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4H-1-benzopyran-4-one, 2-[3,4-bis(2-hydroxyethoxy)phenyl]-3-[[6-O-(6-deoxy-.alpha.-L-mannopyranosyl)-.beta.-D-glucopyranosyl]oxy]-5-hydroxy-7-(2-hydroxyethoxy)-

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CAS Number: 7085-55-4Picture of molecule3D/inchi
Other(deleted CASRN):12041-99-5
ECHA EINECS - REACH Pre-Reg:230-389-4
Nikkaji Web:J9.645H
Beilstein Number:4778232
XlogP3-AA:-2.40 (est)
Molecular Weight:742.68254000
Formula:C33 H42 O19
NMR Predictor:Predict (works with chrome, Edge or firefox)
CAS Number: 31511-30-5Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:250-670-5
XlogP3-AA:-2.90 (est)
Molecular Weight:742.68254000
Formula:C33 H42 O19
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:cosmetic ingredient for skin conditioning
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Pubchem Patents:Search
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Soluble in:
 water, 1.93e+004 mg/L @ 25 °C (est)
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: skin conditioning
Alfa Biotechnology
For experimental / research use only.
Troxerutin 98%
BOC Sciences
For experimental / research use only.
Indis NV
For experimental / research use only.
Safety Information:
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Safety in Use Information:
cosmetic ingredient for skin conditioning
Recommendation for troxerutin usage levels up to:
 not for fragrance use.
Recommendation for troxerutin flavor usage levels up to:
 not for flavor use.
Safety References:
EPI System: View
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA GENetic TOXicology:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :5486699
National Institute of Allergy and Infectious Diseases:Data
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):5486699
Pubchem (sid):134987081
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):10078729
Pubchem (sid):135264760
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
KEGG (GenomeNet):D07180
HMDB (The Human Metabolome Database):HMDB06083
Potential Blenders and core components note
None Found
Potential Uses:
None Found
Occurrence (nature, food, other):note
 not found in nature
4H-1-benzopyran-4-one, 2-[3,4-bis(2-hydroxyethoxy)phenyl]-3-[[6-O-(6-deoxy-.alpha.-L-mannopyranosyl)-.beta.-D-glucopyranosyl]oxy]-5-hydroxy-7-(2-hydroxyethoxy)-
 vitamin P4


PubMed:[Self-tanning and sunless tanning products].
PubMed:Management of Varicose Veins and Chronic Venous Insufficiency in a Comparative Registry with Nine Venoactive Products in Comparison with Stockings.
PubMed:Pharmacological interventions for preventing dry mouth and salivary gland dysfunction following radiotherapy.
PubMed:Troxerutin with copper generates oxidative stress in cancer cells: Its possible chemotherapeutic mechanism against hepatocellular carcinoma.
PubMed:Troxerutin (TXN) potentiated 5-Fluorouracil (5-Fu) treatment of human gastric cancer through suppressing STAT3/NF-κB and Bcl-2 signaling pathways.
PubMed:Erratum: Modulation of hippocampal gene expression of microRNA-146a/microRNA-155-nuclear factor-kappa B inflammatory signaling by troxerutin in healthy and diabetic rats.
PubMed:Troxerutin protects against diabetic cardiomyopathy through NF‑κB/AKT/IRS1 in a rat model of type 2 diabetes.
PubMed:Troxerutin exerts neuroprotection in 6-hydroxydopamine lesion rat model of Parkinson's disease: Possible involvement of PI3K/ERβ signaling.
PubMed:Antifatigue effects of troxerutin on exercise endurance capacity, oxidative stress and matrix metalloproteinase-9 levels in trained male rats.
PubMed:Short-term effects of troxerutin (vitamin P4) on muscle fatigue and gene expression of Bcl-2 and Bax in the hepatic tissue of rats.
PubMed:Effect of troxerutin on 2-aminoanthracene and DNA interaction and its anti-mutagenic property.
PubMed:Modulation of hippocampal gene expression of microRNA-146a/microRNA-155-nuclear factor-kappa B inflammatory signaling by troxerutin in healthy and diabetic rats.
PubMed:Troxerutin Attenuates Enhancement of Hepatic Gluconeogenesis by Inhibiting NOD Activation-Mediated Inflammation in High-Fat Diet-Treated Mice.
