EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

bifonazole
1-((4-biphenylyl)phenylmethyl)-1H-imidazole

Sponsors

Name:1-[phenyl-(4-phenylphenyl)methyl]imidazole
CAS Number: 60628-96-8Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:262-336-6
FDA UNII:QYJ305Z91O
Nikkaji Web:J17.988D
MDL:MFCD00865567
XlogP3-AA:4.80 (est)
Molecular Weight:310.39946000
Formula:C22 H18 N2
NMR Predictor:Predict (works with chrome or firefox)
Category:antidandruff, antimicrobial agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
logP (o/w): 4.770
Soluble in:
 water, 0.9008 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: antidandruff agents
antimicrobial agents
 
Suppliers:
BOC Sciences
For experimental / research use only.
Bifonazole >98%
Santa Cruz Biotechnology
For experimental / research use only.
Bifonazole >95%
Sigma-Aldrich: Sigma
For experimental / research use only.
Bifonazole ≥98% (HPLC)
TCI AMERICA
For experimental / research use only.
Bifonazole >98.0%(GC)(T)
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-dog LD50 > 500 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 33, Pg. 739, 1983.

intravenous-mouse LD50 57 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Oyo Yakuri. Pharmacometrics. Vol. 28, Pg. 23, 1984.

oral-mouse LD50 2629 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 33, Pg. 739, 1983.

oral-rabbit LD50 4000 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 33, Pg. 739, 1983.

intravenous-rat LD50 63 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Oyo Yakuri. Pharmacometrics. Vol. 28, Pg. 23, 1984.

oral-rat LD50 1463 mg/kg
SKIN AND APPENDAGES (SKIN): HAIR: OTHER BEHAVIORAL: ATAXIA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Oyo Yakuri. Pharmacometrics. Vol. 28, Pg. 23, 1984.

Dermal Toxicity:
subcutaneous-mouse LD50 > 15000 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"
Oyo Yakuri. Pharmacometrics. Vol. 28, Pg. 23, 1984.

subcutaneous-rat LD50 > 10000 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"
Oyo Yakuri. Pharmacometrics. Vol. 28, Pg. 23, 1984.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: antidandruff, antimicrobial agents
Recommendation for bifonazole usage levels up to:
 not for fragrance use.
 
Recommendation for bifonazole flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
ClinicalTrials.gov:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
Env. Mutagen Info. Center:Search
NLM Developmental and Reproductive Toxicity:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :2378
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
1-[phenyl-(4-phenylphenyl)methyl]imidazole
Chemidplus:0060628968
RTECS:NI3517000 for cas# 60628-96-8
 
References:
 1-[phenyl-(4-phenylphenyl)methyl]imidazole
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):2378
Pubchem (sid):135006571
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):D01775
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2933.29.4300
ChemSpider:View
Wikipedia:View
RSC Learn Chemistry:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 azolmen
 bifazol
 bifonazol
 bifonazolum
1-((4-biphenylyl)phenylmethyl)-1H-imidazole
 canespor
(+-)-1-(p,alpha-diphenylbenzyl)imidazole
1H-imidazole, 1-([1,1'-biphenyl]-4-ylphenylmethyl)-
1H-imidazole, 1-[(1,1'-biphenyl)-4-ylphenylmethyl]-
 mycospor
1-[phenyl-(4-phenylphenyl)methyl]imidazole
 trifonazole
 
 
Notes:
None found
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