EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

casticin
vitexicarpin

Supplier Sponsors

Name:5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-3,6,7-trimethoxychromen-4-one
CAS Number: 479-91-4Picture of molecule3D/inchi
FDA UNII: 753GT729OU
Nikkaji Web:J94.548J
MDL:MFCD00210481
XlogP3-AA:3.10 (est)
Molecular Weight:374.34606000
Formula:C19 H18 O8
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Flash Point: 32.00 °F. TCC ( 0.00 °C. ) (est)
Soluble in:
 water, 120.7 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
Casticin(Vitexicarpin) 98%
BOC Sciences
For experimental / research use only.
Casticin 98%
Odor: characteristic
Use: Casticin isolated from the fruits of Vitex trifolia L. var. simplicifolia Cham. It may become a potential leading drug in the therapy of prostate carcinoma. cytotoxic activity; antibacterial; anti-tumor;
ExtraSynthese
For experimental / research use only.
Casticin (HPLC) ≥99%
Santa Cruz Biotechnology
For experimental / research use only.
Casticin
Sigma-Aldrich: Sigma
For experimental / research use only.
Casticin from Vitex trifolia, ≥98% (HPLC)
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for casticin usage levels up to:
 not for fragrance use.
 
Recommendation for casticin flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :5315263
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-3,6,7-trimethoxychromen-4-one
Chemidplus:0000479914
 
References:
 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-3,6,7-trimethoxychromen-4-one
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):5315263
Pubchem (sid):135116321
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
HMDB (The Human Metabolome Database):HMDB30660
FooDB:FDB002570
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 chasteberry seed
Search Trop Picture
 vitex rotundifolia fruit
Search Trop Picture
 
Synonyms:
4H-1-benzopyran-4-one, 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-3,6,7-trimethoxy-
3',5-dihydroxy-3,4',6,7-tetramethoxyflavone
5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-3,6,7-trimethoxychromen-4-one
 vitexicarpin
 

Articles:

PubMed:Molecular Mechanisms of Casticin Action: an Update on its Antitumor Functions.
PubMed:Activation of the apoptosis signal-regulating kinase 1/c-Jun N-terminal kinase pathway is involved in the casticin-induced apoptosis of colon cancer cells.
PubMed:Casticin inhibits self-renewal of liver cancer stem cells from the MHCC97 cell line.
PubMed:Casticin induces breast cancer cell apoptosis by inhibiting the expression of forkhead box protein M1.
PubMed:Casticin inhibits epithelial-mesenchymal transition of liver cancer stem cells of the SMMC-7721 cell line through downregulating Twist.
PubMed:Quality evaluation of medicinal products and health foods containing chaste berry (Vitex agnus-castus) in Japanese, European and American markets.
PubMed:The effect of O-methylated flavonoids and other co-metabolites on the crystallization and purification of artemisinin.
PubMed:Casticin suppresses self-renewal and invasion of lung cancer stem-like cells from A549 cells through down-regulation of pAkt.
PubMed:Cytotoxicity of Vitex agnus-castus fruit extract and its major component, casticin, correlates with differentiation status in leukemia cell lines.
PubMed:Involvement of histone H3 phosphorylation through p38 MAPK pathway activation in casticin-induced cytocidal effects against the human promyelocytic cell line HL-60.
PubMed:Low potency homeopathic remedies and allopathic herbal medicines: is there an overlap?
PubMed:[Chemical constituents from ethyl acetate extract of Artemisia rupestris].
PubMed:Casticin induces human glioma cell death through apoptosis and mitotic arrest.
PubMed:Casticin induces ovarian cancer cell apoptosis by repressing FoxM1 through the activation of FOXO3a.
PubMed:Regiospecific methylation of a dietary flavonoid scaffold selectively enhances IL-1β production following Toll-like receptor 2 stimulation in THP-1 monocytes.
PubMed:Effects of sesquiterpene, flavonoid and coumarin types of compounds from Artemisia annua L. on production of mediators of angiogenesis.
PubMed:Compounds from the Fruits of the Popular European Medicinal Plant Vitex agnus-castus in Chemoprevention via NADP(H):Quinone Oxidoreductase Type 1 Induction.
PubMed:Casticin induces caspase-mediated apoptosis via activation of mitochondrial pathway and upregulation of DR5 in human lung cancer cells.
PubMed:Casticin potentiates TRAIL-induced apoptosis of gastric cancer cells through endoplasmic reticulum stress.
PubMed:Development and validation of a rapid ultra-high performance liquid chromatography diode array detector method for Vitex agnus-castus.
PubMed:Evaluation of pharmacological activities and assessment of intraocular penetration of an ayurvedic polyherbal eye drop (Itone™) in experimental models.
PubMed:Casticin, a flavonoid, potentiates TRAIL-induced apoptosis through modulation of anti-apoptotic proteins and death receptor 5 in colon cancer cells.
PubMed:Casticin induces growth suppression and cell cycle arrest through activation of FOXO3a in hepatocellular carcinoma.
PubMed:Drug screening study using glioma stem-like cells.
PubMed:The flavonoids casticin and artemetin are poorly extracted and are unstable in an Artemisia annua tea infusion.
PubMed:Microarray-based mRNA expression profiling of leukemia cells treated with the flavonoid, casticin.
PubMed:Induction of apoptosis by casticin in cervical cancer cells: reactive oxygen species-dependent sustained activation of Jun N-terminal kinase.
PubMed:Metabolism studies of casticin in rats using HPLC-ESI-MS(n).
PubMed:Vitexicarpin induces apoptosis in human prostate carcinoma PC-3 cells through G2/M phase arrest.
PubMed:Quantitative determination and pharmacokinetic study of casticin in rat plasma by liquid chromatography-mass spectrometry.
PubMed:Casticin-induced apoptosis involves death receptor 5 upregulation in hepatocellular carcinoma cells.
PubMed:Mitchellenes A-E, cyclic sesquiterpenes from the Australian plant Eremophila mitchellii.
PubMed:Induction of apoptosis by casticin in cervical cancer cells through reactive oxygen species-mediated mitochondrial signaling pathways.
PubMed:Vascular protective role of vitexicarpin isolated from Vitex rotundifolia in human umbilical vein endothelial cells.
PubMed:[Preparative isolation and purification of the active components from Viticis Fructus by high-speed counter-current chromatography].
PubMed:Inhibitory effects of casticin on migration of eosinophil and expression of chemokines and adhesion molecules in A549 lung epithelial cells via NF-κB inactivation.
PubMed:Flavonoids inhibit angiogenic cytokine production by human glioma cells.
PubMed:Phytoconstituents from Vitex agnus-castus fruits.
PubMed:Casticin, a flavonoid isolated from Vitex rotundifolia, inhibits prolactin release in vivo and in vitro.
PubMed:Opioidergic mechanisms underlying the actions of Vitex agnus-castus L.
PubMed:[Vitexicarpin affects proliferation and apoptosis in mutated p53 breast cancer cell].
PubMed:Semisynthesis of natural flavones inhibiting tubulin polymerization, from hesperidin.
PubMed:Effects of the flavonoid casticin from Brazilian Croton betulaster in cerebral cortical progenitors in vitro: direct and indirect action through astrocytes.
PubMed:Isolation and immunomodulatory properties of a flavonoid, casticin from Vitex agnus-castus.
PubMed:Antiinflammatory and lipoxygenase inhibitory compounds from Vitex agnus-castus.
PubMed:Casticin induces leukemic cell death through apoptosis and mitotic catastrophe.
PubMed:Antiproliferative effect of flavonoids and sesquiterpenoids from Achillea millefolium s.l. on cultured human tumour cell lines.
PubMed:Evaluation of the estrogenic activity of the constituents in the fruits of Vitex rotundifolia L. for the potential treatment of premenstrual syndrome.
PubMed:In vivo effect of casticin on acute inflammation.
PubMed:Isolation of high-purity casticin from Artemisia annua L. by high-speed counter-current chromatography.
PubMed:Anti-nociceptive and anti-hyperprolactinemia activities of Fructus Viticis and its effective fractions and chemical constituents.
PubMed:Diterpenoids and flavonoids from the fruits of Vitex agnus-castus and antioxidant activity of the fruit extracts and their constituents.
PubMed:Are extraction methods in quantitative assays of pharmacopoeia monographs exhaustive? A comparison with pressurized liquid extraction.
PubMed:The flavonoid Casticin has multiple mechanisms of tumor cytotoxicity action.
PubMed:[Vitexicarpin, a flavonoid from Vitex trifolia L., induces apoptosis in K562 cells via mitochondria-controlled apoptotic pathway].
PubMed:G2-M arrest and antimitotic activity mediated by casticin, a flavonoid isolated from Viticis Fructus (Vitex rotundifolia Linne fil.).
PubMed:Characteristics, clinical effect profile and tolerability of a nasal spray preparation of Artemisia abrotanum L. for allergic rhinitis.
PubMed:Cytotoxic flavone analogues of vitexicarpin, a constituent of the leaves of Vitex negundo.
PubMed:Tracheospasmolytic activity of viteosin-A and vitexicarpin isolated from vitex trifolia.
PubMed:New diterpenes and norditerpenes from the fruits of Vitex rotundifolia.
PubMed:New eudesmane sesquiterpenes from Plectranthus cylindraceus.
PubMed:Vitexicarpin, a flavonoid from the fruits of Vitex rotundifolia, inhibits mouse lymphocyte proliferation and growth of cell lines in vitro.
PubMed:[Chemical constituents of the fruits of Vitex trifolia L].
PubMed:Potentiation of the antimalarial activity of qinghaosu by methoxylated flavones.
PubMed:Isolation and identification of three new flavones from Achillea millefolium L.
 
Notes:
from fruit of vitex rotundifolia. Constit. of Vitex agnus-castus (agnus castus) seeds
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