| PubMed:Discovery and development of natural product oridonin-inspired anticancer agents. |
| PubMed:Overview of Medicinally Important Diterpenoids Derived from Plastids. |
| PubMed:The anti-tumor effect of folate-targeted liposome microbubbles loaded with oridonin as ultrasound-triggered tumor-targeted therapeutic carrier system. |
| PubMed:Oridonin enhances the anticancer activity of NVP-BEZ235 against neuroblastoma cells in vitro and in vivo through autophagy. |
| PubMed:Novel anticancer oridonin derivatives possessing a diazen-1-ium-1,2-diolate nitric oxide donor moiety: Design, synthesis, biological evaluation and nitric oxide release studies. |
| PubMed:Antitumor and Antibacterial Derivatives of Oridonin: A Main Composition of Dong-Ling-Cao. |
| PubMed:Effects of Oridonin on growth performance and oxidative stress in broilers challenged with lipopolysaccharide. |
| PubMed:Oridonin Alleviates Visceral Hyperalgesia in a Rat Model of Postinflammatory Irritable Bowel Syndrome: Role of Colonic Enterochromaffin Cell and Serotonin Availability. |
| PubMed:Oridonin upregulates PTEN through activating p38 MAPK and inhibits proliferation in human colon cancer cells. |
| PubMed:Probing the Anticancer Action of Oridonin with Fluorescent Analogues: Visualizing Subcellular Localization to Mitochondria. |
| PubMed:Oridonin inhibits gefitinib-resistant lung cancer cells by suppressing EGFR/ERK/MMP-12 and CIP2A/Akt signaling pathways. |
| PubMed:Oridonin induces apoptosis through the mitochondrial pathway in human gastric cancer SGC-7901 cells. |
| PubMed:Oridonin inhibits the proliferation of human colon cancer cells by upregulating BMP7 to activate p38 MAPK. |
| PubMed:Oridonin, a novel lysine acetyltransferases inhibitor, inhibits proliferation and induces apoptosis in gastric cancer cells through p53- and caspase-3-mediated mechanisms. |
| PubMed:Oridonin Attenuates Synaptic Loss and Cognitive Deficits in an Aβ1-42-Induced Mouse Model of Alzheimer's Disease. |
| PubMed:Oridonin effectively reverses cisplatin drug resistance in human ovarian cancer cells via induction of cell apoptosis and inhibition of matrix metalloproteinase expression. |
| PubMed:Oridonin Suppresses Proliferation of Human Ovarian Cancer Cells via Blockage of mTOR Signaling. |
| PubMed:Oridonin Inhibits Cell Proliferation and Induces Apoptosis in Rheumatoid Arthritis Fibroblast-Like Synoviocytes. |
| PubMed:Therapeutic effect of oridonin on mice with prostate cancer. |
| PubMed:Novel galactosylated biodegradable nanoparticles for hepatocyte-delivery of oridonin. |
| PubMed:Signaling mechanisms of bortezomib in TRAF3-deficient mouse B lymphoma and human multiple myeloma cells. |
| PubMed:Oridonin derivative ameliorates experimental colitis by inhibiting activated T-cells and translocation of nuclear factor-kappa B. |
| PubMed:Inhibition of nuclear factor κB transcription activity drives a synergistic effect of cisplatin and oridonin on HepG2 human hepatocellular carcinoma cells. |
| PubMed:A novel combination of oridonin and valproic acid in enhancement of apoptosis induction of HL-60 leukemia cells. |
| PubMed:Comparative studies on glycerol monooleate- and phytantriol-based cubosomes containing oridonin in vitro and in vivo. |
| PubMed:Inhibition of caspase-9 by oridonin, a diterpenoid isolated from Rabdosia rubescens, augments apoptosis in human laryngeal cancer cells. |
| PubMed:Natural products against hematological malignancies and identification of their targets. |
| PubMed:Identification of metabolites of oridonin in rats with a single run on UPLC-Triple-TOF-MS/MS system based on multiple mass defect filter data acquisition and multiple data processing techniques. |
| PubMed:Qualitative and Quantitative Analysis of ROS-Mediated Oridonin-Induced Oesophageal Cancer KYSE-150 Cell Apoptosis by Atomic Force Microscopy. |
| PubMed:Fok I cleavage-inhibition strategy for the specific and accurate detection of transcription factors. |
| PubMed:Reactive oxygen species mediate oridonin-induced apoptosis through DNA damage response and activation of JNK pathway in diffuse large B cell lymphoma. |
| PubMed:Enhanced effects of novel oridonin analog CYD0682 for hepatic fibrosis. |
| PubMed:Three New Cytotoxic ent-Kaurane Diterpenes from Isodon excisoides. |
| PubMed:Enhanced anti-fibrogenic effects of novel oridonin derivative CYD0692 in hepatic stellate cells. |
| PubMed:Molecular Insight in the Multifunctional Effects of Oridonin. |
| PubMed:Simultaneous determination of ginsenoside Rb1, naringin, ginsenoside Rb2 and oridonin in rat plasma by LC-MS/MS and its application to a pharmacokinetic study after oral administration of Weifuchun tablet. |
