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tolclofos-methyl
phosphorothioic acid, O-(2,6-dichloro-4-methylphenyl) O,O-dimethyl ester

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Name:(2,6-dichloro-4-methylphenoxy)-dimethoxy-sulfanylidene-$l^{5}-phosphane
CAS Number: 57018-04-9Picture of molecule3D/inchi
Other(deleted CASRN):78617-09-1
ECHA EINECS - REACH Pre-Reg:260-515-3
FDA UNII: G42OQL6F5B
Nikkaji Web:J1.904F
Beilstein Number:2136521
MDL:MFCD00078741
XlogP3-AA:4.70 (est)
Molecular Weight:301.12703200
Formula:C9 H11 Cl2 O3 P S
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:herbicides / pesticides
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
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Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 79.00 °C. @ 760.00 mm Hg
Boiling Point: 338.50 °C. @ 760.00 mm Hg (est)
Flash Point: 317.00 °F. TCC ( 158.50 °C. ) (est)
logP (o/w): 4.560
Soluble in:
 water, 1.1 mg/L @ 25 °C (exp)
 water, 1.543 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
Tolclofos-Methyl ≥95%
Odor: characteristic
Use: Tolclofos-methyl is a broad-spectrum aromatic hydrocarbon fungicide as an excellent foundation seed fungicide. An excellent foundation seed fungicide.
Sigma-Aldrich
For experimental / research use only.
Tolclofos-methyl PESTANAL®, analytical standard
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-duck LD50 > 5000 mg/kg
Pesticide Manual. Vol. 9, Pg. 826, 1991.

intraperitoneal-mouse LD50 1070 mg/kg
"Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc of Chemistry, 1983-86Vol. A508, Pg. 1985

oral-mouse LD50 3500 mg/kg
"Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc of Chemistry, 1983-86Vol. A508, Pg. 1985

oral-quail LD50 > 5000 mg/kg
Pesticide Manual. Vol. 8, Pg. 810, 1987.

intraperitoneal-rat LD50 4900 mg/kg
"Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc of Chemistry, 1983-86Vol. A508, Pg. 1985

oral-rat LD50 5000 mg/kg
Farm Chemicals Handbook. Vol. -, Pg. C265, 1991.

Dermal Toxicity:
skin-mouse LD50 > 5000 mg/kg
Japan Pesticide Information. Vol. (41), Pg. 21, 1982.

subcutaneous-mouse LD50 > 5000 mg/kg
Japan Pesticide Information. Vol. (41), Pg. 21, 1982.

skin-rat LD50 > 5000 mg/kg
Japan Pesticide Information. Vol. (41), Pg. 21, 1982.

subcutaneous-rat LD50 > 5000 mg/kg
Japan Pesticide Information. Vol. (41), Pg. 21, 1982.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
herbicides / pesticides
Recommendation for tolclofos-methyl usage levels up to:
 not for fragrance use.
 
Recommendation for tolclofos-methyl flavor usage levels up to:
 not for flavor use.
 
Safety References:
European Food Safety Authority (EFSA) reference(s):

Reasoned opinion on the review of the existing maximum residue levels (MRLs) for tolclofos-methyl according to Article 12 of Regulation (EC) No 396/2005
View page or View pdf

Retrospective analysis of the immunotoxic effects of plant protection products as reported in the Draft Assessment Reports for their peer review at EU level
View page or View pdf

Modification of the existing maximum residue level for tolclofos-methyl in potatoes
View page or View pdf

Peer review of the pesticide risk assessment of the active substance tolclofos-methyl
View page or View pdf

EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :91664
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
(2,6-dichloro-4-methylphenoxy)-dimethoxy-sulfanylidene-$l^{5}-phosphane
Chemidplus:0057018049
RTECS:TF0460000 for cas# 57018-04-9
 
