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dioscin
collettiside III

Supplier Sponsors

CAS Number: 19057-60-4Picture of molecule3D/inchi
FDA UNII: 3B95U4OLWV
Nikkaji Web:J15.520I
XlogP3-AA:1.30 (est)
Molecular Weight:869.05604000
Formula:C45 H72 O16
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
Dioscin 98%
BOC Sciences
For experimental / research use only.
Dioscin
Sigma-Aldrich: Sigma
For experimental / research use only.
Dioscin ≥95% (HPLC)
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for dioscin usage levels up to:
 not for fragrance use.
 
Recommendation for dioscin flavor usage levels up to:
 not for flavor use.
 
Safety References:
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
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Laboratory Chemical Safety Summary :119245
National Institute of Allergy and Infectious Diseases:Data
Chemidplus:0019057604
 
References:
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):119245
Pubchem (cas):19057-60-4
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C08897
HMDB (The Human Metabolome Database):Search
FooDB:FDB000366
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 aletris spicata
Search Trop Picture
 dioscorea zingiberensis
Search Trop Picture
 
Synonyms:
 collettiside III
beta-D-glucopyranoside, (3beta,25R)-spirost-5-en-3-yl O-6-deoxy-alpha-L-mannopyranosyl-(1-2)-O-(6-deoxy-alpha-L-mannopyranosyl-(1-4))-
 

Articles:

PubMed:Protective effect of dioscin against doxorubicin-induced cardiotoxicity via adjusting microRNA-140-5p-mediated myocardial oxidative stress.
PubMed:Dioscin prevents LPS‑induced acute lung injury through inhibiting the TLR4/MyD88 signaling pathway via upregulation of HSP70.
PubMed:Dioscin inhibits stem-cell-like properties and tumor growth of osteosarcoma through Akt/GSK3/β-catenin signaling pathway.
PubMed:Dioscin overcome TKI resistance in EGFR-mutated lung adenocarcinoma cells via down-regulation of tyrosine phosphatase SHP2 expression.
PubMed:Comparative Transcriptome Analysis Identifies Putative Genes Involved in Dioscin Biosynthesis in Dioscorea zingiberensis.
PubMed:Substituting one Paris for another? In vitro cytotoxic and in vivo antitumor activities of Paris forrestii, a substitute of Paris polyphylla var. yunnanensis.
PubMed:Effect of dioscin on promoting liver regeneration via activating Notch1/Jagged1 signal pathway.
PubMed:Dioscin inhibits colon cancer cells' growth by reactive oxygen species-mediated mitochondrial dysfunction and p38 and JNK pathways.
PubMed:Corrigendum to "Autophagy Inhibition Enhances Apoptosis Induced by Dioscin in Huh7 Cells".
PubMed:[Preparation and evaluation of dioscin nanostructured lipid carriers].
PubMed:Effect and mechanism of dioscin from Dioscorea spongiosa on uric acid excretion in animal model of hyperuricemia.
PubMed:[Determination of eight steroidal saponins in 15 kinds of genus Paris].
PubMed:Dioscorea quinqueloba Ameliorates Oxazolone- and 2,4-Dinitrochlorobenzene-induced Atopic Dermatitis Symptoms in Murine Models.
PubMed:Protective effects of dioscin against fructose-induced renal damage via adjusting Sirt3-mediated oxidative stress, fibrosis, lipid metabolism and inflammation.
PubMed:Dioscin Exerts Protective Effects Against Crystalline Silica-induced Pulmonary Fibrosis in Mice.
PubMed:Dioscin inhibits ischemic stroke‑induced inflammation through inhibition of the TLR4/MyD88/NF‑κB signaling pathway in a rat model.
PubMed:Protective effect of dioscin against thioacetamide-induced acute liver injury via FXR/AMPK signaling pathway in vivo.
PubMed:Dioscin Inhibits HSC-T6 Cell Migration via Adjusting SDC-4 Expression: Insights from iTRAQ-Based Quantitative Proteomics.
PubMed:Dioscin enhances osteoblastic cell differentiation and proliferation by inhibiting cell autophagy via the ASPP2/NF-κβ pathway.
PubMed:Comparative metabolic profiling of Costus speciosus leaves and rhizomes using NMR, GC-MS and UPLC/ESI-MS/MS.
