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 Category:cosmetic ingredient for skin conditioning 
  
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information: 
  
Physical Properties: 
| Food Chemicals Codex Listed:  | No |  
 
  
Organoleptic Properties: 
| Odor and/or flavor descriptions from others (if found). |  
 
  
Cosmetic Information: 
  
Suppliers: 
  
Safety Information: 
|   |  
| Hazards identification |  
|   |  
|  Classification of the substance or mixture |  
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |  
| None found. |  
|  GHS Label elements, including precautionary statements |  
|   |  
| Pictogram |  |  
|   |  
                                                                     
| Hazard statement(s) |  
| None found. |  
| Precautionary statement(s) |  
| None found. |  
| Oral/Parenteral Toxicity:  |  
| 
Not determined
 |  
| Dermal Toxicity:  |  
| 
Not determined
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| Inhalation Toxicity:  |  
| 
Not determined
 |  
 
  
Safety in Use Information: 
| Category:  |  | cosmetic ingredient for skin conditioning |  
| Recommendation for tabebuia avellanedae bark powder usage levels up to:  |  |   | not for fragrance use.
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|   |  
| Recommendation for tabebuia avellanedae bark powder flavor usage levels up to:  |  
|   | not for flavor use.
 |  
 
  
Safety References: 
  
References: 
  
Other Information: 
  
Potential Blenders and core components  note 
  
Potential Uses: 
  
Occurrence (nature, food, other): note 
  
Synonyms: 
|   | pau D’arco |  |   | pau d’arco bark powder |  |   | powder obtained from the dried, ground bark of tabebuia avellanedae, bignoniaceae |  
 
  
Articles:
| PubMed:Downregulation of Sp1 is involved in β-lapachone-induced cell cycle arrest and apoptosis in oral squamous cell carcinoma. |  
| PubMed:Melanogenesis inhibition of β-lapachone, a natural product from Tabebuia avellanedae, with effective in vivo lightening potency. |  
| PubMed:Sulindac compounds facilitate the cytotoxicity of β-lapachone by up-regulation of NAD(P)H quinone oxidoreductase in human lung cancer cells. |  
| PubMed:NMDA receptors and the L-arginine-nitric oxide-cyclic guanosine monophosphate pathway are implicated in the antidepressant-like action of the ethanolic extract from Tabebuia avellanedae in mice. |  
| PubMed:Larvicidal activity of the active constituent isolated from Tabebuia avellanedae bark and structurally related derivatives against three mosquito species. |  
| PubMed:Bioactive phenylpropanoid glycosides from Tabebuia avellanedae. |  
| PubMed:Comparative metabolism study of β-lapachone in mouse, rat, dog, monkey, and human liver microsomes using liquid chromatography-tandem mass spectrometry. |  
| PubMed:Antidepressant-like action of the bark ethanolic extract from Tabebuia avellanedae in the olfactory bulbectomized mice. |  
| PubMed:β-Lapachone ameliorization of experimental autoimmune encephalomyelitis. |  
| PubMed:Antiulcer effect of bark extract of Tabebuia avellanedae: activation of cell proliferation in gastric mucosa during the healing process. |  
| PubMed:Analgesic and anti-inflammatory effects in animal models of an ethanolic extract of Taheebo, the inner bark of Tabebuia avellanedae. |  
| PubMed:Synthesis and evaluation of bioactive naphthoquinones from the Brazilian medicinal plant, Tabebuia avellanedae. |  
| PubMed:Red Lapacho (Tabebuia impetiginosa)--a global ethnopharmacological commodity? |  
| PubMed:In vitro and in vivo wound healing-promoting activities of beta-lapachone. |  
| PubMed:In vitro and in vivo anti-inflammatory effects of taheebo, a water extract from the inner bark of Tabebuia avellanedae. |  
| PubMed:Antiulcerogenic activity of bark extract of Tabebuia avellanedae, Lorentz ex Griseb. |  
| PubMed:Comparative studies of the effects of Tabebuia avellanedae bark extract and beta-lapachone on the hematopoietic response of tumour-bearing mice. |  
| PubMed:Tabebuia avellanedae extracts inhibit IL-2-independent T-lymphocyte activation and proliferation. |  
| PubMed:Induction of Egr-1 is associated with anti-metastatic and anti-invasive ability of beta-lapachone in human hepatocarcinoma cells. |  
| PubMed:Beta-lapachone, a quinone isolated from Tabebuia avellanedae, induces apoptosis in HepG2 hepatoma cell line through induction of Bax and activation of caspase. |  
| PubMed:beta-lapachone induces growth inhibition and apoptosis in bladder cancer cells by modulation of Bcl-2 family and activation of caspases. |  
| PubMed:Nitric oxide (NO) production inhibitory constituents of Tabebuia avellanedae from Brazil. |  
| PubMed:Growth inhibition of A549 human lung carcinoma cells by beta-lapachone through induction of apoptosis and inhibition of telomerase activity. |  
| PubMed:beta-Lapachone-induced apoptosis is associated with activation of caspase-3 and inactivation of NF-kappaB in human colon cancer HCT-116 cells. |  
| PubMed:Antinociceptive and antiedematogenic properties and acute toxicity of Tabebuia avellanedae Lor. ex Griseb. inner bark aqueous extract. |  
| PubMed:[Antitumoral and toxicological properties of extracts of bark and various wood components of Pau d'arco (Tabebuia avellanedae)]. |  
 
  
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