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(1alpha, 6beta,7alpha,14R)-7,20-epoxy-1,6,7,14-tetrahydroxykaur-16-en-15-one

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CAS Number: 28957-04-2Picture of molecule3D/inchi
Other(deleted CASRN):18288-82-9
Nikkaji Web:J2.536.938F
XlogP3-AA:0.10 (est)
Molecular Weight:364.43836000
Formula:C20 H28 O6
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:cosmetic ingredient for skin conditioning
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Soluble in:
 water, 2171 mg/L @ 25 °C (est)
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: skin conditioning
Alfa Biotechnology
For experimental / research use only.
Oridonin 98%
BOC Sciences
For experimental / research use only.
Oridonin >98%
Odor: characteristic
Use: Oridonin, a diterpenoid purified from Rabdosia rubescens, is an antitumor agent.
Safety Information:
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD50 35 mg/kg
British Patent Document. Vol. #1476016

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Safety in Use Information:
cosmetic ingredient for skin conditioning
Recommendation for oridonin usage levels up to:
 not for fragrance use.
Recommendation for oridonin flavor usage levels up to:
 not for flavor use.
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :5321010
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
RTECS:NZ8177000 for cas# 28957-04-2
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):5321010
Pubchem (sid):134996883
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):Search
Potential Blenders and core components note
None Found
Potential Uses:
None Found
Occurrence (nature, food, other):note
 not found in nature
(1alpha, 6beta,7alpha,14R)-7,20-epoxy-1,6,7,14-tetrahydroxykaur-16-en-15-one
 kaur-16-en-15-one, 7,20-epoxy-1,6,7,14-tetrahydroxy-, (1alpha,6beta,7alpha,14R)-


PubMed:Discovery and development of natural product oridonin-inspired anticancer agents.
PubMed:Overview of Medicinally Important Diterpenoids Derived from Plastids.
PubMed:The anti-tumor effect of folate-targeted liposome microbubbles loaded with oridonin as ultrasound-triggered tumor-targeted therapeutic carrier system.
PubMed:Oridonin enhances the anticancer activity of NVP-BEZ235 against neuroblastoma cells in vitro and in vivo through autophagy.
PubMed:Novel anticancer oridonin derivatives possessing a diazen-1-ium-1,2-diolate nitric oxide donor moiety: Design, synthesis, biological evaluation and nitric oxide release studies.
PubMed:Antitumor and Antibacterial Derivatives of Oridonin: A Main Composition of Dong-Ling-Cao.
PubMed:Effects of Oridonin on growth performance and oxidative stress in broilers challenged with lipopolysaccharide.
PubMed:Oridonin Alleviates Visceral Hyperalgesia in a Rat Model of Postinflammatory Irritable Bowel Syndrome: Role of Colonic Enterochromaffin Cell and Serotonin Availability.
PubMed:Oridonin upregulates PTEN through activating p38 MAPK and inhibits proliferation in human colon cancer cells.
PubMed:Probing the Anticancer Action of Oridonin with Fluorescent Analogues: Visualizing Subcellular Localization to Mitochondria.
PubMed:Oridonin inhibits gefitinib-resistant lung cancer cells by suppressing EGFR/ERK/MMP-12 and CIP2A/Akt signaling pathways.
PubMed:Oridonin induces apoptosis through the mitochondrial pathway in human gastric cancer SGC-7901 cells.
PubMed:Oridonin inhibits the proliferation of human colon cancer cells by upregulating BMP7 to activate p38 MAPK.
PubMed:Oridonin, a novel lysine acetyltransferases inhibitor, inhibits proliferation and induces apoptosis in gastric cancer cells through p53- and caspase-3-mediated mechanisms.
PubMed:Oridonin Attenuates Synaptic Loss and Cognitive Deficits in an Aβ1-42-Induced Mouse Model of Alzheimer's Disease.
PubMed:Oridonin effectively reverses cisplatin drug resistance in human ovarian cancer cells via induction of cell apoptosis and inhibition of matrix metalloproteinase expression.
PubMed:Oridonin Suppresses Proliferation of Human Ovarian Cancer Cells via Blockage of mTOR Signaling.
PubMed:Oridonin Inhibits Cell Proliferation and Induces Apoptosis in Rheumatoid Arthritis Fibroblast-Like Synoviocytes.
PubMed:Therapeutic effect of oridonin on mice with prostate cancer.
PubMed:Novel galactosylated biodegradable nanoparticles for hepatocyte-delivery of oridonin.
PubMed:Signaling mechanisms of bortezomib in TRAF3-deficient mouse B lymphoma and human multiple myeloma cells.
PubMed:Oridonin derivative ameliorates experimental colitis by inhibiting activated T-cells and translocation of nuclear factor-kappa B.
PubMed:Inhibition of nuclear factor κB transcription activity drives a synergistic effect of cisplatin and oridonin on HepG2 human hepatocellular carcinoma cells.
PubMed:A novel combination of oridonin and valproic acid in enhancement of apoptosis induction of HL-60 leukemia cells.