| PubMed:Nanosuspensions Containing Oridonin/HP-β-Cyclodextrin Inclusion Complexes for Oral Bioavailability Enhancement via Improved Dissolution and Permeability. |
| PubMed:Synergistic anticancer effects of combined γ-tocotrienol and oridonin treatment is associated with the induction of autophagy. |
| PubMed:The Antitumor Activity of the Novel Compound Jesridonin on Human Esophageal Carcinoma Cells. |
| PubMed:Oridonin triggers apoptosis in colorectal carcinoma cells and suppression of microRNA-32 expression augments oridonin-mediated apoptotic effects. |
| PubMed:Oridonin stabilizes retinoic acid receptor alpha through ROS-activated NF-κB signaling. |
| PubMed:Oridonin alters the expression profiles of microRNAs in BxPC-3 human pancreatic cancer cells. |
| PubMed:Interaction of oridonin with human serum albumin by isothermal titration calorimetry and spectroscopic techniques. |
| PubMed:Role of NF-κB/IKK-dependent signaling in functional stimulation of mesenchymal progenitor cells by alkaloid songorine. |
| PubMed:Inhibition of RNA transportation induces glioma cell apoptosis via downregulation of RanGAP1 expression. |
| PubMed:Oridonin inhibits BxPC-3 cell growth through cell apoptosis. |
| PubMed:Reactive oxygen species, redox signaling and neuroinflammation in Alzheimer's disease: the NF-κB connection. |
| PubMed:[Anti-leukemia effect of oridonin on T-cell acute lymphoblastic leukemia]. |
| PubMed:[Experimental study on anti-pancreatic cancer effect of oridonin]. |
| PubMed:Nanostructured lipid carriers used for oral delivery of oridonin: an effect of ligand modification on absorption. |
| PubMed:Oridonin inhibits tumor growth in glioma by inducing cell cycle arrest and apoptosis. |
| PubMed:Oridonin induces apoptosis in uveal melanoma cells by upregulation of Bim and downregulation of Fatty Acid Synthase. |
| PubMed:Oridonin phosphate-induced autophagy effectively enhances cell apoptosis of human breast cancer cells. |
| PubMed:Oridonin inhibits tumor growth and metastasis through anti-angiogenesis by blocking the Notch signaling. |
| PubMed:Key autophagic targets and relevant small-molecule compounds in cancer therapy. |
| PubMed:Oridonin: a small molecule inhibitor of cystic fibrosis transmembrane conductance regulator (CFTR) isolated from traditional Chinese medicine. |
| PubMed:Oridonin, a promising antitumor natural product in the chemotherapy of hematological malignancies. |
| PubMed:Effect of oridonin-mediated hallmark changes on inflammatory pathways in human pancreatic cancer (BxPC-3) cells. |
| PubMed:Attacking c-Myc: targeted and combined therapies for cancer. |
| PubMed:Synthesis and antimycobacterial evaluation of natural oridonin and its enmein-type derivatives. |
| PubMed:Oridonin suppress cell migration via regulation of nonmuscle myosin IIA. |
| PubMed:Enhancement of the effects of gemcitabine against pancreatic cancer by oridonin via the mitochondrial caspase-dependent signaling pathway. |
| PubMed:ent-Kaurane-based regio- and stereoselective inverse electron demand hetero-Diels-Alder reactions: synthesis of dihydropyran-fused diterpenoids. |
| PubMed:Oridonin's therapeutic effect: suppressing Th1/Th17 simultaneously in a mouse model of Crohn's disease. |
| PubMed:Downregulation of Cdk1 and cyclinB1 expression contributes to oridonin-induced cell cycle arrest at G2/M phase and growth inhibition in SGC-7901 gastric cancer cells. |
| PubMed:Oridonin attenuates Aβ1-42-induced neuroinflammation and inhibits NF-κB pathway. |
| PubMed:Oridonin inhibits mTOR signaling and the growth of lung cancer tumors. |
| PubMed:Induction of human CYP3A4 by huperzine A, ligustrazine and oridonin through pregnane X receptor-mediated pathways. |
| PubMed:Role of NF-κB-dependent signaling in the growth capacity of mesenchymal progenitor cells under the influence of basic fibroblast growth factor. |
| PubMed:Novel hybrids of natural oridonin-bearing nitrogen mustards as potential anticancer drug candidates. |
| PubMed:Dose-response of oridonin on hepatic cytochromes P450 mRNA expression and activities in mice. |
| PubMed:Anti-tumor activity of oridonin on SNU-5 subcutaneous xenograft model via regulation of c-Met pathway. |
| PubMed:Oridonin induces NPM mutant protein translocation and apoptosis in NPM1c+ acute myeloid leukemia cells in vitro. |
| PubMed:Preliminary study on the mechanism of oridonin-induced apoptosis in human squamous cell oesophageal carcinoma cell line EC9706. |
| PubMed:Inhibition of miR-17 and miR-20a by oridonin triggers apoptosis and reverses chemoresistance by derepressing BIM-S. |
