EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

licochalcone A

Supplier Sponsors

CAS Number: 58749-22-7Picture of molecule3D/inchi
FDA UNII: JTV5467968
Nikkaji Web:J14.698F
Beilstein Number:4534154
MDL:MFCD01417903
XlogP3-AA:4.90 (est)
Molecular Weight:338.40314000
Formula:C21 H22 O4
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Soluble in:
 water, 1.367 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
Licochalcone A 98%
BOC Sciences
For experimental / research use only.
Licochalcone A >98%
Odor: characteristic
Use: Licochalcone A is a chalconoid, a type of natural phenols. It can be isolated from root of Glycyrrhiza glabra (liquorice) or Glycyrrhiza inflata. It is a potent membrane-active agent that transforms normal erythrocytes into echinocytes.
EMD Millipore
For experimental / research use only.
Licochalcone-A, Synthetic ≥96% by HPLC
Santa Cruz Biotechnology
For experimental / research use only.
Licochalcone A ≥96%
Sigma-Aldrich: Sigma
For experimental / research use only.
Licochalcone A ≥96.0% (HPLC)
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for licochalcone A usage levels up to:
 not for fragrance use.
 
Recommendation for licochalcone A flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :5318998
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
(E)-3-[4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)phenyl]-1-(4-hydroxyphenyl)prop-2-en-1-one
Chemidplus:0058749227
RTECS:UB8755000 for cas# 58749-22-7
 
References:
 (E)-3-[4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)phenyl]-1-(4-hydroxyphenyl)prop-2-en-1-one
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):5318998
Pubchem (cas):58749-22-7
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
HMDB (The Human Metabolome Database):HMDB29514
FooDB:FDB000649
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 glycyrrhiza glabra root
Search Trop Picture
 glycyrrhiza inflata root
Search Trop Picture
 
Synonyms:
3-dimethylallyl-4,4'-dihydroxy-6-methoxychalcone
(E)-3-[4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)phenyl]-1-(4-hydroxyphenyl)prop-2-en-1-one
2-propen-1-one, 3-(5-(1,1-dimethyl-2-propenyl)-4-hydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)-, (E)-
 

Articles:

PubMed:Ion Channels Induced by Antimicrobial Agents in Model Lipid Membranes are Modulated by Plant Polyphenols Through Surrounding Lipid Media.
PubMed:LicA induces autophagy through ULK1/Atg13 and ROS pathway in human hepatocellular carcinoma cells.
PubMed:Randomized investigator-blinded comparative study of moisturizer containing 4-t-butylcyclohexanol and licochalcone A versus 0.02% triamcinolone acetonide cream in facial dermatitis.
PubMed:Licochalcone A inhibits PI3K/Akt/mTOR signaling pathway activation and promotes autophagy in breast cancer cells.
PubMed:Stand-alone Emollient Treatment Reduces Flares After Discontinuation of Topical Steroid Treatment in Atopic Dermatitis: A Double-blind, Randomized, Vehicle-controlled, Left-right Comparison Study.
PubMed:Licochalcone A suppresses hexokinase 2-mediated tumor glycolysis in gastric cancer via downregulation of the Akt signaling pathway.
PubMed:A green and facile preparation approach, licochalcone A capped on hollow gold nanoparticles, for improving the solubility and dissolution of anticancer natural product.
PubMed:Licochalcone A activates Keap1-Nrf2 signaling to suppress arthritis via phosphorylation of p62 at serine 349.
PubMed:Caffeic acid and licochalcone A interfere with the glyoxylate cycle of Trichophyton rubrum.
PubMed:Hepatic metabolism of licochalcone A, a potential chemopreventive chalcone from licorice (Glycyrrhiza inflata), determined using liquid chromatography-tandem mass spectrometry.
PubMed:JNK1 inhibition by Licochalcone A leads to neuronal protection against excitotoxic insults derived of kainic acid.
PubMed:Neuroprotective effect of licochalcone A against oxygen-glucose deprivation/reperfusion in rat primary cortical neurons by attenuating oxidative stress injury and inflammatory response via the SIRT1/Nrf2 pathway.