PubMed:Comparative studies on glycerol monooleate- and phytantriol-based cubosomes containing oridonin in vitro and in vivo.
PubMed:Inhibition of caspase-9 by oridonin, a diterpenoid isolated from Rabdosia rubescens, augments apoptosis in human laryngeal cancer cells.
PubMed:Natural products against hematological malignancies and identification of their targets.
PubMed:Identification of metabolites of oridonin in rats with a single run on UPLC-Triple-TOF-MS/MS system based on multiple mass defect filter data acquisition and multiple data processing techniques.
PubMed:Qualitative and Quantitative Analysis of ROS-Mediated Oridonin-Induced Oesophageal Cancer KYSE-150 Cell Apoptosis by Atomic Force Microscopy.
PubMed:Fok I cleavage-inhibition strategy for the specific and accurate detection of transcription factors.
PubMed:Reactive oxygen species mediate oridonin-induced apoptosis through DNA damage response and activation of JNK pathway in diffuse large B cell lymphoma.
PubMed:Enhanced effects of novel oridonin analog CYD0682 for hepatic fibrosis.
PubMed:Three New Cytotoxic ent-Kaurane Diterpenes from Isodon excisoides.
PubMed:Enhanced anti-fibrogenic effects of novel oridonin derivative CYD0692 in hepatic stellate cells.
PubMed:Molecular Insight in the Multifunctional Effects of Oridonin.
PubMed:Simultaneous determination of ginsenoside Rb1, naringin, ginsenoside Rb2 and oridonin in rat plasma by LC-MS/MS and its application to a pharmacokinetic study after oral administration of Weifuchun tablet.
PubMed:Nanosuspensions Containing Oridonin/HP-β-Cyclodextrin Inclusion Complexes for Oral Bioavailability Enhancement via Improved Dissolution and Permeability.
PubMed:Synergistic anticancer effects of combined γ-tocotrienol and oridonin treatment is associated with the induction of autophagy.
PubMed:The Antitumor Activity of the Novel Compound Jesridonin on Human Esophageal Carcinoma Cells.
PubMed:Oridonin triggers apoptosis in colorectal carcinoma cells and suppression of microRNA-32 expression augments oridonin-mediated apoptotic effects.
PubMed:Oridonin stabilizes retinoic acid receptor alpha through ROS-activated NF-κB signaling.
PubMed:Oridonin alters the expression profiles of microRNAs in BxPC-3 human pancreatic cancer cells.
PubMed:Interaction of oridonin with human serum albumin by isothermal titration calorimetry and spectroscopic techniques.
PubMed:Role of NF-κB/IKK-dependent signaling in functional stimulation of mesenchymal progenitor cells by alkaloid songorine.
PubMed:Inhibition of RNA transportation induces glioma cell apoptosis via downregulation of RanGAP1 expression.
PubMed:Oridonin inhibits BxPC-3 cell growth through cell apoptosis.
PubMed:Reactive oxygen species, redox signaling and neuroinflammation in Alzheimer's disease: the NF-κB connection.
PubMed:[Anti-leukemia effect of oridonin on T-cell acute lymphoblastic leukemia].
PubMed:[Experimental study on anti-pancreatic cancer effect of oridonin].
PubMed:Nanostructured lipid carriers used for oral delivery of oridonin: an effect of ligand modification on absorption.
PubMed:Oridonin inhibits tumor growth in glioma by inducing cell cycle arrest and apoptosis.
PubMed:Oridonin induces apoptosis in uveal melanoma cells by upregulation of Bim and downregulation of Fatty Acid Synthase.
PubMed:Oridonin phosphate-induced autophagy effectively enhances cell apoptosis of human breast cancer cells.
PubMed:Oridonin inhibits tumor growth and metastasis through anti-angiogenesis by blocking the Notch signaling.
PubMed:Key autophagic targets and relevant small-molecule compounds in cancer therapy.
PubMed:Oridonin: a small molecule inhibitor of cystic fibrosis transmembrane conductance regulator (CFTR) isolated from traditional Chinese medicine.
PubMed:Oridonin, a promising antitumor natural product in the chemotherapy of hematological malignancies.
PubMed:Effect of oridonin-mediated hallmark changes on inflammatory pathways in human pancreatic cancer (BxPC-3) cells.
PubMed:Attacking c-Myc: targeted and combined therapies for cancer.
PubMed:Synthesis and antimycobacterial evaluation of natural oridonin and its enmein-type derivatives.
PubMed:Oridonin suppress cell migration via regulation of nonmuscle myosin IIA.
PubMed:Enhancement of the effects of gemcitabine against pancreatic cancer by oridonin via the mitochondrial caspase-dependent signaling pathway.
PubMed:ent-Kaurane-based regio- and stereoselective inverse electron demand hetero-Diels-Alder reactions: synthesis of dihydropyran-fused diterpenoids.
PubMed:Oridonin's therapeutic effect: suppressing Th1/Th17 simultaneously in a mouse model of Crohn's disease.
PubMed:Downregulation of Cdk1 and cyclinB1 expression contributes to oridonin-induced cell cycle arrest at G2/M phase and growth inhibition in SGC-7901 gastric cancer cells.