| PubMed:Oridonin inhibits the proliferation of human osteosarcoma cells by suppressing Wnt/β-catenin signaling. |
| PubMed:Design, synthesis and antimycobacterial activity evaluation of natural oridonin derivatives. |
| PubMed:[Mechanism concerning antitumor effect of oridonin on multiple myeloma cell line U266]. |
| PubMed:Oridonin inhibits hepatic stellate cell proliferation and fibrogenesis. |
| PubMed:Galactosylated bovine serum albumin nanoparticles for parenteral delivery of oridonin: tissue distribution and pharmacokinetic studies. |
| PubMed:Oridonin induces apoptosis and cell cycle arrest of gallbladder cancer cells via the mitochondrial pathway. |
| PubMed:Intracellular glutathione depletion by oridonin leads to apoptosis in hepatic stellate cells. |
| PubMed:Proteomic and functional analyses demonstrate the involvement of oxidative stress in the anticancer activities of oridonin in HepG2 cells. |
| PubMed:[Preparation of freeze-dried long-circulation oridonin liposomes and their pharmacokinetics in rats]. |
| PubMed:Oridonin induces apoptosis in SW1990 pancreatic cancer cells via p53- and caspase-dependent induction of p38 MAPK. |
| PubMed:Role of NF-κB-dependent signaling in the realization of growth potential of mesenchymal progenitor cells in vitro. |
| PubMed:Oridonin protects HaCaT keratinocytes against hydrogen peroxide-induced oxidative stress by altering microRNA expression. |
| PubMed:Oridonin suppresses transplant rejection by depleting T cells from the periphery. |
| PubMed:[Simultaneous determination of rosmarinic acid, oridonin and chrysoplenetin in Isodon rubescens by HPLC]. |
| PubMed:Oridonin induces the apoptosis of metastatic hepatocellular carcinoma cells via a mitochondrial pathway. |
| PubMed:Oridonin exerts protective effects against hydrogen peroxide‑induced damage by altering microRNA expression profiles in human dermal fibroblasts. |
| PubMed:Oridonin ring A-based diverse constructions of enone functionality: identification of novel dienone analogues effective for highly aggressive breast cancer by inducing apoptosis. |
| PubMed:Inhibition of c-Met promoted apoptosis, autophagy and loss of the mitochondrial transmembrane potential in oridonin-induced A549 lung cancer cells. |
| PubMed:Oridonin ameliorates neuropathological changes and behavioural deficits in a mouse model of cerebral amyloidosis. |
| PubMed:Synthesis, characterization, in vitro and in vivo evaluation of PEGylated oridonin conjugates. |
| PubMed:Overcoming synthetic challenges of oridonin A-ring structural diversification: regio- and stereoselective installation of azides and 1,2,3-triazoles at the C-1, C-2, or C-3 position. |
| PubMed:Resonance light scattering technique as a new tool to determine the binding mode of anticancer drug oridonin to DNA. |
| PubMed:Anti-inflammatory effects of 27 selected terpenoid compounds tested through modulating Th1/Th2 cytokine secretion profiles using murine primary splenocytes. |
| PubMed:DNA damage induced by oridonin involves cell cycle arrest at G2/M phase in human MCF-7 cells. |
| PubMed:Novel nitrogen-enriched oridonin analogues with thiazole-fused A-ring: protecting group-free synthesis, enhanced anticancer profile, and improved aqueous solubility. |
| PubMed:Oridonin ameliorates lupus-like symptoms of MRL(lpr/lpr) mice by inhibition of B-cell activating factor (BAFF). |
| PubMed:Enmein-type diterpenoid analogs from natural kaurene-type oridonin: Synthesis and their antitumor biological evaluation. |
| PubMed:ER stress and ASK1-JNK activation contribute to oridonin-induced apoptosis and growth inhibition in cultured human hepatoblastoma HuH-6 cells. |
| PubMed:Recent advances in the molecular basis of anti-neoplastic mechanisms of oridonin. |
| PubMed:Library construction and biological evaluation of enmein-type diterpenoid analogues as potential anticancer agents. |
| PubMed:Preparation and characterization of galactosylated bovine serum albumin nanoparticles for liver-targeted delivery of oridonin. |
| PubMed:LC-MS-MS for the determination of ponicidin in dog plasma. |
| PubMed:[Experimental research on the mechanisms of human multiple myeloma LP-1 cell apoptosis induced by oridonin]. |
| PubMed:Chemical proteomics reveals HSP70 1A as a target for the anticancer diterpene oridonin in Jurkat cells. |
| PubMed:Simultaneous determination of oridonin, ponicidin and rosmarinic acid from Herba Isodi Rubescentis extract by LC-MS-MS in rat plasma. |
| PubMed:Reactive oxygen species H2O2 and •OH, but not O2•(-) promote oridonin-induced phagocytosis of apoptotic cells by human histocytic lymphoma U937 cells. |