PubMed:Licochalcone A induces morphological and biochemical alterations in Schistosoma mansoni adult worms.
PubMed:Intestinal Absorption of Triterpenoids and Flavonoids from Glycyrrhizae radix et rhizoma in the Human Caco-2 Monolayer Cell Model.
PubMed:Licochalcone A Inhibits MMPs and ADAMTSs via the NF-κB and Wnt/β-Catenin Signaling Pathways in Rat Chondrocytes.
PubMed:Licochalcone A Prevents the Loss of Dopaminergic Neurons by Inhibiting Microglial Activation in Lipopolysaccharide (LPS)-Induced Parkinson's Disease Models.
PubMed:Simultaneous quantitation of six aconitum alkaloids and three flavonoids in the herb couple of radix aconiti lateralis-radix glycyrrhizae (Fuzi-Gancao) by UHPLC-ESI-MS/MS.
PubMed:Nrf2 activators from Glycyrrhiza inflata and their hepatoprotective activities against CCl4-induced liver injury in mice.
PubMed:Licochalcone A Inhibits the Proliferation of Human Lung Cancer Cell Lines A549 and H460 by Inducing G2/M Cell Cycle Arrest and ER Stress.
PubMed:Cytochrome P450 inhibition by three licorice species and fourteen licorice constituents.
PubMed:Anti-Inflammatory Effects of Licochalcone A on IL-1β-Stimulated Human Osteoarthritis Chondrocytes.
PubMed:Discovery of a potent angiotensin converting enzyme inhibitor via virtual screening.
PubMed:Licochalcone A Prevents Platelet Activation and Thrombus Formation through the Inhibition of PLCγ2-PKC, Akt, and MAPK Pathways.
PubMed:Efficacy and Tolerability of a Cosmetic Skin Care Product With Trans-4-t-butylcyclohexanol and Licochalcone A in Subjects With Sensitive Skin Prone to Redness and Rosacea.
PubMed:Isolation and structural characterization of dihydrobenzofuran congeners of licochalcone A.
PubMed:Role of licochalcone A in VEGF-induced proliferation of human airway smooth muscle cells: implications for asthma.
PubMed:Licochalcone A specifically induces cell death in glioma stem cells via mitochondrial dysfunction.
PubMed:Licochalcone A Suppresses Specificity Protein 1 as a Novel Target in Human Breast Cancer Cells.
PubMed:Antitumor effects and the underlying mechanism of licochalcone A combined with 5-fluorouracil in gastric cancer cells.
PubMed:YM155 induces apoptosis through proteasome-dependent degradation of MCL-1 in primary effusion lymphoma.
PubMed:Licochalcones extracted from Glycyrrhiza inflata inhibit platelet aggregation accompanied by inhibition of COX-1 activity.
PubMed:Mapping Novel Metabolic Nodes Targeted by Anti-Cancer Drugs that Impair Triple-Negative Breast Cancer Pathogenicity.
PubMed:CBr4as a Halogen Bond Donor Catalyst for the Selective Activation of Benzaldehydes to Synthesize α,β-Unsaturated Ketones.
PubMed:Antioxidative and anticancer properties of Licochalcone A from licorice.
PubMed:Combining Chemical Profiling and Network Analysis to Investigate the Pharmacology of Complex Prescriptions in Traditional Chinese Medicine.
PubMed:A new exploration of licorice metabolome.
PubMed:Cytotoxicity of trans-chalcone and licochalcone A against breast cancer cells is due to apoptosis induction and cell cycle arrest.
PubMed:Systems-biology dissection of mechanisms and chemical basis of herbal formula in treating chronic myocardial ischemia.
PubMed:Identification and Chemical Standardization of Licorice Raw Materials and Dietary Supplements Using UHPLC-MS/MS.
PubMed:Direct analysis of prostaglandin-E2 and -D2 produced in an inflammatory cell reaction and its application for activity screening and potency evaluation using turbulent flow chromatography liquid chromatography-high resolution mass spectrometry.
PubMed:Antimutagenic components in Glycyrrhiza against N-methyl-N-nitrosourea in the Ames assay.
