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symphytum officinale root extract
extract of the roots of the comfrey, symphytum officinale l., boraginaceae

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CAS Number: 84696-05-9
ECHA EC Number:283-625-3
Category:antidandruff agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Physical Properties:
Food Chemicals Codex Listed: No
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: antidandruff agents
skin conditioning
soothing agents
Comfrey Root Symphytum Officinale Root Extract
Grau Aromatics
Grau Aromatics
SRS Aromatics
SRS Aromatics
Vege Tech
Organic Comfrey Root Extract
Safety Information:
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Safety in Use Information:
antidandruff agents
Recommendation for symphytum officinale root extract usage levels up to:
 not for fragrance use.
Recommendation for symphytum officinale root extract flavor usage levels up to:
 not for flavor use.
Safety References:
European Food Safety Authority (EFSA) reference(s):

Outcome of the consultation with Member States and EFSA on the basic substance application for approval of Comfrey steeping to be used in plant protection as an insect repellent and plant elicitor in fruit trees, grass and vegetables
View page or View pdf

Daily Med:search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
National Institute of Allergy and Infectious Diseases:Data
symphytum officinale root extract
 symphytum officinale root extract
Pubchem (sid):135307585
Other Information:
Potential Blenders and core components note
None Found
Potential Uses:
None Found
Occurrence (nature, food, other):note
Search Trop Picture
 comfrey root extract
quaker comfrey root extract
 extract of the roots of the comfrey, symphytum officinale l., boraginaceae
 symphytum officinalis root extract


PubMed:Comparative Study of the Biological Activity of Allantoin and Aqueous Extract of the Comfrey Root.
PubMed:Herbal medicine for low-back pain.
PubMed:TLC densitometric method for screening of lycopsamine in comfrey root (Symphytum officinale L.) extracts using retrorsine as a reference compound.
PubMed:Semi-automated separation of the epimeric dehydropyrrolizidine alkaloids lycopsamine and intermedine: preparation of their N-oxides and NMR comparison with diastereoisomeric rinderine and echinatine.
PubMed:Comfrey root: from tradition to modern clinical trials.
PubMed:Distinct cell-specific expression of homospermidine synthase involved in pyrrolizidine alkaloid biosynthesis in three species of the boraginales.
PubMed:Effect of a blend of comfrey root extract (Symphytum officinale L.) and tannic acid creams in the treatment of osteoarthritis of the knee: randomized, placebo-controlled, double-blind, multiclinical trials.
PubMed:MicroRNAs and their predicted target messenger RNAs are deregulated by exposure to a carcinogenic dose of comfrey in rat liver.
PubMed:Absence of mutagenic effects of a particular Symphytum officinale L. liquid extract in the bacterial reverse mutation assay.
PubMed:Lead chelation to immobilised Symphytum officinale L. (comfrey) root tannins.
PubMed:Comparison of gene expression profiles altered by comfrey and riddelliine in rat liver.
PubMed:Assays of physical stability and antioxidant activity of a topical formulation added with different plant extracts.
PubMed:Efficacy and tolerance of a comfrey root extract (Extr. Rad. Symphyti) in the treatment of ankle distorsions: results of a multicenter, randomized, placebo-controlled, double-blind study.
PubMed:A rapid cleanup method for the isolation and concentration of pyrrolizidine alkaloids in comfrey root.
PubMed:The influence of phytohormones on growth, organ differentiation and fructan production in callus of Symphytum officinale L.
PubMed:Mutagenic effects of aqueous extracts of Symphytum officinale L. and of its alkaloidal fractions.
PubMed:[Development of root-layers of symphytum officinale L. and their storage and consumption of carbohydrates].
PubMed:[Annual developmental cycle of roots and shoots in Symphytum officinale L. in relation to storage and consumption of carbohydrates].
PubMed:Comfrey (Symphytum officinale L.) root; its anatomy and its detection in admixture with chicory in dandelion coffee.
perennial herb symphytum officinale, in the family boraginaceae, used topically for wound healing. it contains allantoin, carotene, essential oils ( oils, volatile); glycosides; mucilage, resin, saponins; tannins; triterpenoids, vitamin b12, and zinc. comfrey also contains pyrrolizidine alkaloids and is hepatotoxic if ingested.
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