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ginsenoside Rb3

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CAS Number: 68406-26-8Picture of molecule3D/inchi
FDA UNII: W6V49A8FJQ
Nikkaji Web:J19.457C
MDL:MFCD10566396
XlogP3-AA:0.30 (est)
Molecular Weight:1079.28270000
Formula:C53 H90 O22
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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US Patents:Search
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Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
Ginsenoside Rb3 98%
BOC Sciences
For experimental / research use only.
Ginsenoside-Rb3
Carbosynth
For experimental / research use only.
Ginsenoside Rb3
Santa Cruz Biotechnology
For experimental / research use only.
Ginsenoside Rb3 ≥98%
Sigma-Aldrich
For experimental / research use only.
Ginsenoside Rb3 analytical standard
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for ginsenoside Rb3 usage levels up to:
 not for fragrance use.
 
Recommendation for ginsenoside Rb3 flavor usage levels up to:
 not for flavor use.
 
Safety References:
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :12912363
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
Chemidplus:0068406268
RTECS:LZ5857000 for cas# 68406-26-8
 
References:
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):12912363
Pubchem (cas):68406-26-8
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
HMDB (The Human Metabolome Database):HMDB34996
FooDB:FDB014034
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 panax ginseng
Search Trop Picture
 
Synonyms:
alpha-D-glucopyranoside, (3-beta,12-beta)-3-((2-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl)oxy)-12-hydroxydammar-24-en-20-yl 6-O-beta-D-xylopyranosyl-
 

Articles:

