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calcium cyclamate
sulfamic acid, N-cyclohexyl-, calcium salt (2:1)

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CAS Number: 139-06-0Picture of molecule3D/inchi
Other(deleted CASRN):1259371-75-9
ECHA EINECS - REACH Pre-Reg:205-349-4
Nikkaji Web:J55.433B
Molecular Weight:396.54048000
Formula:C12 H24 Ca N2 O6 S2
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:masking agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
JECFA Food Additive: Calcium Cyclamate
GSFA Codex: Calcium cyclamate (952(ii))
DG SANTE Food Additives:calcium cyclamate
FDA Regulation:
Subpart C--Substances Generally Prohibited From Direct Addition or Use as Human Food
Sec. 189.135 Cyclamate and its derivatives.
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Soluble in:
 water, 11.38 mg/L @ 25 °C (est)
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: fragrance
BOC Sciences
For experimental / research use only.
Calcium cyclamate
Sigma-Aldrich: Aldrich
For experimental / research use only.
Cyclohexylsulfamic Acid, Calcium Salt Dihydrate
Safety Information:
Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-mouse LDLo 3500 ug/kg
Compilation of LD50 Values of New Drugs.

oral-mouse LDLo 10 mg/kg
Compilation of LD50 Values of New Drugs.

intravenous-rat LDLo 3500 ug/kg
Compilation of LD50 Values of New Drugs.

oral-rat LDLo 10 mg/kg
Compilation of LD50 Values of New Drugs.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Safety in Use Information:
masking agents
Recommendation for calcium cyclamate usage levels up to:
 not for fragrance use.
Recommendation for calcium cyclamate flavor usage levels up to:
 not for flavor use.
Safety References:
European Food Safety Authority (EFSA) reference(s):

Outcome of the public consultation on a draft protocol for assessing exposure to sweeteners as part of their safety assessment under the food additives re-evaluation programme
View page or View pdf

EPI System: View
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA GENetic TOXicology:Search
EPA Substance Registry Services (TSCA):139-06-0
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :8752
National Institute of Allergy and Infectious Diseases:Data
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:139-06-0
Pubchem (cid):8752
Pubchem (sid):134974076
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
KEGG (GenomeNet):D02444
HMDB (The Human Metabolome Database):Search
Potential Blenders and core components note
None Found
Potential Uses:
None Found
Occurrence (nature, food, other):note
 not found in nature
 calcium bis (cyclohexylsulfamate)
 calcium bis(cyclohexylsulfamate)
 calcium cyclohexane sulphamate
 calcium cyclohexylsulphamate
 sulfamic acid, cyclohexyl-, calcium salt (2:1)
 sulfamic acid, N-cyclohexyl-, calcium salt (2:1)


PubMed:The metabolism of cyclamate to cyclohexylamine in humans during long-term administration.
PubMed:Effects of a saccharin and cyclamate mixture on rat embryos.
PubMed:Taste qualities of solutions preferred by hamsters.
PubMed:Gustatory neural coding in the monkey cortex: the quality of sweetness.
PubMed:The metabolism of cyclamate to cyclohexylamine and its cardiovascular consequences in human volunteers.
PubMed:Assessment of the genotoxicity of calcium cyclamate and cyclohexylamine.
PubMed:Myocardial effects of calcium cyclamate in the BIO F1D Alexander Syrian golden hamster.
PubMed:No evidence found for induction of dominant lethal mutations and heritable translocations in male mice by calcium cyclamate.
PubMed:Caffeine intensifies taste of certain sweeteners: role of adenosine receptor.
PubMed:Sensory evaluation of soft drinks with various sweeteners.
PubMed:Cytogenetic effects of cyclamates.
PubMed:The mutagenic activity of 61 agents as determined by the micronucleus, Salmonella, and sperm abnormality assays.
PubMed:Chemical induction of sperm abnormalities in mice.
PubMed:A toxicity method with calcium cyclamate for chronic carcinogenesis experiments.
PubMed:Cytogenetic studies on calcium cyclamate in Meriones unguiculatus (gerbil) in vivo.
PubMed:In vitro cytogenetic investigation of calcium cyclamate, cyclohexylamine and triflupromazine.
PubMed:Aspartylphenylalanine methyl ester: a low-calorie sweetener.
PubMed:Effect of maternal calcium cyclamate intake on cellular development in the young rat.
PubMed:Calcium cyclamate and renal tubular acidosis.
PubMed:Photosensitive dermatitis and renal tubular acidosis after ingestion of calcium cyclamate.
PubMed:Sugar substitute, sodium and calcium cyclamate.
PubMed:Myocardial lesions: a reassessment of the toxicology of calcium cyclamate.
PubMed:Cytogenetic effects of cyclamates on human cells in vitro.
PubMed:[Effects on rat's intestinal mucosa of prolonged calcium cyclamate administration].
PubMed:Feeding and reproduction of rats fed calcium cyclamate.
Used as a food additive, prohibited [EAFUS]
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