PubMed:Oridonin attenuates Aβ1-42-induced neuroinflammation and inhibits NF-κB pathway.
PubMed:Oridonin inhibits mTOR signaling and the growth of lung cancer tumors.
PubMed:Induction of human CYP3A4 by huperzine A, ligustrazine and oridonin through pregnane X receptor-mediated pathways.
PubMed:Role of NF-κB-dependent signaling in the growth capacity of mesenchymal progenitor cells under the influence of basic fibroblast growth factor.
PubMed:Novel hybrids of natural oridonin-bearing nitrogen mustards as potential anticancer drug candidates.
PubMed:Dose-response of oridonin on hepatic cytochromes P450 mRNA expression and activities in mice.
PubMed:Anti-tumor activity of oridonin on SNU-5 subcutaneous xenograft model via regulation of c-Met pathway.
PubMed:Oridonin induces NPM mutant protein translocation and apoptosis in NPM1c+ acute myeloid leukemia cells in vitro.
PubMed:Preliminary study on the mechanism of oridonin-induced apoptosis in human squamous cell oesophageal carcinoma cell line EC9706.
PubMed:Inhibition of miR-17 and miR-20a by oridonin triggers apoptosis and reverses chemoresistance by derepressing BIM-S.
PubMed:Oridonin inhibits the proliferation of human osteosarcoma cells by suppressing Wnt/β-catenin signaling.
PubMed:Design, synthesis and antimycobacterial activity evaluation of natural oridonin derivatives.
PubMed:[Mechanism concerning antitumor effect of oridonin on multiple myeloma cell line U266].
PubMed:Oridonin inhibits hepatic stellate cell proliferation and fibrogenesis.
PubMed:Galactosylated bovine serum albumin nanoparticles for parenteral delivery of oridonin: tissue distribution and pharmacokinetic studies.
PubMed:Oridonin induces apoptosis and cell cycle arrest of gallbladder cancer cells via the mitochondrial pathway.
PubMed:Intracellular glutathione depletion by oridonin leads to apoptosis in hepatic stellate cells.
PubMed:Proteomic and functional analyses demonstrate the involvement of oxidative stress in the anticancer activities of oridonin in HepG2 cells.
PubMed:[Preparation of freeze-dried long-circulation oridonin liposomes and their pharmacokinetics in rats].
PubMed:Oridonin induces apoptosis in SW1990 pancreatic cancer cells via p53- and caspase-dependent induction of p38 MAPK.
PubMed:Role of NF-κB-dependent signaling in the realization of growth potential of mesenchymal progenitor cells in vitro.
PubMed:Oridonin protects HaCaT keratinocytes against hydrogen peroxide-induced oxidative stress by altering microRNA expression.
PubMed:Oridonin suppresses transplant rejection by depleting T cells from the periphery.
PubMed:[Simultaneous determination of rosmarinic acid, oridonin and chrysoplenetin in Isodon rubescens by HPLC].
PubMed:Oridonin induces the apoptosis of metastatic hepatocellular carcinoma cells via a mitochondrial pathway.
PubMed:Oridonin exerts protective effects against hydrogen peroxide‑induced damage by altering microRNA expression profiles in human dermal fibroblasts.
PubMed:Oridonin ring A-based diverse constructions of enone functionality: identification of novel dienone analogues effective for highly aggressive breast cancer by inducing apoptosis.
PubMed:Inhibition of c-Met promoted apoptosis, autophagy and loss of the mitochondrial transmembrane potential in oridonin-induced A549 lung cancer cells.
PubMed:Oridonin ameliorates neuropathological changes and behavioural deficits in a mouse model of cerebral amyloidosis.
PubMed:Synthesis, characterization, in vitro and in vivo evaluation of PEGylated oridonin conjugates.
PubMed:Overcoming synthetic challenges of oridonin A-ring structural diversification: regio- and stereoselective installation of azides and 1,2,3-triazoles at the C-1, C-2, or C-3 position.
PubMed:Resonance light scattering technique as a new tool to determine the binding mode of anticancer drug oridonin to DNA.
PubMed:Anti-inflammatory effects of 27 selected terpenoid compounds tested through modulating Th1/Th2 cytokine secretion profiles using murine primary splenocytes.
PubMed:DNA damage induced by oridonin involves cell cycle arrest at G2/M phase in human MCF-7 cells.
PubMed:Novel nitrogen-enriched oridonin analogues with thiazole-fused A-ring: protecting group-free synthesis, enhanced anticancer profile, and improved aqueous solubility.
PubMed:Oridonin ameliorates lupus-like symptoms of MRL(lpr/lpr) mice by inhibition of B-cell activating factor (BAFF).
PubMed:Enmein-type diterpenoid analogs from natural kaurene-type oridonin: Synthesis and their antitumor biological evaluation.
PubMed:ER stress and ASK1-JNK activation contribute to oridonin-induced apoptosis and growth inhibition in cultured human hepatoblastoma HuH-6 cells.