PubMed:Dioscin induces prostate cancer cell apoptosis through activation of estrogen receptor-β.
PubMed:Dioscin, a potent ITGA5 inhibitor, reduces the synthesis of collagen against liver fibrosis: Insights from SILAC-based proteomics analysis.
PubMed:Connexin 43 upregulation by dioscin inhibits melanoma progression via suppressing malignancy and inducing M1 polarization.
PubMed:Dioscin Induces Gallbladder Cancer Apoptosis by Inhibiting ROS-Mediated PI3K/AKT Signalling.
PubMed:Special metabolites isolated from Urochloa humidicola (Poaceae).
PubMed:Weighted Gene Co-expression Network Analysis of the Dioscin Rich Medicinal PlantDioscorea nipponica.
PubMed:Dioscin suppresses TGF-β1-induced epithelial-mesenchymal transition and suppresses A549 lung cancer migration and invasion.
PubMed:Protodioscin, Isolated from the Rhizome ofDioscorea tokoroCollected in Northern Japan is the Major Antiproliferative Compound to HL-60 
Leukemic Cells.
PubMed:Protective effects of dioscin against cisplatin-induced nephrotoxicity via the microRNA-34a/sirtuin 1 signalling pathway.
PubMed:Erratum to: Dioscin-induced autophagy mitigates cell apoptosis through modulation of PI3K/Akt and ERK and JNK signaling pathways in human lung cancer cell lines.
PubMed:Dioscin induces demethylation of DAPK-1 and RASSF-1alpha genes via the antioxidant capacity, resulting in apoptosis of bladder cancer T24 cells.
PubMed:Protective Effects of Dioscin against Lipopolysaccharide-Induced Acute Lung Injury through Inhibition of Oxidative Stress and Inflammation.
PubMed:Traditional Chinese herbal extracts inducing autophagy as a novel approach in therapy of nonalcoholic fatty liver disease.
PubMed:Inhibitory effects of Dioscin on atherosclerosis and foam cell formation in hyperlipidemia rats.
PubMed:Dioscin Protects ANIT-Induced Intrahepatic Cholestasis Through Regulating Transporters, Apoptosis and Oxidative Stress.
PubMed:Soluplus/TPGS mixed micelles for dioscin delivery in cancer therapy.
PubMed:Potent effects of dioscin against pancreatic cancer via miR-149-3P-mediated inhibition of the Akt1 signalling pathway.
PubMed:Protective effects of dioscin against doxorubicin-induced nephrotoxicity via adjusting FXR-mediated oxidative stress and inflammation.
PubMed:Dioscin relieves endotoxemia induced acute neuro-inflammation and protect neurogenesis via improving 5-HT metabolism.
PubMed:Fingerprinting of strong spermatogenesis steroidal saponins in male flowers of Phoenix dactylifera (Date Palm) by LC-ESI-MS.
PubMed:Combined Application of UHPLC-QTOF/MS, HPLC-ELSD and1H-NMR Spectroscopy for Quality Assessment of DA-9801, A Standardised Dioscorea Extract.
PubMed:Dioscin augments HSV-tk-mediated suicide gene therapy for melanoma by promoting connexin-based intercellular communication.
PubMed:Saponins from Chinese Medicines as Anticancer Agents.
PubMed:Exploration in the cascade working mechanisms of liver injury induced by total saponins extracted from Rhizoma Dioscorea bulbifera.
PubMed:Dioscin suppresses hepatocellular carcinoma tumor growth by inducing apoptosis and regulation of TP53, BAX, BCL2 and cleaved CASP3.
PubMed:Dioscin inhibits gastric tumor growth through regulating the expression level of lncRNA HOTAIR.
PubMed:Dioscin stimulates differentiation of mesenchymal stem cells towards hypertrophic chondrocytesin vitroand endochondral ossificationin vivo.
PubMed:Dioscin attenuates gastric ischemia/reperfusion injury through the down-regulation of PKC/ERK1/2 signaling via PKCα and PKCβ2 inhibition.
PubMed:Multi-component determination and chemometric analysis of Paris polyphylla by ultra high performance liquid chromatography with photodiode array detection.
PubMed:Therapeutic effect of dioscin on collagen-induced arthritis through reduction of Th1/Th2.
PubMed:Dioscin alleviates lipopolysaccharide-induced inflammatory kidney injury via the microRNA let-7i/TLR4/MyD88 signaling pathway.
