EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

grifolin
2-farnesyl-5-methylresorcinol

Supplier Sponsors

CAS Number: 6903-07-7Picture of molecule3D/inchi
FDA UNII: Search
Nikkaji Web:J14.586F
XlogP3-AA:7.20 (est)
Molecular Weight:328.49544000
Formula:C22 H32 O2
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Soluble in:
 water, 0.001658 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
Grifolin 98%
Odor: characteristic
Use: Grifolin is a natural compound isolated from the fresh fruiting bodies of Alba
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for grifolin usage levels up to:
 not for fragrance use.
 
Recommendation for grifolin flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :5372312
National Institute of Allergy and Infectious Diseases:Data
5-methyl-2-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienyl]benzene-1,3-diol
 
References:
 5-methyl-2-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienyl]benzene-1,3-diol
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):5372312
Pubchem (cas):6903-07-7
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEMBL:View
HMDB (The Human Metabolome Database):HMDB30446
FooDB:FDB002311
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 grifola confluens
Search PMC Picture
 
Synonyms:
2-farnesyl-5-methylresorcinol
5-methyl-2-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienyl]benzene-1,3-diol
 

Articles:

PubMed:Grifolin Attenuates White Matter Lesion in Oxygen/Glucose Deprivation.
PubMed:Grifolin induces apoptosis and promotes cell cycle arrest in the A2780 human ovarian cancer cell line via inactivation of the ERK1/2 and Akt pathways.
PubMed:Grifolin exhibits anti-cancer activity by inhibiting the development and invasion of gastric tumor cells.
PubMed:Grifolin derivatives from Albatrellus ovinus as TRPV1 receptor blockers for cosmetic applications.
PubMed:Total Synthesis of Grifolin, Grifolic Acid, LL-Z1272α, LL-Z1272β, and Ilicicolinic Acid A.
PubMed:Grifolin inhibits tumor cells adhesion and migration via suppressing interplay between PGC1α and Fra-1 / LSF- MMP2 / CD44 axes.
PubMed:Grifolin induces autophagic cell death by inhibiting the Akt/mTOR/S6K pathway in human ovarian cancer cells.
PubMed:Grifolin directly targets ERK1/2 to epigenetically suppress cancer cell metastasis.
PubMed:The role of targeting kinase activity by natural products in cancer chemoprevention and chemotherapy (Review).
PubMed:Nine new farnesylphenols from the basidiomycete albatrellus caeruleoporus.
PubMed:A review on antifungal activity of mushroom (basidiomycetes) extracts and isolated compounds.
PubMed:Meroterpenoid pigments from the basidiomycete Albatrellus ovinus.
PubMed:DAPK1 mediates the G1 phase arrest in human nasopharyngeal carcinoma cells induced by grifolin, a potential antitumor natural product.
PubMed:Grifolin, a potent antitumour natural product upregulates death-associated protein kinase 1 DAPK1 via p53 in nasopharyngeal carcinoma cells.
PubMed:Cyathane diterpenoids and nitrogenous terphenyl derivative from the fruiting bodies of basidiomycete Phellodon niger.
PubMed:Cytotoxic grifolin derivatives isolated from the wild mushroom Boletus pseudocalopus (Basidiomycetes).
PubMed:Antibacterial compounds from mushrooms I: a lanostane-type triterpene and prenylphenol derivatives from Jahnoporus hirtus and Albatrellus flettii and their activities against Bacillus cereus and Enterococcus faecalis.
PubMed:Novel selective ligands for free fatty acid receptors GPR120 and GPR40.
PubMed:A new meroterpenoid pigment from the basidiomycete Albatrellus confluens.
PubMed:Grifolin, a potential antitumor natural product from the mushroom Albatrellus confluens, induces cell-cycle arrest in G1 phase via the ERK1/2 pathway.
PubMed:Grifolin induces apoptosis via inhibition of PI3K/AKT signalling pathway in human osteosarcoma cells.
PubMed:Screening of novel nuclear receptor agonists by a convenient reporter gene assay system using green fluorescent protein derivatives.
PubMed:Grifolin derivatives from Albatrellus caeruleoporus, new inhibitors of nitric oxide production in RAW 264.7 cells.
PubMed:Grifolin, a potential antitumor natural product from the mushroom Albatrellus confluens, inhibits tumor cell growth by inducing apoptosis in vitro.
PubMed:Activity in vitro and in vivo against plant pathogenic fungi of grifolin isolated from the basidiomycete Albatrellus dispansus.
PubMed:Use of a modified microplate bioassay method to investigate antibacterial activity in the Peruvian medicinal plant Peperomia galioides.
PubMed:Structures and histamine release inhibitory effects of prenylated orcinol derivatives from Rhododendron dauricum.
PubMed:Activities of prenylphenol derivatives from fruitbodies of Albatrellus spp. on the human and rat vanilloid receptor 1 (VR1) and characterisation of the novel natural product, confluentin.
PubMed:Neogrifolin derivatives possessing anti-oxidative activity from the mushroom Albatrellus ovinus.
PubMed:Antitumor beta glucan from the cultured fruit body of Agaricus blazei.
PubMed:In vitro and in vivo leishmanicidal studies of Peperomia galioides (Piperaceae).
PubMed:Piperogalin, a new prenylated diphenol from Peperomia galioides.
PubMed:Hypocholesterolemic Action of Dietary Grifolin on Rats Fed with a High-cholesterol Diet.
PubMed:Isolation of plasma cholesterol-lowering components from ningyotake (Polyporus confluens) mushroom.
PubMed:A total synthesis of grifolin.
PubMed:Synthesis of grifolin, an antibiotic from a Basidiomycete.
PubMed:The structure of grifolin, an antibiotic from a basidiomycete.
PubMed:Grifolin, an antibiotic from a basidiomycete.
 
Notes:
None found
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