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Category:natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Soluble in: |
| | water, 2281 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
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| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
|
Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
|
Not determined
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Safety in Use Information:
| Category: | | natural substances and extractives |
| Recommendation for Isoacteoside usage levels up to: | | | not for fragrance use.
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| |
| Recommendation for Isoacteoside flavor usage levels up to: |
| | not for flavor use.
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Safety References:
| EPI System: View |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :6476333 |
| National Institute of Allergy and Infectious Diseases:Data |
| [(2R,3R,4S,5R,6R)-6-[2-(3,4-dihydroxyphenyl)ethoxy]-3,5-dihydroxy-4-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]methyl (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate |
| Chemidplus:0061303137 |
References:
| | [(2R,3R,4S,5R,6R)-6-[2-(3,4-dihydroxyphenyl)ethoxy]-3,5-dihydroxy-4-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]methyl (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 6476333 |
| Pubchem (cas): | 61303-13-7 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| [(2R,3R,4S,5R,6R)-6-[2-(3,4- | dihydroxyphenyl)ethoxy]-3,5-dihydroxy-4-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]methyl (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate | | beta-D- | glucopyranoside, 2-(3,4-dihydroxyphenyl)ethyl 3-O-(6-deoxy-alpha-L-mannopyranosyl)-, 6-(3-(3,4-dihydroxyphenyl)-2-propenoate), (E)- |
Articles:
| PubMed:Isoacteoside, a dihydroxyphenylethyl glycoside, exhibits anti-inflammatory effects through blocking toll-like receptor 4 dimerization |
| PubMed:Acteoside and Isoacteoside Protect Amyloid ? Peptide Induced Cytotoxicity, Cognitive Deficit and Neurochemical Disturbances In Vitro and In Vivo |
| PubMed:Anti-inflammatory effects of isoacteoside from Abeliophyllum distichum |
| PubMed:Suppression of in vitro and in vivo human ovarian cancer growth by isoacteoside is mediated via sub-G1 cell cycle arrest, ROS generation, and modulation of AKT/PI3K/m-TOR signalling pathway |
| PubMed:Simultaneous determination of savaside A, acteoside, and isoacteoside in rat plasma by UHPLC-MS/MS: Comparative pharmacokinetic and bioavailability characteristics of Monochasma savatieri via different routes of administra |
| PubMed:A metabolic way to investigate related hurdles causing poor bioavailability in oral delivery of isoacteoside in rats employing ultrahigh-performance liquid chromatography/quadrupole time-of-flight tandem mass spectrometry |
| PubMed:Isolation and purification of acteoside and isoacteoside from Plantago psyllium L. by high-speed counter-current chromatography |
| PubMed:Antioxidant activity of isoacteoside from Clerodendron trichotomum |
| PubMed:Inhibitory activities of acteoside, isoacteoside, and its structural constituents against protein glycation in vitro |
| PubMed:Antioxidant activity of phenylethanoid glycosides on glutamate-induced neurotoxicity |
| PubMed:Medicinal plants with concomitant anti-diabetic and anti-hypertensive effects as potential sources of dual acting therapies against diabetes and hypertension: A review |
| PubMed:Two-phase hollow fiber liquid phase microextraction based on magnetofluid for simultaneous determination of Echinacoside, Tubuloside B, Acteoside and Isoacteoside in rat plasma after oral administration of Cistanche salsa |
| PubMed:Acteoside and Acyl-Migrated Acteoside, Compounds in Chinese Kudingcha Tea, Inhibit à-Amylase In Vitro |