PubMed:Gene expression profiling and pathway analysis data in MCF-7 and MDA-MB-231 human breast cancer cell lines treated with dioscin.
PubMed:Dioscin strengthens the efficiency of adriamycin in MCF-7 and MCF-7/ADR cells through autophagy induction: More than just down-regulation of MDR1.
PubMed:Dioscin alleviates dimethylnitrosamine-induced acute liver injury through regulating apoptosis, oxidative stress and inflammation.
PubMed:Dioscin protects against ANIT-induced cholestasis via regulating Oatps, Mrp2 and Bsep expression in rats.
PubMed:Dioscin Induces Apoptosis in Human Cervical Carcinoma HeLa and SiHa Cells through ROS-Mediated DNA Damage and the Mitochondrial Signaling Pathway.
PubMed:Dioscin reduces ovariectomy-induced bone loss by enhancing osteoblastogenesis and inhibiting osteoclastogenesis.
PubMed:Dioscin reduces lipopolysaccharide-induced inflammatory liver injury via regulating TLR4/MyD88 signal pathway.
PubMed:Characterizing diversity based on nutritional and bioactive compositions of yam germplasm (Dioscorea spp.) commonly cultivated in China.
PubMed:Potent effects of dioscin against gastric cancer in vitro and in vivo.
PubMed:A Rapid Study of Botanical Drug-Drug Interaction with Protein by Re-ligand Fishing using Human Serum Albumin-Functionalized Magnetic Nanoparticles.
PubMed:An Efficient Purification Method for Quantitative Determinations of Protodioscin, Dioscin and Diosgenin in Plasma of Fenugreek-Fed Mice.
PubMed:Dioscin suppresses human laryngeal cancer cells growth via induction of cell-cycle arrest and MAPK-mediated mitochondrial-derived apoptosis and inhibition of tumor invasion.
PubMed:Dioscin alleviates BDL- and DMN-induced hepatic fibrosis via Sirt1/Nrf2-mediated inhibition of p38 MAPK pathway.
PubMed:The anticancer potential of steroidal saponin, dioscin, isolated from wild yam (Dioscorea villosa) root extract in invasive human breast cancer cell line MDA-MB-231 in vitro.
PubMed:[Preliminary study on hepatotoxicity induced by dioscin and its possible mechanism].
PubMed:Dioscin alleviates alcoholic liver fibrosis by attenuating hepatic stellate cell activation via the TLR4/MyD88/NF-κB signaling pathway.
PubMed:Transmembrane transport of steviol glucuronide and its potential interaction with selected drugs and natural compounds.
PubMed:Inhibition of dioscin on Saprolegnia in vitro.
PubMed:Dioscin Derived from Solanum melongena L. "Usukawamarunasu" Attenuates α-MSH-Induced Melanogenesis in B16 Murine Melanoma Cells via Downregulation of Phospho-CREB and MITF.
PubMed:Dioscin attenuates renal ischemia/reperfusion injury by inhibiting the TLR4/MyD88 signaling pathway via up-regulation of HSP70.
PubMed:[New variety breeding of Dioscorea alata, cultivar "Wenshanyao No.1].
PubMed:Corrigendum: Potent effects of dioscin against obesity in mice.
PubMed:Quantitative chemical proteomics for investigating the biomarkers of dioscin against liver fibrosis caused by CCl4 in rats.
PubMed:[Advances in study of dioscin--a natural product].
PubMed:Dioscin and methylprotodioscin isolated from the root of Asparagus cochinchinensis suppressed the gene expression and production of airway MUC5AC mucin induced by phorbol ester and growth factor.
PubMed:In-silico prediction of drug targets, biological activities, signal pathways and regulating networks of dioscin based on bioinformatics.
PubMed:Potent effects of dioscin against liver fibrosis.
PubMed:Rapid Identification of Steroidal Saponins in Trillium tschonoskii Maxim by Ultraperformance Liquid Chromatography Coupled to Electrospray Ionisation Quadrupole Time-of-Flight Tandem Mass Spectrometry.
PubMed:Direct Biotransformation of Dioscin into Diosgenin in Rhizome of Dioscorea zingiberensis by Penicillium dioscin.
PubMed:Dioscin ameliorates cerebral ischemia/reperfusion injury through the downregulation of TLR4 signaling via HMGB-1 inhibition.