PubMed:Effects of troxerutin on cognitive deficits and glutamate cysteine ligase subunits in the hippocampus of streptozotocin-induced type 1 diabetes mellitus rats.
PubMed:Activating AKT to inhibit JNK by troxerutin antagonizes radiation-induced PTEN activation.
PubMed:Troxerutin Preconditioning and Ischemic Postconditioning Modulate Inflammatory Response after Myocardial Ischemia/Reperfusion Injury in Rat Model.
PubMed:Troxerutin attenuates diet-induced oxidative stress, impairment of mitochondrial biogenesis and respiratory chain complexes in mice heart.
PubMed:Troxerutin imparts preservative effects on albumin by preventing Maillard reaction-mediated early and advanced glycation modification.
PubMed:The in vivo antineoplastic and therapeutic efficacy of troxerutin on rat preneoplastic liver: biochemical, histological and cellular aspects.
PubMed:Protective Effect of Troxerutin on Nickel-Induced Testicular Toxicity in Wistar Rats.
PubMed:Troxerutin, a natural flavonoid binds to DNA minor groove and enhances cancer cell killing in response to radiation.
PubMed:The efficiency of O-(beta-hydroxyethyl)-rutosides in reducing the incidence of superficial venous insufficiency in patients with calf muscle pump dysfunction.
PubMed:Involvement of AMPK/SIRT1 pathway in anti-allodynic effect of troxerutin in CCI-induced neuropathic pain.
PubMed:Interventions for varicose veins and leg oedema in pregnancy.
PubMed:Troxerutin, a plant flavonoid, protects cells against oxidative stress-induced cell death through radical scavenging mechanism.
PubMed:Probing the interaction of troxerutin with transfer RNA by spectroscopic and molecular modeling.
PubMed:Phosphorylation of GSK-3β and reduction of apoptosis as targets of troxerutin effect on reperfusion injury of diabetic myocardium.
PubMed:Erratum to: Flavonoids mixture (diosmin, troxerutin, hesperidin) in the treatment of acute hemorrhoidal disease: a prospective, randomized, triple-blind, controlled trial.
PubMed:Development and in vitro-in vivo evaluation of a water-in-oil microemulsion formulation for the oral delivery of troxerutin.
PubMed:Troxerutin reverses fibrotic changes in the myocardium of high-fat high-fructose diet-fed mice.
PubMed:First epidemiological data for venotonics in pregnancy from the EFEMERIS database.
PubMed:Analysis of changes in microRNA expression profiles in response to the troxerutin-mediated antioxidant effect in human dermal papilla cells.
PubMed:Beneficial effect of troxerutin on diabetes-induced vascular damages in rat aorta: histopathological alterations and antioxidation mechanism.
PubMed:Flavonoids mixture (diosmin, troxerutin, hesperidin) in the treatment of acute hemorrhoidal disease: a prospective, randomized, triple-blind, controlled trial.
PubMed:Spectroscopic and molecular docking studies on the interaction of troxerutin with DNA.
PubMed:Troxerutin inhibits 2,2',4,4'-tetrabromodiphenyl ether (BDE-47)-induced hepatocyte apoptosis by restoring proteasome function.
PubMed:A systematic review of the efficacy and tolerability of hydroxyethylrutosides for improvement of the signs and symptoms of chronic venous insufficiency.
PubMed:Validated spectrophotometric methods for simultaneous determination of troxerutin and carbazochrome in dosage form.
PubMed:Troxerutin protects against 2,2',4,4'-tetrabromodiphenyl ether (BDE-47)-induced liver inflammation by attenuating oxidative stress-mediated NAD⁺-depletion.
PubMed:Troxerutin improves hepatic lipid homeostasis by restoring NAD(+)-depletion-mediated dysfunction of lipin 1 signaling in high-fat diet-treated mice.
PubMed:Effect of troxerutin on insulin signaling molecules in the gastrocnemius muscle of high fat and sucrose-induced type-2 diabetic adult male rat.
PubMed:Treatment of endothelial cell with flavonoids modulates transendothelial leukocyte migration.
PubMed:Effect of troxerutin on synaptic plasticity of hippocampal dentate gyrus neurons in a β-amyloid model of Alzheimer׳s disease: an electrophysiological study.
PubMed:Modulatory effect of troxerutin on biotransforming enzymes and preneoplasic lesions induced by 1,2-dimethylhydrazine in rat colon carcinogenesis.
