EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

isoliquiritin

Supplier Sponsors

CAS Number: 5041-81-6Picture of molecule3D/inchi
FDA UNII: 2Y348H1V4W
Nikkaji Web:J27.434H
XlogP3:1.70 (est)
Molecular Weight:418.39914000
Formula:C21 H22 O9
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Soluble in:
 water, 1292 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
Isoliquiritin 98%
BOC Sciences
For experimental / research use only.
Isoliquiritin >98%
Odor: characteristic
Use: Isoliquiritin is extracted from the root of Glycyrrhiza uralensis Fisch. It has antidepressant-like effects and antitussive effect.
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for isoliquiritin usage levels up to:
 not for fragrance use.
 
Recommendation for isoliquiritin flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :5318591
National Institute of Allergy and Infectious Diseases:Data
(E)-1-(2,4-dihydroxyphenyl)-3-[4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]prop-2-en-1-one
Chemidplus:0005041816
 
References:
 (E)-1-(2,4-dihydroxyphenyl)-3-[4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]prop-2-en-1-one
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):5318591
Pubchem (cas):5041-81-6
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C16978
HMDB (The Human Metabolome Database):HMDB37318
FooDB:FDB016338
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 glycyrrhiza uralensis
Search Trop Picture
 
Synonyms:
(E)-1-(2,4-dihydroxyphenyl)-3-[4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]prop-2-en-1-one
2-propen-1-one, 1-(2,4-dihydroxyphenyl)-3-(4-(beta-D-glucopyranosyloxy)phenyl)-, (2E)-
 

Articles:

PubMed:The effect of ethanol extract of Glycyrrhiza uralensis on the voltage-gated sodium channel subtype 1.4.
PubMed:A Comparative Pharmacokinetic Study by UHPLC-MS/MS of Main Active Compounds after Oral Administration of Zushima-Gancao Extract in Normal and Adjuvant-Induced Arthritis Rats.
PubMed:Simultaneous quantification of multiple components in rat plasma by UPLC-MS/MS and pharmacokinetic study after oral administration of Huangqi decoction.
PubMed:[Study on correlation between color and effective components contents of Glycyrrhiza uralensis].
PubMed:Neuroprotective effect of liquiritin as an antioxidant via an increase in glucose-6-phosphate dehydrogenase expression on B65 neuroblastoma cells.
PubMed:Intestinal Absorption of Triterpenoids and Flavonoids from Glycyrrhizae radix et rhizoma in the Human Caco-2 Monolayer Cell Model.
PubMed:Influence of Jiegeng on Pharmacokinetic Properties of Flavonoids and Saponins in Gancao.
PubMed:Spasmolytic Mechanism of Aqueous Licorice Extract on Oxytocin-Induced Uterine Contraction through Inhibiting the Phosphorylation of Heat Shock Protein 27.
PubMed:Simultaneous quantitation of six aconitum alkaloids and three flavonoids in the herb couple of radix aconiti lateralis-radix glycyrrhizae (Fuzi-Gancao) by UHPLC-ESI-MS/MS.
PubMed:Simultaneous Determination of 11 Compounds in Gualou Guizhi Granule and Pharmacokinetics Study by UPLC-MS/MS.
PubMed:Comparison of chemical constituents among licorice, roasted licorice, and roasted licorice with honey.
PubMed:Simultaneous Determination of 8 Compounds in Gancao-Ganjiang-Tang by HPLC-DAD and Analysis of the Relations between Compatibility, Dosage, and Contents of Medicines.
PubMed:Identification of NF-κB as Determinant of Posttraumatic Stress Disorder and Its Inhibition by the Chinese Herbal RemedyFree and Easy Wanderer.
PubMed:Simultaneous determination of multiple active components in rat plasma using ultra-fast liquid chromatography with tandem mass spectrometry and application to a comparative pharmacokinetic study after oral administration of Suan-Zao-Ren decoction and Suan-Zao-Ren granule.
PubMed:Protective effect of isoliquiritin against corticosterone-induced neurotoxicity in PC12 cells.
PubMed:Development and validation of a sensitive and fast UPLC-MS/MS method for simultaneous determination of seven bioactive compounds in rat plasma after oral administration of Guizhi-gancao decoction.
PubMed:Purification and characterization of a novel phloretin-2'-O-glycosyltransferase favoring phloridzin biosynthesis.
PubMed:Identification and Chemical Standardization of Licorice Raw Materials and Dietary Supplements Using UHPLC-MS/MS.
PubMed:Simultaneous Determinations of Eleven Bioactive Components in Suanzaoren Decoction Granules by High-Performance Liquid Chromatography and Its Application to the Quality Control in Productive Processes.
PubMed:Simultaneous Determination of 18 Chemical Constituents in Traditional Chinese Medicine of Antitussive by UPLC-MS-MS.
PubMed:Development and Validation of an UHPLC-QqQ-MS Technique for Simultaneous Determination of Ten Bioactive Components in Fangji Huangqi Tang.
PubMed:Antifungal Activity of Isoliquiritin and Its Inhibitory Effect against Peronophythora litchi Chen through a Membrane Damage Mechanism.
PubMed:[Effect of exogenous brassinolide on morphological characters and contents of seven chemical constituents of Glycyrrhiza uralensis].
PubMed:Online near-infrared analysis coupled with MWPLS and SiPLS models for the multi-ingredient and multi-phase extraction of licorice (Gancao).
PubMed:Simultaneous quantification of catechin, epicatechin, liquiritin, isoliquiritin, liquiritigenin, isoliquiritigenin, piperine and glycyrrhetinic acid in rat plasma by HPLC-MS/MS: application to a pharmacokinetic study of Longhu Rendan pills.
PubMed:Comparison of the Spasmolytic Effects of Jakyak-Gamcho Decoctions Derived via Different Extractants.
PubMed:Suppression of Propionibacterium acnes-Induced Dermatitis by a Traditional Japanese Medicine, Jumihaidokuto, Modifying Macrophage Functions.
PubMed:Combination of the advantages of chromatographic methods based on active components for the quality evaluation of licorice.
PubMed:The constituents of licorice (Glycyrrhiza uralensis) differentially suppress nitric oxide production in interleukin-1β-treated hepatocytes.
PubMed:Flavonoids derived from liquorice suppress murine macrophage activation by up-regulating heme oxygenase-1 independent of Nrf2 activation.
PubMed:Blood-brain barrier permeability of Gualou Guizhi granules and neuroprotective effects in ischemia/reperfusion injury.
PubMed:Monitoring and evaluating the quality consistency of Compound Bismuth Aluminate tablets by a simple quantified ratio fingerprint method combined with simultaneous determination of five compounds and correlated with antioxidant activities.
PubMed:Effect of genotype and environment on five bioactive components of cultivated licorice (Glycyrrhiza uralensis) populations in northern China.
PubMed:Plant-derived natural medicines for the management of depression: an overview of mechanisms of action.
PubMed:Studies on the identification of constituents in ethanol extract of Radix Glycyrrhizae and their anticancer activity.
PubMed:Simultaneous Determination of Nine Active Compounds of the Traditional Chinese Medicinal Prescription Shaoyao-Gancao-Tang and Analysis of the Relationship between Therapeutical Effect and Compatibility of Medicines.
PubMed:Effect of genotype and environment on five bioactive components of cultivated licorice (Glycyrrhiza uralensis FISCH.) populations in northern China.
PubMed:Chemical interaction between Paeonia lactiflora and Glycyrrhiza uralensis, the components of Jakyakgamcho-tang, using a validated high-performance liquid chromatography method: herbal combination and chemical interaction in a decoction.
