EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

cirsiliol

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CAS Number: 34334-69-5Picture of molecule3D/inchi
FDA UNII: Search
Nikkaji Web:J94.517J
XlogP3-AA:2.60 (est)
Molecular Weight:330.29298000
Formula:C17 H14 O7
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Soluble in:
 water, 382.8 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
Cirsiliol >98%
Odor: characteristic
Use: Cirsiliol is a natural flavonoid compound found in several plants.
Sigma-Aldrich: Sigma
For experimental / research use only.
Cirsiliol ≥95% (HPLC)
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for cirsiliol usage levels up to:
 not for fragrance use.
 
Recommendation for cirsiliol flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :160237
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
2-(3,4-dihydroxyphenyl)-5-hydroxy-6,7-dimethoxychromen-4-one
Chemidplus:0034334695
RTECS:DJ3011100 for cas# 34334-69-5
 
References:
 2-(3,4-dihydroxyphenyl)-5-hydroxy-6,7-dimethoxychromen-4-one
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):160237
Pubchem (cas):34334-69-5
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C10033
HMDB (The Human Metabolome Database):Search
FooDB:FDB016700
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 salvia officinalis
Search Trop Picture
 
Synonyms:
4H-1-benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-5-hydroxy-6,7-dimethoxy-
2-(3,4-dihydroxyphenyl)-5-hydroxy-6,7-dimethoxychromen-4-one
6,7-dimethoxy-5,3',4'-trihydroxyflavone
3',4',5-trihydroxy-6,7-dimethoxyflavone
 

Articles:

PubMed:Bioactive flavones isolated from Tunisian Artemisia campestris L. Leaves.
PubMed:Iridoid glycosides and polyphenolic compounds from Teucrium chamaedrys L.
PubMed:[Studies on chemical constituents of Isodon excisoides].
PubMed:Phytochemical Analysis and Antioxidant Activity ofSalvia chloroleucaAerial Extracts.
PubMed:[Chemical constituents from rhizomes of Iris germanica].
PubMed:HPLC-fingerprints and antioxidant constituents of Phyla nodiflora.
PubMed:Further characterization of foliar flavonoids in Crossostephium chinense and their geographic variation.
PubMed:Inhibitory effect of chemical constituents from Artemisia scoparia Waldst. et Kit. on triglyceride accumulation in 3T3-L1 cells and nitric oxide production in RAW 264.7 cells.
PubMed:Antileishmanial Phenylpropanoids from the Leaves of Hyptis pectinata (L.) Poit.
PubMed:Rhamnetin and cirsiliol induce radiosensitization and inhibition of epithelial-mesenchymal transition (EMT) by miR-34a-mediated suppression of Notch-1 expression in non-small cell lung cancer cell lines.
PubMed:[Chemical constituents of Eupatorium lindleyanum].
PubMed:Bioactivity-guided isolation of antiproliferative compounds from Centaurea jacea L.
PubMed:Bis-spirolabdane diterpenoids from Leonotis nepetaefolia.
PubMed:Effects of Teucrium polium spp. capitatum flavonoids on the lipid and carbohydrate metabolism in rats.
PubMed:Flavones and rosmarinic acid from Salvia limbata.
PubMed:Phytotoxic activity of Salvia x jamensis.
PubMed:The methoxylated flavones eupatorin and cirsiliol induce CYP1 enzyme expression in MCF7 cells.
PubMed:Antiproliferative and cytostatic effects of the natural product eupatorin on MDA-MB-468 human breast cancer cells due to CYP1-mediated metabolism.
PubMed:[Determination of flavonoids in buds of Herba Artemisiae Scopariae by HPLC].
PubMed:Three new compounds from Isodon melissoides.
PubMed:[Studies on chemical constituents in buds of Artemisia scoparia].
PubMed:GABA(A)-receptor ligands of flavonoid structure.
PubMed:Antiproliferative constituents in plants 10. Flavones from the leaves of Lantana montevidensis Briq. and consideration of structure-activity relationship.
PubMed:Sedative and hypnotic properties of Salvia guaranitica St. Hil. and of its active principle, Cirsiliol.
PubMed:Cirsiliol and caffeic acid ethyl ester, isolated from Salvia guaranitica, are competitive ligands for the central benzodiazepine receptors.
PubMed:[Resting tonus of isolated airway smooth muscles].
PubMed:Growth inhibition of human malignant glioma cells in vitro by agents which interfere with biosynthesis of eicosanoids.
PubMed:Effects of cirsiliol, a flavone isolated from Achillea fragrantissima, on rat isolated ileum.
PubMed:Anti-inflammatory activity and inhibition of arachidonic acid metabolism by flavonoids.
PubMed:Inhibition of sheep platelet arachidonate metabolism by flavonoids from Spanish and Indian medicinal herbs.
PubMed:Mechanisms of action of lipoxygenase and cytochrome P-450-mono-oxygenase inhibitors in blocking endothelium-dependent vasodilatation.
PubMed:Synergistic enhancement of mitogen responses of human lymphocytes by inhibitors of cyclo-oxygenase and lipoxygenase.
PubMed:Arachidonate 5-lipoxygenase inhibitors show potent antiproliferative effects on human leukemia cell lines.
PubMed:Syntheses of 5,6,7- and 5,7,8-trioxygenated 3',4'-dihydroxyflavones having alkoxy groups and their inhibitory activities against arachidonate 5-lipoxygenase.
PubMed:Methylated Flavones from Teucrium polium.
PubMed:Potent and selective 5-lipoxygenase inhibitors: cirsiliol and AA-861.
PubMed:Studies on arachidonate 5-lipoxygenase of rat basophilic leukemia cells.
PubMed:Arachidonate 5-lipoxygenase and its new inhibitors.
PubMed:Some pharmacological, toxicological and phytochemical investigations on Centaurea phyllocephala.
PubMed:Flavonoids: potent inhibitors of arachidonate 5-lipoxygenase.
 
Notes:
None found
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