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dextro-mannitol
D-mannitol

Supplier Sponsors

Name:(2R,3R,4R,5R)-hexane-1,2,3,4,5,6-hexol
CAS Number: 69-65-8Picture of molecule3D/inchi
Other(deleted CASRN):1081757-07-4
ECHA EINECS - REACH Pre-Reg:200-711-8
FDA UNII: 3OWL53L36A
Nikkaji Web:J2.369H
Beilstein Number:1721898
MDL:MFCD00064287
XlogP3:-3.10 (est)
Molecular Weight:182.17278000
Formula:C6 H14 O6
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:sweeteners, humectants, texturizers, stabilizers, bulking agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 FDA/DG SANTE Petitions, Reviews, Notices:
180.25 Mannitol View - review
EU SANCO Mannitol View - review
JECFA Food Additive: Mannitol

Mannitol
GSFA Codex: Mannitol (421)
DG SANTE Food Additives:D-mannitol
FDA Mainterm (SATF):69-65-8 ; MANNITOL
FDA Regulation:
FDA PART 100 -- GENERAL


FDA PART 101 -- FOOD LABELING
Subpart E--Specific Requirements for Health Claims
Sec. 101.80 Health claims: dietary noncariogenic carbohydrate sweeteners and dental caries.


FDA PART 101 -- FOOD LABELING
Subpart A--General Provisions
Sec. 101.9 Nutrition labeling of food.


FDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS
Subpart C--Substances for Use as Components of Coatings
Sec. 175.300 Resinous and polymeric coatings.


FDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS
Subpart C--Substances for Use as Components of Coatings
Sec. 175.320 Resinous and polymeric coatings for polyolefin films.


FDA PART 177 -- INDIRECT FOOD ADDITIVES: POLYMERS
Subpart B--Substances for Use as Basic Components of Single and Repeated Use Food Contact
Sec. 177.1390 Laminate structures for use at temperatures of 250 deg. F and above.


FDA PART 177 -- INDIRECT FOOD ADDITIVES: POLYMERS
Subpart C--Substances for Use Only as Components of Articles Intended for Repeated Use
Sec. 177.2420 Polyester resins, cross-linked.


FDA PART 180 -- FOOD ADDITIVES PERMITTED IN FOOD OR IN CONTACT WITH FOOD ON AN INTERIM BASIS PENDING ADDITIONAL STUDY
Subpart B--Specific Requirements for Certain Food Additives
Sec. 180.25 Mannitol.
 
Physical Properties:
Appearance:white crystalline powder (est)
Assay: 96.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 164.00 to 168.00 °C. @ 760.00 mm Hg
Boiling Point: 290.00 to 295.00 °C. @ 760.00 mm Hg
Flash Point: 558.00 °F. TCC ( 292.50 °C. ) (est)
logP (o/w): -3.262 (est)
Soluble in:
 acetic acid, slightly
 ethyl alcohol, vary slightly
 water, 216000 mg/L @ 25 °C (exp)
Insoluble in:
 ether
 
Organoleptic Properties:
Odor Type: odorless
Odor Description:at 100.00 %. odorless
Flavor Type: sweet
sweet
Taste Description: sweet
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: binding agents
fragrance
humectants
moisturising agents
skin conditioning
 
