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Category:pharmaceuticals / chemical synthisis
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Flash Point: | 32.00 °F. TCC ( 0.00 °C. ) (est)
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| Soluble in: |
| | water, 3.538e+005 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
parenteral-frog LD50 160 mg/kg
Acta Biologica et Medica Germanica. Vol. 28, Pg. 681, 1972.
intravenous-mouse LD50 18 mg/kg
U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#11778
oral-mouse LD50 600 mg/kg
United States Patent Document. Vol. #4921868
parenteral-rat LD50 270 mg/kg
Acta Biologica et Medica Germanica. Vol. 28, Pg. 681, 1972.
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| Dermal Toxicity: |
subcutaneous-mouse LDLo 65 mg/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 35, Pg. 75, 1929.
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | pharmaceuticals / chemical synthisis |
| Recommendation for arecoline hydrobromide usage levels up to: | | | not for fragrance use.
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| Recommendation for arecoline hydrobromide flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
| | methyl 1-methyl-3,6-dihydro-2H-pyridine-5-carboxylate;hydrobromide |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 9301 |
| Pubchem (sid): | 134975283 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | arecoline bromide | | | arekolinhydrobromid | | | methyl 1-methyl-3,6-dihydro-2H-pyridine-5-carboxylate;hydrobromide | | | methyl 1,2,5,6-tetrahydro-1-methylnicotinate, hydrobromide | | | methyl N-methyl-1,2,5,6-tetrahydronicotinate hydrobromide | | N- | methyltetrahydronicotinic acid methyl ester hydrobromide | | | nicotinic acid, 1,2,5,6-tetrahydro-1-methyl-, methyl ester, hydrobromide | | 3- | pyridinecarboxylic acid, 1,2,5,6-tetrahydro-1-methyl-, methyl ester, hydrobromide (9CI) | | | taeniolin |
Articles:
| PubMed:Determination and pharmacokinetic studies of arecoline in dog plasma by liquid chromatography-tandem mass spectrometry. |
| PubMed:Effects of arecoline on hepatic cytochrome P450 activity and oxidative stress. |
| PubMed:Assessment of the mutagenic potential of arecoline in gpt delta transgenic mice. |
| PubMed:Frequency- and state-dependent blockade of human ether-a-go-go-related gene K+ channel by arecoline hydrobromide. |
| PubMed:Surface plasmon resonance based biosensors for exploring the influence of alkaloids on aggregation of amyloid-β peptide. |
| PubMed:Association constants of pyridine and piperidine alkaloids to amyloid beta peptide determined by electrochemical impedance spectroscopy. |
| PubMed:Echinococcus granulosus and other intestinal helminths in semi-stray dogs in Tunisia: infection and re-infection rates. |
| PubMed:Screening for Echinococcus granulosus in dogs: Comparison between arecoline purgation, coproELISA and coproPCR with necropsy in pre-patent infections. |
| PubMed:Echinococcus granulosus in northern Queensland. 2. Ecological determinants of infection in beef cattle. |
| PubMed:Patent and pre-patent detection of Echinococcus granulosus genotypes in the definitive host. |
| PubMed:Combined use of tertiary amine parasympathomimetics with a quaternary amine parasympatholitic--a new perspective to use parasympathomimetic drugs for systemic analgesia. |
| PubMed:Hydatidosis in the province of La Pampa, Argentina, 1998. |
| PubMed:Further SAR studies of piperidine-based analogues of cocaine. 2. Potent dopamine and serotonin reuptake inhibitors. |
| PubMed:[Echinococcosis/hydatidosis in the VII Region of Chile: diagnosis and educational intervention]. |
| PubMed:Canine echinococcosis: an alternative for surveillance epidemiology. |
| PubMed:Teratogenicity of arecoline hydrobromide on developing chick embryos: a preliminary report. |
| PubMed:An epidemiological survey of Echinococcus granulosus and other helminths in animal populations in northern Israel. |
| PubMed:Chemistry and pharmacology of the piperidine-based analogues of cocaine. Identification of potent DAT inhibitors lacking the tropane skeleton. |
| PubMed:Echinococcus granulosus infection of farm dogs of Iran. |
| PubMed:Echinococcus granulosus infections of dogs in the Durazno region of Uruguay. |
| PubMed:Histological preparation of the Echinococcus sp. tapeworms: staining affinity of the adult form. |
| PubMed:The cholinergic rapid eye movement induction test with arecoline in depression. |
| PubMed:Arecoline, but not haloperidol, induces changes in the permeability of the blood-brain barrier in the rat. |
| PubMed:Multiple-dose arecoline infusions in Alzheimer's disease. |
| PubMed:Memory retention test performance in mice: improvement by chronic oral cholinergic drug treatment. |
| PubMed:Autonomic function in cholinergic urticaria and atopic eczema. |
| PubMed:Memory retention: effect of prolonged cholinergic stimulation in mice. |
| PubMed:[Hydatidosis: epidemiological study in the eastern region of the province of Formosa]. |
| PubMed:The toxicity and efficiency of arecoline hydrobromide in the Tasmanian hydatid control program. |
| PubMed:Activity of uredofos, niclosamide, bunamidine hydrochloride, and arecoline hydrobromide against Mesocestoides corti in experimentally infected dogs. |
| PubMed:Prevalence of Echinococcus granulosus and other cestodes in dogs on the Navajo reservation in Arizona and New Mexico. |
| PubMed:Effect of deworming medication on the microbial flora of the upper gastrointestinal tract of dogs. |
| PubMed:Areca nut: a review. |
| PubMed:Comparative value of arecoline hydrobromide and bunamidine hydrochloride for the treatment of Echinococcus granulosus in dogs. |
| PubMed:[A guide to the use of arecoline hydrobromide for the diagnosis of echinococcus granulosus infection in the dog (author's transl)]. |
| PubMed:Surveillance of Echinococcus granulosus in dogs with arecoline hydrobromide. |
| PubMed:The Styx field-trial. A study on the application of control measures against hydatid disease caused by Echinococcus granulosus. |
| PubMed:Evaluation of selected drugs for the treatment of canine echinococcosis. |
| PubMed:THE RELATION BETWEEN METHOD OF ADMINISTRATION, ROUTE OF ABSORPTION, INHIBITORY ACTIONS AND ACUTE TOXICITY OF ARECOLINE HYDROBROMIDE IN DOGS. |
| PubMed:THE USE OF ARECOLINE HYDROBROMIDE IN THE TREATMENT OF TAENIID INFECTIONS IN DOGS. |
| PubMed:Effect of combined arecoline hydrobromide and n-butyl chloride complex on parasites of dogs. |
| PubMed:[Dehelmintization of geese with arecoline hydrobromide]. |
| PubMed:[Effect of vitamin B1 on arecoline hydrobromide in dye shock]. |
| PubMed:[Effect of arecoline hydrobromide on the peripheral blood vessels in rabbits]. |
| PubMed:Testing arecoline hydrobromide as an anthelminthic for hydatid worms in dogs. |
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3D/inchi