EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

licochalcone B

Supplier Sponsors

CAS Number: 58749-23-8Picture of molecule3D/inchi
FDA UNII: G7383L14F6
Nikkaji Web:J14.699D
XlogP3-AA:2.60 (est)
Molecular Weight:286.28358000
Formula:C16 H14 O5
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Soluble in:
 water, 1011 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
Licochalcone B 98%
BOC Sciences
For experimental / research use only.
Licochalcone B >98%
Odor: characteristic
Use: Licochalcone B is extracted from the roots of Glycyrrhiza glabra L. It inhibits the adhesion,invasion and metastasis of human malignant bladder cancer T24 cells. It could significantly reduce the LPS-induced production of NO, TNFalpha and MCP-1.
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for licochalcone B usage levels up to:
 not for fragrance use.
 
Recommendation for licochalcone B flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :5318999
National Institute of Allergy and Infectious Diseases:Data
(E)-3-(3,4-dihydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one
Chemidplus:0058749238
 
References:
 (E)-3-(3,4-dihydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):5318999
Pubchem (cas):58749-23-8
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEMBL:View
HMDB (The Human Metabolome Database):HMDB37320
FooDB:FDB016340
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 glycyrrhiza glabra root
Search Trop Picture
 glycyrrhiza inflata root
Search Trop Picture
 
Synonyms:
(E)-3-(3,4-dihydroxy-2-methoxy-phenyl)-1-(4-hydroxy-phenyl)-propenone
(E)-3-(3,4-dihydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one
 

Articles:

PubMed:Natural Compound Licochalcone B Induced Extrinsic and Intrinsic Apoptosis in Human Skin Melanoma (A375) and Squamous Cell Carcinoma (A431) Cells.
PubMed:Intestinal Absorption of Triterpenoids and Flavonoids from Glycyrrhizae radix et rhizoma in the Human Caco-2 Monolayer Cell Model.
PubMed:Screening of hepatoprotective compounds from licorice against carbon tetrachloride and acetaminophen induced HepG2 cells injury.
PubMed:Nrf2 activators from Glycyrrhiza inflata and their hepatoprotective activities against CCl4-induced liver injury in mice.
PubMed:Screening for bioactive natural products from a 67-compound library of Glycyrrhiza inflata.
PubMed:Protective role of licochalcone B against ethanol-induced hepatotoxicity through regulation of Erk signaling.
PubMed:Hepatoprotective effects of licochalcone B on carbon tetrachloride-induced liver toxicity in mice.
PubMed:Licochalcone B Arrests Cell Cycle Progression and Induces Apoptosis in Human Breast Cancer MCF-7 Cells.
PubMed:Licochalcone B induces apoptosis of human oral squamous cell carcinoma through the extrinsic- and intrinsic-signaling pathways.
PubMed:(E)-3-(3,4-dihydroxy-2-methoxyphenyl)-1-(2,4-dihydroxyphenyl)prop-2-en-1-one, a novel licochalcone B derivative compound, suppresses lipopolysaccharide-stimulated inflammatory reactions in RAW264.7 cells and endotoxin shock in mice.
PubMed:Cardioprotection against ischemia/reperfusion by licochalcone B in isolated rat hearts.
PubMed:Antimetastatic effects of licochalcone B on human bladder carcinoma T24 by inhibition of matrix metalloproteinases-9 and NF-кB activity.
PubMed:Licochalcone B inhibits growth of bladder cancer cells by arresting cell cycle progression and inducing apoptosis.
PubMed:Synthesis of licochalcone analogues with increased anti-inflammatory activity.
PubMed:Antioxidant and anti-inflammatory activities of six flavonoids separated from licorice.
PubMed:[Phenolic constituents from Lysimachia patungensis].
PubMed:Glycyrrhiza inflata-derived chalcones, Licochalcone A, Licochalcone B and Licochalcone D, inhibit phosphorylation of NF-kappaB p65 in LPS signaling pathway.
PubMed:Activity of wen-pi-tang, and purified constituents of rhei rhizoma and glycyrrhizae radix against glucose-mediated protein damage.
PubMed:Phenolic constituents of licorice. II. Structures of licopyranocoumarin, licoarylcoumarin and glisoflavone, and inhibitory effects of licorice phenolics on xanthine oxidase.
 
Notes:
None found
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