| PubMed:Oridonin induces apoptosis, inhibits migration and invasion on highly-metastatic human breast cancer cells. |
| PubMed:Oridonin induces apoptosis in gastric cancer through Apaf-1, cytochrome c and caspase-3 signaling pathway. |
| PubMed:Chemical constituents of flowers and fruits of Rabdosia excisa. |
| PubMed:Synthesis of spirolactone-type diterpenoid derivatives from kaurene-type oridonin with improved antiproliferative effects and their apoptosis-inducing activity in human hepatoma Bel-7402 cells. |
| PubMed:Selection for high oridonin yield in the Chinese medicinal plant Isodon (Lamiaceae) using a combined phylogenetics and population genetics approach. |
| PubMed:Hydroxyl radical (·OH) played a pivotal role in oridonin-induced apoptosis and autophagy in human epidermoid carcinoma A431 cells. |
| PubMed:Polyphenols inhibit indoleamine 3,5-dioxygenase-1 enzymatic activity--a role of immunomodulation in chemoprevention. |
| PubMed:In vitro and in vivo studies of galactose-modified liver-targeting liposomes. |
| PubMed:Oridonin: targeting programmed cell death pathways as an anti-tumour agent. |
| PubMed:[Anti-leukemia effect of oridonin on Ph(+) acute lymphoblastic leukemia cell SUP-B15]. |
| PubMed:The cell death of C6 astrocytoma cells induced by oridonin and its mechanism. |
| PubMed:In vivo studies on the oridonin-loaded nanostructured lipid carriers. |
| PubMed:Oridonin in combination with imatinib exerts synergetic anti-leukemia effect in Ph+ acute lymphoblastic leukemia cells in vitro by inhibiting activation of LYN/mTOR signaling pathway. |
| PubMed:The tyrphostin AG1478 augments oridonin-induced A431 cell apoptosis by blockage of JNK MAPK and enhancement of oxidative stress. |
| PubMed:Oridonin-induced apoptosis in SW620 human colorectal adenocarcinoma cells. |
| PubMed:Oridonin induces apoptosis and autophagy in murine fibrosarcoma L929 cells partly via NO-ERK-p53 positive-feedback loop signaling pathway. |
| PubMed:Downregulation of nucleoporin 88 and 214 induced by oridonin may protect OCIM2 acute erythroleukemia cells from apoptosis through regulation of nucleocytoplasmic transport of NF-κB. |
| PubMed:[Anti-tumor effect of tanshinone II A, tetrandrine, honokiol, curcumin, oridonin and paeonol on leukemia cell lines]. |
| PubMed:Interruption of hepatocyte growth factor signaling augmented oridonin-induced death in human non-small cell lung cancer A549 cells via c-met-nuclear factor-κB-cyclooxygenase-2 and c-Met-Bcl-2-caspase-3 pathways. |
| PubMed:Plant natural compounds: targeting pathways of autophagy as anti-cancer therapeutic agents. |
| PubMed:Oridonin up-regulates expression of P21 and induces autophagy and apoptosis in human prostate cancer cells. |
| PubMed:Melanogenesis inhibitors from Rabdosia japonica. |
| PubMed:[Longikaurin A induces apoptosis of multiple myeloma H929 cells]. |
| PubMed:Galactosylated chitosan nanoparticles for hepatocyte-targeted delivery of oridonin. |
| PubMed:The anticancer effect of oridonin is mediated by fatty acid synthase suppression in human colorectal cancer cells. |
| PubMed:Oridonin enhances antitumor activity of gemcitabine in pancreatic cancer through MAPK-p38 signaling pathway. |
| PubMed:Synthesis and biological evaluation of novel furozan-based nitric oxide-releasing derivatives of oridonin as potential anti-tumor agents. |
| PubMed:Optimisation of an ultrasound-assisted extraction followed by RP-HPLC separation for the simultaneous determination of oleanolic acid, ursolic acid and oridonin content in Rabdosia rubescens. |
| PubMed:Nitric oxide augments oridonin-induced efferocytosis by human histocytic lymphoma U937 cells via autophagy and the NF-κB-COX-2-IL-1β pathway. |
| PubMed:Oridonin nanosuspension was more effective than free oridonin on G2/M cell cycle arrest and apoptosis in the human pancreatic cancer PANC-1 cell line. |
| PubMed:Biodegradable self-assembled MPEG-PCL micelles for hydrophobic oridonin delivery in vitro. |
| PubMed:The conversion of oridonin to spirolactone-type or enmein-type diterpenoid: synthesis and biological evaluation of ent-6,7-seco-oridonin derivatives as novel potential anticancer agents. |
| PubMed:Targeting of AML1-ETO in t(8;21) leukemia by oridonin generates a tumor suppressor-like protein. |
| PubMed:Triggering Fbw7-mediated proteasomal degradation of c-Myc by oridonin induces cell growth inhibition and apoptosis. |
| PubMed:[Study on pharmacokinetics of oridonin in mice]. |
| PubMed:In vitro and in vivo evaluation of oridonin-loaded long circulating nanostructured lipid carriers. |
| PubMed:Oridonin induces apoptosis and senescence by increasing hydrogen peroxide and glutathione depletion in colorectal cancer cells. |
