EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

acemannan

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CAS Number: 110042-95-0Picture of molecule3D/inchi
Other(deleted CASRN):110865-83-3
FDA UNII: UZ29E6L2X8
XlogP3-AA:-12.20 (est)
Molecular Weight:1691.49080000
Formula:C66 H100 N O49
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
Acemannan > 95%
Odor: characteristic
Use: Acemannan is a D-isomer mucopolysaccharide in aloe vera leaves. This compound has been known to have immunostimulant, antiviral, antineoplastic and gastrointestinal properties.
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for acemannan usage levels up to:
 not for fragrance use.
 
Recommendation for acemannan flavor usage levels up to:
 not for flavor use.
 
Safety References:
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :72041
National Institute of Allergy and Infectious Diseases:Data
Chemidplus:0110042950
 
References:
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):72041
Pubchem (cas):110042-95-0
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):HMDB40717
FooDB:FDB020524
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 aloe barbadensis
Search Trop Picture
 aloe arborescens
Search Trop Picture
 aloe ferox
Search Trop Picture
 
Synonyms:
 carrisyn
 polymannoacetate
 

Articles:

PubMed:Acemannan and Fructans from Aloe vera (Aloe barbadensis Miller) Plants as Novel Prebiotics.
PubMed:Stimulation of Dentin Regeneration by Using Acemannan in Teeth with Lipopolysaccharide-induced Pulp Inflammation.
PubMed:Effect of different drying procedures on the bioactive polysaccharide acemannan from Aloe vera (Aloe barbadensis Miller).
PubMed:Acemannan increases NF-κB/DNA binding and IL-6/-8 expression by selectively binding Toll-like receptor-5 in human gingival fibroblasts.
PubMed:Could We Really UseAloe veraFood Supplements to Treat Diabetes? Quality Control Issues.
PubMed:Time-kill Kinetics of a Novel Antimicrobial Silver Wound Gel Against Select Wound Pathogens.
PubMed:The effect of Aloe vera gel on viability of dental pulp stem cells.
PubMed:Effects of Plants on Osteogenic Differentiation and Mineralization of Periodontal Ligament Cells: A Systematic Review.
PubMed:Deacetylation affects the physical properties and bioactivity of acemannan, an extracted polysaccharide from Aloe vera.
PubMed:Clinical, radiographic, and histologic analysis of the effects of acemannan used in direct pulp capping of human primary teeth: short-term outcomes.
PubMed:Acemannan accelerates cell proliferation and skin wound healing through AKT/mTOR signaling pathway.
PubMed:In vitro assessment of the prebiotic potential of Aloe vera mucilage and its impact on the human microbiota.
PubMed:Physical properties and antibacterial activity of chitosan/acemannan mixed systems.
PubMed:Acemannan, an extracted polysaccharide from Aloe vera: A literature review.
PubMed:Acute effects of a dietary non-starch polysaccharide supplement on cognitive performance in healthy middle-aged adults.
PubMed:Acemannan sponges stimulate alveolar bone, cementum and periodontal ligament regeneration in a canine class II furcation defect model.
PubMed:Effect of acemannan, an extracted polysaccharide from Aloe vera, on BMSCs proliferation, differentiation, extracellular matrix synthesis, mineralization, and bone formation in a tooth extraction model.
PubMed:Acemannan, a polysaccharide extracted from Aloe vera, is effective in the treatment of oral aphthous ulceration.
PubMed:Mass spectrometry characterization of an Aloe vera mannan presenting immunostimulatory activity.
PubMed:Anticancer potential of aloes: antioxidant, antiproliferative, and immunostimulatory attributes.
PubMed:Antimicrobial efficacy of oral topical agents on microorganisms associated with radiated head and neck cancer patients: an in vitro study.
PubMed:Comparison of alvogyl, SaliCept patch, and low-level laser therapy in the management of alveolar osteitis.
PubMed:In vivo evidence of the immunomodulatory activity of orally administered Aloe vera gel.
PubMed:Aloe vera as a functional ingredient in foods.
PubMed:Single-laboratory validation of an NMR method for the determination of aloe vera polysaccharide in pharmaceutical formulations.
PubMed:Acemannan, an extracted product from Aloe vera, stimulates dental pulp cell proliferation, differentiation, mineralization, and dentin formation.
PubMed:Acemannan stimulates gingival fibroblast proliferation; expressions of keratinocyte growth factor-1, vascular endothelial growth factor, and type I collagen; and wound healing.
PubMed:A randomized study of chemotherapy versus biochemotherapy with chemotherapy plus Aloe arborescens in patients with metastatic cancer.
