osajin
4H,8H-benzo(1,2-b:3,4-b')dipyran-4-one, 5-hydroxy-3-(p-hydroxyphenyl)-8,8-dimethyl-6-(3-methyl-2-butenyl)-
 
Notes:
None found
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5-hydroxy-3-(4-hydroxyphenyl)-8,8-dimethyl-6-(3-methylbut-2-enyl)pyrano[2,3-h]chromen-4-one (Click)
CAS Number: 482-53-1Picture of molecule
FDA UNII: 83R5N9X74B
Nikkaji Web: J13.174A
MDL: MFCD00076045
XlogP3-AA: 5.90 (est)
Molecular Weight: 404.46228000
Formula: C25 H24 O5
NMR Predictor: Predict (works with chrome or firefox)
Category: antioxidants
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Soluble in:
 water, 0.005882 mg/L @ 25 °C (est)
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: antioxidants
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Suppliers:
BOC Sciences
For experimental / research use only.
Osajin >97%
Odor: characteristic
Use: Osajin is a natural flavonoid found in the herbs of Derris robusta. Through multiple apoptotic pathways, osajin can induce apoptosis in human NPC cells. Osajin also exhibits antitumor activity in different tumor cell lines. antitumor
Sigma-Aldrich: Sigma
For experimental / research use only.
Osajin ≥95% (LC/MS-ELSD)
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Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: antioxidants
Recommendation for osajin usage levels up to:
 not for fragrance use.
 
Recommendation for osajin flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 95168
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 3
 5-hydroxy-3-(4-hydroxyphenyl)-8,8-dimethyl-6-(3-methylbut-2-enyl)pyrano[2,3-h]chromen-4-one
Chemidplus: 0000482531
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References:
 5-hydroxy-3-(4-hydroxyphenyl)-8,8-dimethyl-6-(3-methylbut-2-enyl)pyrano[2,3-h]chromen-4-one
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 95168
Pubchem (sid): 135055080
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
CHEBI: View
CHEMBL: View
KEGG (GenomeNet): C10511
HMDB (The Human Metabolome Database): Search
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 orange osage orange fruit
Search Trop  Picture
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Synonyms:
4H,8H-benzo(1,2-b:3,4-b')dipyran-4-one, 5-hydroxy-3-(p-hydroxyphenyl)-8,8-dimethyl-6-(3-methyl-2-butenyl)-
4H,8H-benzo[1,2-b:3,4-b']dipyran-4-one, 5-hydroxy-3-(4-hydroxyphenyl)-8,8-dimethyl-6-(3-methyl-2-buten-1-yl)-
5-hydroxy-3-(4-hydroxyphenyl)-8,8-dimethyl-6-(3-methyl-2-buten-1-yl)-4H,8H-pyrano[2,3-f]chromen-4-one
5-hydroxy-3-(4-hydroxyphenyl)-8,8-dimethyl-6-(3-methylbut-2-enyl)pyrano[2,3-H]chromen-4-one
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Articles:
PubMed: Potential of Horse Apple Isoflavones in Targeting Inflammation and Tau Protein Fibrillization.
PubMed: Semi-synthetic derivatives of natural isoflavones from Maclura pomifera as a novel class of PDE-5A inhibitors.
PubMed: Effect of osajin and pomiferin on antidiabetic effects from normal and streptozotocin-induced diabetic rats.
PubMed: In vitro and ex vivo examination of topical Pomiferin treatments.
PubMed: Prenylated and geranylated flavonoids increase production of reactive oxygen species in mouse macrophages but inhibit the inflammatory response.
PubMed: HPLC determination of isoflavone levels in osage orange from the Midwest and southern United States.
PubMed: Antiproliferative activity of pomiferin in normal (MCF-10A) and transformed (MCF-7) breast epithelial cells.
PubMed: Activation of multiple apoptotic pathways in human nasopharyngeal carcinoma cells by the prenylated isoflavone, osajin.
PubMed: Vapor-phase toxicity of Derris scandens Benth.-derived constituents against four stored-product pests.
PubMed: Examining the genomic influence of skin antioxidants in vitro.
PubMed: [Flavonoids from roots of Flemingia philippinensis].
PubMed: Cholinesterase inhibitory effects of the extracts and compounds of Maclura pomifera (Rafin.) Schneider.
PubMed: Electrochemical and spectrometric study of antioxidant activity of pomiferin, isopomiferin, osajin and catalposide.
PubMed: [Testing of antidiabetic and antioxidative effect of the flavonoid osajin in an experiment].
PubMed: Pomiferin, histone deacetylase inhibitor isolated from the fruits of Maclura pomifera.
PubMed: Effects of prenylated isoflavones osajin and pomiferin in premedication on heart ischemia-reperfusion.
PubMed: [Protective effects of the flavonoids osajin and pomiferin on heart ischemia-reperfusion].
PubMed: Interactions of genistein and related isoflavones with lipid micelles.
PubMed: Protective effects of osajin in ischemia-reperfusion of laboratory rat kidney.
PubMed: Neuroprotective flavonoids from Flemingia macrophylla.
PubMed: Antioxidative and EROD activities of osajin and pomiferin.
PubMed: Antioxidant isoflavones in Osage orange, Maclura pomifera (Raf.) Schneid.
PubMed: Isolation of 19alpha-H-lupeol from Maclura pomifera.
PubMed: Inhibition of valyl angiotensinamide II by osajin.
PubMed: Osage orange pigments; complete structures of osajin and pomiferin.
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