PubMed:Recent advances in the molecular basis of anti-neoplastic mechanisms of oridonin.
PubMed:Library construction and biological evaluation of enmein-type diterpenoid analogues as potential anticancer agents.
PubMed:Preparation and characterization of galactosylated bovine serum albumin nanoparticles for liver-targeted delivery of oridonin.
PubMed:LC-MS-MS for the determination of ponicidin in dog plasma.
PubMed:[Experimental research on the mechanisms of human multiple myeloma LP-1 cell apoptosis induced by oridonin].
PubMed:Chemical proteomics reveals HSP70 1A as a target for the anticancer diterpene oridonin in Jurkat cells.
PubMed:Simultaneous determination of oridonin, ponicidin and rosmarinic acid from Herba Isodi Rubescentis extract by LC-MS-MS in rat plasma.
PubMed:Reactive oxygen species H2O2 and •OH, but not O2•(-) promote oridonin-induced phagocytosis of apoptotic cells by human histocytic lymphoma U937 cells.
PubMed:Oridonin induces apoptosis, inhibits migration and invasion on highly-metastatic human breast cancer cells.
PubMed:Oridonin induces apoptosis in gastric cancer through Apaf-1, cytochrome c and caspase-3 signaling pathway.
PubMed:Chemical constituents of flowers and fruits of Rabdosia excisa.
PubMed:Synthesis of spirolactone-type diterpenoid derivatives from kaurene-type oridonin with improved antiproliferative effects and their apoptosis-inducing activity in human hepatoma Bel-7402 cells.
PubMed:Selection for high oridonin yield in the Chinese medicinal plant Isodon (Lamiaceae) using a combined phylogenetics and population genetics approach.
PubMed:Hydroxyl radical (·OH) played a pivotal role in oridonin-induced apoptosis and autophagy in human epidermoid carcinoma A431 cells.
PubMed:Polyphenols inhibit indoleamine 3,5-dioxygenase-1 enzymatic activity--a role of immunomodulation in chemoprevention.
PubMed:In vitro and in vivo studies of galactose-modified liver-targeting liposomes.
PubMed:Oridonin: targeting programmed cell death pathways as an anti-tumour agent.
PubMed:[Anti-leukemia effect of oridonin on Ph(+) acute lymphoblastic leukemia cell SUP-B15].
PubMed:The cell death of C6 astrocytoma cells induced by oridonin and its mechanism.
PubMed:In vivo studies on the oridonin-loaded nanostructured lipid carriers.
PubMed:Oridonin in combination with imatinib exerts synergetic anti-leukemia effect in Ph+ acute lymphoblastic leukemia cells in vitro by inhibiting activation of LYN/mTOR signaling pathway.
PubMed:The tyrphostin AG1478 augments oridonin-induced A431 cell apoptosis by blockage of JNK MAPK and enhancement of oxidative stress.
PubMed:Oridonin-induced apoptosis in SW620 human colorectal adenocarcinoma cells.
PubMed:Oridonin induces apoptosis and autophagy in murine fibrosarcoma L929 cells partly via NO-ERK-p53 positive-feedback loop signaling pathway.
PubMed:Downregulation of nucleoporin 88 and 214 induced by oridonin may protect OCIM2 acute erythroleukemia cells from apoptosis through regulation of nucleocytoplasmic transport of NF-κB.
PubMed:[Anti-tumor effect of tanshinone II A, tetrandrine, honokiol, curcumin, oridonin and paeonol on leukemia cell lines].
PubMed:Interruption of hepatocyte growth factor signaling augmented oridonin-induced death in human non-small cell lung cancer A549 cells via c-met-nuclear factor-κB-cyclooxygenase-2 and c-Met-Bcl-2-caspase-3 pathways.
PubMed:Plant natural compounds: targeting pathways of autophagy as anti-cancer therapeutic agents.
PubMed:Oridonin up-regulates expression of P21 and induces autophagy and apoptosis in human prostate cancer cells.
PubMed:Melanogenesis inhibitors from Rabdosia japonica.
PubMed:[Longikaurin A induces apoptosis of multiple myeloma H929 cells].
PubMed:Galactosylated chitosan nanoparticles for hepatocyte-targeted delivery of oridonin.
PubMed:The anticancer effect of oridonin is mediated by fatty acid synthase suppression in human colorectal cancer cells.
PubMed:Oridonin enhances antitumor activity of gemcitabine in pancreatic cancer through MAPK-p38 signaling pathway.
PubMed:Synthesis and biological evaluation of novel furozan-based nitric oxide-releasing derivatives of oridonin as potential anti-tumor agents.
PubMed:Optimisation of an ultrasound-assisted extraction followed by RP-HPLC separation for the simultaneous determination of oleanolic acid, ursolic acid and oridonin content in Rabdosia rubescens.
PubMed:Nitric oxide augments oridonin-induced efferocytosis by human histocytic lymphoma U937 cells via autophagy and the NF-κB-COX-2-IL-1β pathway.
PubMed:Oridonin nanosuspension was more effective than free oridonin on G2/M cell cycle arrest and apoptosis in the human pancreatic cancer PANC-1 cell line.