PubMed:UPLC-QTOF-MS identification of metabolites in rat biosamples after oral administration of Dioscorea saponins: a comparative study.
PubMed:Metabolic profiles of dioscin in rats revealed by ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry.
PubMed:[Study on steroidal saponins from Dioscorea zingiberensis and their platelet aggregation activities].
PubMed:Potent effects of dioscin against obesity in mice.
PubMed:Potent anti-inflammatory effect of dioscin mediated by suppression of TNF-α-induced VCAM-1, ICAM-1and EL expression via the NF-κB pathway.
PubMed:Steroidal saponins obtained by biotransformation of total furostanol glycosides from Dioscorea zingiberensis with Absidia coerulea.
PubMed:[Chemical constituents from Solanum rostratum].
PubMed:Simultaneous quantification of five steroid saponins from Dioscorea zingiberensis C.H. Wright in rat plasma by HPLC-MS/MS and its application to the pharmacokinetic studies.
PubMed:Dioscin inhibits adipogenesis through the AMPK/MAPK pathway in 3T3-L1 cells and modulates fat accumulation in obese mice.
PubMed:Dioscin inhibits colon tumor growth and tumor angiogenesis through regulating VEGFR2 and AKT/MAPK signaling pathways.
PubMed:Dioscin attenuates hepatic ischemia-reperfusion injury in rats through inhibition of oxidative-nitrative stress, inflammation and apoptosis.
PubMed:Rapid metabolic discrimination and prediction of dioscin content from African yam tubers using Fourier transform-infrared spectroscopy combined with multivariate analysis.
PubMed:Paris polyphylla: chemical and biological prospectives.
PubMed:Anti-hyperuricemic and nephroprotective effects of Rhizoma Dioscoreae septemlobae extracts and its main component dioscin via regulation of mOAT1, mURAT1 and mOCT2 in hypertensive mice.
PubMed:Separation and purification of steroidal saponins from Paris polyphylla by microwave-assisted extraction coupled with countercurrent chromatography using evaporative light scattering detection.
PubMed:Dioscin induces caspase-independent apoptosis through activation of apoptosis-inducing factor in breast cancer cells.
PubMed:Dioscin induced activation of p38 MAPK and JNK via mitochondrial pathway in HL-60 cell line.
PubMed:Dioscin promotes osteoblastic proliferation and differentiation via Lrp5 and ER pathway in mouse and human osteoblast-like cell lines.
PubMed:[Effects of dioscin on apoptosis in pancreatic cancer MiaPaCa-2 cells and its mechanism].
PubMed:Dioscin enhances methotrexate absorption by down-regulating MDR1 in vitro and in vivo.
PubMed:Dioscin-induced apoptosis of human LNCaP prostate carcinoma cells through activation of caspase-3 and modulation of Bcl-2 protein family.
PubMed:iTRAQ-based proteomic analysis of dioscin on human HCT-116 colon cancer cells.
PubMed:Dioscin inhibits osteoclast differentiation and bone resorption though down-regulating the Akt signaling cascades.
PubMed:Protective effects of dioscin against alcohol-induced liver injury.
PubMed:Liquid chromatography tandem mass spectrometry in study of the pharmacokinetics of six steroidal saponins in rats.
PubMed:[Effects of dioscornin tablet containing serum on NF-kappaB p65, STAT3, and VEGF mRNA expressions in rats' synovial cell strain RSC-364 induced by IL-17 and TNF-alpha].
PubMed:Characterization of in vitro ADME properties of diosgenin and dioscin from Dioscorea villosa.
PubMed:Dioscin prevents the mitochondrial apoptosis and attenuates oxidative stress in cardiac H9c2 cells.
PubMed:New ionic liquid-based preparative method for diosgenin from Rhizoma dioscoreae nipponicae.
PubMed:Dioscin, a natural steroid saponin, induces apoptosis and DNA damage through reactive oxygen species: a potential new drug for treatment of glioblastoma multiforme.
PubMed:Anti-cancer effects of dioscin on three kinds of human lung cancer cell lines through inducing DNA damage and activating mitochondrial signal pathway.
PubMed:Convergent synthesis and cytotoxic activities of 26-thio- and selenodioscin.
PubMed:Two spirostan steroid glycoside fatty esters from Dioscorea cayenensis.