| PubMed:Advances in the treatment of ovarian cancer: a potential role of antiinflammatory phytochemicals. |
| PubMed:RGD-modified poly(D,L-lactic acid) nanoparticles enhance tumor targeting of oridonin. |
| PubMed:Study on the autophagy of prostate cancer PC-3 cells induced by oridonin. |
| PubMed:Autophagy counteracts apoptosis in human multiple myeloma cells exposed to oridonin in vitro via regulating intracellular ROS and SIRT1. |
| PubMed:Autophagy enhanced phagocytosis of apoptotic cells by oridonin-treated human histocytic lymphoma U937 cells. |
| PubMed:Isolation and purification of oridonin from the whole plant of Isodon rubescens by high-speed counter-current chromatography. |
| PubMed:Galactose-decorated pH-responsive nanogels for hepatoma-targeted delivery of oridonin. |
| PubMed:Synergistic antitumor activity of oridonin and arsenic trioxide on hepatocellular carcinoma cells. |
| PubMed:Oridonin induced the apoptosis of PC-3 cells and its mechanism. |
| PubMed:A sensitive analysis method for 7 diterpenoids in rat plasma by liquid chromatography-electrospray ionization mass spectrometry and its application to pharmacokinetic study of Isodon serra extract. |
| PubMed:Reactive oxygen species contribute to oridonin-induced apoptosis and autophagy in human cervical carcinoma HeLa cells. |
| PubMed:NMR spectra and structures of oridonin derivatives complexes with β-cyclodextrin. |
| PubMed:Anti-cancer natural products isolated from chinese medicinal herbs. |
| PubMed:Oridonin nanosuspension enhances anti-tumor efficacy in SMMC-7721 cells and H22 tumor bearing mice. |
| PubMed:Synthesis and revision of stereochemistry of rubescensin S. |
| PubMed:Stimulation of suicidal erythrocyte death by oridonin. |
| PubMed:[Study on preparation and characterization of resveratrol solid lipid nanoparticles and its anticancer effects in vitro]. |
| PubMed:Development and in-vivo assessment of the bioavailability of oridonin solid dispersions by the gas anti-solvent technique. |
| PubMed:Downregulation of AP-1 gene expression is an initial event in the oridonin-mediated inhibition of colorectal cancer: studies in vitro and in vivo. |
| PubMed:A highly selective, label-free, homogenous luminescent switch-on probe for the detection of nanomolar transcription factor NF-kappaB. |
| PubMed:Chitosan-g-poly(N-isopropylacrylamide) based nanogels for tumor extracellular targeting. |
| PubMed:Oridonin: An active diterpenoid targeting cell cycle arrest, apoptotic and autophagic pathways for cancer therapeutics. |
| PubMed:Sensitization to TRAIL-induced apoptosis in human neuroblastoma SK-N-AS cells by NF-κB inhibitors is dependent on reactive oxygen species (ROS). |
| PubMed:[Autophagy of prostate cancer PC-3 cells under the induction of oridonin]. |
| PubMed:Growth inhibition and induction of apoptosis in MCF-7 breast cancer cells by oridonin nanosuspension. |
| PubMed:Oridonin induces apoptosis and senescence in colorectal cancer cells by increasing histone hyperacetylation and regulation of p16, p21, p27 and c-myc. |
| PubMed:Effects of oridonin nanosuspension on cell proliferation and apoptosis of human prostatic carcinoma PC-3 cell line. |
| PubMed:Genomic and in vivo evidence of synergy of a herbal extract compared to its most active ingredient: Rabdosia rubescens vs. oridonin. |
| PubMed:Proteomic and functional analyses reveal the potential involvement of endoplasmic reticulum stress and α-CP1 in the anticancer activities of oridonin in HepG2 cells. |
| PubMed:Combined activity of oridonin and wogonin in advanced-stage ovarian cancer cells: sensitivity of ovarian cancer cells to phyto-active chemicals. |
| PubMed:Proteomic identification of proteins involved in the anticancer activities of oridonin in HepG2 cells. |
| PubMed:Oridonin induces G2/M cell cycle arrest and apoptosis through MAPK and p53 signaling pathways in HepG2 cells. |
| PubMed:A novel analysis method for diterpenoids in rat plasma by liquid chromatography-electrospray ionization mass spectrometry. |
| PubMed:Induction of G(2)/M phase arrest and apoptosis by oridonin in human laryngeal carcinoma cells. |
| PubMed:Inhibition of EGFR signaling augments oridonin-induced apoptosis in human laryngeal cancer cells via enhancing oxidative stress coincident with activation of both the intrinsic and extrinsic apoptotic pathways. |
| PubMed:[Study on the antibacterial activity of compounds from the isodon species]. |
| PubMed:The effect of stealth liposomes on pharmacokinetics, tissue distribution and anti-tumor activity of oridonin. |
