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Category:natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Soluble in: |
| | water, 10.64 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
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| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
|
Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | natural substances and extractives |
| Recommendation for saussurea lactone usage levels up to: | | | not for fragrance use.
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| |
| Recommendation for saussurea lactone flavor usage levels up to: |
| | not for flavor use.
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Safety References:
| EPI System: View |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :11160662 |
| National Institute of Allergy and Infectious Diseases:Data |
| (3S,3aS,6S,7S,7aS)-6-ethenyl-3,6-dimethyl-7-prop-1-en-2-yl-3,3a,4,5,7,7a-hexahydro-1-benzofuran-2-one |
References:
| | (3S,3aS,6S,7S,7aS)-6-ethenyl-3,6-dimethyl-7-prop-1-en-2-yl-3,3a,4,5,7,7a-hexahydro-1-benzofuran-2-one |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 11160662 |
| Pubchem (cas): | 23527-07-3 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| (3S,3aS,6S,7S,7aS)-6- | ethenyl-3,6-dimethyl-7-prop-1-en-2-yl-3,3a,4,5,7,7a-hexahydro-1-benzofuran-2-one |
Articles:
| PubMed:Anti-allergic effects of sesquiterpene lactones from Saussurea costus (Falc.) Lipsch. determined using in vivo and in vitro experiments. |
| PubMed:Inhibition of TNF-α-Induced Inflammation by Sesquiterpene Lactones from Saussurea lappa and Semi-Synthetic Analogues. |
| PubMed:Costunolide and dehydrocostuslactone combination treatment inhibit breast cancer by inducing cell cycle arrest and apoptosis through c-Myc/p53 and AKT/14-3-3 pathway. |
| PubMed:Bioassay-guided isolation of dehydrocostus lactone from Saussurea lappa: A new targeted cytosolic thioredoxin reductase anticancer agent. |
| PubMed:"Click" reaction mediated synthesis of costunolide and dehydrocostuslactone derivatives and evaluation of their cytotoxic activity. |
| PubMed:Costunolide induces G1/S phase arrest and activates mitochondrial-mediated apoptotic pathways in SK-MES 1 human lung squamous carcinoma cells. |
| PubMed:A new sesquiterpenoid from Saussurea lappa roots. |
| PubMed:Bioactivity-Guided Isolation of Antiproliferative Sesquiterpene Lactones from Centaurea solstitialis L. ssp. solstitialis. |
| PubMed:The Genome-Wide Expression Profile of Saussurea lappa Extract on House Dust Mite-Induced Atopic Dermatitis in Nc/Nga Mice. |
| PubMed:Potential anti-cancer activities and mechanisms of costunolide and dehydrocostuslactone. |
| PubMed:Sesquiterpene lactones derived from Saussurea lappa induce apoptosis and inhibit invasion and migration in neuroblastoma cells. |
| PubMed:Alantolactone from Saussurea lappa Exerts Antiinflammatory Effects by Inhibiting Chemokine Production and STAT1 Phosphorylation in TNF-α and IFN-γ-induced in HaCaT cells. |
| PubMed:Estimation of Costunolide and Dehydrocostus Lactone in Saussurea lappa and its Polyherbal Formulations followed by their Stability Studies Using HPLC-DAD. |
| PubMed:Inhibition of Wnt/β-Catenin Pathway by Dehydrocostus Lactone and Costunolide in Colon Cancer Cells. |
| PubMed:UPLC/MS/MS method for quantification and cytotoxic activity of sesquiterpene lactones isolated from Saussurea lappa. |
| PubMed:Dehydrocostuslactone inhibits LPS-induced inflammation by p38MAPK-dependent induction of hemeoxygenase-1 in vitro and improves survival of mice in CLP-induced sepsis in vivo. |
| PubMed:Saussurea lappa Clarke-Derived Costunolide Prevents TNF α -Induced Breast Cancer Cell Migration and Invasion by Inhibiting NF- κ B Activity. |
| PubMed:Volatile constituents of Saussurea costus roots cultivated in Uttarakhand Himalayas, India. |
| PubMed:Pulchellamin G, an amino acid-sesquiterpene lactone, from Saussurea pulchella suppresses lipopolysaccharide-induced inflammatory responses via heme oxygenase-1 expression in murine peritoneal macrophages. |
| PubMed:A note on Aucklandia lappa. |
| PubMed:Studies on lymphangiogenesis inhibitors from Korean and Japanese crude drugs. |
| PubMed:Effect of costunolide and dehydrocostus lactone on cell cycle, apoptosis, and ABC transporter expression in human soft tissue sarcoma cells. |
| PubMed:[Chemical constituents from a portion of ethanolicextract of Saussurea lappa roots]. |
| PubMed:NF-κB dependent anti-inflammatory activity of chlorojanerin isolated from Saussurea heteromalla. |
| PubMed:Santamarin, a sesquiterpene lactone isolated from Saussurea lappa, represses LPS-induced inflammatory responses via expression of heme oxygenase-1 in murine macrophage cells. |
| PubMed:Dehydrocostuslactone suppresses angiogenesis in vitro and in vivo through inhibition of Akt/GSK-3β and mTOR signaling pathways. |
| PubMed:Essential oil composition and larvicidal activity of Saussurea lappa roots against the mosquito Aedes albopictus (Diptera: Culicidae). |
