EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

cuscohygrine

Supplier Sponsors

CAS Number: 454-14-8Picture of molecule3D/inchi
FDA UNII: 93FJ3823VL
Nikkaji Web:J662.616E
XlogP3-AA:1.00 (est)
Molecular Weight:224.34748000
Formula:C13 H24 N2 O
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
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Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Soluble in:
 water, 7.576e+004 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
Cuscohygrine 95% (TLC)
Odor: characteristic
Use: It was the main alkaloid found in medicinal plants Datura metel. . ADCs Cytotoxin
Santa Cruz Biotechnology
For experimental / research use only.
Cuscohygrine (mixture of diastereomers)
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for cuscohygrine usage levels up to:
 not for fragrance use.
 
Recommendation for cuscohygrine flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :1201543
National Institute of Allergy and Infectious Diseases:Data
1-[(2S)-1-methylpyrrolidin-2-yl]-3-[(2R)-1-methylpyrrolidin-2-yl]propan-2-one
Chemidplus:0000454148
 
References:
 1-[(2S)-1-methylpyrrolidin-2-yl]-3-[(2R)-1-methylpyrrolidin-2-yl]propan-2-one
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):1201543
Pubchem (cas):454-14-8
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
KEGG (GenomeNet):C06521
HMDB (The Human Metabolome Database):HMDB30290
FooDB:FDB002126
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 cyphomandra betacea root
Search Trop Picture
 potato root
Search Trop Picture
 
Synonyms:
(R*,S*)-1,3-bis(1-methyl-2-pyrrolidinyl)-2-propanone
1-[(2S)-1-methylpyrrolidin-2-yl]-3-[(2R)-1-methylpyrrolidin-2-yl]propan-2-one
2-propanone, 1,3-bis(1-methyl-2-pyrrolidinyl)-, (R*,S*)-
 

Articles:

PubMed:Multi-analysis determination of tropane alkaloids in cereals and solanaceaes seeds by liquid chromatography coupled to single stage Exactive-Orbitrap.
PubMed:Behaviour of hygrine and cuscohygrine in illicit cocaine production establishes their use as markers for chewing coca leaves in contrast with cocaine abuse.
PubMed:Possibilities for discrimination between chewing of coca leaves and abuse of cocaine by hair analysis including hygrine, cuscohygrine, cinnamoylcocaine and cocaine metabolite/cocaine ratios.
PubMed:Application of hygrine and cuscohygrine as possible markers to distinguish coca chewing from cocaine abuse on WDT and forensic cases.
PubMed:Production of tropane alkaloids in Hyoscyamus niger (black henbane) hairy roots grown in bubble-column and spray bioreactors.
PubMed:Multi-development-HPTLC method for quantitation of hyoscyamine, scopolamine and their biosynthetic precursors in selected solanaceae plants grown in natural conditions and as in vitro cultures.
PubMed:Chemical composition and biological evaluation of Physalis peruviana root as hepato-renal protective agent.
PubMed:Hygrine and cuscohygrine as possible markers to distinguish coca chewing from cocaine abuse in workplace drug testing.
PubMed:Tropane and pyrrolidine alkaloids from Convolvulus lanatus Vahl.
PubMed:Heterologous expression of Vitreoscilla hemoglobin (VHb) and cultivation conditions affect the alkaloid profile of Hyoscyamus muticus hairy roots.
PubMed:Alkaloid content of the seeds from Erythroxylum Coca var. Coca.
PubMed:Total synthesis of (+)-dihydrocuscohygrine and cuscohygrine.
PubMed:1-Methylpyrrolidine-2-acetic Acid is not a Precursor of Tropane Alkaloids.
PubMed:Toxicity of field bindweed (Convolvulus arvensis) to mice.
PubMed:Tropane alkaloids and toxicity of Convolvulus arvensis.
PubMed:Determination and in-depth chromatographic analyses of alkaloids in South American and greenhouse-cultivated coca leaves.
PubMed:Biological activity of the alkaloids of Erythroxylum coca and Erythroxylum novogranatense.
PubMed:Przewalskia tangutica - A tropane alkaloid-containing plant.
PubMed:The role of hygrine in the biosynthesis of cuscohygrine and hyoscyamine.
PubMed:[Studies on alkaloids of Scopolia lurida Dun. Assays of atropine, scopolamine and cuscohygrine].
PubMed:Syntheses of hygrine and cuscohygrine.
 
Notes:
None found
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