PubMed:Novel Chemical Ligands to Ebola Virus and Marburg Virus Nucleoproteins Identified by Combining Affinity Mass Spectrometry and Metabolomics Approaches.
PubMed:In Vitro and In Vivo Antifungal Activity of Lichochalcone-A against Candida albicans Biofilms.
PubMed:Licochalcone A induces T24 bladder cancer cell apoptosis by increasing intracellular calcium levels.
PubMed:Induction of C/EBP homologous protein-mediated apoptosis and autophagy by licochalcone A in non-small cell lung cancer cells.
PubMed:Design, synthesis and biological evaluation of novel benzimidazole-2-substituted phenyl or pyridine propyl ketene derivatives as antitumour agents.
PubMed:Assessment of the inhibition potential of Licochalcone A against human UDP-glucuronosyltransferases.
PubMed:Skin compatibility and efficacy of a cosmetic skin care regimen with licochalcone A and 4-t-butylcyclohexanol in patients with rosacea subtype I.
PubMed:Effective treatment for sensitive skin: 4-t-butylcyclohexanol and licochalcone A.
PubMed:Licochalcone A Induced Suicidal Death of Human Erythrocytes.
PubMed:The antiviral and antimicrobial activities of licorice, a widely-used Chinese herb.
PubMed:Lico A Enhances Nrf2-Mediated Defense Mechanisms against t-BHP-Induced Oxidative Stress and Cell Death via Akt and ERK Activation in RAW 264.7 Cells.
PubMed:Licochalcone A Attenuates Lipopolysaccharide-Induced Acute Kidney Injury by Inhibiting NF-κB Activation.
PubMed:[Determination of the Plant Origin of Licorice Oil Extract, a Natural Food Additive, by Principal Component Analysis Based on Chemical Components].
PubMed:Induction of NAD(P)H:Quinone Oxidoreductase 1 (NQO1) by Glycyrrhiza Species Used for Women's Health: Differential Effects of the Michael Acceptors Isoliquiritigenin and Licochalcone A.
PubMed:Licochalcone A induces autophagy through PI3K/Akt/mTOR inactivation and autophagy suppression enhances Licochalcone A-induced apoptosis of human cervical cancer cells.
PubMed:A double-blinded, randomized, vehicle-controlled study to access skin tolerability and efficacy of an anti-inflammatory moisturizer in treatment of acne with 0.1% adapalene gel.
PubMed:Identification of Glycyrrhiza as the rikkunshito constituent with the highest antagonistic potential on heterologously expressed 5-HT3A receptors due to the action of flavonoids.
PubMed:Differential Effects of Glycyrrhiza Species on Genotoxic Estrogen Metabolism: Licochalcone A Downregulates P450 1B1, whereas Isoliquiritigenin Stimulates It.
PubMed:Inhibition of human cytochrome P450 enzymes by licochalcone A, a naturally occurring constituent of licorice.
PubMed:Licochalcone A-induced human gastric cancer BGC-823 cells apoptosis by regulating ROS-mediated MAPKs and PI3K/AKT signaling pathways.
PubMed:Selective inhibition of liver X receptor α-mediated lipogenesis in primary hepatocytes by licochalcone A.
PubMed:Effects of natural nuclear factor-kappa B inhibitors on anticancer drug efflux transporter human P-glycoprotein.
PubMed:Licochalcone A, a polyphenol present in licorice, suppresses UV-induced COX-2 expression by targeting PI3K, MEK1, and B-Raf.
PubMed:Licochalcone A induces apoptosis in malignant pleural mesothelioma through downregulation of Sp1 and subsequent activation of mitochondria-related apoptotic pathway.
PubMed:Licochalcone-A induces intrinsic and extrinsic apoptosis via ERK1/2 and p38 phosphorylation-mediated TRAIL expression in head and neck squamous carcinoma FaDu cells.
PubMed:The anthraquinone rhein exhibits synergistic antibacterial activity in association with metronidazole or natural compounds and attenuates virulence gene expression in Porphyromonas gingivalis.