| PubMed:The hexane extract of Saussurea lappa and its active principle, dehydrocostus lactone, inhibit prostate cancer cell migration. |
| PubMed:Matrix solid-phase dispersion extraction coupled with HPLC-diode array detection method for the analysis of sesquiterpene lactones in root of Saussurea lappa C.B.Clarke. |
| PubMed:Sesquiterpene lactones from Saussurea involucrata. |
| PubMed:Antitrypanosomal sesquiterpene lactones from Saussurea costus. |
| PubMed:Dehydrocostus lactone prevents mitochondrial dysfunction in osteoblastic MC3T3-E1 cells. |
| PubMed:A new sesquiterpene and other constituents from Saussurea lappa root. |
| PubMed:Quantitative analysis of costunolide and dehydrocostuslactone in rat plasma by ultraperformance liquid chromatography-electrospray ionization-mass spectrometry. |
| PubMed:[Lactone constituents of Saussurea involucrata]. |
| PubMed:Evaluation of anticancer activity of dehydrocostuslactone in vitro. |
| PubMed:Dehydrocostuslactone, a medicinal plant-derived sesquiterpene lactone, induces apoptosis coupled to endoplasmic reticulum stress in liver cancer cells. |
| PubMed:Isolation of betulinic acid, its methyl ester and guaiane sesquiterpenoids with protein tyrosine phosphatase 1B inhibitory activity from the roots of Saussurea lappa C.B.Clarke. |
| PubMed:Apoptosis of DU145 human prostate cancer cells induced by dehydrocostus lactone isolated from the root of Saussurea lappa. |
| PubMed:A new sesquiterpene lactone from the roots of Saussurea lappa: structure-anticancer activity study. |
| PubMed:Sulfonated guaianolides from Saussurea lappa. |
| PubMed:Guaiane sesquiterpene lactones and amino acid-sesquiterpene lactone conjugates from the aerial parts of Saussurea pulchella. |
| PubMed:The chemopreventive effects of Saussurea salicifolia through induction of apoptosis and phase II detoxification enzyme. |
| PubMed:Two new butenolide derivatives from Saussurea katochaete. |
| PubMed:A new sesquiterpene lactone with sulfonic acid group from Saussurea lappa. |
| PubMed:The alpha-methylene-gamma-butyrolactone moiety in dehydrocostus lactone is responsible for cytoprotective heme oxygenase-1 expression through activation of the nuclear factor E2-related factor 2 in HepG2 cells. |
| PubMed:Sesquiterpene lactones from Saussurea alata. |
| PubMed:Saussurea costus: botanical, chemical and pharmacological review of an ayurvedic medicinal plant. |
| PubMed:PTP1B inhibitors from Saussrurea lappa. |
| PubMed:Cytotoxic sesquiterpene lactones from Saussurea calcicola. |
| PubMed:Two new sesquiterpene lactones with the sulfonic acid group from Saussurea lappa. |
| PubMed:In vitro cytotoxicity of Mokko lactone in human leukemia HL-60 cells: induction of apoptotic cell death by mitochondrial membrane potential collapse. |
| PubMed:Dehydrocostus lactone enhances tumor necrosis factor-alpha-induced apoptosis of human leukemia HL-60 cells. |
| PubMed:Cytotoxic and pro-apoptotic activities of cynaropicrin, a sesquiterpene lactone, on the viability of leukocyte cancer cell lines. |
| PubMed:Costunolide inhibits interleukin-1beta expression by down-regulation of AP-1 and MAPK activity in LPS-stimulated RAW 264.7 cells. |
| PubMed:Cytotoxic sesquiterpene lactones from the root of Saussurea lappa. |
| PubMed:Evaluation of sesquiterpene lactone fraction of Saussurea lappa on transudative, exudative and proliferative phases of inflammation. |
| PubMed:Effects of sesquiterpenes and amino acid-sesquiterpene conjugates from the roots of Saussurea lappa on inducible nitric oxide synthase and heat shock protein in lipopolysaccharide-activated macrophages. |
| PubMed:Costunolide triggers apoptosis in human leukemia U937 cells by depleting intracellular thiols. |
| PubMed:Costunolide, a sesquiterpene lactone from Saussurea lappa, inhibits the VEGFR KDR/Flk-1 signaling pathway. |
| PubMed:Germacrenes from fresh costus roots. |
| PubMed:In vitro anti-inflammatory effects of cynaropicrin, a sesquiterpene lactone, from Saussurea lappa. |
| PubMed:Inhibition of LPS-induced NO production and NF-kappaB activation by a sesquiterpene from Saussurea lappa. |
| PubMed:A sesquiterpene, dehydrocostus lactone, inhibits the expression of inducible nitric oxide synthase and TNF-alpha in LPS-activated macrophages. |
| PubMed:Inhibitory effect of sesquiterpene lactones from Saussurea lappa on tumor necrosis factor-alpha production in murine macrophage-like cells. |
| PubMed:Effect of dehydrocostus lactone and costunolide from Saussurea root on the central nervous system in mice. |
| PubMed:Costunolide and dehydrocostus lactone as inhibitors of killing function of cytotoxic T lymphocytes. |
| PubMed:Active compounds from Saussurea lappa Clarks that suppress hepatitis B virus surface antigen gene expression in human hepatoma cells. |
| PubMed:Saussureamines A, B, C, D, and E, new anti-ulcer principles from Chinese Saussureae Radix. |
| PubMed:Allergic contact dermatitis to costus: removal of haptens with polymers. |
| PubMed:Pharmacological investigations on Saussurea lappa (Clarke). |
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3D/inchi