PubMed:Biodegradable self-assembled MPEG-PCL micelles for hydrophobic oridonin delivery in vitro.
PubMed:The conversion of oridonin to spirolactone-type or enmein-type diterpenoid: synthesis and biological evaluation of ent-6,7-seco-oridonin derivatives as novel potential anticancer agents.
PubMed:Targeting of AML1-ETO in t(8;21) leukemia by oridonin generates a tumor suppressor-like protein.
PubMed:Triggering Fbw7-mediated proteasomal degradation of c-Myc by oridonin induces cell growth inhibition and apoptosis.
PubMed:[Study on pharmacokinetics of oridonin in mice].
PubMed:In vitro and in vivo evaluation of oridonin-loaded long circulating nanostructured lipid carriers.
PubMed:Oridonin induces apoptosis and senescence by increasing hydrogen peroxide and glutathione depletion in colorectal cancer cells.
PubMed:Advances in the treatment of ovarian cancer: a potential role of antiinflammatory phytochemicals.
PubMed:RGD-modified poly(D,L-lactic acid) nanoparticles enhance tumor targeting of oridonin.
PubMed:Study on the autophagy of prostate cancer PC-3 cells induced by oridonin.
PubMed:Autophagy counteracts apoptosis in human multiple myeloma cells exposed to oridonin in vitro via regulating intracellular ROS and SIRT1.
PubMed:Autophagy enhanced phagocytosis of apoptotic cells by oridonin-treated human histocytic lymphoma U937 cells.
PubMed:Isolation and purification of oridonin from the whole plant of Isodon rubescens by high-speed counter-current chromatography.
PubMed:Galactose-decorated pH-responsive nanogels for hepatoma-targeted delivery of oridonin.
PubMed:Synergistic antitumor activity of oridonin and arsenic trioxide on hepatocellular carcinoma cells.
PubMed:Oridonin induced the apoptosis of PC-3 cells and its mechanism.
PubMed:A sensitive analysis method for 7 diterpenoids in rat plasma by liquid chromatography-electrospray ionization mass spectrometry and its application to pharmacokinetic study of Isodon serra extract.
PubMed:Reactive oxygen species contribute to oridonin-induced apoptosis and autophagy in human cervical carcinoma HeLa cells.
PubMed:NMR spectra and structures of oridonin derivatives complexes with β-cyclodextrin.
PubMed:Anti-cancer natural products isolated from chinese medicinal herbs.
PubMed:Oridonin nanosuspension enhances anti-tumor efficacy in SMMC-7721 cells and H22 tumor bearing mice.
PubMed:Synthesis and revision of stereochemistry of rubescensin S.
PubMed:Stimulation of suicidal erythrocyte death by oridonin.
PubMed:[Study on preparation and characterization of resveratrol solid lipid nanoparticles and its anticancer effects in vitro].
PubMed:Development and in-vivo assessment of the bioavailability of oridonin solid dispersions by the gas anti-solvent technique.
PubMed:Downregulation of AP-1 gene expression is an initial event in the oridonin-mediated inhibition of colorectal cancer: studies in vitro and in vivo.
PubMed:A highly selective, label-free, homogenous luminescent switch-on probe for the detection of nanomolar transcription factor NF-kappaB.
PubMed:Chitosan-g-poly(N-isopropylacrylamide) based nanogels for tumor extracellular targeting.
PubMed:Oridonin: An active diterpenoid targeting cell cycle arrest, apoptotic and autophagic pathways for cancer therapeutics.
PubMed:Sensitization to TRAIL-induced apoptosis in human neuroblastoma SK-N-AS cells by NF-κB inhibitors is dependent on reactive oxygen species (ROS).
PubMed:[Autophagy of prostate cancer PC-3 cells under the induction of oridonin].
PubMed:Growth inhibition and induction of apoptosis in MCF-7 breast cancer cells by oridonin nanosuspension.
PubMed:Oridonin induces apoptosis and senescence in colorectal cancer cells by increasing histone hyperacetylation and regulation of p16, p21, p27 and c-myc.
PubMed:Effects of oridonin nanosuspension on cell proliferation and apoptosis of human prostatic carcinoma PC-3 cell line.
PubMed:Genomic and in vivo evidence of synergy of a herbal extract compared to its most active ingredient: Rabdosia rubescens vs. oridonin.
PubMed:Proteomic and functional analyses reveal the potential involvement of endoplasmic reticulum stress and α-CP1 in the anticancer activities of oridonin in HepG2 cells.
PubMed:Combined activity of oridonin and wogonin in advanced-stage ovarian cancer cells: sensitivity of ovarian cancer cells to phyto-active chemicals.
PubMed:Proteomic identification of proteins involved in the anticancer activities of oridonin in HepG2 cells.
PubMed:Oridonin induces G2/M cell cycle arrest and apoptosis through MAPK and p53 signaling pathways in HepG2 cells.
PubMed:A novel analysis method for diterpenoids in rat plasma by liquid chromatography-electrospray ionization mass spectrometry.
