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levistolide A

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CAS Number:	89708-23-6	3D/inchi
FDA UNII:	Search
Nikkaji Web:	J470.616A
XlogP3-AA:	4.90 (est)
Molecular Weight:	380.48396000
Formula:	C24 H28 O4
NMR Predictor:	Predict (works with chrome, Edge or firefox)

Category:natural substances and extractives

US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:

Google Scholar:	Search
Google Books:	Search
Google Scholar: with word "volatile"	Search
Google Scholar: with word "flavor"	Search
Google Scholar: with word "odor"	Search
Google Patents:	Search
US Patents:	Search
EU Patents:	Search
Pubchem Patents:	Search
PubMed:	Search
NCBI:	Search

Physical Properties:

Assay:	95.00 to 100.00
Food Chemicals Codex Listed:	No
Soluble in:
	water, 0.2291 mg/L @ 25 °C (est)

Organoleptic Properties:

Odor and/or flavor descriptions from others (if found).

Cosmetic Information:

None found

Suppliers:

None found

Safety Information:


Hazards identification

Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements

Pictogram

Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in Use Information:

Category:
natural substances and extractives
Recommendation for levistolide A usage levels up to:
	not for fragrance use.

Recommendation for levistolide A flavor usage levels up to:
	not for flavor use.

Safety References:

EPI System: View

AIDS Citations:Search

Cancer Citations:Search

Toxicology Citations:Search

EPA ACToR:Toxicology Data

EPA Substance Registry Services (SRS):Registry

Laboratory Chemical Safety Summary :70698035

National Institute of Allergy and Infectious Diseases:Data

References:

NIST Chemistry WebBook:	Search Inchi
Pubchem (cid):	70698035
Pubchem (cas):	89708-23-6

Other Information:

(IUPAC):	Atomic Weights of the Elements 2011 (pdf)
Videos:	The Periodic Table of Videos
tgsc:	Atomic Weights use for this web site
(IUPAC):	Periodic Table of the Elements
CHEBI:	View
HMDB (The Human Metabolome Database):	Search
FooDB:	FDB012532
VCF-Online:	VCF Volatile Compounds in Food
EFSA Update of results on the monitoring of furan levels in food:	Read Report
EFSA Previous report: Results on the monitoring of furan levels in food:	Read Report
EFSA Report of the CONTAM Panel on provisional findings on furan in food:	Read Report

Potential Blenders and core components note

None Found

Potential Uses:

None Found

Occurrence (nature, food, other):note

ligusticum glaucescens
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Synonyms:

(Z,Z)-	diligustilide
1H-5,10c-	ethanonaphtho(1,2-c:7,8-c')difuran-3,10-dione, 1,8-dibutylidene-5,5a,6,7,8,10b-hexahydro-, (1Z,5S,5aS,8Z,10bS,10cs)-

Articles:

PubMed:Diligustilide releases H₂S and stabilizes S-nitrosothiols in ethanol-induced lesions on rat gastric mucosa.

PubMed:Levistolide A Induces Apoptosis via ROS-Mediated ER Stress Pathway in Colon Cancer Cells.

PubMed:The variation in the major constituents of the dried rhizome of Ligusticum chuanxiong (Chuanxiong) after herbal processing.

PubMed:Gastroprotective effect of diligustilide isolated from roots of Ligusticum porteri coulter & rose (Apiaceae) on ethanol-induced lesions in rats.

PubMed:Sulfur dioxide residue in sulfur-fumigated edible herbs: The fewer, the safer?

PubMed:Vasorelaxant effects of Shunaoxin pill are mediated by NO/cGMP pathway, HO/CO pathway and calcium channel blockade in isolated rat thoracic aorta.

PubMed:Screening anti-tumor compounds from Ligusticum wallichii using cell membrane chromatography combined with high-performance liquid chromatography and mass spectrometry.

PubMed:Study on Pharmacokinetics of Three Preparations from Levistolide A by LC-MS-MS.

PubMed:Optimization of high-pressure ultrasonic-assisted simultaneous extraction of six major constituents from Ligusticum chuanxiong rhizome using response surface methodology.

PubMed:[Optimization of supercritical fluid extraction of bioactive components in Ligusticum chuanxiong by orthogonal array design].

PubMed:[Chemical change of chuanxiong raw materials during storage].

PubMed:Online isolation and purification of four phthalide compounds from Chuanxiong rhizoma using high-speed counter-current chromatography coupled with semi-preparative liquid chromatography.

PubMed:Antimycobacterials from lovage root (Ligusticum officinale Koch).

PubMed:Quantitative HPLC method for determining two of the major active phthalides from Ligusticum porteri roots.

PubMed:Two phthalide dimers from the radix of Angelica sinensis.

PubMed:Identification of the absorbed components and metabolites in rat plasma after oral administration of Rhizoma Chuanxiong decoction by HPLC-ESI-MS/MS.

PubMed:[Studies on the chemical constituents of Ligusticum sinense].

PubMed:[Studies on the chemical constituents of the root and rhizoma of Ligusticum jeholense].

PubMed:Identification and determination of the major constituents in Traditional Chinese Medicinal formula Danggui-Shaoyao-San by HPLC-DAD-ESI-MS/MS.

PubMed:[Study on biligustilides from Angelica sinensis].

PubMed:Levistolide A overcomes P-glycoprotein-mediated drug resistance in human breast carcinoma cells.

PubMed:Studies on antiproliferative effects of phthalides from Ligusticum chuanxiong in hepatic stellate cells.

PubMed:[Studies on chemical constituents from Ligusticum glaucescens Franch].

PubMed:Post-harvest alteration of the main chemical ingredients in Ligusticum chuanxiong Hort. (Rhizoma Chuanxiong).

PubMed:Dimeric progestins from rhizomes of Ligusticum chuanxiong.

PubMed:Development of high-performance liquid chromatographic fingerprints for distinguishing Chinese Angelica from related umbelliferae herbs.

PubMed:[New dimeric phthalide derivative from Angelica sinensis].

PubMed:[Study on fingerprint of rhizoma chuanxiong by HPLC-DAD-MS].

PubMed:Simultaneous analysis of seventeen chemical ingredients of Ligusticum chuanxiong by on-line high performance liquid chromatography-diode array detector-mass spectrometry.

Notes:

None found

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