| PubMed:Preparation and characteristics of oridonin-loaded nanostructured lipid carriers as a controlled-release delivery system. |
| PubMed:[Preparation and characterization of oridonin submicron emulsions]. |
| PubMed:[Empirical study of oridonin-induced gastric cancer cells MKN45 apoptosis]. |
| PubMed:Sigma-1 receptors regulate Bcl-2 expression by reactive oxygen species-dependent transcriptional regulation of nuclear factor kappaB. |
| PubMed:[Two en-kaurene diterpenoids from Tibetan medicine Caryopteris toroetii]. |
| PubMed:Loss of endogenous interleukin-12 activates survival signals in ultraviolet-exposed mouse skin and skin tumors. |
| PubMed:Oridonin induces G2/M arrest and apoptosis via activating ERK-p53 apoptotic pathway and inhibiting PTK-Ras-Raf-JNK survival pathway in murine fibrosarcoma L929 cells. |
| PubMed:Ent-kaurane diterpenoids from Rabdosia rubescens and their cytotoxic effects on human cancer cell lines. |
| PubMed:NF-kappab facilitates oridonin-induced apoptosis and autophagy in HT1080 cells through a p53-mediated pathway. |
| PubMed:Comparison of cytotoxicity and DNA damage potential induced by ent-kaurene diterpenoids from Isodon plant. |
| PubMed:Effects and mechanism of oridonin on pulmonary hypertension induced by chronic hypoxia-hypercapnia in rats. |
| PubMed:In vitro and in vivo antitumor activity of oridonin nanosuspension. |
| PubMed:NF-kappaB inhibition leads to increased synthesis and secretion of MIF in human CD4+ T cells. |
| PubMed:[Study on stability of oridonin solution]. |
| PubMed:Apoptosis inducing and differentiation enhancement effect of oridonin on the all-trans-retinoic acid-sensitive and -resistant acute promyelocytic leukemia cells. |
| PubMed:Molecular mechanisms of oridonin-induced apoptosis and autophagy in murine fibrosarcoma L929 cells. |
| PubMed:Autophagy inhibits reactive oxygen species-mediated apoptosis via activating p38-nuclear factor-kappa B survival pathways in oridonin-treated murine fibrosarcoma L929 cells. |
| PubMed:Multiple-modulation effects of Oridonin on the production of proinflammatory cytokines and neurotrophic factors in LPS-activated microglia. |
| PubMed:[Release kinetics of oridonin self-microemulsifying drug delivery system in vitro]. |
| PubMed:Involvement of PKC signal pathways in oridonin-induced autophagy in HeLa cells: a protective mechanism against apoptosis. |
| PubMed:[Effect of N, P, K on yield and quality of Rabdosia rubescens]. |
| PubMed:Caspase inhibition augmented oridonin-induced cell death in murine fibrosarcoma l929 by enhancing reactive oxygen species generation. |
| PubMed:Oridonin confers protection against arsenic-induced toxicity through activation of the Nrf2-mediated defensive response. |
| PubMed:Optimization and in situ intestinal absorption of self-microemulsifying drug delivery system of oridonin. |
| PubMed:Reactive oxygen species mediate oridonin-induced HepG2 apoptosis through p53, MAPK, and mitochondrial signaling pathways. |
| PubMed:Oridonin induces human melanoma A375-S2 cell death partially through inhibiting insulin-like growth factor 1 receptor signaling. |
| PubMed:[Inhibitory effect of Oridonin injection on heterotransplanted gastric adenocarcinoma in nude mice and its mechanism]. |
| PubMed:Synthesis and biological evaluation of novel 1-O- and 14-O-derivatives of oridonin as potential anticancer drug candidates. |
| PubMed:Oridonin-loaded poly(epsilon-caprolactone)-poly(ethylene oxide)-poly(epsilon-caprolactone) copolymer nanoparticles: preparation, characterization, and antitumor activity on mice with transplanted hepatoma. |
| PubMed:Characterization and in vivo evaluation of an inclusion complex of oridonin and 2-hydroxypropyl-beta-cyclodextrin. |
| PubMed:An HPLC method for determination of oridonin in rabbits using isopsoralen as an internal standard and its application to pharmacokinetic studies for oridonin-loaded nanoparticles. |
| PubMed:Apoptosis-suppressing and autophagy-promoting effects of calpain on oridonin-induced L929 cell death. |
| PubMed:Oridonin promotes CD4+/CD25+ Treg differentiation, modulates Th1/Th2 balance and induces HO-1 in rat splenic lymphocytes. |
| PubMed:[Determination of oridonin and rosemarinic acid in Rabdosia rubescens by HPLC]. |
| PubMed:Studies on pharmacokinetics and tissue distribution of oridonin nanosuspensions. |
| PubMed:Preparation and evaluation of self-microemulsifying drug delivery system of oridonin. |
| PubMed:[Effects of Oridonin on proliferation in human nasopharyngeal carcinoma line CNE 2 in vitro]. |
| PubMed:Down-regulation of androgen-receptor and PSA by phytochemicals. |