PubMed:[Studies on effects of Achyranthes bidentata on tongsaimai pellets main active ingredients chlorogenic acid, isoliquiritin, harpagoside and glycyrrhizin in vivo pharmacokinetics].
PubMed:Distribution patterns of the contents of five active components in taproot and stolon of Glycyrrhiza uralensis.
PubMed:Preparative isolation and analysis of alcohol dehydrogenase inhibitors from Glycyrrhiza uralensis root using ultrafiltration combined with high-performance liquid chromatography and high-speed countercurrent chromatography.
PubMed:Simultaneous determination of 12 index components and compatibility changes in Longchai decoction by liquid chromatography-mass spectrometry.
PubMed:[Multi-index determination and optimization of liquirtin separated from polyamide resin].
PubMed:Antidepressant-like effects of Xiaochaihutang in a rat model of chronic unpredictable mild stress.
PubMed:Correlation analysis between the rate of respiration in the root and the active components in licorice (Glycyrrhiza uralensis).
PubMed:Combination of liquiritin, isoliquiritin and isoliquirigenin induce apoptotic cell death through upregulating p53 and p21 in the A549 non-small cell lung cancer cells.
PubMed:Analysis of the traditional medicine YiGan San by the fragmentation patterns of cadambine indole alkaloids using HPLC coupled with high-resolution MS.
PubMed:[Development of a rapid screening method for discovering neuroprotective components from traditional Chinese medicine].
PubMed:Evaluation of cytotoxiciy and tumor-specificity of licorice flavonoids based on chemical structure.
PubMed:Employing bifunctional enzymes for enhanced extraction of bioactives from plants: flavonoids as an example.
PubMed:Pharmacokinetic comparisons of two different combinations of Shaoyao-Gancao Decoction in rats: competing mechanisms between paeoniflorin and glycyrrhetinic acid.
PubMed:Pharmacokinetic comparisons of different combinations of Shaoyao-Gancao-Decoction in rats: simultaneous determination of ten active constituents by HPLC-MS/MS.
PubMed:Pharmacokinetic study of four flavones of Glycyrrhiza in rat plasma using HPLC-MS.
PubMed:HPLC method determination of isoliquiritin apioside and isoliquiritin in rat plasma for application in pharmacokinetic study after an oral administration of zhigancao extract.
PubMed:Simultaneous quantitative determination of nine active chemical compositions in traditional Chinese medicine Glycyrrhiza by RP-HPLC with full-time five-wavelength fusion method.
PubMed:Comparative study of bioactive constituents in crude and processed Glycyrrhizae radix and their respective metabolic profiles in gastrointestinal tract in vitro by HPLC-DAD and HPLC-ESI/MS analyses.
PubMed:Antispasmodic effect of shakuyakukanzoto extract on experimental muscle cramps in vivo: role of the active constituents of Glycyrrhizae radix.
PubMed:Comparative analysis of the main bioactive components of San-ao decoction and its series of formulations.
PubMed:Analytical strategy to reveal the in vivo process of multi-component herbal medicine: a pharmacokinetic study of licorice using liquid chromatography coupled with triple quadrupole mass spectrometry.
PubMed:The isolation of bioactive flavonoids from Jacaranda obtusifolia H. B. K. ssp. rhombifolia (G. F. W. Meijer) Gentry.
PubMed:Influence of honey-roasting on the main pharmacological activities and the water-soluble active glycosides of licorice.
PubMed:Simultaneous determination of five flavonoids in licorice using pressurized liquid extraction and capillary electrochromatography coupled with peak suppression diode array detection.
PubMed:Evaluation of antigenotoxic activity of isoliquiritin apioside from Glycyrrhiza glabra L.
PubMed:Survey of Glycyrrhizae Radix resources in Mongolia: chemical assessment of the underground part of Glycyrrhiza uralensis and comparison with Chinese Glycyrrhizea Radix.
PubMed:Transport and metabolism of flavonoids from Chinese herbal remedy Xiaochaihu- tang across human intestinal Caco-2 cell monolayers.
PubMed:[Selective adsorption of multi-walled carbon nanotubes with liquiritin and isoliquiritin].
PubMed:Isoliquiritigenin isolated from the roots of Glycyrrhiza uralensis inhibits LPS-induced iNOS and COX-2 expression via the attenuation of NF-kappaB in RAW 264.7 macrophages.
PubMed:Antidepressant-like effects of liquiritin and isoliquiritin from Glycyrrhiza uralensis in the forced swimming test and tail suspension test in mice.
PubMed:Constituent properties of licorices derived from Glycyrrhiza uralensis, G. glabra, or G. inflata identified by genetic information.
PubMed:In vitro and in vivo antiallergic effects of Glycyrrhiza glabra and its components.
PubMed:Simultaneous quantification of multiple licorice flavonoids in rat plasma.
PubMed:Isoliquiritigenin, one of the antispasmodic principles of Glycyrrhiza ularensis roots, acts in the lower part of intestine.
PubMed:Isolation and identification of flavonoids in licorice and a study of their inhibitory effects on tyrosinase.
PubMed:Antitussive principles of Glycyrrhizae radix, a main component of the Kampo preparations Bakumondo-to (Mai-men-dong-tang).
PubMed:Relationship between the antidiarrhoeal effects of Hange-Shashin-To and its active components.
PubMed:Inhibitory effect of isoliquiritin, a compound in licorice root, on angiogenesis in vivo and tube formation in vitro.
PubMed:[Chemical components of decoction of radix Paeoniae and radix Glycyrrhizae].
PubMed:Saponin and sapogenol. L. On the constituents of the roots of Glycyrrhiza uralensis Fischer from Xinjiang, China. Chemical structures of licorice-saponin L3 and isoliquiritin apioside.
PubMed:[Quality evaluation of Chinese licorice].
PubMed:[HPLC analysis of flavonoids in the root of six Glycyrrhiza species].
PubMed:The existence of aldose reductase inhibitors in some kampo medicines (Oriental herb prescriptions).
PubMed:[Studies on chemical constituents of Glycyrrhiza eurycarpa P. C. Li].
 
Notes:
None found
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