PubMed:Licochalcone-A sensitizes human esophageal carcinoma cells to TRAIL-mediated apoptosis by proteasomal degradation of XIAP.
PubMed:Studies on the identification of constituents in ethanol extract of Radix Glycyrrhizae and their anticancer activity.
PubMed:Licochalcone A up-regulates of FasL in mesenchymal stem cells to strengthen bone formation and increase bone mass.
PubMed:Licochalcone A activates Nrf2 in vitro and contributes to licorice extract-induced lowered cutaneous oxidative stress in vivo.
PubMed:Phenotype and expression profile analysis of Staphylococcus aureus biofilms and planktonic cells in response to licochalcone A.
PubMed:Licochalcone A inhibits the migration and invasion of human lung cancer cells via inactivation of the Akt signaling pathway with downregulation of MMP-1/-3 expression.
PubMed:Role of licochalcone A on thymic stromal lymphopoietin expression: implications for asthma.
PubMed:Anti-carcinogenic effects of non-polar components containing licochalcone A in roasted licorice root.
PubMed:Effects of licochalcone A on the bioavailability and pharmacokinetics of nifedipine in rats: possible role of intestinal CYP3A4 and P-gp inhibition by licochalcone A.
PubMed:Licochalcone A, a natural chalconoid isolated from Glycyrrhiza inflata root, induces apoptosis via Sp1 and Sp1 regulatory proteins in oral squamous cell carcinoma.
PubMed:Licochalcone Suppresses LXRα-Induced Hepatic Lipogenic Gene Expression through AMPK/Sirt1 Pathway Activation.
PubMed:Antimetastatic effects of licochalcone A on oral cancer via regulating metastasis-associated proteases.
PubMed:Design, economical synthesis and antiplasmodial evaluation of vanillin derived allylated chalcones and their marked synergism with artemisinin against chloroquine resistant strains of Plasmodium falciparum.
PubMed:A randomized, investigator-blinded efficacy assessment study of stand-alone emollient use in mild to moderately severe atopic dermatitis flares.
PubMed:Licochalcone A as a potent antitumor agent suppresses growth of human oral cancer SCC-25 cells in vitro via caspase-3 dependent pathways.
PubMed:Aqueous extract of Glycyrrhiza inflata inhibits aggregation by upregulating PPARGC1A and NFE2L2-ARE pathways in cell models of spinocerebellar ataxia 3.
PubMed:Special licorice extracts containing lowered glycyrrhizin and enhanced licochalcone A prevented Helicobacter pylori-initiated, salt diet-promoted gastric tumorigenesis.
PubMed:[Advance in studies on pharmacological effects of licochalcone A].
PubMed:Licochalcone A suppresses migration and invasion of human hepatocellular carcinoma cells through downregulation of MKK4/JNK via NF-κB mediated urokinase plasminogen activator expression.
PubMed:Immunomodulatory effects of licochalcone A on experimental autoimmune encephalomyelitis.
PubMed:The effect of licochalcone A on cell-aggregates ECM secretion and osteogenic differentiation during bone formation in metaphyseal defects in ovariectomized rats.
PubMed:Anti-hepatitis C virus compounds obtained from Glycyrrhiza uralensis and other Glycyrrhiza species.
PubMed:Effects of licochalcon A on the pharmacokinetics of losartan and its active metabolite, EXP-3174, in rats.
PubMed:Homology modeling of T. cruzi and L. major NADH-dependent fumarate reductases: ligand docking, molecular dynamics validation, and insights on their binding modes.
PubMed:Licochalcone A induces apoptosis through endoplasmic reticulum stress via a phospholipase Cγ1-, Ca(2+)-, and reactive oxygen species-dependent pathway in HepG2 human hepatocellular carcinoma cells.
PubMed:Licochalcone A induces apoptosis in KB human oral cancer cells via a caspase-dependent FasL signaling pathway.
PubMed:Synthesis of licochalcone analogues with increased anti-inflammatory activity.
PubMed:Licochalcone A, a natural inhibitor of c-Jun N-terminal kinase 1.
PubMed:Licochalcone A inhibiting proliferation of bladder cancer T24 cells by inducing reactive oxygen species production.