| PubMed:Enzyme inhibitory assessment of the isolated constituents from Plantago holosteum Scop |
| PubMed:A new macrocyclic diterpenoid from Anisomeles indica |
| PubMed:Isoacteoside attenuates acute kidney injury induced by severe acute pancreatitis |
| PubMed:UPLC-QTOF-MS/MS screening and identification of bioactive compounds in fresh, aged, and browned Magnolia denudata flower extracts |
| PubMed:Computational Determination of Potential Inhibitors of SARS-CoV-2 Main Protease |
| PubMed:[Chemome profiling and comparison of three Orobanche medicinal plants] |
| PubMed:Antineoplastic agents, 107. Isolation of acteoside and isoacteoside from Castilleja linariaefolia |
| PubMed:Screening and identification of three typical phenylethanoid glycosides metabolites from Cistanches Herba by human intestinal bacteria using UPLC/Q-TOF-MS |
| PubMed:Active compounds isolated from Plantago subulata L. via wound healing and antiinflammatory activity guided studies |
| PubMed:Cistanches Herba: An overview of its chemistry, pharmacology, and pharmacokinetics property |
| PubMed:Quality Assessment of Commercial Spagyric Tinctures of Harpagophytum procumbens and Their Antioxidant Properties |
| PubMed:[Comparative studies of three Cistanche speices based on UPLC specific chromatogram and determination of main components] |
| PubMed:Antioxidative activities of phenylethanoid glycosides from Ligustrum purpurascens |
| PubMed:Bioactivity, Compounds Isolated, Chemical Qualitative, and Quantitative Analysis of Cymbaria daurica Extracts |
| PubMed:Fixed oil from seeds of narrow-leaved ash (F. angustifolia subsp. angustifolia): Chemical profile, antioxidant and antiproliferative activities |
| PubMed:Biosynthesis of acteoside in cultured cells of Olea europaea |
| PubMed:Antioxidant Activity, Enzyme Inhibition Potentials, and Phytochemical Profiling of Premna serratifolia L. Leaf Extracts |
| PubMed:The Difference of Chemical Components and Biological Activities of the Raw Products slices and the Wine Steam-Processed Product from Cistanche deserticola |
| PubMed:Simultaneous Quantification of Four Phenylethanoid Glycosides in Rat Plasma by UPLC-MS/MS and Its Application to a Pharmacokinetic Study of Acanthus Ilicifolius Herb |
| PubMed:Antiproliferative constituents in the plants 7. Leaves of Clerodendron bungei and leaves and bark of C. trichotomum |
| PubMed:Extract of Plantago asiatica L. Seeds Ameliorates Hypertension in Spontaneously Hypertensive Rats by Inhibition of Angiotensin Converting Enzyme |
| PubMed:Acylated phenylethanoid oligoglycosides with hepatoprotective activity from the desert plant Cistanche tubulosa |
| PubMed:The influence of light quality on the production of bioactive metabolites - verbascoside, isoverbascoside and phenolic acids and the content of photosynthetic pigments in biomass of Verbena officinalis L. cultured in vitro |
| PubMed:In-silico prediction of potential inhibitors against phosphatidylinositol 3-kinase catalytic subunit alpha involved in head and neck squamous cell carcinomas |
| PubMed:Simultaneous quantification of five bioactive phenylethanoid, iridoid, and flavonol glycosides in Duranta erecta L.: Ultra performance liquid chromatography method validation and uncertainty measurement |
| PubMed:Production of Verbascoside, Isoverbascoside and Phenolic Acids in Callus, Suspension, and Bioreactor Cultures of Verbena officinalis and Biological Properties of Biomass Extracts |
| PubMed:Xanthine oxidase inhibitors from Brandisia hancei |
| PubMed:Effect of phenylethanoid glycosides and polysaccharides from the seed of Plantago asiatica L. on the maturation of murine bone marrow-derived dendritic cells |
| PubMed:Caffeoylated phenylpropanoid glycosides from Brandisia hancei inhibit advanced glycation end product formation and aldose reductase in vitro and vessel dilation in larval zebrafish in vivo |