Suppliers:
Anhui Haibei
Mannito
BOC Sciences
For experimental / research use only.
D-Mannitol
Carbosynth
For experimental / research use only.
D-Mannitol
Cargill, Inc.
Mannidex® mannitol
Flavor: characteristic
Mannitol polyol sugar substitutes have very low hygroscopicity, provides bulk, texture and preservative benefits of sucrose in sugar-free and calorie-reduced products. Mannitol is suitable for dental health, weight management and sugar avoiders. Mannitol also has a cooling effect in the mouth.
Charkit Chemical
MANNITOL ACS
ECSA Chemicals
D-MANNITOL RPE-FOR ANALYSIS, G 250
ECSA TRADE THE MOST UPDATED FINANCIAL PUBLICATION ON THE WORLD OF CHEMISTRY
ECSA Chemicals
MANNITOL PH.EUR.(C*Pharm Mannidex 16700)
EMD Millipore
For experimental / research use only.
D(-)-Mannitol
sds
Farbest-Tallman Foods
Mannitol
Foodchem International
Mannitol
George Uhe Company
D-Mannitol
Glentham Life Sciences
D-Mannitol, EP, USP grade
Glentham Life Sciences
D-Mannitol
Indis NV
For experimental / research use only.
Mannitol
Kao Corporation
MANNITOL KAO (JP GRADE)
Odor: characteristic
Use: Sweetener: Masking agent for medicines giving cool and fresh sweetness, low calorie content sweetener.
Kraft Chemical
Mannitol
O'Laughlin Industries
MANNITOL
Penta International
MANNITOL GRANULAR USP
Penta International
MANNITOL POWDER USP
Pfanstiehl, Inc
D-Mannitol, High Purity Low Endotoxin USP, EP, JP, ChP
Odor: characteristic
Use: Mannitol is classified as a sugar alcohol and is derived from a sugar (mannose) by reduction. Other widely known polyols are xylitol and sorbitol. Mannitol and sorbitol are isomers, differing only in the orientation of the hydroxyl group on carbon two. The physical properties of mannitol make it suitable for use as a bulking agent in tableting. However, it also has unique chemical properties that enable it to stabilize a wide variety of pharmaceutical preparations, including liquid formulations, as well as protect proteins from denaturation/degradation upon lyophilization, spray drying, and reconstitution.
Prinova
Mannitol
Qingdao Dacon Trading
Mannitol Powder
Santa Cruz Biotechnology
For experimental / research use only.
D(-)Mannitol ≥98%
Sigma-Aldrich
For experimental / research use only.
D-Mannitol meets EP, FCC, USP testing specifications
Sinofi Food Ingredients
Mannitol
Flavor: characteristic
Sugar Substitutes, Chewing Gum, Confections, Spirit Drinks, Dried Fruit and Vegetables, Alcoholic Beverages, Texturizer, Humectant, Flavoring Agent, Lubricant, Release Agent, Bulking Agent, Anticaking Agent, Firming Agent.
TCI AMERICA
For experimental / research use only.
D-Mannitol >99.0%(T)
sds
United International
Mannitol Nat.
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 13500 mg/kg
Yakkyoku. Pharmacy. Vol. 32, Pg. 1367, 1981.

intravenous-rat LD50 9690 mg/kg
Yakkyoku. Pharmacy. Vol. 32, Pg. 1367, 1981.

oral-mouse LD50 22000 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE
FAO Nutrition Meetings Report Series. Vol. 40, Pg. 160, 1967.

intravenous-mouse LD50 7470 mg/kg
Yakkyoku. Pharmacy. Vol. 32, Pg. 1367, 1981.

intraperitoneal-mouse LD50 14000 mg/kg
Proceedings of the Society for Experimental Biology and Medicine. Vol. 35, Pg. 98, 1936.

intravenous-man TDLo 17143 mg/kg/2D
VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION GASTROINTESTINAL: NAUSEA OR VOMITING KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"
Archives of Internal Medicine. Vol. 144, Pg. 2053, 1984.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
sweeteners, humectants, texturizers, stabilizers, bulking agents
Recommendation for dextro-mannitol usage levels up to:
 not for fragrance use.
 
Recommendation for dextro-mannitol flavor usage levels up to:
 not for flavor use.
 
Safety References:
European Food Safety Authority (EFSA) reference(s):

Outcome of the public consultation on a draft protocol for assessing exposure to sweeteners as part of their safety assessment under the food additives re-evaluation programme
View page or View pdf

EPI System: View
ClinicalTrials.gov:search
Daily Med:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
Carcinogenic Potency Database:Search
EPA GENetic TOXicology:Search
EPA Substance Registry Services (TSCA):69-65-8
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :6251
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
(2R,3R,4R,5R)-hexane-1,2,3,4,5,6-hexol
Chemidplus:0000069658
EPA/NOAA CAMEO:hazardous materials
RTECS:OP2060000 for cas# 69-65-8
 
References:
 (2R,3R,4R,5R)-hexane-1,2,3,4,5,6-hexol
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:69-65-8
Pubchem (cid):6251
Pubchem (sid):134971672
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
CHEBI:View
CHEMBL:View
Golm Metabolome Database:Search
Metabolomics Database:Search
KEGG (GenomeNet):C00392
HMDB (The Human Metabolome Database):HMDB00765
FooDB:FDB001982
YMDB (Yeast Metabolome Database):YMDB00830
Export Tariff Code:2905.43.0000
FDA Listing of Food Additive Status:View
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
 binder in adhesives
FLflavor enhancers
 humectants
 