PubMed:Altered miRNA expression profiles are involved in the protective effects of troxerutin against ultraviolet B radiation in normal human dermal fibroblasts.
PubMed:Troxerutin induces protective effects against ultraviolet B radiation through the alteration of microRNA expression in human HaCaT keratinocyte cells.
PubMed:Oral supplementation with troxerutin (trihydroxyethylrutin), modulates lipid peroxidation and antioxidant status in 1,2-dimethylhydrazine-induced rat colon carcinogenesis.
PubMed:Troxerutin suppresses lipid abnormalities in the heart of high-fat-high-fructose diet-fed mice.
PubMed:[Potentials for the conservative therapy in the complex treatment of varicocele in adolescents].
PubMed:Ameliorating effects of troxerutin on nickel-induced oxidative stress in rats.
PubMed:[Mechanisms of antioedemic effect of bioflavonoids in experiment].
PubMed:Veno-active drugs for chronic venous disease: A randomized, double-blind, placebo-controlled parallel-design trial.
PubMed:Troxerutin counteracts domoic acid-induced memory deficits in mice by inhibiting CCAAT/enhancer binding protein β-mediated inflammatory response and oxidative stress.
PubMed:Phlebotonics for haemorrhoids.
PubMed:Radioprotective effects of troxerutin against gamma irradiation in mice liver.
PubMed:Radioprotective effects of troxerutin against gamma irradiation in V79 cells and mice.
PubMed:Venoruton®: post thrombotic syndrome. Clinical improvement in venous insufficiency (signs and symptoms) with Venoruton®. A five-year, open-registry, efficacy study.
PubMed:Battling brain diabetes: antioxidants may reduce cognitive deficits induced by cholesterol.
PubMed:[Effect of troxerutin and cerebroproptein hydrolysate injection on platelet aggregation and thrombosis].
PubMed:Combination of flavonoids with Centella asiatica and Melilotus for diabetic cystoid macular edema without macular thickening.
PubMed:Troxerutin protects against high cholesterol-induced cognitive deficits in mice.
PubMed:Pharmacological treatment of primary chronic venous disease: rationale, results and unanswered questions.
PubMed:Varicose veins of lower extremities in pregnant women and birth outcomes.
PubMed:Clinical improvement in chronic venous insufficiency signs and symptoms with Venoruton® (HR): an 8-month, open-registry, cost-efficacy study.
PubMed:Pharmacological treatment in patients with C4, C5 and C6 venous disease.
PubMed:Ultrasound-promoted enzymatic synthesis of troxerutin esters in nonaqueous solvents.
PubMed:Chronic administration of troxerutin protects mouse kidney against D-galactose-induced oxidative DNA damage.
PubMed:NGF-Dependent activation of TrkA pathway: A mechanism for the neuroprotective effect of troxerutin in D-galactose-treated mice.
PubMed:Calcium dobesilate and oxerutin: effectiveness of combination therapy.
PubMed:[Urgent urinary incontinence due to taking troxerutine sachets].
PubMed:Conversion from nonischemic to ischemic retinal vein occlusion: prediction by venous velocity on color Doppler imaging.
PubMed:Chronic administration of troxerutin protects mouse brain against D-galactose-induced impairment of cholinergic system.
PubMed:Troxerutin protects the mouse liver against oxidative stress-mediated injury induced by D-galactose.
PubMed:Pharmacological agents in the treatment of venous disease: an update of the available evidence.
PubMed:Comparison of the effects of troxerutin and heparinoid on flap necrosis.
PubMed:[Photophoresis and mesophotophoresis of angioprotectant group preparations for comprehensive treatment of patients with chronic generalized parodontitis].
PubMed:New multifunctional textile biomaterials for the treatment of leg venous insufficiency.
PubMed:Troxerutin protects the mouse kidney from d-galactose-caused injury through anti-inflammation and anti-oxidation.
PubMed:5-Year control and treatment of edema and increased capillary filtration in venous hypertension and diabetic microangiopathy using O-(beta-hydroxyethyl)-rutosides: a prospective comparative clinical registry.
PubMed:O-(beta-hydroxyethyl)-rutosides systemic and local treatment in chronic venous disease and microangiopathy: an independent prospective comparative study.
PubMed:O-(beta-hydroxyethyl)-rutosides (Paroven; Venoruton): new studies, improved safety, and novel cardiovascular applications.