PubMed:Randomized, double-blind, split-side, comparison study of moisturizer containing licochalcone A and 1% hydrocortisone in the treatment of childhood atopic dermatitis.
PubMed:Attenuation of allergic airway inflammation in a murine model of asthma by Licochalcone A.
PubMed:Licochalcone A-induced human bladder cancer T24 cells apoptosis triggered by mitochondria dysfunction and endoplasmic reticulum stress.
PubMed:Effect of licochalcone A on growth and properties of Streptococcus suis.
PubMed:Licochalcone A enhances geldanamycin-induced apoptosis through reactive oxygen species-mediated caspase activation.
PubMed:Antioxidant and anti-inflammatory activities of six flavonoids separated from licorice.
PubMed:A double-blind, randomized, vehicle-controlled efficacy assessment study of a skin care formulation for improvement of mild to moderately severe acne.
PubMed:Efficacy of a new tonic containing urea, lactate, polidocanol, and glycyrrhiza inflata root extract in the treatment of a dry, itchy, and subclinically inflamed scalp.
PubMed:Licochalcone A regulates hepatic lipid metabolism through activation of AMP-activated protein kinase.
PubMed:The inhibitory effect of roasted licorice extract on human metastatic breast cancer cell-induced bone destruction.
PubMed:Synthesis and insight into the structure-activity relationships of chalcones as antimalarial agents.
PubMed:Targeting death receptor TRAIL-R2 by chalcones for TRAIL-induced apoptosis in cancer cells.
PubMed:Licochalcone A prevents adipocyte differentiation and lipogenesis via suppression of peroxisome proliferator-activated receptor γ and sterol regulatory element-binding protein pathways.
PubMed:Cranberry proanthocyanidins act in synergy with licochalcone A to reduce Porphyromonas gingivalis growth and virulence properties, and to suppress cytokine secretion by macrophages.
PubMed:Guanylate cyclase activator YC-1 potentiates apoptotic effect of licochalcone A on human epithelial ovarian carcinoma cells via activation of death receptor and mitochondrial pathways.
PubMed:Antimalarial activity of newly synthesized chalcone derivatives in vitro.
PubMed:Licochalcone a inhibits lipopolysaccharide-induced inflammatory response in vitro and in vivo.
PubMed:Licorice and its potential beneficial effects in common oro-dental diseases.
PubMed:Effect of licorice compounds licochalcone A, glabridin and glycyrrhizic acid on growth and virulence properties of Candida albicans.
PubMed:Design, synthesis, and evaluation of bromo-retrochalcone derivatives as protein tyrosine phosphatase 1B inhibitors.
PubMed:In vitro and in vivo osteogenic activity of licochalcone A.
PubMed:Xenoestrogens regulate the activity of arginine methyltransferases.
PubMed:Licochalcone A inhibits growth of gastric cancer cells by arresting cell cycle progression and inducing apoptosis.
PubMed:Identification of Glycyrrhiza species by direct analysis in real time mass spectrometry.
PubMed:Comparative trial of moisturizer containing licochalcone A vs. hydrocortisone lotion in the treatment of childhood atopic dermatitis: a pilot study.
PubMed:Antiangiogenic effect of licochalcone A.
PubMed:Up-regulation of licochalcone A biosynthesis and secretion by Tween 80 in hairy root cultures of Glycyrrhiza uralensis Fisch.
PubMed:Aldose reductase inhibitory compounds from Glycyrrhiza uralensis.
PubMed:Influence of subinhibitory concentrations of licochalcone A on the secretion of enterotoxins A and B by Staphylococcus aureus.
PubMed:Licochalcones suppress degranulation by decreasing the intracellular Ca2+ level and tyrosine phosphorylation of ERK in RBL-2H3 cells.
PubMed:Antitumor and antimetastatic effects of licochalcone A in mouse models.
PubMed:Chalcones enhance TRAIL-induced apoptosis in prostate cancer cells.
PubMed:The fixed structure of Licochalcone A by alpha, beta-unsaturated ketone is necessary for anti-inflammatory activity through the inhibition of NF-kappaB activation.
