acetyl carnosine
N-Acetylcarnosine (NAC) is a naturally-occurring compound chemically related to the dipeptide carnosine. Its molecular structure is similar to carnosine with the exception that it carries an additional acetyl group. This makes NAC a more stable molecule which is not easily destroyed by carnosinase, an enzyme that breaks down carnosine to its constituent amino acids, beta-alanine and histidine.; NAC is a free-radical scavenger and is particularly active against lipid peroxidation in the different parts of the lens in the eye. It is the active ingredient of eye drops used in order to prevent or treat cataract. [HMDB]
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(2S)-2-(3-acetamidopropanoylamino)-3-(1H-imidazol-5-yl)propanoic acid (Click)
CAS Number: 56353-15-2Picture of molecule
Other: 13523-80-3
ECHA EINECS - REACH Pre-Reg: 260-123-2
Nikkaji Web: J296.643C
MDL: MFCD04039376
XlogP3: -1.50 (est)
Molecular Weight: 268.27332000
Formula: C11 H16 N4 O4
NMR Predictor: Predict (works with chrome or firefox)
Category: cosmetic ingredient for skin protecting
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Soluble in:
 water, 3.613e+004 mg/L @ 25 °C (est)
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Organoleptic Properties:
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: skin protecting agents
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For experimental / research use only.
Santa Cruz Biotechnology
For experimental / research use only.
N-Acetyl-L-carnosine ≥98%
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Safety Information:
Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: cosmetic ingredient for skin protecting
Recommendation for acetyl carnosine usage levels up to:
 not for fragrance use.
Recommendation for acetyl carnosine flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
Cancer Citations: Search
Toxicology Citations: Search
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 9903482
National Institute of Allergy and Infectious Diseases: Data
 (2S)-2-(3-acetamidopropanoylamino)-3-(1H-imidazol-5-yl)propanoic acid
Chemidplus: 0056353152
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 (2S)-2-(3-acetamidopropanoylamino)-3-(1H-imidazol-5-yl)propanoic acid
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 9903482
Pubchem (sid): 135048149
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
HMDB (The Human Metabolome Database): HMDB12881
FooDB: FDB029196
ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
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Potential Blenders and core components note
None Found
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 not found in nature
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(2S)-2-(3-acetamidopropanoylamino)-3-(1H-imidazol-5-yl)propanoic acid
L-histidine, N-acetyl-b-alanyl-
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PubMed: Individual variability in human blood metabolites identifies age-related differences.
PubMed: Oxaliplatin complexes with carnosine and its derivatives: in vitro cytotoxicity, mass spectrometric and computational studies with a focus on complex fragmentation.
PubMed: Salsolinol, a catechol neurotoxin, induces modification of ferritin: Protection by histidine dipeptide.
PubMed: Inhibitory effect of carnosine and N-acetyl carnosine on LPS-induced microglial oxidative stress and inflammation.
PubMed: Differential neuroprotective effects of carnosine, anserine, and N-acetyl carnosine against permanent focal ischemia.
PubMed: [Chaperon-like anticataract agents, the antiaggregants of lens crystallin. Communication 4. Study of the effect of a mixture of di- and tetrapeptides on a prolonged rat model of UV-induced cataract].
PubMed: [Like anticataract agents, the antiaggregants of lens crystallin. Communication 2. Study of the impact of chaperon-like (protective) activity of short-chain peptides on the rate of UV-induced aggregation of betaL-crystallins by eximer laser].
PubMed: [Search for chaperon-like anticataract drugs, the antiaggregants of lens crystallins. Communication. 1. Chaperon-like activity of N-acetyl carnosine dipeptide: in vitro study on a model of ultraviolet-induced aggregation of betaL-crystallin].
PubMed: The effect of a topical antioxidant formulation including N-acetyl carnosine on canine cataract: a preliminary study.
PubMed: Carnosine is a quencher of 4-hydroxy-nonenal: through what mechanism of reaction?
PubMed: Effects of carnosine and related compounds on the stability and morphology of erythrocytes from alcoholics.
PubMed: [Effect of carnosine and its N-acetyl derivative on the stability of erythrocytes in patients with alcoholism during abstinence].
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