Occurrence (nature, food, other):note
 anise root
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 barley root
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 bay laurel root
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 buckthorn sea buckthorn fruit
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 caraway
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 celery leaf
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 celery plant
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 celery root
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 celery shoot
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 celery stem
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 cherry sour cherry fruit
Search Trop Picture
 chicory plant
Search Trop Picture
 cinnamon ceylon cinnamon plant
Search Trop Picture
 coriander fruit
Search Trop Picture
 cumin seed
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 dandelion root
Search Trop Picture
 leek wild leek plant
Search Trop Picture
 lettuce plant
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 not found in nature
 olive leaf
Search Trop Picture
 onion bulb
Search Trop Picture
 pomegranate leaf
Search Trop Picture
 pomegranate pericarp
Search Trop Picture
 pomegranate root
Search Trop Picture
 pomegranate seed
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 pomegranate stem
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 pomegranate stem bark
Search Trop Picture
 pomegranate twig
Search Trop Picture
 raspberry red raspberry fruit
Search Trop Picture
 
Synonyms:
 cordycepic acid
 cosmospheres GYAM-M
 diosmol
(2R,3R,4R,5R)-hexan-1,2,3,4,5,6-hexol
(2R,3R,4R,5R)-hexane-1,2,3,4,5,6-hexol
(2R,3R,4R,5R)-1,2,3,4,5,6-hexanehexol
 invenex
 isotol
 maniton S
 maniton-s
 manna sugar
 mannazucker
 mannidex
 mannigen
 mannisol
 mannistol
 mannit
D-mannit
 mannit p
D-mannitol
D(-)-mannitol
 mannitol granular USP
 mannitol powder USP
 mannogem 2080
 marine crystal
 mushroom sugar
 osmitrol
 osmofundin
 osmosal
 resectisol
 rightsweet mannitol
 

Articles:

PubMed:Construction of an efficient Escherichia coli whole-cell biocatalyst for d-mannitol production.
PubMed:[Determination of alditols in foods by ion chromatography-mass spectrometry].
PubMed:Solution behaviour and sweetness response of D-Mannitol at different temperatures.
PubMed:[Production of D-mannitol by metabolically engineered Escherichia coli].
PubMed:[Determination of alditols in wine by gas chromatography-mass spectrometry after acetate derivatization].
PubMed:Characterization of plant-derived lactococci on the basis of their volatile compounds profile when grown in milk.
PubMed:Engineering of photosynthetic mannitol biosynthesis from CO2 in a cyanobacterium.
PubMed:[Method of quantitative analysis by HPLC and confirmation by LC-MS of sugar alcohols in foods].
PubMed:Differential trafficking of saccharidic probes following aspirin in clinical tests of intestinal permeability in young healthy women.
PubMed:Signaling specificity provided by the Arabidopsis thaliana heterotrimeric G-protein γ subunits AGG1 and AGG2 is partially but not exclusively provided through transcriptional regulation.
PubMed:Enhancing the sensitivity of the comet assay as a genotoxicity test, by combining it with bacterial repair enzyme FPG.
PubMed:Production of the α-glycosidase inhibitor 1-deoxynojirimycin from Bacillus species.
PubMed:Soy-derived di- and tripeptides alleviate colon and ileum inflammation in pigs with dextran sodium sulfate-induced colitis.
PubMed:An international validation study of a Bhas 42 cell transformation assay for the prediction of chemical carcinogenicity.
PubMed:Risperidone solid dispersion for orally disintegrating tablet: its formulation design and non-destructive methods of evaluation.
PubMed:Structural characterization of laminaran and galactofucan extracted from the brown seaweed Saccharina longicruris.
PubMed:Effect of D-mannitol on feed digestion and cecotrophic system in rabbits.
PubMed:Correlation of mannitol fermentation with virulence-associated genotypic characteristics in Vibrio vulnificus isolates from oysters and water samples in the Gulf of Mexico.
PubMed:l-Tryptophan exhibits therapeutic function in a porcine model of dextran sodium sulfate (DSS)-induced colitis.
PubMed:Syntheses of dopa glycosides using glucosidases.
PubMed:Inhibitory action of palatinose and its hydrogenated derivatives on the hydrolysis of alpha-glucosylsaccharides in the small intestine.
PubMed:Lactobacillus ghanensis sp. nov., a motile lactic acid bacterium isolated from Ghanaian cocoa fermentations.
PubMed:Generation of antibodies specific to D-mannitol, a unique haptenic allergen, using reductively aminated D-mannose-bovine serum albumin conjugate as the immunogen.
PubMed:Amyloglucosidase-catalyzed synthesis of eugenyl and curcuminyl glycosides.
PubMed:[Isolation and identification of a bacterial strain JS018 capable of degrading several kinds of organophosphate pesticides].
PubMed:Glycosides and amino acyl esters of carbohydrates as potent inhibitors of angiotensin converting enzyme.
PubMed:Antioxidant activity of Myristica malabarica extracts and their constituents.
PubMed:Embryotoxic effects of CKD-602, a new camptothecin anticancer agent, in rats.
PubMed:Inhibitors of carbohydrate metabolism reduce undirected song production at doses that do not alter food intake in singly housed male zebra finches.
PubMed:Anaphylaxis to excipient mannitol: evidence for an immunoglobulin E-mediated mechanism.
PubMed:Evaluation of the Xpa-deficient transgenic mouse model for short-term carcinogenicity testing: 9-month studies with haloperidol, reserpine, phenacetin, and D-mannitol.
PubMed:Etomoxir, a fatty acid oxidation inhibitor, increases food intake and reduces hepatic energy status in rats.
PubMed:Scale-up of a new bacterial mannitol production process.
PubMed:Staphylococcus equorum subsp. linens, subsp. nov., a starter culture component for surface ripened semi-hard cheeses.
PubMed:Inhibition of diphenolase activity of tyrosinase by vitamin b(6) compounds.
PubMed:Age- and diet-related increase in transepithelial colon permeability of Fischer 344 rats.
PubMed:Examining the relative timing of hydrogen abstraction steps during NAD(+)-dependent oxidation of secondary alcohols catalyzed by long-chain D-mannitol dehydrogenase from Pseudomonas fluorescens using pH and kinetic isotope effects.
PubMed:Interactions of dietary fat and 2,5-anhydro-D-mannitol on energy metabolism in isolated rat hepatocytes.
PubMed:High-fat diet prevents eating response and attenuates liver ATP decline in rats given 2,5-anhydro-D-mannitol.
PubMed:Hydrogenation of fructose on Ru/C catalysts.
PubMed:Determination of sugar alcohols in confectioneries by high-performance liquid chromatography after nitrobenzoylation.
PubMed:Differentiation of Tetragenococcus populations occurring in products and manufacturing processes of puffer fish ovaries fermented with rice-bran.
PubMed:Metabolic inhibitors synergistically decrease hepatic energy status and increase food intake.
PubMed:Kinetic study of the catalytic mechanism of mannitol dehydrogenase from Pseudomonas fluorescens.
PubMed:Liquid chromatographic determination of sugar alcohols in beverages and foods after nitrobenzoylation.
PubMed:Neural substrate for an integrated metabolic control of feeding behavior.
PubMed:Brain fos-like immunoreactivity in chronic decerebrate and neurologically intact rats given 2,5-anhydro-D-mannitol.
PubMed:Metabolic inhibition increases feeding and brain Fos-like immunoreactivity as a function of diet.
PubMed:Hyperpolarization of the rat hepatocyte membrane by 2,5-anhydro-D-mannitol in vivo.
PubMed:Temporal relationships between eating behavior and liver adenine nucleotides in rats treated with 2,5-AM.
PubMed:2,5-Anhydro-D-mannitol induces Fos-like immunoreactivity in hindbrain and forebrain: relationship to eating behavior.
PubMed:Effects of the fructose analog, 2,5-anhydro-D-mannitol, on food intake and estrous cyclicity in Syrian hamsters.
PubMed:Hyperpolarization of hepatocytes by 2,5-AM: implications for hepatic control of food intake.
PubMed:Intraportal infusion of 2,5-anhydro-D-mannitol increases afferent activity in the common hepatic vagus branch.
PubMed:Glucoprivation attenuates the hypophagia induced by epinephrine in mice.
PubMed:Influnce of oat saponins on intestinal permeability in vitro and in vivo in the rat.
PubMed:Fatty acid oxidation modulates the eating response to the fructose analogue 2,5-anhydro-D-mannitol.
PubMed:A comparison of the effects of food deprivation and 2,5-anhydro-D-mannitol on metabolism and ingestion.
PubMed:Regulation of food intake by metabolic fuels in white-crowned sparrows.
PubMed:Whole body energy expenditure and fuel oxidation after 2,5-anhydro-D-mannitol administration.
PubMed:L-ethionine, an amino acid analogue, stimulates eating in rats.
PubMed:Phosphate loading prevents the decrease in ATP and increase in food intake produced by 2,5-anhydro-D-mannitol.
PubMed:Induction of Fos-like immunoreactivity (Fos-li) and stimulation of feeding by 2,5-anhydro-D-mannitol (2,5-AM) require the vagus nerve.
PubMed:Increased feeding after treatment with fructose, but not glucose, antimetabolites in rats with dopamine-depleting brain lesions.
PubMed:Insulin and IGE-1 receptors in a human intestinal adenocarcinoma cell line (CACO-2): regulation of Na+ glucose transport across the brush border.
PubMed:Feeding modulation by pentose and hexose analogues.
PubMed:2,5-Anhydro-D-mannitol: its unique central action on food intake and blood glucose in rats.
PubMed:2,5-anhydro-D-mannitol acts in liver to initiate feeding.
PubMed:Acetaldehyde stimulation of net gluconeogenic carbon movement from applied malic Acid in tomato fruit pericarp tissue.
PubMed:DNA damage by smoke: protection by turmeric and other inhibitors of ROS.
PubMed:Plasma osmolality predicts extracellular fluid catechol concentrations in the lateral hypothalamus.
PubMed:A selective and diagnostic medium for use in the enumeration of Listeria spp. in foods.
PubMed:2,5-anhydro-D-mannitol: a fructose analogue that increases food intake in rats.
PubMed:Fasting and refeeding modulate neutral amino acid transport activity in the basolateral membrane of the rat exocrine pancreatic epithelium: fasting-induced insulin insensitivity.
PubMed:No evidence of carcinogenicity of D-mannitol and propyl gallate in F344 rats or B6C3F1 mice.
PubMed:Vibrio furnissii (formerly aerogenic biogroup of Vibrio fluvialis), a new species isolated from human feces and the environment.
PubMed:Bioavailability of glucose from Palatinit.
PubMed:Absence of carcinogenic response in F344 rats and B6C3F1 mice given D-mannitol in the diet for two years.
PubMed:Carcinogenesis Bioassay of D-Mannitol (CAS No. 69-65-8) in F344/N Rats and B6C3F1 Mice (Feed Study).
PubMed:Atypical biogroups of Escherichia coli found in clinical specimens and description of Escherichia hermannii sp. nov.
PubMed:Detection and growth of enteropathogenic Escherichia coli in soft ripened cheese.
 