| PubMed:Preparation and characterization of an oridonin nanosuspension for solubility and dissolution velocity enhancement. |
| PubMed:Oridonin induced autophagy in human cervical carcinoma HeLa cells through Ras, JNK, and P38 regulation. |
| PubMed:Oridonin induces human epidermoid carcinoma A431 cell apoptosis through tyrosine kinase and mitochondrial pathway. |
| PubMed:Authentication and chemical study of isodonis herba and isodonis extracts. |
| PubMed:Oridonin induces apoptosis via PI3K/Akt pathway in cervical carcinoma HeLa cell line. |
| PubMed:Inactivation of ras and changes of mitochondrial membrane potential contribute to oridonin-induced autophagy in a431 cells. |
| PubMed:Effects of oridonin on proliferation of HT29 human colon carcinoma cell lines both in vitro and in vivo in mice. |
| PubMed:P53-mediated cell cycle arrest and apoptosis through a caspase-3- independent, but caspase-9-dependent pathway in oridonin-treated MCF-7 human breast cancer cells. |
| PubMed:[Mechanism of downregulation of apoptosis by autophagy induced by oridonin in HeLa cells]. |
| PubMed:Studies on the cell-immunosuppressive mechanism of Oridonin from Isodon serra. |
| PubMed:Autophagy preceded apoptosis in oridonin-treated human breast cancer MCF-7 cells. |
| PubMed:Back to the future of oridonin: again, compound from medicinal herb shows potent antileukemia efficacies in vitro and in vivo. |
| PubMed:Effective two-dimensional counter-current chromatographic method for simultaneous isolation and purification of oridonin and ponicidin from the crude extract of Rabdosia rubescens. |
| PubMed:Oridonin inhibited the tyrosine kinase activity and induced apoptosis in human epidermoid carcinoma A431 cells. |
| PubMed:[Change of Bcl-2 expression and telomerase during apoptosis induced by oridonin on human hepatocelluar carcinoma cells]. |
| PubMed:Oridonin-induced A431 cell apoptosis partially through blockage of the Ras/Raf/ERK signal pathway. |
| PubMed:Oridonin induced apoptosis through Akt and MAPKs signaling pathways in human osteosarcoma cells. |
| PubMed:Oridonin, a diterpenoid extracted from medicinal herbs, targets AML1-ETO fusion protein and shows potent antitumor activity with low adverse effects on t(8;21) leukemia in vitro and in vivo. |
| PubMed:Fibroblast growth factor-2 suppresses oridonin-induced L929 apoptosis through extracellular signal-regulated kinase-dependent and phosphatidylinositol 3-kinase-independent pathway. |
| PubMed:Pharmacokinetic behaviors and oral bioavailability of oridonin in rat plasma. |
| PubMed:A rapid HPLC/ESI-MS method for the quantitative determination of oridonin in rat plasma. |
| PubMed:Determination of oridonin in rat plasma by reverse-phase high-performance liquid chromatography. |
| PubMed:Fas/FasL signaling allows extracelluar-signal regulated kinase to regulate cytochrome c release in oridonin-induced apoptotic U937 cells. |
| PubMed:Studies on the oridonin-loaded poly(D,L-lactic acid) nanoparticles in vitro and in vivo. |
| PubMed:Augmentation of oridonin-induced apoptosis observed with reduced autophagy. |
| PubMed:Celastrol, a triterpene extracted from the Chinese "Thunder of God Vine," is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice. |
| PubMed:Oridonin inhibits cell growth by induction of apoptosis on human hepatocelluar carcinoma BEL-7402 cells. |
| PubMed:Isolation and purification of oridonin from Rabdosia rubescens using upright counter-current chromatography. |
| PubMed:[Oridonin induced U937 cell apoptosis through ERK pathway]. |
| PubMed:Antiproliferation effects of oridonin on HPB-ALL cells and its mechanisms of action. |
| PubMed:A comparison of the signal pathways between the TNF alpha- and oridonin-induced murine L929 fibrosarcoma cell death. |
| PubMed:Roles of Ras and extracellular signal-regulated kinase-dependent IkappaBalpha degradation in oridonin-enhanced phagocytosis of apoptotic cells by human macrophage-like U937 cells. |
| PubMed:Bcl-2 up-regulation and P-p53 down-regulation account for the low sensitivity of murine L929 fibrosarcoma cells to oridonin-induced apoptosis. |
| PubMed:Differential control of growth, cell cycle progression, and expression of NF-kappaB in human breast cancer cells MCF-7, MCF-10A, and MDA-MB-231 by ponicidin and oridonin, diterpenoids from the chinese herb Rabdosia rubescens. |
| PubMed:The effects of oridonin on cell growth, cell cycle, cell migration and differentiation in melanoma cells. |
| PubMed:[The tissue distribution in mice and pharmacokinetics in rabbits of oridonin-solid lipid nanoparticles]. |
| PubMed:Two novel ent-kauranoid diterpenoids from Isodon japonica leaves. |
