EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

baicalein
5,6,7-trihydroxyflavone

Supplier Sponsors

Name:5,6,7-trihydroxy-2-phenylchromen-4-one
CAS Number: 491-67-8Picture of molecule3D/inchi
FDA UNII:49QAH60606
Nikkaji Web:J22.048E
Beilstein Number:0272683
MDL:MFCD00017459
XlogP3:1.70 (est)
Molecular Weight:270.24070000
Formula:C15 H10 O5
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 264.50 °C. @ 760.00 mm Hg
Boiling Point: 575.90 °C. @ 760.00 mm Hg (est)
Flash Point: 438.00 °F. TCC ( 225.30 °C. ) (est)
logP (o/w): 3.310 (est)
Soluble in:
 water, 112.5 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
Baicalein >98%
Odor: characteristic
Use: Baicalein (5,6,7-trihydroxyflavone) is a flavone, a type of flavonoid, originally isolated from the roots of Scutellaria baicalensis and Scutellaria lateriflora.Baicalein is a CYP2C9 and prolyl endopeptidase inhibitor.
ExtraSynthese
For experimental / research use only.
Baicalein (HPLC) ≥95%
Santa Cruz Biotechnology
For experimental / research use only.
Baicalein >95%
Sigma-Aldrich: Aldrich
For experimental / research use only.
Baicalein 98%
TCI AMERICA
For experimental / research use only.
Baicalein >98.0%(T)
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for baicalein usage levels up to:
 not for fragrance use.
 
Recommendation for baicalein flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :5281605
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
5,6,7-trihydroxy-2-phenylchromen-4-one
Chemidplus:0000491678
RTECS:DJ3100898 for cas# 491-67-8
 
References:
 5,6,7-trihydroxy-2-phenylchromen-4-one
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):5281605
Pubchem (sid):135023119
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C10023
HMDB (The Human Metabolome Database):Search
FooDB:FDB012057
Export Tariff Code:2932.99.7000
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 skullcap baikal skullcap root
Search Trop Picture
 
Synonyms:
 baikalein
 biacalein
 noroxylin
5,6,7-trihydroxy-2-phenylchromen-4-one
5,6,7-trihydroxyflavone
 

Articles:

PubMed:Prophylactic effect of baicalein against renal dysfunction in type 2 diabetic rats.
PubMed:Baicalein Protects against Type 2 Diabetes via Promoting Islet β-Cell Function in Obese Diabetic Mice.
PubMed:Differential effects of baicalein and its sulfated derivatives in inhibiting proliferation of human breast cancer MCF-7 cells.
PubMed:[Baicalein induces HeLa cell growth inhibition by down-regulation of matrix metalloproteinases and activating extracellular signal-regulated kinase].
PubMed:Phenolic profile, antioxidant, anti-inflammatory and cytotoxic activities of black (Tuber aestivum Vittad.) and white (Tuber magnatum Pico) truffles.
PubMed:Effects of chemopreventive natural products on non-homologous end-joining DNA double-strand break repair.
PubMed:Baicalein modulates Nrf2/Keap1 system in both Keap1-dependent and Keap1-independent mechanisms.
PubMed:Skullcap (Scutellaria baicalensis) extract and its active compound, wogonin, inhibit ovalbumin-induced Th2-mediated response.
PubMed:Baicalein inhibits lipid accumulation by regulating early adipogenesis and m-TOR signaling.
PubMed:Antidepressant-like effects of Xiaochaihutang in a rat model of chronic unpredictable mild stress.
PubMed:5,6,7-trimethoxyflavone suppresses pro-inflammatory mediators in lipopolysaccharide-induced RAW 264.7 macrophages and protects mice from lethal endotoxin shock.
PubMed:Synergistic Action of Flavonoids, Baicalein, and Daidzein in Estrogenic and Neuroprotective Effects: A Development of Potential Health Products and Therapeutic Drugs against Alzheimer's Disease.
PubMed:HPLC and chemometrics for the quality consistency evaluation of Shuanghuanglian injection.
PubMed:Bioconversion of flavones during fermentation in milk containing Scutellaria baicalensis extract by Lactobacillus brevis.
PubMed:Inhibitory effect of skullcap (Scutellaria baicalensis) extract on ovalbumin permeation in vitro and in vivo.
PubMed:Inhibitory effect of baicalin and baicalein on ovarian cancer cells.
PubMed:Identification of flavone glucuronide isomers by metal complexation and tandem mass spectrometry: regioselectivity of uridine 5'-diphosphate-glucuronosyltransferase isozymes in the biotransformation of flavones.
PubMed:Molecular effects of baicalein in Hct116 cells and Caenorhabditis elegans : activation of the Nrf2 signaling pathway and prolongation of lifespan.
PubMed:Effects of baicalein on apoptosis, cell cycle arrest, migration and invasion of osteosarcoma cells.
PubMed:Anti-inflammatory effect of Sosihotang via inhibition of nuclear factor-κB and mitogen-activated protein kinases signaling pathways in lipopolysaccharide-stimulated RAW 264.7 macrophage cells.
PubMed:Baicalein protects against 6-OHDA-induced neurotoxicity through activation of Keap1/Nrf2/HO-1 and involving PKCα and PI3K/AKT signaling pathways.
PubMed:The role of intestinal microflora in anti-inflammatory effect of baicalin in mice.
PubMed:Protective effects of baicalein against excess L-DOPA-induced dopamine quinone neurotoxicity.
PubMed:FDA-approved drugs that protect mammalian neurons from glucose toxicity slow aging dependent on cbp and protect against proteotoxicity.
PubMed:Study of the chemical composition and antimicrobial activities of ethanolic extracts from roots of Scutellaria baicalensis Georgi.
PubMed:Evaluation of antioxidant and inhibitory activities for different subclasses flavonoids on enzymes for rheumatoid arthritis.
PubMed:Structure-metabolism relationships for the glucuronidation of flavonoids by UGT1A3 and UGT1A9.
PubMed:Thermodynamic versus kinetic control of antioxidant synergism between β-carotene and (iso)flavonoids and their glycosides in liposomes.
PubMed:[Study on optimizing prescription of baicalein long circulating liposomes].
PubMed:Structure-affinity relationship of flavones on binding to serum albumins: effect of hydroxyl groups on ring A.
PubMed:Dietary flavonoids activate the constitutive androstane receptor (CAR).
PubMed:Glycosylation of dietary flavonoids decreases the affinities for plasma protein.
PubMed:Antihepatotoxic effect of corn peptides against Bacillus Calmette-Guerin/lipopolysaccharide-induced liver injury in mice.
PubMed:Synergistic anti-cancer effect of baicalein and silymarin on human hepatoma HepG2 Cells.
PubMed:Multiple compounds determination and fingerprint analysis of Lidanpaishi tablet and keli by high-performance liquid chromatography.
PubMed:Sodium borohydride/chloranil-based assay for quantifying total flavonoids.
PubMed:Baicalein inhibits osteoclast differentiation and induces mature osteoclast apoptosis.
PubMed:Biotransformation of ginsenoside Rb1, crocin, amygdalin, geniposide, puerarin, ginsenoside Re, hesperidin, poncirin, glycyrrhizin, and baicalin by human fecal microflora and its relation to cytotoxicity against tumor cells.
PubMed:Comparison of the major flavonoid content of S. baicalensis, S. lateriflora, and their commercial products.
PubMed:Synthesis and biological evaluation of novel C(6) modified baicalein derivatives as antioxidative agents.
PubMed:Cytoprotective effect of baicalein against peroxynitrite-induced toxicity in LLC-PK(1) cells.
PubMed:[Effects of flavonoids with different structures on proliferation of leukemia cell line HL-60].
PubMed:Influence of food polyphenols on aryl hydrocarbon receptor-signaling pathway estimated by in vitro bioassay.
PubMed:Chemopreventive effects of minor dietary constituents in common foods on human cancer cells.
PubMed:Baicalein, a flavonoid extracted from a methanolic extract of Oroxylum indicum inhibits proliferation of a cancer cell line in vitro via induction of apoptosis.
PubMed:Flavonoids possess neuroprotective effects on cultured pheochromocytoma PC12 cells: a comparison of different flavonoids in activating estrogenic effect and in preventing beta-amyloid-induced cell death.
PubMed:Baicalein induction of hydroxyl radical formation via 12-lipoxygenase in human platelets: an ESR study.
PubMed:Wogonin suppresses TNF-alpha-induced MMP-9 expression by blocking the NF-kappaB activation via MAPK signaling pathways in human aortic smooth muscle cells.
PubMed:Inhibition of 12-lipoxygenase during baicalein-induced human lung nonsmall carcinoma H460 cell apoptosis.
PubMed:Assessing 12(S)-lipoxygenase inhibitory activity using colorectal cancer cells overexpressing the enzyme.
PubMed:Baicalein inhibits adipocyte differentiation by enhancing COX-2 expression.
PubMed:Beneficial effect of flavonoid baicalein in cisplatin-induced cell death of human glioma cells.
PubMed:Ultrasound-assisted extraction methodology as a tool to improve the antioxidant properties of herbal drug Xiao-chia-hu-tang.
PubMed:alpha-Glucosidase inhibition of 6-hydroxyflavones. Part 3: Synthesis and evaluation of 2,3,4-trihydroxybenzoyl-containing flavonoid analogs and 6-aminoflavones as alpha-glucosidase inhibitors.
PubMed:Importance of the B ring and its substitution on the alpha-glucosidase inhibitory activity of baicalein, 5,6,7-trihydroxyflavone.
PubMed:Potent Inhibitory effect of flavonoids in Scutellaria baicalensis on amyloid beta protein-induced neurotoxicity.
PubMed:Kinetic study of flavonoid reactions with stable radicals.
PubMed:Effects of Sho-saiko-to extract and its components, Baicalin, baicalein, glycyrrhizin and glycyrrhetic acid, on pharmacokinetic behavior of salicylamide in carbon tetrachloride intoxicated rats.
PubMed:Structure-activity relationships for alpha-glucosidase inhibition of baicalein, 5,6,7-trihydroxyflavone: the effect of A-ring substitution.
PubMed:Flavonoids as aryl hydrocarbon receptor agonists/antagonists: effects of structure and cell context.
PubMed:Baicalein induced in vitro apoptosis undergo caspases activity in human promyelocytic leukemia HL-60 cells.
PubMed:Insect antifeedant activity of flavones and chromones against Spodoptera litura.
PubMed:Inhibition of thyroid type 1 deiodinase activity by flavonoids.
PubMed:Effects of scutellariae radix extract and its components (baicalein, baicalin, and wogonin) on the experimental elevation of aqueous flare in pigmented rabbits.
PubMed:Effect of Sho-saiko-to extract on HGF and TGF-beta levels of intraorgans in liver-injured rats after partial hepatectomy.
PubMed:Effects of Sho-saiko-to extract on liver fibrosis in relation to the changes in hydroxyproline and retinoid levels of the liver in rats.
 
Notes:
None found
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