PubMed:Aescin and troxerutin as a successful combination for the treatment of inner ear perfusion disturbances.
PubMed:The simultaneous separation and determination of six flavonoids and troxerutin in rat urine and chicken plasma by reversed-phase high-performance liquid chromatography with ultraviolet-visible detection.
PubMed:Interventions for branch retinal vein occlusion: an evidence-based systematic review.
PubMed:Interventions for central retinal vein occlusion: an evidence-based systematic review.
PubMed:Liquid chromatography/tandem mass spectrometry assay for the quantification of troxerutin in human plasma.
PubMed:The electrochemical oxidation of troxerutin and its sensitive determination in pharmaceutical dosage forms at PVP modified carbon paste electrode.
PubMed:Circulating endothelial cells in venous blood as a marker of endothelial damage in chronic venous insufficiency: improvement with venoruton.
PubMed:Effect on capillary permeability in rabbits of iridoids from Buddleia scordioides.
PubMed:Venoruton vs Daflon: evaluation of effects on quality of life in chronic venous insufficiency.
PubMed:HNE-dependent molecular damage in diabetic nephropathy and its possible prevention by N-acetyl-cysteine and oxerutin.
PubMed:Protection of cellular DNA from gamma-radiation-induced damages and enhancement in DNA repair by troxerutin.
PubMed:Efficacy of troxerutin on streptozotocin-induced rat model in the early stage of diabetic retinopathy.
PubMed:[Butcher's Broom, in the treatment of venous insufficiency].
PubMed:Effect of Xuesaitong soft capsule on hemorrheology and in auxiliarily treating patients with acute cerebral infarction.
PubMed:HR, 0-(beta-hydroxyethyl)-rutosides; (Venoruton): rapid relief of signs/symptoms in chronic venous insufficiency and microangiopathy: a prospective, controlled study.
PubMed:Troxerutin protects the isolated perfused rat liver from a possible lipid peroxidation by coumarin.
PubMed:Treatment of the common cold with troxerutin.
PubMed:Medical treatment of retinal vein occlusions.
PubMed:Comparative study on the inclusion behaviour of cyclodextrin derivatives with venoruton and rutin by thin layer chromatography.
PubMed:Epidemiology of restless legs syndrome as diagnosed in UK primary care.
PubMed:Radioprotection of normal tissues in tumor-bearing mice by troxerutin.
PubMed:Treatment of the leg ulcers by skin grafting.
PubMed:The regulation of rhinovirus infection in vitro by IL-8, HuIFN-alpha, and TNF-alpha.
PubMed:Benzo-pyrones for reducing and controlling lymphoedema of the limbs.
PubMed:Evaluation of the safety of a coumarin-troxerutin combination.
PubMed:Clinical study of the Ginko biloba--Troxerutin-Heptaminol Hce in the treatment of acute hemorrhoidal attacks.
PubMed:[Effectiveness of Troxerutin in association with Pycnogenol in the pharmacological treatment of venous insufficiency].
PubMed:Flight microangiopathy on long-haul flights: prevention of edema and microcirculation alterations with Venoruton.
PubMed:Safety aspects of a coumarin-troxerutin combination regarding liver function in a double-blind placebo-controlled study.
PubMed:Single copy of variant CYP2A6 alleles does not confer susceptibility to liver dysfunction in patients treated with coumarin.
PubMed:Vascular permeabilization by intravenous arachidonate in the rat peritoneal cavity: antagonism by ethamsylate.
PubMed:Vascular permeabilization by intravenous arachidonate in the rat peritoneal cavity: antagonism by antioxidants.
PubMed:The LONFLIT4-VENORUTON study: a randomized trial prophylaxis of flight-edema in normal subjects.
PubMed:Comparative trial of N-acetyl-cysteine, taurine, and oxerutin on skin and kidney damage in long-term experimental diabetes.
PubMed:Pharmacokinetics of mono-3'- and mono-4'-0-(beta-hydroxyethyl)-rutoside derivatives, after single doses of Venoruton powder in healthy volunteers.
PubMed:The efficacy and safety of a coumarin-/troxerutin-combination (SB-LOT) in patients with chronic venous insufficiency: a double blind placebo-controlled randomised study.
PubMed:HR (Venoruton1000, Paroven, 0-[beta-hydroxyethyl]-rutosides) vs. Daflon 500 in chronic venous disease and microangiopathy: an independent prospective, controlled, randomized trial.