| PubMed:Activation of phosphoinositide 3-kinase, protein kinase C, and extracellular signal-regulated kinase is required for oridonin-enhanced phagocytosis of apoptotic bodies in human macrophage-like U937 cells. |
| PubMed:Apoptotic effect of oridonin on NB4 cells and its mechanism. |
| PubMed:Oridonin-induced apoptosis in leukemia K562 cells and its mechanism. |
| PubMed:Novel mechanism of inhibition of nuclear factor-kappa B DNA-binding activity by diterpenoids isolated from Isodon rubescens. |
| PubMed:Oridonin, a diterpenoid purified from Rabdosia rubescens, inhibits the proliferation of cells from lymphoid malignancies in association with blockade of the NF-kappa B signal pathways. |
| PubMed:Oridonin enhances phagocytosis of UV-irradiated apoptotic U937 cells. |
| PubMed:The cytostatic and cytotoxic effects of oridonin (Rubescenin), a diterpenoid from Rabdosia rubescens, on tumor cells of different lineage. |
| PubMed:[Regulation of telomerase activity and cell cycle of K562 cells by oridonin]. |
| PubMed:Ent-kauranoids from Isodon rubescens var. taihangensis. |
| PubMed:Anti-proliferative effects of oridonin on SPC-A-1 cells and its mechanism of action. |
| PubMed:Cytochrome c release from oridonin-treated apoptotic A375-S2 cells is dependent on p53 and extracellular signal-regulated kinase activation. |
| PubMed:Oridonin induces a caspase-independent but mitochondria- and MAPK-dependent cell death in the murine fibrosarcoma cell line L929. |
| PubMed:Antiproliferation effects of oridonin on HL-60 cells. |
| PubMed:Anti-proliferation effect of oridonin on HL-60 cells and its mechanism. |
| PubMed:Oridonin induces apoptosis of HeLa cells via altering expression of Bcl-2/Bax and activating caspase-3/ICAD pathway. |
| PubMed:Cytotoxic ent-kauranoids from Isodon leucophyllus. |
| PubMed:Oridonin induced A375-S2 cell apoptosis via bax-regulated caspase pathway activation, dependent on the cytochrome c/caspase-9 apoptosome. |
| PubMed:Ponicidin and oridonin are responsible for the antiangiogenic activity of Rabdosia rubescens, a constituent of the herbal supplement PC SPES. |
| PubMed:Oridonin induces growth inhibition and apoptosis of a variety of human cancer cells. |
| PubMed:Ent-kaurane diterpenoids from Isodon rubescens var. lushanensis. |
| PubMed:Diterpenoids from Isodon japonica. |
| PubMed:[Study on the inclusion of oridonin-beta-cyclodextrin]. |
| PubMed:A new diepoxy-ent-kauranoid, rugosinin, from Isodon rugosus. |
| PubMed:PC-SPES: herbal formulation for prostate cancer. |
| PubMed:Taibaijaponicains C and D: two new diterpenoids from Isodon japonica. |
| PubMed:A new diterpene glycoside from Rabdosia rubescens. |
| PubMed:[New method for preparing oridonin by column chromatography]. |
| PubMed:Antibacterial activity of trichorabdal A from Rabdosia trichocarpa against Helicobacter pylori. |
| PubMed:[Determination of oridonin in Rabdosia rubescens by TLC-scanning method]. |
| PubMed:[Chemical constituents of Rabdosia nervosa (Hemsl) C.Y. Wu et H. W. Li]. |
| PubMed:Synergistic effect of oridonin and cisplatin on cytotoxicity and DNA cross-link against mouse sarcoma S180 cells in culture. |
| PubMed:The stereo-, regio-, and chemo-selective conversion of diterpenoids, kamebakaurin to oriaonin. |
| PubMed:[Chemical constituents of Isodon parvifolia (Batalin) Hara]. |
| PubMed:Terpenoids. LIII. Antitumor activity of trichorabdals and related compounds. |
| PubMed:[Effect of oridonin on cell-free DNA synthesis in vitro]. |
| PubMed:Effect of oridonin, a Rabdosia diterpenoid, on radiosensitization with misonidazole. |
| PubMed:[Effect of oridonin on metabolism of thymine nucleotides in tumor cells in mice]. |
| PubMed:[Effects of oridonin on DNA, RNA and protein syntheses of leukemia L 1210 cells studied by autoradiography]. |
| PubMed:[Effect of oridonin and bleomycin A5 combination on DNA syntheses in tumor and bone marrow cells]. |
| PubMed:[Antitumor effects of different combinations of oridonin, bleomycin A5 and nitrocaphane]. |
| PubMed:[Characteristics of the cytostatic effects of oridonin in vitro]. |
| PubMed:[Comparison of in vitro assays for the cytotoxic effect of anticancer drugs]. |
| PubMed:[Cytokinetic effects of oridonin on leukemia L1210 cells]. |
| PubMed:Antitumor activity of acylated oridonin. |
| PubMed:The use of herbs as anticancer agents. |
| PubMed:Antitumor activity of the Isodon diterpenoids: structural requirements for the activity. |
| PubMed:Biosynthesis of natural products. Part 1. Incorporations of ent-Kaur-16-ene and ent-Kaur-16-en-15-one into enmein and oridonin. |
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