Notes:
a diuretic and renal diagnostic aid related to sorbitol. it has little significant energy value as it is largely eliminated from the body before any metabolism can take place. it can be used to treat oliguria associated with kidney failure or other manifestations of inadequate renal function and has been used for determination of glomerular filtration rate. mannitol is also commonly used as a research tool in cell biological studies, usually to control osmolarity. Permitted bulk sweetener for foods. Sweetening agent. Food additive, used as anticaking agent, lubricant, for stabiliser and thickener, and for other uses in food processing A diuretic and renal diagnostic aid related to sorbitol. It has little significant energy value as it is largely eliminated from the body before any metabolism can take place. It can be used to treat oliguria associated with kidney failure or other manifestations of inadequate renal function and has been used for determination of glomerular filtration rate. Mannitol is also commonly used as a research tool in cell biological studies, usually to control osmolarity.; Chemically, mannitol is an alcohol and a sugar, or a polyol; Mannitol is a non-permeating molecule i.e. it cannot cross biological membranes.; Mannitol is a sugar alcohol, that is, it is derived from a sugar by reduction. Other sugar alcohols include xylitol and sorbitol. Aqueous solutions of mannitol are mildly acidic and sometimes such solutions are treated to raise the pH. Chemical Abstracts Registry Numbers for mannitol are 123897-58-5, 69-65-8 (D-Mannitol), 75398-80-0, 85085-15-0, and 87-78-5 (mannitol with unspecified stereochemistry).; Mannitol is an organic compound with the formula (C6H8(OH)6). This polyol is used as an osmotic diuretic agent and a weak renal vasodilator. It was originally isolated from the secretions of the flowering ash, called manna after their resemblance to the Biblical food, and is also be referred to as mannite and manna sugar.; Mannitol or hexan-1,2,3,4,5,6-hexol (C6H8(OH)6) is an osmotic diuretic agent and a weak renal vasodilator. It is a sorbitol isomer.; it is similar to xylitol or sorbitol. However, mannitol has a tendency to lose a hydrogen ion in aqueous solutions, which causes the solution to become acidic. For this, it is not uncommon to add a substance to adjust its pH, such as sodium bicarbonate.
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