PubMed:Induction of G(2)/M phase arrest and apoptosis by oridonin in human laryngeal carcinoma cells.
PubMed:Inhibition of EGFR signaling augments oridonin-induced apoptosis in human laryngeal cancer cells via enhancing oxidative stress coincident with activation of both the intrinsic and extrinsic apoptotic pathways.
PubMed:[Study on the antibacterial activity of compounds from the isodon species].
PubMed:The effect of stealth liposomes on pharmacokinetics, tissue distribution and anti-tumor activity of oridonin.
PubMed:Preparation and characteristics of oridonin-loaded nanostructured lipid carriers as a controlled-release delivery system.
PubMed:[Preparation and characterization of oridonin submicron emulsions].
PubMed:[Empirical study of oridonin-induced gastric cancer cells MKN45 apoptosis].
PubMed:Sigma-1 receptors regulate Bcl-2 expression by reactive oxygen species-dependent transcriptional regulation of nuclear factor kappaB.
PubMed:[Two en-kaurene diterpenoids from Tibetan medicine Caryopteris toroetii].
PubMed:Loss of endogenous interleukin-12 activates survival signals in ultraviolet-exposed mouse skin and skin tumors.
PubMed:Oridonin induces G2/M arrest and apoptosis via activating ERK-p53 apoptotic pathway and inhibiting PTK-Ras-Raf-JNK survival pathway in murine fibrosarcoma L929 cells.
PubMed:Ent-kaurane diterpenoids from Rabdosia rubescens and their cytotoxic effects on human cancer cell lines.
PubMed:NF-kappab facilitates oridonin-induced apoptosis and autophagy in HT1080 cells through a p53-mediated pathway.
PubMed:Comparison of cytotoxicity and DNA damage potential induced by ent-kaurene diterpenoids from Isodon plant.
PubMed:Effects and mechanism of oridonin on pulmonary hypertension induced by chronic hypoxia-hypercapnia in rats.
PubMed:In vitro and in vivo antitumor activity of oridonin nanosuspension.
PubMed:NF-kappaB inhibition leads to increased synthesis and secretion of MIF in human CD4+ T cells.
PubMed:[Study on stability of oridonin solution].
PubMed:Apoptosis inducing and differentiation enhancement effect of oridonin on the all-trans-retinoic acid-sensitive and -resistant acute promyelocytic leukemia cells.
PubMed:Molecular mechanisms of oridonin-induced apoptosis and autophagy in murine fibrosarcoma L929 cells.
PubMed:Autophagy inhibits reactive oxygen species-mediated apoptosis via activating p38-nuclear factor-kappa B survival pathways in oridonin-treated murine fibrosarcoma L929 cells.
PubMed:Multiple-modulation effects of Oridonin on the production of proinflammatory cytokines and neurotrophic factors in LPS-activated microglia.
PubMed:[Release kinetics of oridonin self-microemulsifying drug delivery system in vitro].
PubMed:Involvement of PKC signal pathways in oridonin-induced autophagy in HeLa cells: a protective mechanism against apoptosis.
PubMed:[Effect of N, P, K on yield and quality of Rabdosia rubescens].
PubMed:Caspase inhibition augmented oridonin-induced cell death in murine fibrosarcoma l929 by enhancing reactive oxygen species generation.
PubMed:Oridonin confers protection against arsenic-induced toxicity through activation of the Nrf2-mediated defensive response.
PubMed:Optimization and in situ intestinal absorption of self-microemulsifying drug delivery system of oridonin.
PubMed:Reactive oxygen species mediate oridonin-induced HepG2 apoptosis through p53, MAPK, and mitochondrial signaling pathways.
PubMed:Oridonin induces human melanoma A375-S2 cell death partially through inhibiting insulin-like growth factor 1 receptor signaling.
PubMed:[Inhibitory effect of Oridonin injection on heterotransplanted gastric adenocarcinoma in nude mice and its mechanism].
PubMed:Synthesis and biological evaluation of novel 1-O- and 14-O-derivatives of oridonin as potential anticancer drug candidates.
PubMed:Oridonin-loaded poly(epsilon-caprolactone)-poly(ethylene oxide)-poly(epsilon-caprolactone) copolymer nanoparticles: preparation, characterization, and antitumor activity on mice with transplanted hepatoma.
PubMed:Characterization and in vivo evaluation of an inclusion complex of oridonin and 2-hydroxypropyl-beta-cyclodextrin.
PubMed:An HPLC method for determination of oridonin in rabbits using isopsoralen as an internal standard and its application to pharmacokinetic studies for oridonin-loaded nanoparticles.
PubMed:Apoptosis-suppressing and autophagy-promoting effects of calpain on oridonin-induced L929 cell death.
PubMed:Oridonin promotes CD4+/CD25+ Treg differentiation, modulates Th1/Th2 balance and induces HO-1 in rat splenic lymphocytes.
PubMed:[Determination of oridonin and rosemarinic acid in Rabdosia rubescens by HPLC].
PubMed:Studies on pharmacokinetics and tissue distribution of oridonin nanosuspensions.
