ajmaline, 4360-12-7

Supplier Sponsors

Best of Chemicals Supplier
Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
BOC Sciences provides a wide range of services to support the pharmaceutical industry through all stages of drug discovery including Custom Synthesis of those chemicals that are not in stock, Isotope Labeling Service, Chiral Synthesis and Resolution, Bioconjugation, PEGylation services, analytical services.
BOC Sciences is a brand of BOCSCI Inc. We leverage our wide spectrum of business in the fields of development, manufacturing, marketing, and distribution to help you make best-informed decisions tailored to your evolving needs for premium chemicals. Our complete suite of CRO services spans the entire molecule development pipeline including contract research for target identification, building blocks, compound synthesis, biochemical and cellular analysis, preclinical animal tests, and clinical studies.
Email:	Marketing
US Email:	Marketing
Email:	Sales
US Email:	Sales
Voice: 1-631-485-4226
Fax: 1-631-614-7828
US Voice: 1-631-485-4226
US Fax: 1-631-614-7828
Europe	44-203-286-1088
Facebook
Twitter
Linkedin
Blog
Get the App!
CODE170178 CODE170178
Product(s):
4360-12-7 Ajmaline:Ajmalan-17,21-diol,(17R,21)-, 95%
Ajmaline is an alkaloid which could extracted from Rauwolfia serpentina. It is an antiarrhythmic agent, acting through changing the shreshold and the shape of cardiac action potentials. Ajmaline is an antiarrhythmic agent acting through changing the shreshold and the shape of cardiac action potentials

CAS Number:	4360-12-7	3D/inchi
ECHA EINECS - REACH Pre-Reg:	224-439-4
FDA UNII:	1PON08459R
MDL:	MFCD00135652
XlogP3:	1.80 (est)
Molecular Weight:	326.43962000
Formula:	C20 H26 N2 O2
NMR Predictor:	Predict (works with chrome, Edge or firefox)

Category:natural substances and extractives

US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:

Google Scholar:	Search
Google Books:	Search
Google Scholar: with word "volatile"	Search
Google Scholar: with word "flavor"	Search
Google Scholar: with word "odor"	Search
Google Patents:	Search
US Patents:	Search
EU Patents:	Search
Pubchem Patents:	Search
PubMed:	Search
NCBI:	Search

Physical Properties:

Assay:	95.00 to 100.00
Food Chemicals Codex Listed:	No
Melting Point:	206.00 °C. @ 760.00 mm Hg
Boiling Point:	519.40 °C. @ 760.00 mm Hg (est)
Flash Point:	545.00 °F. TCC ( 285.20 °C. ) (est)
logP (o/w):	1.810
Soluble in:
	water, 490 mg/L @ 30 °C (exp)
	water, 2486 mg/L @ 25 °C (est)

Organoleptic Properties:

Odor and/or flavor descriptions from others (if found).

Cosmetic Information:

None found

Suppliers:

BOC Sciences

For experimental / research use only.

Ajmaline:Ajmalan-17,21-diol,(17R,21)-, 95%

Odor: characteristic

Use: Ajmaline is an alkaloid which could extracted from Rauwolfia serpentina. It is an antiarrhythmic agent, acting through changing the shreshold and the shape of cardiac action potentials. Ajmaline is an antiarrhythmic agent acting through changing the shreshold and the shape of cardiac action potentials

Carbosynth

For experimental / research use only.

Ajmaline

ExtraSynthese

For experimental / research use only.

Ajmaline (HPLC) ≥90%

Sigma-Aldrich: Sigma

For experimental / research use only.

Ajmaline

sds

Safety Information:

Preferred SDS: View

Hazards identification

Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements

Pictogram

Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-bird - wild LD50 178 mg/kg Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983. oral-child LDLo 53125 ug/kg GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" GASTROINTESTINAL: NAUSEA OR VOMITING LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA Journal of Forensic Sciences. Vol. 33, Pg. 558, 1988. intravenous-guinea pig LDLo 28 mg/kg CARDIAC: CHANGE IN RATE Farmaco, Edizione Scientifica. Vol. 19, Pg. 865, 1964. oral-man TDLo 32 mg/kg CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE BEHAVIORAL: GENERAL ANESTHETIC LUNGS, THORAX, OR RESPIRATION: CYANOSIS American Heart Journal. Vol. 70, Pg. 719, 1965. intraperitoneal-mouse LD50 75 mg/kg National Technical Information Service. Vol. AD691-490 intravenous-mouse LD50 21 mg/kg European Journal of Toxicology and Environmental Hygiene. Vol. 8, Pg. 188, 1975. oral-mouse LD50 255 mg/kg CARDIAC: CHANGE IN RATE Farmaco, Edizione Scientifica. Vol. 19, Pg. 865, 1964. unreported-mouse LD50 220 mg/kg Pharmaceutical Chemistry Journal Vol. 21, Pg. 331, 1987. oral-quail LDLo 316 mg/kg Ecotoxicology and Environmental Safety. Vol. 6, Pg. 149, 1982. intraperitoneal-rat LD50 94 mg/kg Pharmaceutical Chemistry Journal Vol. 21, Pg. 331, 1987. intravenous-rat LD50 26 mg/kg CARDIAC: OTHER CHANGES Pharmazie. Vol. 31, Pg. 36, 1976. oral-rat LD50 360 mg/kg BEHAVIORAL: ATAXIA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) Pharmazie. Vol. 31, Pg. 39, 1976.
Dermal Toxicity:
subcutaneous-mouse LD50 180 mg/kg CARDIAC: CHANGE IN RATE Farmaco, Edizione Scientifica. Vol. 19, Pg. 865, 1964. subcutaneous-rat LD50 216 mg/kg CARDIAC: CHANGE IN RATE Farmaco, Edizione Scientifica. Vol. 19, Pg. 865, 1964.
Inhalation Toxicity:
Not determined

