EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

gamma-fagarine

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CAS Number: 524-15-2Picture of molecule3D/inchi
FDA UNII: 0000524152
Nikkaji Web:J6.637K
Beilstein Number:0212820
XlogP3-AA:2.90 (est)
Molecular Weight:229.23527000
Formula:C13 H11 N O3
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Soluble in:
 water, 8.779 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
gamma-Fagarine 98%
BOC Sciences
For experimental / research use only.
gamma-Fagarine 98%. (NMR)
Odor: characteristic
Use: A natural compound extracted from Phellodendron chinense, exhibits a near planar framework ADCs Cytotoxin
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for gamma-fagarine usage levels up to:
 not for fragrance use.
 
Recommendation for gamma-fagarine flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :107936
National Institute of Allergy and Infectious Diseases:Data
4,8-dimethoxyfuro[2,3-b]quinoline
Chemidplus:0000524152
 
References:
 4,8-dimethoxyfuro[2,3-b]quinoline
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):107936
Pubchem (cas):524-15-2
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C10676
HMDB (The Human Metabolome Database):HMDB30195
FooDB:FDB002013
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 aegle marmelos fruit
Search Trop Picture
 dictamni radicis cortex
Search Trop Picture
 
Synonyms:
4,8-dimethoxyfuro[2,3-b]quinoline
 furo(2,3-b)quinoline, 4,8-dimethoxy-
 

Articles:

PubMed:A Novel Alkaloid Isolated from Spiranthera atlantica (Rutaceae).
PubMed:Inhibition of hepatitis C virus replication by chalepin and pseudane IX isolated from Ruta angustifolia leaves.
PubMed:A new quinoline alkaloid from the roots of Dictamnus angustifolius.
PubMed:Secondary metabolites from the stem of Ravenia spectabilis Lindl.
PubMed:Furoquinoline alkaloids isolated from Balfourodendron riedelianum as photosynthetic inhibitors in spinach chloroplasts.
PubMed:4,8-Dimeth-oxy-furo[2,3-b]quinoline (γ-fagarine).
PubMed:Inhibitory alkaloids from Dictamnus dasycarpus root barks on lipopolysaccharide-induced nitric oxide production in BV2 cells.
PubMed:A new quinoline epoxide from the Australian plant Drummondita calida.
PubMed:Antileishmanial activity of furoquinolines and coumarins from Helietta apiculata.
PubMed:Secondary metabolites and cytotoxic activities from the stem bark of Zanthoxylum nitidum.
PubMed:Cytotoxic activity and cell cycle analysis of quinoline alkaloids isolated from Haplophyllum canaliculatum Boiss.
PubMed:Biological activity of secondary metabolites from Peltostigma guatemalense.
PubMed:Alkaloids from the roots of Zanthoxylum nitidum and their antiviral and antifungal effects.
PubMed:Constituents of the root wood of Zanthoxylum wutaiense with antitubercular activity.
PubMed:In vitro antiplasmodial activity of extract and constituents from Esenbeckia febrifuga, a plant traditionally used to treat malaria in the Brazilian Amazon.
PubMed:In vitro and in vivo activities of Haplophyllum myrtifolium against Leishmania tropica.
PubMed:Identification of Ruta graveolens L. metabolites accumulated in the presence of abiotic elicitors.
PubMed:Effective biotic elicitation of Ruta graveolens L. shoot cultures by lysates from Pectobacterium atrosepticum and Bacillus sp.
PubMed:Synthesis, structure and stereochemistry of quinoline alkaloids from Choisya ternata.
PubMed:Isolation of limonoids and alkaloids from Phellodendron amurense and their multidrug resistance (MDR) reversal activity.
PubMed:[Studies on chemical constituents in bark of dictamnus dasycarpus].
PubMed:Screening of 14 alkaloids isolated from Haplophyllum A. Juss. for their cytotoxic properties.
PubMed:Two new sesquiterpenoids and anti-HIV principles from the root bark of Zanthoxylum ailanthoides.
PubMed:Inhibitory effects of furoquinoline alkaloids from Melicope confusa and Dictamnus albus against human phosphodiesterase 5 (hPDE5A) in vitro.
PubMed:New indolopyridoquinazoline, benzo[c]phenanthridines and cytotoxic constituents from Zanthoxylum integrifoliolum.
PubMed:Antibacterial activity and cytotoxicity of extractives from Ravenia spectabilis.
PubMed:A new prenylated arylnaphthalene lignan from Haplophyllum myrtifolium.
PubMed:Plants traditionally prescribed to treat tazo (malaria) in the eastern region of Madagascar.
PubMed:A new diprenyl coumarin and alkaloids from the bark of Zanthoxylum dimorphophyllum (Rutaceae).
PubMed:Quinoline alkaloids from Acronychia laurifolia.
PubMed:Mutagenic compounds in an extract from Rutae Herba (Ruta graveolens L.). II. UV-A mediated mutagenicity in the green alga Chlamydomonas reinhardtii by furoquinoline alkaloids and furocoumarins present in a commercial tincture from Rutae Herba.
PubMed:The SCE-inducing potency of the furoquinoline alkaloid, gamma-fagarine, and a gamma-fagarine-containing tincture from Rutae Herba, in cultured human lymphocytes.
PubMed:Mutagenicity of furoquinoline alkaloids in the Salmonella/microsome assay. Mutagenicity of dictamnine is modified by various enzyme inducers and inhibitors.
PubMed:Mutagenic compounds in an extract from rutae herba (Ruta graveolens L.). I. Mutagenicity is partially caused by furoquinoline alkaloids.
PubMed:Mutagenic activities of dictamnine and gamma-fagarine from dictamni radicis cortex (Rutaceae).
PubMed:A Contribution to the Phytochemistry of Zanthoxylum tessmannii1.
PubMed:Further alkaloids from bark of Fagara mayu.
PubMed:Synthesis of dihydro-gamma-fagarine and edulitine.
 
Notes:
None found
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