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piperic acid
isopiperinic acid

Supplier Sponsors

CAS Number: 5285-18-7Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:226-118-4
FDA UNII: Search
MDL:MFCD00047282
XlogP3:2.70 (est)
Molecular Weight:218.20850000
Formula:C12 H10 O4
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Soluble in:
 water, 291.7 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
5-(1,3-Benzodioxol-5-yl)-2,4-pentadienoic acid
Sigma-Aldrich: Aldrich
For experimental / research use only.
5-(1,3-Benzodioxol-5-yl)-2,4-pentadienoic acid 97%
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for piperic acid usage levels up to:
 not for fragrance use.
 
Recommendation for piperic acid flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :13001421
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
benzodioxol-5-yl)penta-2,4-dienoic acid
Chemidplus:0005285187
 
References:
 benzodioxol-5-yl)penta-2,4-dienoic acid
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):13001421
Pubchem (cas):5285-18-7
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):HMDB33779
FooDB:FDB011933
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 mentha piperita
Search Trop Picture
 piper nigrum fruit
Search Trop Picture
 
Synonyms:
5-(1,3-benzodioxol-5-yl)penta-2,4-dienoic acid
2,4-pentadienoic acid, 5-(1,3-benzodioxol-5-yl)- (9CI)
isopiperinic acid
 

Articles:

PubMed:Quantitative Structure-Cytotoxicity Relationship of Newly Synthesized Piperic Acid Esters.
PubMed:Restoration of plasma markers of liver and kidney functions/integrity in alloxan-induced diabetic rabbits by aqueous extract of Pleurotus tuberregium sclerotia.
PubMed:Synthesis of some monosaccharide-related ester derivatives as insecticidal and acaricidal agents.
PubMed:Targeting P-glycoprotein: Investigation of piperine analogs for overcoming drug resistance in cancer.
PubMed:Structure-activity relationship of piperine and its synthetic amide analogs for therapeutic potential to prevent experimentally induced ER stress in vitro.
PubMed:Amino acid amides of piperic acid (PA) and 4-ethylpiperic acid (EPA) as NorA efflux pump inhibitors of Staphylococcus aureus.
PubMed:Novel Piperine Derivatives with Antidiabetic Effect as PPAR-γ Agonists.
PubMed:Inhibition of Invasion in Pancreatic Cancer Cells by Conjugate of EPA with β(3,3)-Pip-OH via PI3K/Akt/NF-kB Pathway.
PubMed:Synthesis and biological evaluation of piperic acid amides as free radical scavengers and α-glucosidase inhibitors.
PubMed:Synthesis and antihyperlipidemic activity of piperic acid derivatives.
PubMed:Design, synthesis and biological evaluation of piperic acid triazolyl derivatives as potent anti-inflammatory agents.
PubMed:Development of piperic acid derivatives from Piper nigrum as UV protection agents.
PubMed:Derivatives form better lipoxygenase inhibitors than piperine: in vitro and in silico study.
PubMed:Quantitative structure-cytotoxicity relationship of piperic acid amides.
PubMed:Curcumin conjugates induce apoptosis via a mitochondrion dependent pathway in MCF-7 and MDA-MB-231 cell lines.
PubMed:Human papilloma virus 16 E6 protein as a target for curcuminoids, curcumin conjugates and congeners for chemoprevention of oral and cervical cancers.
PubMed:Synthesis and antileishmanial activity of piperoyl-amino acid conjugates.
PubMed:Bioconjugates of curcumin display improved protection against glutathione depletion mediated oxidative stress in a dopaminergic neuronal cell line: Implications for Parkinson's disease.
PubMed:Design, synthesis and characterization of some bioactive conjugates of curcumin with glycine, glutamic acid, valine and demethylenated piperic acid and study of their antimicrobial and antiproliferative properties.
PubMed:Design, development and synthesis of mixed bioconjugates of piperic acid-glycine, curcumin-glycine/alanine and curcumin-glycine-piperic acid and their antibacterial and antifungal properties.
PubMed:Metabolic disposition of piperine in the rat.
PubMed:The metabolites of piperic acid and some related compounds in the rat.
 
Notes:
None found
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