EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

psoralidin

Supplier Sponsors

CAS Number: 18642-23-4Picture of molecule3D/inchi
FDA UNII: G16ZUQ069L
Nikkaji Web:J14.254I
XlogP3-AA:4.70 (est)
Molecular Weight:336.34352000
Formula:C20 H16 O5
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Soluble in:
 water, 0.9815 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
Psoralidin 98%
BOC Sciences
For experimental / research use only.
Psoralidin >98%
Odor: characteristic
Use: Psoralidin is a furanocoumarin natural product used in Chinese medicine. Psoralidin, a PTP1B inhibitor, has been shown to have anticancer activity with a variety of mechanisms proposed. Psoralidin induces ROS generation in androgen-independent prostate c
Sigma-Aldrich
For experimental / research use only.
Psoralidin ≥98% (HPLC)
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for psoralidin usage levels up to:
 not for fragrance use.
 
Recommendation for psoralidin flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :5281806
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
3,9-dihydroxy-2-(3-methylbut-2-enyl)-[1]benzofuro[3,2-c]chromen-6-one
Chemidplus:0018642234
 
References:
 3,9-dihydroxy-2-(3-methylbut-2-enyl)-[1]benzofuro[3,2-c]chromen-6-one
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):5281806
Pubchem (cas):18642-23-4
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
KEGG (GenomeNet):C10523
HMDB (The Human Metabolome Database):HMDB34050
FooDB:FDB012294
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 dolichos biflorus
Search Trop Picture
 phaseolus lunatus
Search Trop Picture
 
Synonyms:
6H-benzofuro(3,2-c)(1)benzopyran-6-one, 3,9-dihydroxy-2-(3-methyl-2-butenyl)-
3,9-dihydroxy-2-(3-methyl-2-butenyl)-6H-benzofuro(3,2-c)(1)benzopyran-6-one
3,9-dihydroxy-2-(3-methylbut-2-enyl)-[1]benzofuro[3,2-c]chromen-6-one
 

Articles:

PubMed:Bavachalcone from Cullen corylifolium induces apoptosis and autophagy in HepG2 cells.
PubMed:Plasma pharmacokinetics and cerebral nuclei distribution of major constituents of Psoraleae fructus in rats after oral administration.
PubMed:Protective effects of psoralidin on IL‑1β‑induced chondrocyte apoptosis.
PubMed:Rapid separation and simultaneous quantitative determination of 13 constituents in Psoraleae Fructus by a single marker using high-performance liquid chromatography with diode array detection.
PubMed:Isoflavones and anti-inflammatory constituents from the fruits of Psoralea corylifolia.
PubMed:Psoralidin suppresses osteoclastogenesis in BMMs and attenuates LPS-mediated osteolysis by inhibiting inflammatory cytokines.
PubMed:Qualitative analysis of Psoraleae Fructus by HPLC-DAD/TOF-MS fingerprint and quantitative analysis of multiple components by single marker.
PubMed:Inhibition of autophagy prevents cadmium-induced prostate carcinogenesis.
PubMed:Psoralidin, a prenylated coumestan, as a novel anti-osteoporosis candidate to enhance bone formation of osteoblasts and decrease bone resorption of osteoclasts.
PubMed:The Benzopyrone Biochanin-A as a reversible, competitive, and selective monoamine oxidase B inhibitor.
PubMed:Targeting aberrant expression of Notch-1 in ALDH+cancer stem cells in breast cancer.
PubMed:Synthesis of Psoralidin derivatives and their anticancer activity: First synthesis of Lespeflorin I1.
PubMed:[Biosynthesis of a new psoralidin glucoside by enzymatic glycosylation].
PubMed:Quantitative Analysis of Psoralea corylifolia Linne and its Neuroprotective and Anti-Neuroinflammatory Effects in HT22 Hippocampal Cells and BV-2 Microglia.
PubMed:Psoralidin inhibits proliferation and enhances apoptosis of human esophageal carcinoma cells via NF-κB and PI3K/Akt signaling pathways.
PubMed:Comparison of the in vitro metabolism of psoralidin among different species and characterization of its inhibitory effect against UDP- glucuronosyltransferase (UGT) or cytochrome p450 (CYP450) enzymes.
PubMed:Psoralidin induced reactive oxygen species (ROS)-dependent DNA damage and protective autophagy mediated by NOX4 in breast cancer cells.
PubMed:Nanoencapsulation of psoralidin via chitosan and Eudragit S100 for enhancement of oral bioavailability.
PubMed:The molecular pathway of psoralidin-induced apoptosis in HepG2 cell line.
PubMed:Quality Assessment of Psoralea fructus by HPLC Fingerprint Coupled with Multi-components Analysis.
PubMed:Differential effect of psoralidin in enhancing apoptosis of colon cancer cells via nuclear factor-κB and B-cell lymphoma-2/B-cell lymphoma-2-associated X protein signaling pathways.
PubMed:Inhibition behavior of fructus psoraleae's ingredients towards human carboxylesterase 1 (hCES1).
PubMed:In vitro and in vivo assessment of the effect of antiprotozoal compounds isolated from Psoralea corylifolia against Ichthyophthirius multifiliis in fish.
PubMed:Regio- and isoform-specific glucuronidation of psoralidin: evaluation of 3-o-glucuronidation as a functional marker for UGT1A9.
PubMed:Plant-derived natural medicines for the management of depression: an overview of mechanisms of action.
PubMed:Dealing naturally with stumbling blocks on highways and byways of TRAIL induced signaling.
PubMed:Psoralidin induces autophagy through ROS generation which inhibits the proliferation of human lung cancer A549 cells.
PubMed:Herb-drug interaction between irinotecan and psoralidin-containing herbs.
PubMed:Psoralidin, a coumestan analogue, as a novel potent estrogen receptor signaling molecule isolated from Psoralea corylifolia.
PubMed:[Chemical constituents from Psoralea corylifolia and their antioxidant alpha-glucosidase inhibitory and antimicrobial activities].
PubMed:Silencing NOTCH signaling causes growth arrest in both breast cancer stem cells and breast cancer cells.
PubMed:[Study on effect of psoralidin on anti-experimental postmenopausal osteoporosis and its mechanism].
PubMed:Isobavachalcone and bavachinin from Psoraleae Fructus modulate Aβ42 aggregation process through different mechanisms in vitro.
PubMed:Psoralea corylifolia L. (Buguchi) - folklore to modern evidence: review.
PubMed:Induction of reactive oxygen species generation inhibits epithelial-mesenchymal transition and promotes growth arrest in prostate cancer cells.
PubMed:Phenolic phytochemical displaying SARS-CoV papain-like protease inhibition from the seeds of Psoralea corylifolia.
PubMed:The coumarin psoralidin enhances anticancer effect of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL).
PubMed:[Study on the chemical constituents of Psoralea corylifolia].
PubMed:[Variation of 4 kinds of compounds in Psoralea corylifolia processed by different methods].
PubMed:Retraction. Psoralidin, an herbal molecule, inhibits phosphatidylinositol 3-kinase-mediated Akt signaling in androgen-independent prostate cancer cells.
PubMed:Psoralidin, a dual inhibitor of COX-2 and 5-LOX, regulates ionizing radiation (IR)-induced pulmonary inflammation.
PubMed:Enhanced TRAIL-mediated apoptosis in prostate cancer cells by the bioactive compounds neobavaisoflavone and psoralidin isolated from Psoralea corylifolia.
PubMed:Psoralidin inhibits LPS-induced iNOS expression via repressing Syk-mediated activation of PI3K-IKK-IκB signaling pathways.
PubMed:Activating stress-activated protein kinase-mediated cell death and inhibiting epidermal growth factor receptor signaling: a promising therapeutic strategy for prostate cancer.
PubMed:Isolation of antioxidants from Psoralea corylifolia fruits using high-speed counter-current chromatography guided by thin layer chromatography-antioxidant autographic assay.
PubMed:Inhibiting TNF-mediated signaling: a novel therapeutic paradigm for androgen independent prostate cancer.
PubMed:Induction of quinone reductase activity by psoralidin isolated from Psoralea corylifolia in mouse hepa 1c1c7 cells.
PubMed:Total synthesis of psoralidin, an anticancer natural product.
PubMed:Psoralidin, an herbal molecule, inhibits phosphatidylinositol 3-kinase-mediated Akt signaling in androgen-independent prostate cancer cells.
PubMed:Bioactive constituents from Chinese natural medicines. XXXIII. Inhibitors from the seeds of Psoralea corylifolia on production of nitric oxide in lipopolysaccharide-activated macrophages.
PubMed:[Studies on chemical constituents from seed of Psoralea corylifolia].
PubMed:Transcriptional regulation of corticotrophin releasing factor gene by furocoumarins isolated from seeds of Psoralea corylifolia.
PubMed:Antidepressant-like effects of psoralidin isolated from the seeds of Psoralea Corylifolia in the forced swimming test in mice.
PubMed:Chemical fingerprint and quantitative analysis of fructus psoraleae by high-performance liquid chromatography.
PubMed:Bioactive constituents from Chinese natural medicines. XX. Inhibitors of antigen-induced degranulation in RBL-2H3 cells from the seeds of Psoralea corylifolia.
PubMed:[Isolation and structure identification of a new isoflavone from Psoralea corylifolias].
PubMed:Fingerprint analysis of Psoralea corylifolia L. by HPLC and LC-MS.
PubMed:In vitro protein tyrosine phosphatase 1B inhibitory phenols from the seeds of Psoralea corylifolia.
PubMed:Antibacterial compounds from the seeds of Psoralea corylifolia.
PubMed:Cytotoxic constituents of Psoralea corylifolia.
PubMed:The cytotoxicity of psoralidin from Psoralea corylifolia.
 
Notes:
None found
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