EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

hydroxy-alpha-sanshool

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CAS Number: 83883-10-7Picture of molecule3D/inchi
FDA UNII: Search
Nikkaji Web:J674.642J
XlogP3-AA:2.80 (est)
Molecular Weight:263.38065000
Formula:C16 H25 N O2
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Soluble in:
 water, 33.25 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
Hydroxy-alpha-Sanshool 98%
BOC Sciences
For experimental / research use only.
Hydroxy-alpha-sanshool
Odor: characteristic
Use: Hydroxy-alpha-sanshool is a compound isolated from the genus Zanthoxylum. It stimulates D-hair afferent nerve fibers.
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for hydroxy-alpha-sanshool usage levels up to:
 not for fragrance use.
 
Recommendation for hydroxy-alpha-sanshool flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :10084135
National Institute of Allergy and Infectious Diseases:Data
(2E,6Z,8E,10E)-N-(2-hydroxy-2-methylpropyl)dodeca-2,6,8,10-tetraenamide
 
References:
 (2E,6Z,8E,10E)-N-(2-hydroxy-2-methylpropyl)dodeca-2,6,8,10-tetraenamide
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):10084135
Pubchem (cas):83883-10-7
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEMBL:View
HMDB (The Human Metabolome Database):HMDB29567
FooDB:FDB000722
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 zanthoxylum piperitum
Search Trop Picture
 
Synonyms:
(2E,6Z,8E,10E)-N-(2-hydroxy-2-methylpropyl)dodeca-2,6,8,10-tetraenamide
 

Articles:

PubMed:Anesthetic constituents of Zanthoxylum bungeanum Maxim.: A pharmacokinetic study.
PubMed:Complementary and synergistic therapeutic effects of compounds found in Kampo medicine: analysis of daikenchuto.
PubMed:Contraction of gut smooth muscle cells assessed by fluorescence imaging.
PubMed:Hydroxy-α sanshool induces colonic motor activity in rat proximal colon: a possible involvement of KCNK9.
PubMed:All-trans-configuration in Zanthoxylum alkylamides swaps the tingling with a numbing sensation and diminishes salivation.
PubMed:Preventive Effect of TU-100 on a Type-2 Model of Colitis in Mice: Possible Involvement of Enhancing Adrenomedullin in Intestinal Epithelial Cells.
PubMed:Characterization and comparison of the pungent components in commercial Zanthoxylum bungeanum oil and Zanthoxylum schinifolium oil.
PubMed:A 'toothache tree' alkylamide inhibits Aδ mechanonociceptors to alleviate mechanical pain.
PubMed:Population pharmacokinetic analysis of daikenchuto, a traditional Japanese medicine (Kampo) in Japanese and US health volunteers.
PubMed:Inhibition by TRPA1 agonists of compound action potentials in the frog sciatic nerve.
PubMed:Total synthesis of hydroxy-α- and hydroxy-β-sanshool using Suzuki-Miyaura coupling.
PubMed:Daikenchuto (TU-100) ameliorates colon microvascular dysfunction via endogenous adrenomedullin in Crohn's disease rat model.
PubMed:Pharmacokinetics of daikenchuto, a traditional Japanese medicine (kampo) after single oral administration to healthy Japanese volunteers.
PubMed:A tingling sanshool derivative excites primary sensory neurons and elicits nocifensive behavior in rats.
PubMed:Profiling of the compounds absorbed in human plasma and urine after oral administration of a traditional Japanese (kampo) medicine, daikenchuto.
PubMed:Physiological basis of tingling paresthesia evoked by hydroxy-alpha-sanshool.
PubMed:Molecular and cellular mechanisms of trigeminal chemosensation.
PubMed:Compounds from Sichuan and Melegueta peppers activate, covalently and non-covalently, TRPA1 and TRPV1 channels.
PubMed:Activation of lumbar spinal wide-dynamic range neurons by a sanshool derivative.
PubMed:Pungent agents from Szechuan peppers excite sensory neurons by inhibiting two-pore potassium channels.
PubMed:Aroma constituents and alkylamides of red and green huajiao (Zanthoxylum bungeanum and Zanthoxylum schinifolium).
PubMed:Hydroxy-alpha-sanshool activates TRPV1 and TRPA1 in sensory neurons.
PubMed:Characterization of the pungent principles and the essential oil of Zanthoxylum schinifolium pericarp.
PubMed:Quantitative analysis of sanshool compounds in Japanese pepper (Xanthoxylum piperitum DC.) and their pungent characteristics.
PubMed:Pungent qualities of sanshool-related compounds evaluated by a sensory test and activation of rat TRPV1.
PubMed:Alkylamides that produce tingling paresthesia activate tactile and thermal trigeminal neurons.
 
Notes:
None found
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