| PubMed:Simultaneous quantification of six phenylethanoid glycosides in some Turkish Scutellaria species by a new HPLC-DAD method |
| PubMed:Neuroprotective Effects of Four Phenylethanoid Glycosides on H?O?-Induced Apoptosis on PC12 Cells via the Nrf2/ARE Pathway |
| PubMed:Phenylpropanoids from the stem bark of Jacaranda mimosaefolia |
| PubMed:Phenylethanoid and flavone glycosides from Ruellia tuberosa L |
| PubMed:Seasonal variation in the chemical composition of two chemotypes of Lippia alba |
| PubMed:Cholinesterase inhibitors from the roots of Harpagophytum procumbens |
| PubMed:Antigout Effects of Plantago asiatica: Xanthine Oxidase Inhibitory Activities Assessed by Electrochemical Biosensing Method |
| PubMed:Phenylpropanoid glycosides from Orobanche caerulescens |
| PubMed:On-line HPLC-DPPH bioactivity-guided assay for isolated of antioxidative phenylpropanoids from Qinghai-Tibet Plateau medicinal plant Lancea tibetica |
| PubMed:Iridoid glycosides from Globularia davisiana |
| PubMed:Plant-derived verbascoside and isoverbascoside regulate Toll-like receptor 2 and 4-driven neutrophils priming and activation |
| PubMed:Antioxidant principles from Bauhinia tarapotensis |
| PubMed:Iridoid, phenylethanoid and flavonoid glycosides from Sideritis trojana |
| PubMed:Layer-by-layer assembly strategy for fabrication of polydopamine-polyethyleneimine hybrid modified fibers and their application to solid-phase microextraction of bioactive molecules from medicinal plant samples followed by |
| PubMed:Separation of phenylpropanoid glycosides from a Chinese herb by HSCCC |
| PubMed:Iridoid glycosides from Globularia trichosantha |
| PubMed:Chemical characterization and biological activity in young sesame leaves (Sesamum indicum L.) and changes in iridoid and polyphenol content at different growth stages |
| PubMed:A Novel HPLC Method for Direct Detection of Nitric Oxide Scavengers from Complex Plant Matrices and Its Application to Aloysia triphylla Leaves |
| PubMed:Anti-inflammatory phenylpropanoid glycosides from Clerodendron trichotomum leaves |
| PubMed:Degradation of phenylethanoid glycosides in Osmanthus fragrans Lour. flowers and its effect on anti-hypoxia activity |
| PubMed:[Caffeoyl phenylethanoid glycosides from Callicarpa kwangtungensis] |
| PubMed:Antiproliferative constituents in plants 9. Aerial parts of Lippia dulcis and Lippia canescens |
| PubMed:Phenylethanoid Glycoside Profiles and Antioxidant Activities of Osmanthus fragrans Lour. Flowers by UPLC/PDA/MS and Simulated Digestion Model |
| PubMed:Amphipaniculosides A-D, triterpenoid glycosides, and amphipaniculoside E, an aliphatic alcohol glycoside from the leaves of Amphilophium paniculatum |
| PubMed:Antihepatotoxic activity and chemical constituents of Buddleja asiatica Lour |
| PubMed:Phenylpropanoid glycosides from the leaves of Paulownia coreana |
| PubMed:Pro-oxidative action of polyphenols as action mechanism for their pro-apoptotic activity |
| PubMed:[Chemical Constitutes from Seeds of Plantago asiatica] |
| PubMed:Phenylethanoid and iridoid glycosides from Veronica persica |
| PubMed:Alteration of Neutrophil Reactive Oxygen Species Production by Extracts of Devil's Claw (Harpagophytum) |
| PubMed:Rational quality assessment procedure for less-investigated herbal medicines: Case of a Congolese antimalarial drug with an analytical report |
| PubMed:Antiradical activity of Paulownia tomentosa (Scrophulariaceae) extracts |
| PubMed:Acylated phenylethanoid glycosides, echinacoside and acteoside from Cistanche tubulosa, improve glucose tolerance in mice |
| PubMed:Antioxidant phenylethanoid glycosides and a neolignan from Jacaranda caucana |
| PubMed:Evaluation of anticandidal and antioxidant activities of phenolic compounds from Pyrostegia venusta (Ker Gawl.) Miers |
| PubMed:The Osmanthus fragrans flower phenylethanoid glycoside-rich extract: Acute and subchronic toxicity studies |