PubMed:7-Oxodioscin, a new spirostan steroid glycoside from the rhizomes of Dioscorea nipponica.
PubMed:Dioscin restores the activity of the anticancer agent adriamycin in multidrug-resistant human leukemia K562/adriamycin cells by down-regulating MDR1 via a mechanism involving NF-κB signaling inhibition.
PubMed:Therapeutic effect of Rhizoma Dioscoreae Nipponicae on gouty arthritis based on the SDF-1/CXCR 4 and p38 MAPK pathway: an in vivo and in vitro study.
PubMed:Stereoselective determination of ginsenosides Rg3 and Rh2 epimers in rat plasma by LC-MS/MS: application to a pharmacokinetic study.
PubMed:Dioscin-induced autophagy mitigates cell apoptosis through modulation of PI3K/Akt and ERK and JNK signaling pathways in human lung cancer cell lines.
PubMed:Protodioscin-glycosidase-1 hydrolyzing 26-O-β-D-glucoside and 3-O-(1 → 4)-α-L-rhamnoside of steroidal saponins from Aspergillus oryzae.
PubMed:Highly efficient sample preparation and quantification of constituents from traditional Chinese herbal medicines using matrix solid-phase dispersion extraction and UPLC-MS/MS.
PubMed:Influence of different particle processing on hypocholesterolemic and antiatherogenic activities of yam (Dioscorea pseudojaponica) in cholesterol-fed rabbit model.
PubMed:Involvement of organic anion-transporting polypeptides in the hepatic uptake of dioscin in rats and humans.
PubMed:Evaluation of DA-9801, a new herbal drug for diabetic neuropathy, on metabolism-mediated interaction.
PubMed:Development of an analytical method for yam saponins using HPLC with pulsed amperometric detection at different column temperatures.
PubMed:The antifungal activity and membrane-disruptive action of dioscin extracted from Dioscorea nipponica.
PubMed:Dioscin's antiviral effect in vitro.
PubMed:Autophagy inhibition enhances apoptosis induced by dioscin in huh7 cells.
PubMed:Formulation and in vitro absorption analysis of Rhizoma paridis steroidal saponins.
PubMed:Dioscin: a synergistic tyrosinase inhibitor from the roots of Smilax china.
PubMed:Dioscin, a natural steroid saponin, shows remarkable protective effect against acetaminophen-induced liver damage in vitro and in vivo.
PubMed:Dioscin sensitizes cells to TRAIL-induced apoptosis through downregulation of c-FLIP and Bcl-2.
PubMed:Natural products: a safest approach for obesity.
PubMed:A novel β-glucosidase from Aspergillus fumigates releases diosgenin from spirostanosides of Dioscorea zingiberensis C. H. Wright (DZW).
PubMed:Solanum incanum and S. heteracanthum as sources of biologically active steroid glycosides: confirmation of their synonymy.
PubMed:Mechanism investigation of dioscin against CCl4-induced acute liver damage in mice.
PubMed:Application of high-speed countercurrent chromatography-evaporative light scattering detection for the separation of seven steroidal saponins from Dioscorea villosa.
PubMed:A 90-day subchronic toxicological assessment of dioscin, a natural steroid saponin, in Sprague-Dawley rats.
PubMed:Cytotoxicity of dioscin in human gastric carcinoma cells through death receptor and mitochondrial pathways.
PubMed:Absorption, disposition, and pharmacokinetics of saponins from Chinese medicinal herbs: what do we know and what do we need to know more?
PubMed:A high-throughput fluorescence resonance energy transfer (FRET)-based endothelial cell apoptosis assay and its application for screening vascular disrupting agents.
PubMed:Dioscin induces cancer cell apoptosis through elevated oxidative stress mediated by downregulation of peroxiredoxins.
PubMed:Paris chinensis dioscin induces G2/M cell cycle arrest and apoptosis in human gastric cancer SGC-7901 cells.
PubMed:Saponins do not affect the ecdysteroid receptor complex but cause membrane permeation in insect culture cell lines.
PubMed:[Studies on the chemical constituents from the flowers of Ophiopogon japonicus].
PubMed:Apoptosis of human ovarian cancer cells induced by Paris chinensis dioscin via a Ca(2+)-mediated mitochondrion pathway.
PubMed:[Effects of organic solvents on proliferation of Hela cells line].