PubMed:Preparation and evaluation of self-microemulsifying drug delivery system of oridonin.
PubMed:[Effects of Oridonin on proliferation in human nasopharyngeal carcinoma line CNE 2 in vitro].
PubMed:Down-regulation of androgen-receptor and PSA by phytochemicals.
PubMed:Preparation and characterization of an oridonin nanosuspension for solubility and dissolution velocity enhancement.
PubMed:Oridonin induced autophagy in human cervical carcinoma HeLa cells through Ras, JNK, and P38 regulation.
PubMed:Oridonin induces human epidermoid carcinoma A431 cell apoptosis through tyrosine kinase and mitochondrial pathway.
PubMed:Authentication and chemical study of isodonis herba and isodonis extracts.
PubMed:Oridonin induces apoptosis via PI3K/Akt pathway in cervical carcinoma HeLa cell line.
PubMed:Inactivation of ras and changes of mitochondrial membrane potential contribute to oridonin-induced autophagy in a431 cells.
PubMed:Effects of oridonin on proliferation of HT29 human colon carcinoma cell lines both in vitro and in vivo in mice.
PubMed:P53-mediated cell cycle arrest and apoptosis through a caspase-3- independent, but caspase-9-dependent pathway in oridonin-treated MCF-7 human breast cancer cells.
PubMed:[Mechanism of downregulation of apoptosis by autophagy induced by oridonin in HeLa cells].
PubMed:Studies on the cell-immunosuppressive mechanism of Oridonin from Isodon serra.
PubMed:Autophagy preceded apoptosis in oridonin-treated human breast cancer MCF-7 cells.
PubMed:Back to the future of oridonin: again, compound from medicinal herb shows potent antileukemia efficacies in vitro and in vivo.
PubMed:Effective two-dimensional counter-current chromatographic method for simultaneous isolation and purification of oridonin and ponicidin from the crude extract of Rabdosia rubescens.
PubMed:Oridonin inhibited the tyrosine kinase activity and induced apoptosis in human epidermoid carcinoma A431 cells.
PubMed:[Change of Bcl-2 expression and telomerase during apoptosis induced by oridonin on human hepatocelluar carcinoma cells].
PubMed:Oridonin-induced A431 cell apoptosis partially through blockage of the Ras/Raf/ERK signal pathway.
PubMed:Oridonin induced apoptosis through Akt and MAPKs signaling pathways in human osteosarcoma cells.
PubMed:Oridonin, a diterpenoid extracted from medicinal herbs, targets AML1-ETO fusion protein and shows potent antitumor activity with low adverse effects on t(8;21) leukemia in vitro and in vivo.
PubMed:Fibroblast growth factor-2 suppresses oridonin-induced L929 apoptosis through extracellular signal-regulated kinase-dependent and phosphatidylinositol 3-kinase-independent pathway.
PubMed:Pharmacokinetic behaviors and oral bioavailability of oridonin in rat plasma.
PubMed:A rapid HPLC/ESI-MS method for the quantitative determination of oridonin in rat plasma.
PubMed:Determination of oridonin in rat plasma by reverse-phase high-performance liquid chromatography.
PubMed:Fas/FasL signaling allows extracelluar-signal regulated kinase to regulate cytochrome c release in oridonin-induced apoptotic U937 cells.
PubMed:Studies on the oridonin-loaded poly(D,L-lactic acid) nanoparticles in vitro and in vivo.
PubMed:Augmentation of oridonin-induced apoptosis observed with reduced autophagy.
PubMed:Celastrol, a triterpene extracted from the Chinese "Thunder of God Vine," is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice.
PubMed:Oridonin inhibits cell growth by induction of apoptosis on human hepatocelluar carcinoma BEL-7402 cells.
PubMed:Isolation and purification of oridonin from Rabdosia rubescens using upright counter-current chromatography.
PubMed:[Oridonin induced U937 cell apoptosis through ERK pathway].
PubMed:Antiproliferation effects of oridonin on HPB-ALL cells and its mechanisms of action.
PubMed:A comparison of the signal pathways between the TNF alpha- and oridonin-induced murine L929 fibrosarcoma cell death.
PubMed:Roles of Ras and extracellular signal-regulated kinase-dependent IkappaBalpha degradation in oridonin-enhanced phagocytosis of apoptotic cells by human macrophage-like U937 cells.
PubMed:Bcl-2 up-regulation and P-p53 down-regulation account for the low sensitivity of murine L929 fibrosarcoma cells to oridonin-induced apoptosis.
PubMed:Differential control of growth, cell cycle progression, and expression of NF-kappaB in human breast cancer cells MCF-7, MCF-10A, and MDA-MB-231 by ponicidin and oridonin, diterpenoids from the chinese herb Rabdosia rubescens.
PubMed:The effects of oridonin on cell growth, cell cycle, cell migration and differentiation in melanoma cells.
PubMed:[The tissue distribution in mice and pharmacokinetics in rabbits of oridonin-solid lipid nanoparticles].