| PubMed:Convenient TLC-based Identification Test for the Crude Drug "Pogostemoni Herba" |
| PubMed:Identification of bioactive ingredients with immuno-enhancement and anti-oxidative effects from Fufang-Ejiao-Syrup by LC-MS(n) combined with bioassays |
| PubMed:Analysis of the inhibitory activity of Abeliophyllum distichum leaf constituents against aldose reductase by using high-speed counter current chromatography |
| PubMed:Three new flavonoid glycosides, byzantionoside B 6'-O-sulfate and xyloglucoside of (Z)-hex-3-en-1-ol from Ruellia patula |
| PubMed:Identification of major metal complexing compounds in Blepharis aspera |
| PubMed:Preparative isolation and purification of four compounds from Cistanches deserticola Y.C. Ma by high-speed counter-current chromatography |
| PubMed:The antioxidant activity and thermal stability of lemon verbena (Aloysia triphylla) infusion |
| PubMed:Diterpenoids and phenylethanoid glycosides from the roots of Clerodendrum bungei and their inhibitory effects against angiotensin converting enzyme and à-glucosidase |
| PubMed:Verbascoside, isoverbascoside, and their derivatives recovered from olive mill wastewater as possible food antioxidants |
| PubMed:Bioguided isolation of angiotensin-converting enzyme inhibitors from the seeds of Plantago asiatica L |
| PubMed:[Isolation and characterization of phenylethanoid glycosides from Clerodendron bungei] |
| PubMed:[Effects of phenylethanoid glycosides from seeds of Plantago asiatica on maturation of dendritic cells] |
| PubMed:Changes in Levels of Phenylethanoid Glycosides, Antioxidant Activity, and Other Quality Traits in Cistanche deserticola Slices by Steam Processing |
| PubMed:New metabolites of acteoside identified by ultra-performance liquid chromatography/quadrupole-time-of-flight MS(E) in rat plasma, urine, and feces |
| PubMed:Hepatoprotective activity of phenylethanoids from Cistanche deserticola |
| PubMed:Phenylpropanoid and iridoid glycosides from Pedicularis striata |
| PubMed:Phenylpropanoid glycosides from Scrophularia scorodonia: in vitro anti-inflammatory activity |
| PubMed:Preparation and physicochemical characterization of Ag nanoparticles biosynthesized by Lippia citriodora (Lemon Verbena) |
| PubMed:UPLC-ESI-Q-TOF-MS-Based Metabolite Profiling, Antioxidant and Anti-Inflammatory Properties of Different Organ Extracts of Abeliophyllum distichum |
| PubMed:Immunosuppressive principles of Rehmannia glutinosa var. hueichingensis |
| PubMed:Induction of differentiation in human hepatocarcinoma cells by isoverbascoside |
| PubMed:In vitro neuroprotective activities of phenylethanoid glycosides from Callicarpa dichotoma |
| PubMed:Immunosuppressive Principles of Rehmannia glutinosa var. hueichingensis1 |
| PubMed:Isolation and purification of phenylethanoid glycosides from Cistanche deserticola by high-speed counter-current chromatography |
| PubMed:[Chemical Constituents from Leaves of Acanthus ilicifolius and Their Anti-influenza Virus Activities] |
| PubMed:Antioxidative effects of phenylethanoids from Cistanche deserticola |
| PubMed:New Bisabolane-Type Sesquiterpenes from the Aerial Parts of Lippia dulcis |
| PubMed:Evaluation of the intestinal transport of a phenylethanoid glycoside-rich extract from Cistanche deserticola across the Caco-2 cell monolayer model |
| PubMed:Chemical constituents of Acanthus ilicifolius L. and effect on osteoblastic MC3T3E1 cells |
| PubMed:Antioxidant constituents of the aerial parts of Globularia alypum growing in Morocco |
| PubMed:Caffeic Acid Derivatives from Bacopa monniera Plants as Inhibitors of Pancreatic Lipase Activity and their Structural Requirements |
| PubMed:Antispasmodic activity of an extract from Plantago lanceolata L. and some isolated compounds |
| PubMed:[Identification of Chinese Traditional Medicine Cistanches Herba from Different Places by HPLC-ESI-MS and FTIR Methods] |