PubMed:Free radical scavenging and skin penetration of troxerutin and vitamin derivatives.
PubMed:Limb salvage instead of amputation in 10 cases of nonreconstructible "end-point ischemia" treated with i.v. hydroxyethylrutosides plus oral anticoagulation.
PubMed:Oxerutins (Venoruton): efficacy in chronic venous insufficiency--a double-blind, randomized, controlled study.
PubMed:Crystallization of water in multilamellar vesicles.
PubMed:Variations in plasma free radicals in patients with venous hypertension with HR (Paroven, Venoruton; 0-(beta-hydroxyethyl)-rutosides): a clinical, prospective, placebo-controlled, randomized trial.
PubMed:Treatment of edema and increased capillary filtration in venous hypertension with HR (Paroven, Venoruton; 0-(beta-hydroxyethyl)-rutosides): a clinical, prospective, placebo-controlled, randomized, dose-ranging trial.
PubMed:Flight microangiopathy in medium-to-long distance flights: prevention of edema and microcirculation alterations with HR (Paroven, Venoruton; 0-(beta-hydroxyethyl)-rutosides): a prospective, randomized, controlled trial.
PubMed:Treatment of diabetic microangiopathy and edema with HR (Paroven, Venoruton; 0-(beta-hydroxyethyl)-rutosides): a prospective, placebo-controlled, randomized study.
PubMed:HR (Paroven, Venoruton; 0-(beta-hydroxyethyl)-rutosides) in venous hypertensive microangiopathy: a prospective, placebo-controlled, randomized trial.
PubMed:Natural drugs in vascular medicine: new observations.
PubMed:Parenteral troxerutin and carbazochrome combination in the treatment of post-hemorrhoidectomy status: a randomized, double-blind, placebo-controlled, phase IV study.
PubMed:[High-altitude retinopathy].
PubMed:[New aspects in the pathogenesis of chronic venous insufficiency and the place of localized action of Venoruton].
PubMed:Double-blind, randomized clinical trial of troxerutin-carbazochrome in patients with hemorrhoids.
PubMed:Prophylaxis of radiogenic sialadenitis and mucositis by coumarin/troxerutine in patients with head and neck cancer--a prospective,randomized, placebo-controlled, double-blind study.
PubMed:[Prospective double-blind study of prophylaxis of radioxerostomia with Coumarin/Troxerutine in patients with head and neck cancer].
PubMed:Microvascular protective activity of flavonoid glucuronides fraction from Tulipa gesneriana.
PubMed:Effects of Venoruton on early postradiation damage in the lungs of rats.
PubMed:Inhibition of postvitrectomy fibrin using troxerutin.
PubMed:[The effect of antioxidant therapy on indicators of activity of free radicals in workers exposed to risks of styrene].
PubMed:[The effect of bioflavonoids and lecithin on the course of experimental atherosclerosis in rabbits].
PubMed:Modelling cortical cataractogenesis. XVIII. In vitro diabetic cataract reduction by venoruton. A flavonoid which prevents lens opacification.
PubMed:Effect of troxerutin on laser-induced thrombus formation in rat mesenteric vessels, coagulation parameters and platelet function.
PubMed:Investigation of the therapeutic equivalence of different galenical preparations of O-(beta-hydroxyethyl)-rutosides following multiple dose peroral administration.
PubMed:Comparative clinical efficacy and tolerability of oxerutins and horse chestnut extract in patients with chronic venous insufficiency.
PubMed:Investigation of the efficacy of oxerutins compared to placebo in patients with chronic venous insufficiency treated with compression stockings.
PubMed:[Transport and localization of troxerutin in the venous wall].
PubMed:The affinity of troxerutin for the venous wall measured by laser scanning microscopy.
PubMed:Fibrinolysis and hemorheology in chronic venous insufficiency: a double blind study of troxerutin efficiency.
PubMed:[Bilateral central retinal vein occlusion and circulating anticoagulant].
PubMed:A randomized, double-masked study on the treatment of retinal vein occlusion with troxerutin.
PubMed:Studies on the effect of short-term oral dihydroergotamine and troxerutin in patients with varicose veins.
PubMed:[The use of the phonophoresis of Venoruton ointment and millimeter-range electromagnetic waves for the correction of trophic capillary failure in myocardial infarct patients].
PubMed:Influence of 0-(beta-hydroxyethyl)-rutin on the oedema-inhibiting effect of indomethacin.