PubMed:Two novel ent-kauranoid diterpenoids from Isodon japonica leaves.
PubMed:Activation of phosphoinositide 3-kinase, protein kinase C, and extracellular signal-regulated kinase is required for oridonin-enhanced phagocytosis of apoptotic bodies in human macrophage-like U937 cells.
PubMed:Apoptotic effect of oridonin on NB4 cells and its mechanism.
PubMed:Oridonin-induced apoptosis in leukemia K562 cells and its mechanism.
PubMed:Novel mechanism of inhibition of nuclear factor-kappa B DNA-binding activity by diterpenoids isolated from Isodon rubescens.
PubMed:Oridonin, a diterpenoid purified from Rabdosia rubescens, inhibits the proliferation of cells from lymphoid malignancies in association with blockade of the NF-kappa B signal pathways.
PubMed:Oridonin enhances phagocytosis of UV-irradiated apoptotic U937 cells.
PubMed:The cytostatic and cytotoxic effects of oridonin (Rubescenin), a diterpenoid from Rabdosia rubescens, on tumor cells of different lineage.
PubMed:[Regulation of telomerase activity and cell cycle of K562 cells by oridonin].
PubMed:Ent-kauranoids from Isodon rubescens var. taihangensis.
PubMed:Anti-proliferative effects of oridonin on SPC-A-1 cells and its mechanism of action.
PubMed:Cytochrome c release from oridonin-treated apoptotic A375-S2 cells is dependent on p53 and extracellular signal-regulated kinase activation.
PubMed:Oridonin induces a caspase-independent but mitochondria- and MAPK-dependent cell death in the murine fibrosarcoma cell line L929.
PubMed:Antiproliferation effects of oridonin on HL-60 cells.
PubMed:Anti-proliferation effect of oridonin on HL-60 cells and its mechanism.
PubMed:Oridonin induces apoptosis of HeLa cells via altering expression of Bcl-2/Bax and activating caspase-3/ICAD pathway.
PubMed:Cytotoxic ent-kauranoids from Isodon leucophyllus.
PubMed:Oridonin induced A375-S2 cell apoptosis via bax-regulated caspase pathway activation, dependent on the cytochrome c/caspase-9 apoptosome.
PubMed:Ponicidin and oridonin are responsible for the antiangiogenic activity of Rabdosia rubescens, a constituent of the herbal supplement PC SPES.
PubMed:Oridonin induces growth inhibition and apoptosis of a variety of human cancer cells.
PubMed:Ent-kaurane diterpenoids from Isodon rubescens var. lushanensis.
PubMed:Diterpenoids from Isodon japonica.
PubMed:[Study on the inclusion of oridonin-beta-cyclodextrin].
PubMed:A new diepoxy-ent-kauranoid, rugosinin, from Isodon rugosus.
PubMed:PC-SPES: herbal formulation for prostate cancer.
PubMed:Taibaijaponicains C and D: two new diterpenoids from Isodon japonica.
PubMed:A new diterpene glycoside from Rabdosia rubescens.
PubMed:[New method for preparing oridonin by column chromatography].
PubMed:Antibacterial activity of trichorabdal A from Rabdosia trichocarpa against Helicobacter pylori.
PubMed:[Determination of oridonin in Rabdosia rubescens by TLC-scanning method].
PubMed:[Chemical constituents of Rabdosia nervosa (Hemsl) C.Y. Wu et H. W. Li].
PubMed:Synergistic effect of oridonin and cisplatin on cytotoxicity and DNA cross-link against mouse sarcoma S180 cells in culture.
PubMed:The stereo-, regio-, and chemo-selective conversion of diterpenoids, kamebakaurin to oriaonin.
PubMed:[Chemical constituents of Isodon parvifolia (Batalin) Hara].
PubMed:Terpenoids. LIII. Antitumor activity of trichorabdals and related compounds.
PubMed:[Effect of oridonin on cell-free DNA synthesis in vitro].
PubMed:Effect of oridonin, a Rabdosia diterpenoid, on radiosensitization with misonidazole.
PubMed:[Effect of oridonin on metabolism of thymine nucleotides in tumor cells in mice].
PubMed:[Effects of oridonin on DNA, RNA and protein syntheses of leukemia L 1210 cells studied by autoradiography].
PubMed:[Effect of oridonin and bleomycin A5 combination on DNA syntheses in tumor and bone marrow cells].
PubMed:[Antitumor effects of different combinations of oridonin, bleomycin A5 and nitrocaphane].
PubMed:[Characteristics of the cytostatic effects of oridonin in vitro].
PubMed:[Comparison of in vitro assays for the cytotoxic effect of anticancer drugs].
PubMed:[Cytokinetic effects of oridonin on leukemia L1210 cells].
PubMed:Antitumor activity of acylated oridonin.
PubMed:The use of herbs as anticancer agents.
PubMed:Antitumor activity of the Isodon diterpenoids: structural requirements for the activity.
PubMed:Biosynthesis of natural products. Part 1. Incorporations of ent-Kaur-16-ene and ent-Kaur-16-en-15-one into enmein and oridonin.
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