Safety in Use Information:

Category:
natural substances and extractives
Recommendation for ajmaline usage levels up to:
	not for fragrance use.

Recommendation for ajmaline flavor usage levels up to:
	not for flavor use.

Safety References:

EPI System: View

ClinicalTrials.gov:search

AIDS Citations:Search

Cancer Citations:Search

Toxicology Citations:Search

EPA ACToR:Toxicology Data

EPA Substance Registry Services (SRS):Registry

Laboratory Chemical Safety Summary :174236

National Institute of Allergy and Infectious Diseases:Data

WGK Germany:3

Chemidplus:0004360127

RTECS:AX8050000 for cas# 4360-12-7

References:

NIST Chemistry WebBook:	Search Inchi
Pubchem (cid):	174236
Pubchem (sid):	134985550

Other Information:

(IUPAC):	Atomic Weights of the Elements 2011 (pdf)
Videos:	The Periodic Table of Videos
tgsc:	Atomic Weights use for this web site
(IUPAC):	Periodic Table of the Elements
CHEBI:	View
HMDB (The Human Metabolome Database):	HMDB15495
VCF-Online:	VCF Volatile Compounds in Food
ChemSpider:	View
Wikipedia:	View

Potential Blenders and core components note

None Found

Potential Uses:

None Found

Occurrence (nature, food, other):note

rauwolfia serpentina root
Search Trop Picture

Synonyms:

	ajmalan-17,21-diol
(17R,21-alpha)-	ajmalan-17,21-diol
(17R,21alpha)-	ajmalan-17,21-diol
	ajmalan-17,21-diol, (17R,21-alpha)- (9CI)
	ajmalan-17,21-diol, (17R,21alpha)-, compound with methanol (1:1)
	ajmalin
	aritmina
	cardiorythmine
	cartagine
	gilurytmal
	ignazin
	merabitol
	raugalline
	rauwolfin
	rauwolfine
	rhytmaton
	ritmos
	rytmalin
	siddiqui
	tachmalin
	tajmalin
	takhmalin
	takycor

Articles:

PubMed:Investigation following resuscitated cardiac arrest.

PubMed:[Studies on predict of absorption of corynanthine, yohimbine, ajmalicine and ajmaline across human intestinal epithelial by using human Caco-2 cells monolayers].

PubMed:Purification, cloning, functional expression and characterization of perakine reductase: the first example from the AKR enzyme family, extending the alkaloidal network of the plant Rauvolfia.

PubMed:Structural biology in plant natural product biosynthesis--architecture of enzymes from monoterpenoid indole and tropane alkaloid biosynthesis.

PubMed:The structure of Rauvolfia serpentina strictosidine synthase is a novel six-bladed beta-propeller fold in plant proteins.

PubMed:Acetyltransfer in natural product biosynthesis--functional cloning and molecular analysis of vinorine synthase.

PubMed:Purification and partial amino acid sequences of the enzyme vinorine synthase involved in a crucial step of ajmaline biosynthesis.

PubMed:In vivo monitoring of alkaloid metabolism in hybrid plant cell cultures by 2D cryo-NMR without labelling.

PubMed:[Chagasic myocardiopathy: historical perspective].

PubMed:Inhibitory effects of plant secondary metabolites on cytotoxic activity of polymorphonuclear leucocytes.

PubMed:[Antiarrhythmic activity of ajmaline obtained from Rauwolfia serpentina biomass grown in tissue culture].

PubMed:[Clinical and electrophysiological aspects of median intra-His bundle block with normal electrocardiogram at rest].

PubMed:Usefulness of the ajmaline test in patients with latent bundle branch block.

PubMed:Unmasking of ventricular preexcitation by vagal stimulation or isoproterenol administration.

PubMed:Immobilized plant cells for the production and transformation of natural products.

Notes:

an alkaloid found in the root of rauwolfia serpentina, among other plant sources. it is a class ia antiarrhythmic agent that apparently acts by changing the shape and threshold of cardiac action potentials.

ajmaline (17R,21-alpha)-ajmalan-17,21-diol

Supplier Sponsors

Articles:

ajmaline
(17R,21-alpha)-ajmalan-17,21-diol