PubMed:Pharmacodynamics and pharmacokinetics of Veliten (rutine, alpha-tocopherol and ascorbic acid) in patients with chronic venous insufficiency.
PubMed:Red blood cell aggregation and microcirculation in rat cremaster muscle.
PubMed:Cardioprotective properties of O-(beta-hydroxyethyl)-rutosides in doxorubicin-pretreated BALB/c mice.
PubMed:Comparison between the efficacy and tolerability of oxerutins and troxerutin in the treatment of patients with chronic venous insufficiency.
PubMed:Topical treatment of acute hindlimb lymphedema of the rat using a troxerutin-phosphatidylcholine complex in liposomal-like microdispersion.
PubMed:[Venoruton in chronic venous insufficiency].
PubMed:[Diffusion of lipid fractions through the barrier of cantharidin blisters in hyperlipidemias under conditions of clofibrate and rutinosid interaction].
PubMed:[Effects of administration of 50 mg heparan sulfate tablets to patients with varicose dilatation of the hemorrhoid plexus (hemorrhoids)].
PubMed:[Effect of 0-(beta-hydroxyethyl)-rutoside (Venoruton) on symptomatic venous insufficiency in the lower limbs].
PubMed:Alterations in the hematological profile in rat following whole body gamma radiation with and without venoruton pretreatment.
PubMed:[The status of the lymphoid organs in the maternal organism as a reflection of the efficacy of correcting venous congestion during pregnancy in rats].
PubMed:Paroven: not much effect in trials.
PubMed:Uptake and localisation of O-(beta-hydroxyethyl)-rutosides in the venous wall, measured by laser scanning microscopy.
PubMed:Modern treatment of lymphoedema. II. The benzopyrones.
PubMed:[A comparison of various phlebotonic agents on human endothelial cells of veins subjected to hypoxia].
PubMed:Oxerutins in the prevention of recurrence in chronic venous ulceration: randomized controlled trial.
PubMed:Homocysteine content of plasma in ischemic heart disease, the reducing effect of pyridoxine, folate, cobalamin, choline, riboflavin and troxerutin. Correction of a calculation error.
PubMed:[Clinical and rheological efficacy of troxerutin in obstetric gynecology].
PubMed:[Venous insufficiency in the pregnant woman. Rheological correction by troxerutin].
PubMed:[Hemorrheology in clinical practice. Applications in an in vitro study of troxerutin].
PubMed:[Kinetic effect characterization of 0-beta-hydroxyethylrutoside (Venoruton) in healthy probands].
PubMed:No effect of O-(beta-hydroxyethyl)-rutoside on red cell filterability in patients with acute myocardial infarction.
PubMed:[Interaction between collagen and various vasoactive agents. Effect on in vitro fibrillogenesis of collagen].
PubMed:[Several years observation of a Catergen (cyanidanol-3) induced immunohemolysis].
PubMed:Influence of flavonoids and lanthanides on kappa-carrageenin rat tail thrombosis.
PubMed:Venoruton as a radioprotector: a haematological assessment.
PubMed:Pharmacodynamics of troxerutine in patients with chronic venous insufficiency: correlations with plasma drug levels.
PubMed:[Erythrocyte aggregation and retinal vein occlusion. Preliminary data for a randomized study on the efficacy of anti-erythrocyte aggregation (troxerutin) in retinal vein occlusion].
PubMed:A double blind three center clinical trial on the short-term efficacy of 0-(beta-hydroxyethyl)-rutosides in patients with post-thrombotic syndrome.
PubMed:[Venoruton and capillary permeability].
PubMed:Effect of venoruton on hypoxic stress-induced neurotoxicity in mice and oxygen free radical generation by human neutrophils.
PubMed:Reduction of plasma lipid and homocysteine levels by pyridoxine, folate, cobalamin, choline, riboflavin, and troxerutin in atherosclerosis.
PubMed:[Treatment of sudden deafness of vascular etiology with venoruton].
PubMed:Treatment of acute superficial thrombosis and follow-up by computerized thermography.
PubMed:Evaluation of the microcirculatory effects of Venoruton in patients with chronic venous hypertension by laserdoppler flowmetry, transcutaneous PO2 and PCO2 measurements, leg volumetry and ambulatory venous pressure measurements.