PubMed:Analysis of bioactive components and multi-component pharmacokinetics of saponins from the leaves of Panax notoginseng in rat plasma after oral administration by LC-MS/MS.
PubMed:Involvement of N-Methyl-D-Aspartic Acid Receptor and DL-α-Amino-3-Hydroxy-5- Methyl-4-Isoxazole Propionic Acid Receptor in Ginsenosides Rb1 and Rb3 against Oxygen-Glucose Deprivation-Induced Injury in Hippocampal Slices from Rat.
PubMed:Ginsenoside-Rb3 inhibits endothelial-mesenchymal transition of cardiac microvascular endothelial cells.
PubMed:Ginsenosides Rb3 and Rd reduce polyps formation while reinstate the dysbiotic gut microbiota and the intestinal microenvironment in ApcMin/+mice.
PubMed:[Study on UPLC fingerprint of red ginseng based on good separation and good purity of chromatographic peaks].
PubMed:Ginsenoside Rb3 strengthens the hypoglycemic effect through AMPK for inhibition of hepatic gluconeogenesis.
PubMed:Chemical Comparison of Two Drying Methods of Mountain Cultivated Ginseng by UPLC-QTOF-MS/MS and Multivariate Statistical Analysis.
PubMed:Transcriptome profiling shows gene regulation patterns in ginsenoside pathway in response to methyl jasmonate in Panax Quinquefolium adventitious root.
PubMed:Fungal elicitors enhance ginsenosides biosynthesis, expression of functional genes as well as signal molecules accumulation in adventitious roots of Panax ginseng C. A. Mey.
PubMed:The pharmacokinetic screening of multiple components of the Nao Mai Tong formula in rat plasma by liquid chromatography tandem mass spectrometry combined with pattern recognition method and its application to comparative pharmacokinetics.
PubMed:Antidepressant-like effects of ginsenosides: A comparison of ginsenoside Rb3 and its four deglycosylated derivatives, Rg3, Rh2, compound K, and 20(S)-protopanaxadiol in mice models of despair.
PubMed:Protective properties of ginsenoside Rb3 against UV-B radiation-induced oxidative stress in HaCaT keratinocytes.
PubMed:[The estrogen-like protective effect of ginsenoside Rb3 on oxidative stress and dysfunction of endothelial cells induced by oxidized low-density lipoprotein].
PubMed:Ginsenoside-Rb3 protects the myocardium from ischemia-reperfusion injury via the inhibition of apoptosis in rats.
PubMed:Antitumor effects of dammarane-type saponins from steamed Notoginseng.
PubMed:Ginsenoside Rb3 protects cardiomyocytes against ischemia-reperfusion injury via the inhibition of JNK-mediated NF-κB pathway: a mouse cardiomyocyte model.
PubMed:Ginsenoside Rb3 attenuates oxidative stress and preserves endothelial function in renal arteries from hypertensive rats.
PubMed:Hydrophilic interaction chromatography for selective separation of isomeric saponins.
PubMed:[Screening of pregnane X receptor activation from ginsenosides].
PubMed:[High-resolution THz spectra of six biological and pharmaceutical materials].
PubMed:Saponins composition of rhizomes, taproots, and lateral roots of Satsuma-ninjin (Panax japonicus).
PubMed:Four new triterpenoid saponins from the leaves of Panax japonicus grown in southern Miyazaki Prefecture (4).
PubMed:Anti-diabetic effect of ginsenoside Rb(3) in alloxan-induced diabetic mice.
PubMed:Determination of ginsenosides Rb1, Rb2, and Rb3 in rat plasma by a rapid and sensitive liquid chromatography tandem mass spectrometry method: Application in a pharmacokinetic study.
PubMed:New triterpenoid saponins from fruits specimens of Panax japonicus collected in Kumamoto and Miyazaki prefectures (1).
PubMed:Ginsenoside Rb3 exerts antidepressant-like effects in several animal models.
PubMed:Ginsenoside Rb3 ameliorates myocardial ischemia-reperfusion injury in rats.
PubMed:Inactivation of GABA(A) receptor reduces ginsenoside Rb3 neuroprotection in mouse hippocampal slices after oxygen-glucose deprivation.
PubMed:Ginsenoside Rb3 inhibits angiotensin II-induced vascular smooth muscle cells proliferation.
PubMed:Effect of ginsenoside Rb3 on myocardial injury and heart function impairment induced by isoproterenol in rats.
PubMed:Microbial transformation of ginsenosides Rb1, Rb3 and Rc by Fusarium sacchari.
PubMed:Protective effects of ginsenoside Rb(3) on oxygen and glucose deprivation-induced ischemic injury in PC12 cells.
PubMed:[Comparative studies on the amount of ginsenosides between the crown galls and Chinese medicinal materials of Panax quinquefolium].
PubMed:Inhibition of NMDA receptors underlies the neuroprotective effect of ginsenoside Rb3.
PubMed:Panax ginseng C.A. Meyer modulates the levels of MMP3 in S12 murine articular cartilage cell line.
PubMed:[A quantitative method using one marker for simultaneous assay of ginsenosides in Panax ginseng and P. notoginseng].
PubMed:[Purification and characterization of a beta-D-xylosidase from Leifsonia shinshuensis DICP 16].
PubMed:The inhibitory effects of garlic and Panax ginseng extract standardized with ginsenoside Rg3 on the genotoxicity, biochemical, and histological changes induced by ethylenediaminetetraacetic acid in male rats.
PubMed:Chemical characteristics of three medicinal plants of the Panax genus determined by HPLC-ELSD.
PubMed:[Protective effects of ginsenoside RB3 on hypoxic/ischemic brain injury and involved mechanisms].
PubMed:Saponins composition in American ginseng leaf and berry assayed by high-performance liquid chromatography.
PubMed:Chemical characteristics for different parts of Panax notoginseng using pressurized liquid extraction and HPLC-ELSD.
PubMed:[Effects and mechanisms of ginsenoside Rb3 on glutamate excitotoxic injury in cultured neurons of rat hippocampus].
PubMed:The growth characteristics and ginsenosides isolation of suspension-cultured crown gall of Panax quinquefolium.
PubMed:Inhibitory influence of ginsenoside Rb(3) on activation of strychnine-sensitive glycine receptors in hippocampal neurons of rat.
PubMed:A dammarane glycoside derived from ginsenoside Rb3.
PubMed:Dammarane-type Saponins from Panax japonicus and their neurite outgrowth activity in SK-N-SH cells.
PubMed:Effects of ginsenosides from Panax ginseng on cell-to-cell communication function mediated by gap junctions.
PubMed:Influences of ginsenosides Rb1, Rb2, and Rb3 on electric and contractile activities of normal and damaged cultured myocardiocytes.
PubMed:[Chemical constituents of flower-buds of Panax ginseng--isolation and identification of ginsenoside-Rb3 and ginsenoside-Rc].
 
Notes:
None found
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