PubMed:Paridis saponins inhibiting carcinoma growth and metastasis in vitro and in vivo.
PubMed:Cytotoxic saponin against lung cancer cells from Dioscorea birmanica Prain & Burkill.
PubMed:Reversal effect of Dioscin on multidrug resistance in human hepatoma HepG2/adriamycin cells.
PubMed:Application of proteomic and bioinformatic techniques for studying the hepatoprotective effect of dioscin against CCl₄-induced liver damage in mice.
PubMed:Rapid probe and isolation of bioactive compounds from Dioscorea panthaica using human serum albumin functionalized magnetic nano-particles (HSA-MNPs)-based ligand fishing coupled with electrospray ionization mass spectrometry.
PubMed:Anti-thrombotic activity and chemical characterization of steroidal saponins from Dioscorea zingiberensis C.H. Wright.
PubMed:Ligand fishing from Dioscorea nipponica extract using human serum albumin functionalized magnetic nanoparticles.
PubMed:New dioscin-glycosidase hydrolyzing multi-glycosides of dioscin from Absidia strain.
PubMed:Anthelmintic activity of steroidal saponins from Paris polyphylla.
PubMed:Chemical study and medical application of saponins as anti-cancer agents.
PubMed:Structural analogues of diosgenyl saponins: synthesis and anticancer activity.
PubMed:Characterization of steroidal saponins in saponin extract from Paris polyphylla by liquid chromatography tandem multi-stage mass spectrometry.
PubMed:Screening of some saponins and phenolic components of Tribulus terrestris and Smilax excelsa as MDR modulators.
PubMed:Steroidal saponins from Smilax excelsa rhizomes.
PubMed:Hemolytic mechanism of dioscin proposed by molecular dynamics simulations.
PubMed:[Study on optimization of the hydrolysis process of dioscin catalyzed by hydrochloric acid].
PubMed:Rat growth-hormone release stimulators from fenugreek seeds.
PubMed:Preparative separation of dioscin derivatives from Dioscorea villosa by centrifugal partition chromatography coupled with evaporative light scattering detection.
PubMed:Pregnane glycosides and steroid saponins from Smilax bockii Warb. and their NGF-potentiating activity.
PubMed:[Selection of the microorganism for dioscin hydrolyze].
PubMed:Induction of growth hormone release by dioscin from Dioscorea batatas DECNE.
PubMed:Dioscin (saponin)-induced generation of reactive oxygen species through mitochondria dysfunction: a proteomic-based study.
PubMed:Large scale analysis of genes contributing to the herbal preparation dependent hippocampal plasticity in postischemic rehabilitation.
PubMed:Synthesis, cytotoxicity, and hemolytic activity of 6'-O-substituted dioscin derivatives.
PubMed:[Study on extraction of the total saponins of Chinese yam].
PubMed:Characterization of steroidal saponins in crude extract from Dioscorea nipponica Makino by liquid chromatography tandem multi-stage mass spectrometry.
PubMed:Distribution of steroidal saponins in Tribulus terrestris from different geographical regions.
PubMed:Synthesis of neosaponins and neoglycolipids containing a chacotriosyl moiety.
PubMed:Fingerprint analysis of Dioscorea nipponica by high-performance liquid chromatography with evaporative light scattering detection.
PubMed:Medicinal flowers. XII.(1)) New spirostane-type steroid saponins with antidiabetogenic activity from Borassus flabellifer.
PubMed:[Study on steroidal saponins of Dioscorea septemloba thunb].
PubMed:[Study on steroidal compounds from Dioscorea zingiberensis].
PubMed:Synthesis and cytotoxicities of dioscin derivatives with decorated chacotriosyl residues.
PubMed:Structural identification of methyl protodioscin metabolites in rats' urine and their antiproliferative activities against human tumor cell lines.
PubMed:Facile conversion of spirostan saponin into furostan saponin: synthesis of methyl protodioscin and its 26-thio-analogue.
PubMed:Atropurosides A-G, new steroidal saponins from Smilacina atropurpurea.
PubMed:Effect of ethanol extract of dried Chinese yam (Dioscorea batatas) flour containing dioscin on gastrointestinal function in rat model.
PubMed:Proteomic approach to study the cytotoxicity of dioscin (saponin).
PubMed:Purification and characterization of dioscin-alpha-L-rhamnosidase from pig liver.