PubMed:Evaluation of capillary permeability and microcirculation in patients with chronic venous hypertension treated with venoruton by the vacuum suction chamber (VSC) device and laser-Doppler flowmetry.
PubMed:New pharmacological and clinical properties of the venoactive agent: Venoruton (Paroven). Studies presented at the 1st Mediterranean Congress of Angiology. Corfu, Greece, May 29 to June 3, 1988. Abstracts.
PubMed:[Light and electron microscopic studies on the dose and time dependency of the hepatotoxicity of benzopyrones].
PubMed:Human myeloperoxidase activity is inhibited in vitro by quercetin. Comparison with three related compounds.
PubMed:[Comparative evaluation of the effectiveness of drugs influencing the microrheological properties of the blood in the treatment of retinal vein thrombosis].
PubMed:o-(beta-Hydroxyethyl)-rutoside-mediated protection of renal injury associated with cis-diamminedichloroplatinum(II)/hyperthermia treatment.
PubMed:Anticatatonic effect of venoruton.
PubMed:A double-blind, cross-over trial of O-(beta-hydroxyethyl)-rutosides (benzo-pyrones) in the treatment of lymphoedema of the arms and legs.
PubMed:Effects of Troxerutin on the hemorheological parameters of patients with moderate arterial hypertension.
PubMed:Effect of troxerutin and methionine on spin trapping of free oxy-radicals.
PubMed:[Effect of troxerutin on bronchial spasm induced by inhalation of a specific allergen and on the neutrophil activity in patients with atopic bronchial asthma].
PubMed:Some aspects of the inhibitory activity of hypolaetin-8-glucoside in acute inflammation.
PubMed:Cianidanol and its metabolites bind tightly to red cells and are responsible for the production of auto- and/or drug-dependent antibodies against these cells.
PubMed:Study of mutagenic activity of troxerutin, a flavonoid derivative.
PubMed:[Do troxerutin and sodium rutin sulfate still possess the properties of rutin?].
PubMed:Radical trapping and lipid peroxidation during myocardial reperfusion injury--radical scavenging by troxerutin in comparison to mannitol.
PubMed:Antithrombotics in view of thrombosis models.
PubMed:Benzo-pyrones in the treatment of chronic schizophrenic diseases.
PubMed:The effect of antithrombotics in a new model of arterial thrombosis.
PubMed:[IE and IgG antibodies against flavonoids following therapy with flavonoid-containing drugs].
PubMed:Protective effect of oxygen-derived free radical scavengers on the endothelium in vivo.
PubMed:Effects of two venotropic drugs on inactivation and O-methylation of catecholamines in an isolated canine vein.
PubMed:[Efficacy of troxerutin on the flow properties of blood under defined conditions of circulation. A double-blind study of patients with diabetic retinopathy and arteriosclerotic retinopathy].
PubMed:[Effect of O-(beta-hydroxyethyl)-rutoside (venoruton) on the adherence of leukocytes in patients with arteriosclerosis obliterans of the lower limbs].
PubMed:Protective effects of O-(beta-hydroxyethyl)-rutosides (HR) against adriamycin-induced toxicity in rats.
PubMed:[HPLC determination of troxerutin in plasma and urine following oral administration in man].
PubMed:[Pharmacolymphography with Venalot and Venoruton--a 7 years' report].
PubMed:[The behavior of blood clotting and its inhibitors under long term treatment with 5,6-benzo-alpha-pyrone (coumarin). Double blind study].
PubMed:Venoruton in the therapy of central retinal vein occlusion.
PubMed:The effect of HR (O-Beta-Hydroxyethylo-Rutoside, Venoruton) on the deformability of erythrocytes in patients with arteriosclerosis obliterans of lower limbs.
PubMed:O-(beta-hydroxyethyl)-rutoside (Venoruton) fails to block histamine or bradykinin-induced edema formation in the canine forelimb perfused at constant arterial inflow.
PubMed:Antiaggregatory effects of flavonoids in vivo and their influence on lipoxygenase and cyclooxygenase in vitro.
PubMed:[Reproduction toxicologic studies on rats following oral administration of benzopyrone preparations].
PubMed:[Effect of troxerutin on platelet aggregation in patients with arteriosclerosis].
PubMed:[Prevention of esophageal hemorrhage in patients with portal hypertension].
PubMed:[Capillary resistance raising action of Venoruton. Experimental data on the therapeutic effects of Venoruton].