PubMed:Subinhibitory concentrations of licochalcone A decrease alpha-toxin production in both methicillin-sensitive and methicillin-resistant Staphylococcus aureus isolates.
PubMed:Licorice and licochalcone-A induce autophagy in LNCaP prostate cancer cells by suppression of Bcl-2 expression and the mTOR pathway.
PubMed:Inhibitory effect of chalcones and their derivatives from Glycyrrhiza inflata on protein tyrosine phosphatase 1B.
PubMed:Licochalcone A potently inhibits tumor necrosis factor alpha-induced nuclear factor-kappaB activation through the direct inhibition of IkappaB kinase complex activation.
PubMed:Licochalcone A bound to bovine serum albumin: a spectroscopic, photophysical and structural study.
PubMed:Glycyrrhiza inflata-derived chalcones, Licochalcone A, Licochalcone B and Licochalcone D, inhibit phosphorylation of NF-kappaB p65 in LPS signaling pathway.
PubMed:Licochalcone A significantly suppresses LPS signaling pathway through the inhibition of NF-kappaB p65 phosphorylation at serine 276.
PubMed:Phytochemical licochalcone A enhances antimalarial activity of artemisinin in vitro.
PubMed:Structure and properties of licochalcone A-human serum albumin complexes in solution: a spectroscopic, photophysical and computational approach to understand drug-protein interaction.
PubMed:Anti-proliferative effect of licochalcone A on vascular smooth muscle cells.
PubMed:Licochalcone A is a potent inhibitor of TEL-Jak2-mediated transformation through the specific inhibition of Stat3 activation.
PubMed:Licochalcone A isolated from licorice suppresses lipopolysaccharide-stimulated inflammatory reactions in RAW264.7 cells and endotoxin shock in mice.
PubMed:Anti-inflammatory activity of licochalcone A isolated from Glycyrrhiza inflata.
PubMed:Licochalcone A inhibits the formation and bone resorptive activity of osteoclasts.
PubMed:Licochalcone A inhibits the growth of colon carcinoma and attenuates cisplatin-induced toxicity without a loss of chemotherapeutic efficacy in mice.
PubMed:Functionalized chalcones with basic functionalities have antibacterial activity against drug sensitive Staphylococcus aureus.
PubMed:Antispasmodic activity of licochalcone A, a species-specific ingredient of Glycyrrhiza inflata roots.
PubMed:Constituent properties of licorices derived from Glycyrrhiza uralensis, G. glabra, or G. inflata identified by genetic information.
PubMed:Topoisomerase I inhibition and cytotoxicity of licochalcones A and E from Glycyrrhiza inflata.
PubMed:Skin tolerance, efficacy, and quality of life of patients with red facial skin using a skin care regimen containing Licochalcone A.
PubMed:[Ri plasmid transformation of Glycyrrhiza uralensis and effects of some factors on growth of hairy roots].
PubMed:Anti-inflammatory efficacy of Licochalcone A: correlation of clinical potency and in vitro effects.
PubMed:Gateways to clinical trials.
PubMed:Parasite mitochondria as a target of chemotherapy: inhibitory effect of licochalcone A on the Plasmodium falciparum respiratory chain.
PubMed:Inhibition by licochalcone A, a novel flavonoid isolated from liquorice root, of IL-1beta-induced PGE2 production in human skin fibroblasts.
PubMed:New syntheses and potential antimalarial activities of new 'retinoid-like chalcones'.
PubMed:Activity of wen-pi-tang, and purified constituents of rhei rhizoma and glycyrrhizae radix against glucose-mediated protein damage.
PubMed:Isolation and identification of flavonoids in licorice and a study of their inhibitory effects on tyrosinase.
PubMed:Gateways to clinical trials.
PubMed:Analysis and comparison of Radix Glycyrrhizae (licorice) from Europe and China by capillary-zone electrophoresis (CZE).
PubMed:Cytotoxic allyl retrochalcone from the roots of Glycyrrhiza inflata.
PubMed:Synthesis of prenylated benzaldehydes and their use in the synthesis of analogues of licochalcone A.
