EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

panaxydol

Supplier Sponsors

CAS Number: 72800-72-7Picture of molecule3D/inchi
FDA UNII: Search
Nikkaji Web:J361.085C
XlogP3-AA:4.50 (est)
Molecular Weight:260.37668000
Formula:C17 H24 O2
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Soluble in:
 water, 7.872 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
Panaxydol > 95%
Odor: characteristic
Use: Panaxydol, extracted from the roots of Panax ginseng C. A. Mey, inhibits the growth of cancer cells through EGFR activation and ER stress.
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for panaxydol usage levels up to:
 not for fragrance use.
 
Recommendation for panaxydol flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :126312
National Institute of Allergy and Infectious Diseases:Data
(3R)-8-[(2R,3S)-3-heptyloxiran-2-yl]oct-1-en-4,6-diyn-3-ol
Chemidplus:0072800727
 
References:
 (3R)-8-[(2R,3S)-3-heptyloxiran-2-yl]oct-1-en-4,6-diyn-3-ol
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):126312
Pubchem (cas):72800-72-7
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
HMDB (The Human Metabolome Database):HMDB34000
FooDB:FDB012234
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 panax ginseng
Search Trop Picture
 panax quinquefolium
Search Trop Picture
 
Synonyms:
(3R)-8-[(2R,3S)-3-heptyloxiran-2-yl]oct-1-en-4,6-diyn-3-ol
1-octene-4,6-diyn-3-ol, 8-(3-heptyloxiranyl)-
 

Articles:

PubMed:Inhibitory Effects of Polyacetylene Compounds from Panax ginseng on Neurotrophin Receptor-Mediated Hair Growth.
PubMed:Isolation and characterization of bioactive polyacetylenes Panax ginseng Meyer roots.
PubMed:Determining the mode of action of anti-mycobacterial C17 diyne natural products using expression profiling: evidence for fatty acid biosynthesis inhibition.
PubMed:Panaxydol, a component of Panax ginseng, induces apoptosis in cancer cells through EGFR activation and ER stress and inhibits tumor growth in mouse models.
PubMed:Gas chromatography/mass spectrometry-based metabolic profiling and differentiation of ginseng roots according to cultivation age using variable selection.
PubMed:Biosynthesis of panaxynol and panaxydol in Panax ginseng.
PubMed:Anti-mycobacterial diynes from the Canadian medicinal plant Aralia nudicaulis.
PubMed:[Simultaneous determination of panaxynol and panaxydol in fibrous root of Panax ginseng by HPLC].
PubMed:Induction of apoptosis in human promyelocytic leukemia HL60 cells by panaxynol and panaxydol.
PubMed:Induction of differentiation by panaxydol in human hepatocarcinoma SMMC-7721 cells via cAMP and MAP kinase dependent mechanism.
PubMed:Panaxydol induces apoptosis through an increased intracellular calcium level, activation of JNK and p38 MAPK and NADPH oxidase-dependent generation of reactive oxygen species.
PubMed:Quantitative comparison of ginsenosides and polyacetylenes in wild and cultivated American ginseng.
PubMed:Differential effects of falcarinol and related aliphatic C(17)-polyacetylenes on intestinal cell proliferation.
PubMed:Panaxydol inhibits the proliferation and induces the differentiation of human hepatocarcinoma cell line HepG2.
PubMed:Rapid method for simultaneous determination of flavonoid, saponins and polyacetylenes in folium ginseng and radix ginseng by pressurized liquid extraction and high-performance liquid chromatography coupled with diode array detection and mass spectrometry.
PubMed:Phosphatidylinositol 3-kinase activity is required for the induction of differentiation in C6 glioma cells by panaxydol.
PubMed:Biomass and content of ginsenosides and polyacetylenes in American ginseng roots can be increased without affecting the profile of bioactive compounds.
PubMed:Cyclic AMP-dependent regulation of differentiation of rat C6 glioma cells by panaxydol.
PubMed:Panaxydol treatment enhances the biological properties of Schwann cells in vitro.
PubMed:Effect of panaxydol on hypoxia-induced cell death and expression and secretion of neurotrophic factors (NTFs) in hypoxic primary cultured Schwann cells.
PubMed:Polyacetylenes from the roots of cultivated-wild ginseng and their cytotoxicity in vitro.
PubMed:Panaxydol and panaxynol protect cultured cortical neurons against Abeta25-35-induced toxicity.
PubMed:Growth inhibition and induction of differentiation by panaxydol in rat C6 glioma cells.
PubMed:Quantification of two polyacetylenes in Radix Ginseng and roots of related Panax species using a gas chromatography-mass spectrometric method.
PubMed:Induction of apoptosis in rat C6 glioma cells by panaxydol.
PubMed:Simultaneous determination of ginsenosides and polyacetylenes in American ginseng root (Panax quinquefolium L.) by high-performance liquid chromatography.
PubMed:Structural changes of polyacetylenes in American ginseng root can be observed in situ by using Raman spectroscopy.
PubMed:Protective effect of panaxydol and panaxynol on sodium nitroprusside-induced apoptosis in cortical neurons.
PubMed:Polyacetylenes in hairy roots of a panax hybrid.
PubMed:Determination of polyacetylenes and ginsenosides in Panax species using high performance liquid chromatography.
PubMed:Inducible nitric oxide synthase inhibitors from Saposhnikovia divaricata and Panax quinquefolium.
PubMed:Induction of G(1) cell cycle arrest and p27(KIP1) increase by panaxydol isolated from Panax ginseng.
PubMed:Synthesis of ginseng diyne analogues and their antiproliferative activity against L1210 cells.
PubMed:Effect of petroleum ether extract of Panax ginseng roots on proliferation and cell cycle progression of human renal cell carcinoma cells.
PubMed:Polyacetylene analogs, isolated from hairy roots of Panax ginseng, inhibit Acyl-CoA : cholesterol acyltransferase.
PubMed:Screening of polyacetylenic alcohols in crude drugs using the ELISA for panaxytriol.
PubMed:[Relationship between antiproliferative activity of acetylenic alcohol, panaxydol, and its affinity for target cell membrane].
PubMed:The first specific antibody against cytotoxic polyacetylenic alcohol, panaxynol.
PubMed:Cytotoxic activity of polyacetylene compounds in Panax ginseng C. A. Meyer.
PubMed:[Acetylpanaxydol and panaxydolchlorohydrin, two new polyenes from Korean ginseng with cytotoxic activity against L1210 cells].
PubMed:[Relation between structure and cytotoxic activity of panaxydol analogs against L1210 cells].
 
Notes:
None found
Please share your Comments.
Email Address:
Top of Page Home
Copyright © 1980-2021 The Good Scents Company (tgsc) ™ Disclaimer Privacy Policy