| PubMed:Four glycosides from the leaves of Abeliophyllum distichum with inhibitory effects on angiotensin converting enzyme |
| PubMed:Integrated Strategy Drives Direct Infusion-Tandem Mass Spectrometry as an Eligible Tool for Shotgun Pseudo-Targeted Metabolomics of Medicinal Plants |
| PubMed:Gastroprotection as an example: antiadhesion against Helicobacter pylori, anti-inflammatory and antioxidant activities of aqueous extracts from the aerial parts of Lippia integrifolia Hieron |
| PubMed:[Structure-activity relationships of phenylethanoid glycosides in plants of Cistanche salsa on antioxidative activity] |
| PubMed:Comparative analysis of three Callicarpa herbs using high performance liquid chromatography with diode array detector and electrospray ionization-trap mass spectrometry method |
| PubMed:Verbascosides from olive mill waste water: assessment of their bioaccessibility and intestinal uptake using an in vitro digestion/Caco-2 model system |
| PubMed:Inhibition of nitric oxide by phenylethanoids in activated macrophages |
| PubMed:Acteoside and 6-O-acetylacteoside downregulate cell adhesion molecules induced by IL-1beta through inhibition of ERK and JNK in human vascular endothelial cells |
| PubMed:[Isolation and identification of compounds from marine mangrove plant Avicennia marina] |
| PubMed:Antioxidative and chelating activities of phenylpropanoid glycosides from Pedicularis striata |
| PubMed:A comparative study of some Veronica species |
| PubMed:Isolation, structure elucidation and antioxidant potential of the major phenolic and flavonoid compounds in brined olive drupes |
| PubMed:Phenylethanoids in the herb of Plantago lanceolata and inhibitory effect on arachidonic acid-induced mouse ear edema |
| PubMed:Pedicularioside A from Buddleia lindleyana inhibits cell death induced by 1-methyl-4-phenylpyridinium ions (MPP+) in primary cultures of rat mesencephalic neurons |
| PubMed:Effect of isoverbascoside, a phenylpropanoid glycoside antioxidant, on proliferation and differentiation of human gastric cancer cell |
| PubMed:New and known iridoid- and phenylethanoid glycosides from Harpagophytum procumbens and their in vitro inhibition of human leukocyte elastase |
| PubMed:[Phenylethanoid glucosides from flos Buddlejae] |
| PubMed:Chemical constituents of the aerial parts of Scutellaria lateriflora and their alpha-glucosidase inhibitory activities |
| PubMed:Antioxidant and anti-cholinesterase activity of Globularia meridionalis extracts and isolated constituents |
| PubMed:A new rearranged abietane diterpene and other constituents from Clerodendrum philipinum |
| PubMed:[Analysis of phenylethanoid glycosides in the extract of herba Cistanchis by LC/ESI-MS/MS] |
| PubMed:Isolation, purification and structure identification of two phenolic glycosides from the roots of Incarvillea younghusbandii Sprague and their antioxidant activities |
| PubMed:Simultaneous separation and determination of four phenylethanoid glycosides in rat plasma sample after oral administration of Cistanche salsa extract by microemulsion liquid chromatography |
| PubMed:[Chemical constituents from rhizome of Phlomis umbrosa] |
| PubMed:Hypoglycemic and hypolipidemic effects of total glycosides of Cistanche tubulosa in diet/streptozotocin-induced diabetic rats |
| PubMed:[Study on chemical constituents of mangrove Acanthus ilcifolius] |
| PubMed:[Induced-differentiation and cytotoxicity of isoverbascoside on HL-60 cells] |
| PubMed:[Metabolic regulation of phenylethanoid glycosides from Herba cistanches in dogs' gastrointestine] |
| PubMed:Protection of phenylpropanoid glycosides from Pedicularis against oxidative hemolysis in vitro |
| PubMed:[Studies on the chemical constituents from herba of Corallodiscus flabellata] |
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3D/inchi