma and IL-2 cytokines as compared to IL-4, and IL-10 productions in DS-treated mice. By treatment of DS-given mice with anti-mouse IFNgamma, the protection was also abolished. Our studies show that DS protects mice against disseminated candidiasis by the CD4+ Th1 immune response. |
| Sigma-Aldrich |
| For experimental / research use only. |
| β-Sitosterol β-D-glucoside
analytical standard |
Safety Information:
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intraperitoneal-mouse LD50 62 mg/kg
Indian Journal of Pharmacy. Vol. 29, Pg. 91, 1967.
|
| Dermal Toxicity: |
|
Not determined
|
| Inhalation Toxicity: |
|
Not determined
|
Safety in Use Information:
| Category: | | pharmaceuticals / chemical synthisis |
| Recommendation for sitogluside usage levels up to: | | | not for fragrance use.
|
| |
| Recommendation for sitogluside flavor usage levels up to: |
| | not for flavor use.
|
Safety References:
European Food Safety Authority (EFSA) reference(s):
|
A combination of beta-sitosterol and beta-sitosterol glucoside and normal function of the immune system: evaluation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006
View page or View pdf
|
| EPI System: View |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :71628 |
| National Institute of Allergy and Infectious Diseases:Data |
| WGK Germany:3 |
| (2R,3R,4S,5S,6R)-2-[[(8S,9S,10R,13R,14S)-17-[(2R,5R)-5-ethyl-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol |
| Chemidplus:0000474588 |
References:
| | (2R,3R,4S,5S,6R)-2-[[(8S,9S,10R,13R,14S)-17-[(2R,5R)-5-ethyl-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 71628 |
| Pubchem (sid): | 135029615 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | alexandrin | | | coriandrinol | | | daucosterin | | | daucosterol | | | doursterol | | | eleutheroside A | | (2R,3R,4S,5S,6R)-2-[[(8S,9S,10R,13R,14S)-17-[(2R,5R)-5- | ethyl-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol | | beta-d- | glucopyranoside, (3beta)-stigmast-5-en-3-yl | | 3-beta-(beta-d- | glucopyranosyloxy)stigmast-5-ene | | 3beta-(beta-D- | glucopyranosyloxy)stigmast-5-ene | | | lyoniside | | | sitoglusidum | | | sitosterol D-glucoside | | beta- | sitosterol glucoside | | beta- | sitosterol monoglucoside | | beta- | sitosteryl glucoside | | beta- | sitosteryl glucoside
| | | sitosteryl glycoside | | | sterolin | | (3-beta)- | stigmast-5-en-3-yl-beta-D-glucopyranoside | | | stigmast-5-ene, 3-beta-(beta-D-glucopyranosyloxy)- |
Articles:
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