PubMed:Characterization of the pharmacokinetics of dioscin in rat.
PubMed:Syntheses of chlorogenin 6alpha-O-acyl-3-O-beta-chacotriosides and their antitumor activities.
PubMed:[Steroidal constituents from Dioscorea parviflora].
PubMed:Discovery of structurally diverse natural product antagonists of chemokine receptor CXCR3.
PubMed:Liquid chromatography/tandem mass spectrometry for pharmacokinetic studies of 20(R)-ginsenoside Rg3 in dog.
PubMed:Fluorophore-appended steroidal saponin (dioscin and polyphyllin D) derivatives.
PubMed:Determination of dioscin in rat plasma by liquid chromatography-tandem mass spectrometry.
PubMed:A new steroidal saponin from Dioscorea cayenensis.
PubMed:The mitotic-arresting and apoptosis-inducing effects of diosgenyl saponins on human leukemia cell lines.
PubMed:Microbial metabolism of pseudoprotodioscin.
PubMed:Synthesis of bidesmosidic dihydrodiosgenin saponins bearing a 3-O-beta-chacotriosyl moiety.
PubMed:Microarray analysis of gene expression on herbal glycoside recipes improving deficient ability of spatial learning memory in ischemic mice.
PubMed:Antifungal steroid saponins from Dioscorea cayenensis.
PubMed:Isolation and identification of steroidal saponins in Taiwanese yam cultivar (Dioscorea pseudojaponica Yamamoto).
PubMed:[Apoptosis of human chronic myeloid leukemia k562 cell induced by prosapogenin B of dioscin (P.B) in vitro].
PubMed:Anti-obesity effect of Dioscorea nipponica Makino with lipase-inhibitory activity in rodents.
PubMed:A new steroidal saponin from Dioscorea zingiberensis Wright.
PubMed:[Studies on chemical constituents of two plants from Costus].
PubMed:The synthesis of gracillin and dioscin: two typical representatives of spirostanol glycosides.
PubMed:[Isolation and identification of steroidal saponins in total saponin from Dioscorea nipponica Makino].
PubMed:Synthesis of monomethylated dioscin derivatives and their antitumor activities.
PubMed:Glycosyl trifluoroacetimidates. 2. Synthesis of dioscin and xiebai saponin I.
PubMed:A facile approach to diosgenin and furostan type saponins bearing a 3beta-chacotriose moiety.
PubMed:Bioactive saponins from Dioscorea futschauensis.
PubMed:Evaluation of the potential cancer chemotherapeutic efficacy of natural product isolates employing in vivo hollow fiber tests.
PubMed:Apoptosis induced by dioscin in Hela cells.
PubMed:Effects of two saponins extracted from the polygonatum Zanlanscianense pamp on the human leukemia (HL-60) cells.
PubMed:Synthesis of three diosgenyl saponins: dioscin, polyphyllin D, and balanitin 7.
PubMed:New antifungal and cytotoxic steroidal saponins from the bulbs of an elephant garlic mutant.
PubMed:Abutiloside A, a 26-acylamino-3 beta, 16 alpha-dihydroxy-5 alpha-cholesta-22-one glycoside from Solanum abutiloides.
PubMed:Antineoplastic agents; I. Three spirostanol glycosides from rhizomes of Dioscorea collettii var. hypoglauca.
PubMed:Immunomodulating effects of the hydrolysis products of formosanin C and beta-ecdysone from Paris formosana Hayata.
PubMed:Steroidal saponins from the rhizomes of Smilax menispermoidea.
PubMed:Antiviral activity of constituents of Tamus communis.
PubMed:Experimental antitumor agents from Solanum indicum L.
PubMed:Steroidal glycosides of Tamus communis.
PubMed:Isolation and characterization of an intermediate steroid metabolite in diosgenin biosynthesis in suspension cultures of Dioscorea deltoidea cells.
PubMed:Effect of food toxicants on voluntary wheel running in rats.
PubMed:Structures of prosapogenin-B and -A of dioscin and cooccurrence of B with dioscin in the rhizoma of Dioscorea tokoro Makino.
PubMed:Structures of dioscin, gracillin, and kikuba-saponin. 2. (Saponins of Japanese Dioscoreaceae. XI.
PubMed:Saponins of Japanese Dioscoreaceae. V. On the structure of dioscin.
 
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