PubMed:Isolation and purification of inflacoumarin A and licochalcone A from licorice by high-speed counter-current chromatography.
PubMed:The antiparasitic compound licochalcone a is a potent echinocytogenic agent that modifies the erythrocyte membrane in the concentration range where antiplasmodial activity is observed.
PubMed:Licochalcone-A, a novel flavonoid isolated from licorice root (Glycyrrhiza glabra), causes G2 and late-G1 arrests in androgen-independent PC-3 prostate cancer cells.
PubMed:Antibacterial chalcones--bioisosteric replacement of the 4'-hydroxy group.
PubMed:Antinephritis and radical scavenging activity of prenylflavonoids.
PubMed:Herbal composition PC-SPES for management of prostate cancer: identification of active principles.
PubMed:Anti-Helicobacter pylori flavonoids from licorice extract.
PubMed:[Determination of three flavonoids and ferulic acid in Pleurospermum hookeri C. B. Clarke var. thomsonii C. B. Clarke by HPLC].
PubMed:In vitro antimycobacterial and antilegionella activity of licochalcone A from Chinese licorice roots.
PubMed:Chalcones from Chinese liquorice inhibit proliferation of T cells and production of cytokines.
PubMed:Antibacterial activity of licochalcone A against spore-forming bacteria.
PubMed:Inhibition of fumarate reductase in Leishmania major and L. donovani by chalcones.
PubMed:[Chemical constituents of the roots of Glycyrrhiza eurycarpa P.C.Li].
PubMed:A drug over the millennia: pharmacognosy, chemistry, and pharmacology of licorice.
PubMed:Phenolic constituents of licorice. VIII. Structures of glicophenone and glicoisoflavanone, and effects of licorice phenolics on methicillin-resistant Staphylococcus aureus.
PubMed:Modulation of bcl-2 and cytotoxicity by licochalcone-A, a novel estrogenic flavonoid.
PubMed:The antileishmanial activity of novel oxygenated chalcones and their mechanism of action.
PubMed:Recent advances in the fight against leishmaniasis with natural products.
PubMed:Licochalcone A: an inducer of cell differentiation and cytotoxic agent from Pogostemon cablin.
PubMed:Mode of antibacterial action of retrochalcones from Glycyrrhiza inflata.
PubMed:Antioxidative and superoxide scavenging activities of retrochalcones in Glycyrrhiza inflata.
PubMed:The novel oxygenated chalcone, 2,4-dimethoxy-4'-butoxychalcone, exhibits potent activity against human malaria parasite Plasmodium falciparum in vitro and rodent parasites Plasmodium berghei and Plasmodium yoelii in vivo.
PubMed:Protective effects of Wen-Pi-Tang against cultured renal epithelial cellular injury.
PubMed:High-performance liquid chromatographic determination of licochalcone A and its metabolites in biological fluids.
PubMed:Synthesis, isolation and identification of glucuronides and mercapturic acids of a novel antiparasitic agent, licochalcone A.
PubMed:The antileishmanial agent licochalcone A interferes with the function of parasite mitochondria.
PubMed:Licochalcone A, a new antimalarial agent, inhibits in vitro growth of the human malaria parasite Plasmodium falciparum and protects mice from P. yoelii infection.
PubMed:Antileishmanial activity of licochalcone A in mice infected with Leishmania major and in hamsters infected with Leishmania donovani.
PubMed:Anti-tumorigenic chalcones.
PubMed:Licochalcone A, a novel antiparasitic agent with potent activity against human pathogenic protozoan species of Leishmania.
PubMed:Inhibitory effects of licochalcone A isolated from Glycyrrhiza inflata root on inflammatory ear edema and tumour promotion in mice.
PubMed:[Quality evaluation of Chinese licorice].
PubMed:[HPLC analysis of flavonoids in the root of six Glycyrrhiza species].
PubMed:Phenolic constituents of licorice. II. Structures of licopyranocoumarin, licoarylcoumarin and glisoflavone, and inhibitory effects of licorice phenolics on xanthine oxidase.
 
Notes:
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