References:
 (2,6-dichloro-4-methylphenoxy)-dimethoxy-sulfanylidene-$l^{5}-phosphane
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):91664
Pubchem (sid):135047759
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C18407
HMDB (The Human Metabolome Database):Search
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
(2,6-dichloro-4-methylphenoxy)-dimethoxy-sulfanylidene-$l^{5}-phosphane
O-(2,6-dichloro-4-methylphenyl) O,O-dimethyl phosphorothioate (9CI)
O-2,6-dichloro-p-tolyl O,O-dimethyl phosphorothioate
O-(2,6-dichloro-p-tolyl) O,O-dimethyl ester of phosphorothioic acid
O-(2,6-dichloro-p-tolyl) O,O-dimethyl thiophosphate
O,O-dimethyl O-(2,6-dichloro-4-methylphenyl)phosphorothioate
 phosphorothioic acid, O-(2,6-dichloro-4-methylphenyl) O,O-dimethyl ester
 phosphorothioic acid, O-(2,6-dichloro-p-tolyl) O,O-dimethyl ester
 risolex
 rizolex
 toclofos-methyl
 

Articles:

PubMed:Application of zirconium dioxide nanoparticle sorbent for the clean-up step in post-harvest pesticide residue analysis.
PubMed:Spatio-temporal patterns of pesticide residues in the Turia and Júcar Rivers (Spain).
PubMed:Molecularly imprinted nanomicrospheres as matrix solid-phase dispersant combined with gas chromatography for determination of four phosphorothioate pesticides in carrot and yacon.
PubMed:Spatial distribution and partitioning of organophosphates pesticide in water and sediment from Sarno River and Estuary, Southern Italy.
PubMed:TESTING SIDE-EFFECTS OF COMMON PESTICIDES ON A. SWIRSKII UNDER GREENHOUSE CIRCUMSTANCES.
PubMed:Analytical approaches for the determination of pesticide residues in nutraceutical products and related matrices by chromatographic techniques coupled to mass spectrometry.
PubMed:Effect of phenylpyrrole-resistance on fitness parameters and ochratoxin production in Aspergillus carbonarius.
PubMed:Multiresidue pesticide analysis in Korean ginseng by gas chromatography-triple quadrupole tandem mass spectrometry.
PubMed:Residues behavior of some fungicides applied on two greenhouse tomato varieties different in shape and weight.
PubMed:Determination of organophosphorus pesticides in peanut oil by dispersive solid phase extraction gas chromatography-mass spectrometry.
PubMed:Reduction of the movement and persistence of pesticides in soil through common agronomic practices.
PubMed:Monitoring of pesticide residues in vegetables marketed in Al-Qassim region, Saudi Arabia.
PubMed:Effects of chlorine on organophosphorus pesticides adsorbed on activated carbon: desorption and oxon formation.
PubMed:Evaluation of the estrogenic activities of some pesticides and their combinations using MtT/Se cell proliferation assay.
PubMed:Effect of pesticides on estrogen receptor transactivation in vitro: a comparison of stable transfected MVLN and transient transfected MCF-7 cells.
PubMed:Evaluation of estrogenic activities of pesticides using an in vitro reporter gene assay.
PubMed:Solid-phase microextraction liquid chromatography/tandem mass spectrometry to determine postharvest fungicides in fruits.
PubMed:Interactions between nematophagous fungi and consequences for their potential as biological agents for the control of potato cyst nematodes.
PubMed:Monitoring of five postharvest fungicides in fruit and vegetables by matrix solid-phase dispersion and liquid chromatography/mass spectrometry.
PubMed:Effects of currently used pesticides in assays for estrogenicity, androgenicity, and aromatase activity in vitro.
PubMed:Determination of fungicide residues in fruits and vegetables by liquid chromatography-atmospheric pressure chemical ionization mass spectrometry.
PubMed:Evaluation of respiratory and cutaneous doses and urinary excretion of alkylphosphates by workers in greenhouses treated with omethoate, fenitrothion, and tolclofos-methyl.
PubMed:Spontaneous reactivation of mouse plasma cholinesterase after inhibition by various organophosphorus compounds.
 
Notes:
None found
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