PubMed:Toxicity of venalot (a mixture of coumarin and troxerutin) in the baboon.
PubMed:General practice treatment of symptoms of venous insufficiency with oxerutins. Results of a 660 patient multicentre study in the UK.
PubMed:[Current therapeutic problems of crural ulcers].
PubMed:[Pharmakokinetik von 7,3', 4'-Tri-O-(2-hydroxyethyl)-rutin (Troxerutin) nach oraler Applikation am Menschen].
PubMed:[Juxtaglomerular apparatus and interstitial cells of the kidney medulla after the administration of certain drugs and use of hyperbaric oxygenation].
PubMed:[Polymer-based delayed action matrices with solubility varying as a function of pH. II. Optimization of the formulation of cellulose matrices of trihydroxyethylrutin by direct compression].
PubMed:[Venoruton--used not only in venopathies? Symposium on O-(beta-hydroxyethyl)-rutoside (=Venoruton) in vascular diseases].
PubMed:[Efficacy of benzopyrones in posttraumatic inflammations/Clinical double blind study in the postoperative treatment of episiotomy (author's transl)].
PubMed:The evaluation of the effect of the venous tonic 263-E on capillary permeability in the rabbit after administration by intradermal and intravenous routes.
PubMed:Painful legs: the GP's dilemma.
PubMed:Troxerutin in Raynaud's syndrome.
PubMed:Methionine, pyridoxine and endothelial lesion in rats.
PubMed:[Critical study of the therapeutic effects of phlebotropic drugs on chronic venous insufficiency].
PubMed:The effect of digoxin on endothelaemia in rats and its modification by a combination of troxerutin and coumarin.
PubMed:[The influence of the combination of coumarin and troxerutin on infantile blood parameter in lactation period. Short communication (author's transl)].
PubMed:Antithrombotic effects of some flavonoids alone and combined with acetylsalicylic acid.
PubMed:[Test of combination of the agents coumarin and troxerutin for embryotoxic and teratogenic side-effects in Göttingen miniature pigs (author's transl)].
PubMed:[Effect of a benzopyrone compound on liver function. Short communication (author's transl)].
PubMed:[Experimental investigation of cardiac lymph vascular system (author's transl)].
PubMed:A fine structural demonstration that some benzopyrones act as vitamin P in the rat.
PubMed:Fine structural aspects of lymphoedema in various tissues and the effects of treatment with coumarin and troxerutin.
PubMed:Comparative investigations on the treatment of the varicose syndrome with 4-methyl-6,7-(bis-beta-diethyl-aminoethoxy)-coumarine hydrochloride (oxamarine), with the disodium salt of disulphuric ester of 4-methyl-aesculetol and with tri-hydroxy-ethylrutoside (troxerutin).
PubMed:Troxerutin in the treatment of haemorrhoids.
PubMed:A clinical trial of troxerutin in venous insufficiency of the lower limb.
PubMed:[Treatment of the varicose symptom complex with Venoruton P4 capsules].
PubMed:[Clinical experiences with Venoruton P4 in surgery].
PubMed:[Pure vitamin P4 in venous diseases].
Bioflavonoid Troxerutin is a flavonol, a type of flavonoid. It is more acurately a hydroxyethylrutoside. It can be isolated from Sophora japonica, the japanese pagoda tree.; Troxerutin is a rutoside, a naturally occurring flavonoid. Flavonoids are polyphenolic compounds that are present in most fruits and vegetables. Although flavonoids are devoid of classical nutritional value, they are increasingly viewed as beneficial dietary components that act as potential protectors against human diseases such as coronary heart disease, cancers, and inflammatory bowel disease. Troxerutin is a beneficial cofactor in coumarin preparations used for the therapy of chronic venous insufficiency, since has hepatoprotective properties and thus protects the liver from a possible lipid peroxidation caused by coumarin. Oxidative stress might be involved in the upregulation of retinal vascular endothelial growth factor (VEGF) during early diabetes, and it is likely that troxerutin has comparatively effective antioxidant properties; therefore, troxerutin might be a useful treatment for attenuating diabetic retinopathy. Troxerutin offers protection against gamma-radiation-induced micronuclei formation and DNA strand breaks and enhances repair of radiation-induced DNA strand breaks, in addition to anti-erythrocytic, anti-thrombic, fibrinolytic and oedema-protective rheological activity. (PMID: 15601310, 15693708, 16294503, 16311905)
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