glycerol formal
1,3-dioxolane-4-methanol

Sponsors

Name: 1,3-dioxan-5-ol
CAS Number: 4740-78-7Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg: 225-248-9
FDA UNII: F6UP32GBII
Nikkaji Web: J262.422B
MDL: MFCD10039829
XlogP3-AA: -0.80 (est)
Molecular Weight: 104.10536000
Formula: C4 H8 O3
NMR Predictor: Predict (works with chrome or firefox)
Category: antimicrobial agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
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Google Scholar: with word "volatile"Search
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Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Soluble in:
 water, 1e+006 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: antimicrobial agents
 
Suppliers:
BOC Sciences
For experimental / research use only.
Glycerol formal 98%
TCI AMERICA
For experimental / research use only.
Glycerol Formal >98.0%(GC)
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: antimicrobial agents
Recommendation for glycerol formal usage levels up to:
 not for fragrance use.
 
Recommendation for glycerol formal flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 78475
National Institute of Allergy and Infectious Diseases: Data
 1,3-dioxan-5-ol
Chemidplus: 0004740787
 
References:
 1,3-dioxan-5-ol
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 78475
Pubchem (sid): 135036612
 
Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
HMDB (The Human Metabolome Database): Search
Export Tariff Code: 2932.99.9090
Typical G.C.
ChemSpider: View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other): note
 not found in nature
 ulva rigida oil greece @ 11.80%
Data GC Search PMC Picture
 
Synonyms:
1,3-dioxan-5-ol
5-m-dioxanol
1,3-dioxolane-4-methanol
1,3-formalglycerol
 glycerol formal, alpha,alpha'
 

Articles:

PubMed: Synthesis of the Fatty Esters of Solketal and Glycerol-Formal: Biobased Specialty Chemicals.
PubMed: Green acetylation of solketal and glycerol formal by heterogeneous acid catalysts to form a biodiesel fuel additive.
PubMed: Evaluation of degradation kinetics for abamectin in formulations using a stability indicating method.
PubMed: Neurotoxic effects of ivermectin administration in genetically engineered mice with targeted insertion of the mutated canine ABCB1 gene.
PubMed: Multi-seasonal barnacle (Balanus improvisus) protection achieved by trace amounts of a macrocyclic lactone (ivermectin) included in rosin-based coatings.
PubMed: The influence of co-solvents on the stability and bioavailability of rapamycin formulated in self-microemulsifying drug delivery systems.
PubMed: Age, dose, and time-dependency of plasma and tissue distribution of deltamethrin in immature rats.
PubMed: Delivery of resveratrol, a red wine polyphenol, from solutions and hydrogels via the skin.
PubMed: Toxicokinetics and tissue distribution of deltamethrin in adult Sprague-Dawley rats.
PubMed: Ivermectin (3.15%) long-acting formulations in cattle: absorption pattern and pharmacokinetic considerations.
PubMed: Cardiovascular effects of selected water-miscible solvents for pharmaceutical injections and embolization materials: a comparative hemodynamic study using a sheep model.
PubMed: Formulation-dependent toxicokinetics explains differences in the GI absorption, bioavailability and acute neurotoxicity of deltamethrin in rats.
PubMed: Development and evaluation of emulsion-liposome blends for resveratrol delivery.
PubMed: Ontogeny of hepatic and plasma metabolism of deltamethrin in vitro: role in age-dependent acute neurotoxicity.
PubMed: Isotropic systems of medium-chain mono- and diglycerides for solubilization of lipophilic and hydrophilic drugs.
PubMed: The effect of Calcicol as calcium tonic on delayed neurotoxicity induced by organophosphorus compounds.
PubMed: Comparative hemolytic activity of undiluted organic water-miscible solvents for intravenous and intra-arterial injection.
PubMed: Organic solvents for pharmaceutical parenterals and embolic liquids: a review of toxicity data.
PubMed: Stable prodrugs of n-butyric acid: suppression of T cell alloresponses in vitro and prolongation of heart allograft survival in a fully allogeneic rat strain combination.
PubMed: Bioequivalence of ivermectin formulations in pigs and cattle.
PubMed: Protective effect of pralidoxime on muscle fiber necrosis induced by organophosphate compounds.
PubMed: Potentiation of organophosphorus compound-induced delayed neurotoxicity (OPIDN) in the central and peripheral nervous system of the adult hen: distribution of axonal lesions.
PubMed: Clastogenic and aneugenic effects of tamoxifen and some of its analogues in hepatocytes from dosed rats and in human lymphoblastoid cells transfected with human P450 cDNAs (MCL-5 cells).
PubMed: Effect of omeprazole on sodium and potassium output in pentagastrin-stimulated equine gastric contents.
PubMed: Vehicle and route dependent effects of a pyrethroid insecticide, deltamethrin, on motor function in the rat.
PubMed: Viscoelastic properties of poly(ethylene oxide) solution.
PubMed: Viscoelastic properties of polyacrylic acid gels in mixed solvents.
PubMed: Inotropic and chronotropic effect of glycerol formal on the isolated rabbit heart.
PubMed: Teratogenic assessment of four solvents using the Frog Embryo Teratogenesis Assay--Xenopus (FETAX).
PubMed: Mixture experimental design in the development of a mucoadhesive gel formulation.
PubMed: Effects of glycerolformal on sympathetic neurotransmission in the isolated rabbit heart.
PubMed: Cardiovascular action of penta-O-ethylquercetin in the rat.
PubMed: Topical application of penetration enhancers to the skin of nude mice: a histopathological study.
PubMed: [Pharmacologic effects of glycerolformal on the central nervous system].
PubMed: Bioavailability and tissue elimination of chloramphenicol following parenteral administration in the preruminant calf.
PubMed: Anti-strongyle activity of a propylene glycol-glycerol formal formulation of ivermectin in horses (mares).
PubMed: Inactivity of glycerol formal in a mouse micronucleus assay: relationship to its teratogenicity.
PubMed: [Toxico-pharmacological study of glycerolformal].
PubMed: Mass spectrometric techniques in solving drug metabolism problems.
PubMed: [Action of glycerolformal on the cardiovascular system].
PubMed: Separation and determination of the two components of glycerol formal by high-performance liquid chromatography.
PubMed: Toxicological studies of deltamethrin.
PubMed: Histopathologic features of canine heartworm microfilarial infection after treatment with ivermectin.
PubMed: Gas-liquid chromatography-chemical ionization selected ion monitoring assay for glycerol formal in animal tissues.
PubMed: Biochemical and biomedical applications of capillary column GLC using SIM.
PubMed: Elevated cerebellar cyclic GMP levels during the deltamethrin-induced motor syndrome.
PubMed: Morphogenesis of aortic arch malformations in rat embryos after maternal treatment with glycerol formal during pregnancy.
PubMed: Effects of glycerol formal on embryonic development in the rat.
PubMed: Cardiovascular malformations experimentally induced in the rat.
PubMed: The loss of creatine phosphokinase (CK) from intramuscular injection sites in rabbits. A predictive tool for local toxicity.
PubMed: [Effect of glycerol formal on the embryonic development of the rat].
PubMed: Glycerol formal as a solvent for detoxification of isoniazid.
PubMed: The dietary toxicity of glycerol formal in the rat.
PubMed: A note on glycerol formal as a solvent in toxicity testing.
 
Notes:
None found
 
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