EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

morusin
mulberrochromene

Supplier Sponsors

CAS Number: 62596-29-6Picture of molecule3D/inchi
FDA UNII: T4VGD5NP9B
Nikkaji Web:J94.468H
MDL:MFCD09953814
XlogP3-AA:5.50 (est)
Molecular Weight:420.46148000
Formula:C25 H24 O6
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Soluble in:
 water, 0.01202 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
Morusin 98%
BOC Sciences
For experimental / research use only.
Morusin 97%
Odor: characteristic
Use: Morusin isolated from the root bark of Morus alba L. antinociceptive; anti-oxidant and anti-inflammatory effects
Carbosynth
For experimental / research use only.
Morusin
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for morusin usage levels up to:
 not for fragrance use.
 
Recommendation for morusin flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :5281671
National Institute of Allergy and Infectious Diseases:Data
2-(2,4-dihydroxyphenyl)-5-hydroxy-8,8-dimethyl-3-(3-methylbut-2-enyl)pyrano[2,3-h]chromen-4-one
Chemidplus:0062596296
 
References:
 2-(2,4-dihydroxyphenyl)-5-hydroxy-8,8-dimethyl-3-(3-methylbut-2-enyl)pyrano[2,3-h]chromen-4-one
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):5281671
Pubchem (cas):62596-29-6
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C10106
HMDB (The Human Metabolome Database):HMDB36631
FooDB:FDB015550
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 morus alba root bark
Search Trop Picture
 
Synonyms:
4H,8H-benzo(1,2-b:3,4-b')dipyran-4-one, 2-(2,4-dihydroxyphenyl)-5-hydroxy-8,8-dimethyl-3-(3-methyl-2-butenyl)-
2-(2,4-dihydroxyphenyl)-5-hydroxy-8,8-dimethyl-3-(3-methylbut-2-enyl)pyrano[2,3-h]chromen-4-one
 mulberrochromene
 

Articles:

PubMed:UGT-mediated metabolism plays a dominant role in the pharmacokinetic behavior and the disposition of morusin in vivo and in vitro.
PubMed:Synergism of prenylflavonoids from Morus alba root bark against clinical MRSA isolates.
PubMed:Morusin induces paraptosis-like cell death through mitochondrial calcium overload and dysfunction in epithelial ovarian cancer.
PubMed:Morusin inhibits cell proliferation and tumor growth by down-regulating c-Myc in human gastric cancer.
PubMed:Prenylated flavonoid morusin protects against TNBS-induced colitis in rats.
PubMed:Morusin shows potent antitumor activity for human hepatocellular carcinoma in vitro and in vivo through apoptosis induction and angiogenesis inhibition.
PubMed:Two new prenylflavonoids from Morus alba.
PubMed:Morusin induces apoptosis by regulating expression of Bax and Survivin in human breast cancer cells.
PubMed:Quantification of morusin using LC-MS in rat plasma: Application to a pharmacokinetic study.
PubMed:Two novel compounds from the root bark of Morus alba L.
PubMed:Rapid, microwave-accelerated synthesis and anti-osteoporosis activities evaluation of Morusin scaffolds and Morusignin L scaffolds.
PubMed:Autophagy inhibits cell death induced by the anti-cancer drug morusin.
PubMed:Anti-Melanogenic Properties of Greek Plants. A Novel Depigmenting Agent from Morus alba Wood.
PubMed:Involvement of the antioxidative property of morusin in blocking phorbol ester-induced malignant transformation of JB6 P+mouse epidermal cells.
PubMed:Pharmacological Evaluation of the Recuperative Effect of Morusin Against Aluminium Trichloride (AlCl3)-Induced Memory Impairment in Rats.
PubMed:Identification of the Metabolic Enzyme Involved Morusin Metabolism and Characterization of Its Metabolites by Ultraperformance Liquid Chromatography Quadrupole Time-of-Flight Mass Spectrometry (UPLC/Q-TOF-MS/MS).
PubMed:Morusin Induces TRAIL Sensitization by Regulating EGFR and DR5 in Human Glioblastoma Cells.
PubMed:Blockage of STAT3 Signaling Pathway by Morusin Induces Apoptosis and Inhibits Invasion in Human Pancreatic Tumor Cells.
PubMed:Morusin suppresses breast cancer cell growth in vitro and in vivo through C/EBPβ and PPARγ mediated lipoapoptosis.
PubMed:The different metabolism of morusin in various species and its potent inhibition against UDP-glucuronosyltransferase (UGT) and cytochrome p450 (CYP450) enzymes.
PubMed:[Chemical constituents from Morus notabilis and their cytotoxic effect].
PubMed:Morusin induces cell death through inactivating STAT3 signaling in prostate cancer cells.
PubMed:Morusin inhibits glioblastoma stem cell growth in vitro and in vivo through stemness attenuation, adipocyte transdifferentiation, and apoptosis induction.
PubMed:Antitumor progression potential of morusin suppressing STAT3 and NFκB in human hepatoma SK-Hep1 cells.
PubMed:Preparation of morusin from Ramulus mori and its effects on mice with transplanted H22 hepatocarcinoma.
PubMed:Effects of Morus alba L. and Natural Products Including Morusin on In Vivo Secretion and In Vitro Production of Airway MUC5AC Mucin.
PubMed:A new antioxidant stilbene and other constituents from the stem bark of Morus nigra L.
PubMed:[Study on the chemical constituents of mori cortex].
PubMed:Morusin inhibits human cervical cancer stem cell growth and migration through attenuation of NF-κB activity and apoptosis induction.
PubMed:Virtual screening of Indonesian herbal database as HIV-1 reverse transcriptase inhibitor.
PubMed:Protection of prenylated flavonoids from Mori Cortex Radicis (Moraceae) against nitric oxide-induced cell death in neuroblastoma SH-SY5Y cells.
PubMed:Induction of Biologically Active Flavonoids in Cell Cultures of Morus nigra and Testing their Hypoglycemic Efficacy.
PubMed:Inhibitory effects of constituents from Morus alba var. multicaulis on differentiation of 3T3-L1 cells and nitric oxide production in RAW264.7 cells.
PubMed:Isolation of cholinesterase-inhibiting flavonoids from Morus lhou.
PubMed:New isoprenylated flavonoid from Morus alba.
PubMed:Cytotoxic prenylated flavonoids from Morus alba.
PubMed:New isoprenylated flavonoids and cytotoxic constituents from Artocarpus tonkinensis.
PubMed:Prenylated flavones from Artocarpus altilis.
PubMed:[Studies on chemical constituents from twigs of Morus atropurpurea].
PubMed:Inhibitory effects on mushroom tyrosinase by flavones from the stem barks of Morus lhou (S.) Koidz.
PubMed:Morusin induces apoptosis and suppresses NF-kappaB activity in human colorectal cancer HT-29 cells.
PubMed:Phenolic constituents from the wood of Morus australis with cytotoxic activity.
PubMed:[Studies on chemical constituents from bark of Morus nigra].
PubMed:[Determination of morusin in cortex mori].
PubMed:Hypoglycemic effect of Egyptian Morus alba root bark extract: effect on diabetes and lipid peroxidation of streptozotocin-induced diabetic rats.
PubMed:Antimicrobial and cytotoxic activity of 18 prenylated flavonoids isolated from medicinal plants: Morus alba L., Morus mongolica Schneider, Broussnetia papyrifera (L.) Vent, Sophora flavescens Ait and Echinosophora koreensis Nakai.
PubMed:Antinephritis and radical scavenging activity of prenylflavonoids.
PubMed:Root turnover: an important source of microbial substrates in rhizosphere remediation of recalcitrant contaminants.
PubMed:Effects of naturally occurring prenylated flavonoids on enzymes metabolizing arachidonic acid: cyclooxygenases and lipoxygenases.
PubMed:Effects of prenylated flavonoids and biflavonoids on lipopolysaccharide-induced nitric oxide production from the mouse macrophage cell line RAW 264.7.
PubMed:Antinociceptive properties of morusin, a prenylflavonoid isolated from Morus nigra root bark.
PubMed:Accurate mass measurement of low molecular weight compounds by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.
PubMed:Chemistry and biological activities of constituents from Morus australis.
PubMed:Bioactive constituents of Morus australis and Broussonetia papyrifera.
PubMed:A prenylflavone, artonin E, as arachidonate 5-lipoxygenase inhibitor.
PubMed:Chemistry and anti-tumor promoting activity of Morus flavonoids.
PubMed:Components of root bark of morus lhou1 1. Structures of two new natural diels-alder adducts, kuwanons N and o.
PubMed:[Components of Root Bark of Morus australis.].
PubMed:Constituents of the Chinese crude drug "sāng-bái-pí" (Morus root bark).
PubMed:Constituents of the cultivated mulberry tree.
 
Notes:
None found
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