PubMed:Final report on the safety assessment of AloeAndongensis Extract, Aloe Andongensis Leaf Juice,aloe Arborescens Leaf Extract, Aloe Arborescens Leaf Juice, Aloe Arborescens Leaf Protoplasts, Aloe Barbadensis Flower Extract, Aloe Barbadensis Leaf, Aloe Barbadensis Leaf Extract, Aloe Barbadensis Leaf Juice,aloe Barbadensis Leaf Polysaccharides, Aloe Barbadensis Leaf Water, Aloe Ferox Leaf Extract, Aloe Ferox Leaf Juice, and Aloe Ferox Leaf Juice Extract.
PubMed:Topical treatments in equine wound management.
PubMed:Fractionation of Aloe vera L. inner gel, purification and molecular profiling of activity.
PubMed:Isolation and characterization of structural components of Aloe vera L. leaf pulp.
PubMed:Evaluation and comparison of commercially available Aloe vera L. products using size exclusion chromatography with refractive index and multi-angle laser light scattering detection.
PubMed:[Anti-inflammatory constituents, aloesin and aloemannan in Aloe species and effects of tanshinon VI in Salvia miltiorrhiza on heart].
PubMed:Reduction in the incidence of alveolar osteitis in patients treated with the SaliCept patch, containing Acemannan hydrogel.
PubMed:Acemannan purified from Aloe vera induces phenotypic and functional maturation of immature dendritic cells.
PubMed:Characterization of Aloeride, a new high-molecular-weight polysaccharide from Aloe vera with potent immunostimulatory activity.
PubMed:In vivo macrophage activation in chickens with Acemannan, a complex carbohydrate extracted from Aloe vera.
PubMed:Acemannan. CARN 1000, CARN 750, polymannoacetate, Aliminase, Alovex, Carrisyn.
PubMed:Acemannan hydrogel dressing versus saline dressing for pressure ulcers. A randomized, controlled trial.
PubMed:Medical therapy of inflammatory bowel disease for the 21st century.
PubMed:In vitro evaluation of complex carbohydrate denture adhesive formulations.
PubMed:Biological response modifiers: interferons, interleukins, recombinant products, liposomal products.
PubMed:Induction of apoptosis in a macrophage cell line RAW 264.7 by acemannan, a beta-(1,4)-acetylated mannan.
PubMed:Plant-derived leading compounds for chemotherapy of human immunodeficiency virus (HIV) infection.
PubMed:A comparison of antibody responses to veterinary vaccine antigens potentiated by different adjuvants.
PubMed:Optimizing therapy for inflammatory bowel disease.
PubMed:Upregulation of phagocytosis and candidicidal activity of macrophages exposed to the immunostimulant acemannan.
PubMed:In vitro evaluation of denture adhesives: possible efficacy of complex carbohydrates.
PubMed:Hematopoietic augmentation by a beta-(1,4)-linked mannan.
PubMed:Activation of a mouse macrophage cell line by acemannan: the major carbohydrate fraction from Aloe vera gel.
PubMed:Acemannan, a beta-(1,4)-acetylated mannan, induces nitric oxide production in macrophage cell line RAW 264.7.
PubMed:Double-blind placebo-controlled pilot trial of acemannan in advanced human immunodeficiency virus disease.
PubMed:The effect of Acemannan Immunostimulant in combination with surgery and radiation therapy on spontaneous canine and feline fibrosarcomas.
PubMed:Acemannan-containing wound dressing gel reduces radiation-induced skin reactions in C3H mice.
PubMed:Nitric oxide production by chicken macrophages activated by Acemannan, a complex carbohydrate extracted from Aloe vera.
PubMed:A beta-linked mannan inhibits adherence of Pseudomonas aeruginosa to human lung epithelial cells.
PubMed:Oral ulcers remedy gets FDA clearance.
PubMed:Virus-induced immunosuppression in chickens.
PubMed:Determination of the position of the O-acetyl group in a beta-(1-->4)-mannan (acemannan) from Aloe barbardensis Miller.
PubMed:Pilot study of the effect of acemannan in cats infected with feline immunodeficiency virus.
PubMed:Toxicologic evaluation of injectable acemannan in the mouse, rat and dog.
PubMed:Subchronic oral administration of acemannan in the rat and dog.
PubMed:The impact of acemannan on the generation and function of cytotoxic T-lymphocytes.
PubMed:Antigen dependent adjuvant activity of a polydispersed beta-(1,4)-linked acetylated mannan (acemannan).
PubMed:Efficacy of acemannan in treatment of canine and feline spontaneous neoplasms.
PubMed:In vitro evaluation of the synergistic antiviral effects of acemannan in combination with azidothymidine and acyclovir.
PubMed:Use of immunomodulators as an aid to clinical management of feline leukemia virus-infected cats.
PubMed:Inhibition of AIDS virus replication by acemannan in vitro.
PubMed:Decreased mortality of Norman murine sarcoma in mice treated with the immunomodulator, Acemannan.
PubMed:Studies of the effect of acemannan on retrovirus infections: clinical stabilization of feline leukemia virus-infected cats.
PubMed:Enhancement of allo-responsiveness of human lymphocytes by acemannan (Carrisyn).
 
Notes:
None found
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