EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

3',4'-dihydroxyflavone
4-hydroxyflavonol

Supplier Sponsors

Name:2-(3,4-dihydroxyphenyl)chromen-4-one
CAS Number: 4143-64-0Picture of molecule3D/inchi
FDA UNII: KOH101S66V
Nikkaji Web:J354.017K
Beilstein Number:212540
MDL:MFCD00017600
XlogP3:2.80 (est)
Molecular Weight:254.24150000
Formula:C15 H10 O4
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:information only not used for fragrances or flavors
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 482.30 °C. @ 760.00 mm Hg (est)
Flash Point: 371.00 °F. TCC ( 188.40 °C. ) (est)
logP (o/w): 3.080 (est)
Soluble in:
 water, 568.4 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
3',4'-Dihydroxyflavone 95%
Carbosynth
For experimental / research use only.
3',4'-Dihydroxyflavone
ExtraSynthese
For experimental / research use only.
3',4'-Dihydroxyflavone (HPLC) ≥95%
Santa Cruz Biotechnology
For experimental / research use only.
3',4'-Dihydroxyflavone
TCI AMERICA
For experimental / research use only.
3',4'-Dihydroxyflavone >97.0%(GC)
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
information only not used for fragrances or flavors
Recommendation for 3',4'-dihydroxyflavone usage levels up to:
 not for fragrance use.
 
Recommendation for 3',4'-dihydroxyflavone flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :145726
National Institute of Allergy and Infectious Diseases:Data
2-(3,4-dihydroxyphenyl)chromen-4-one
Chemidplus:0004143640
 
References:
 2-(3,4-dihydroxyphenyl)chromen-4-one
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):145726
Pubchem (sid):135102608
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEMBL:View
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2932.99.7000
ChemSpider:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
4H-1-benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-
2-(3,4-dihydroxyphenyl)-4H-chromen-4-one
2-(3,4-dihydroxyphenyl)chromen-4-one
4-hydroxyflavonol
 

Articles:

PubMed:The O-methylation of chrysin markedly improves its intestinal anti-inflammatory properties: Structure-activity relationships of flavones.
PubMed:3,3',4',5,5'-Pentahydroxyflavone is a potent inhibitor of amyloid β fibril formation.
PubMed:Characterization of an O-methyltransferase from Streptomyces avermitilis MA-4680.
PubMed:Flavonoid-induced morphological modifications of endothelial cells through microtubule stabilization.
PubMed:Evaluation of novel chromogenic substrates for the detection of bacterial beta-glucosidase.
PubMed:The anti-apoptotic and anti-oxidant effect of eriodictyol on UV-induced apoptosis in keratinocytes.
PubMed:Spectroscopic and theoretical studies of the Zn(II) chelation with hydroxyflavones.
PubMed:Time dependent density functional theory study of electronic absorption properties of lead(II) complexes with a series of hydroxyflavones.
PubMed:Influence of biotransformation of luteolin, luteolin 7-O-glucoside, 3',4'-dihydroxyflavone and apigenin by cultured rat hepatocytes on antioxidative capacity and inhibition of EGF receptor tyrosine kinase activity.
PubMed:Vasorelaxant and antioxidant activity of flavonols and flavones: structure-activity relationships.
PubMed:Stability of ferric complexes with 3-hydroxyflavone (flavonol), 5,7-dihydroxyflavone (chrysin), and 3',4'-dihydroxyflavone.
PubMed:Preparative separation of flavonoid glycosides in leaves extract of Ampelopsis grossedentata using high-speed counter-current chromatography.
PubMed:3',4'-Dihydroxyflavonol reduces infarct size and injury associated with myocardial ischaemia and reperfusion in sheep.
PubMed:Evaluation of novel beta-ribosidase substrates for the differentiation of Gram-negative bacteria.
PubMed:The regioselectivity of glutathione adduct formation with flavonoid quinone/quinone methides is pH-dependent.
PubMed:Complexes of Al(III) with 3'4'-dihydroxy-flavone: characterization, theoretical and spectroscopic study.
PubMed:Phytoestrogens and inhibition of angiogenesis.
PubMed:Flavonoids, dietary-derived inhibitors of cell proliferation and in vitro angiogenesis.
PubMed:Microbiological transformation of flavone and isoflavone.
PubMed:5,8-dihydroxyflavone (primetin) the contact sensitizer of Primula mistassinica Michaux.
PubMed:Flavonoids and related compounds as inhibition of arachidonic acid peroxidation.
PubMed:Chromosome number and flavonoid synthesis in Briza L. (Gramineae).
PubMed:[Synthesis of various 3',4'-dihydroxyflavone derivatives].
PubMed:Studies on flavonoid metabolism. Metabolism of flavone in the guinea pig.
 
Notes:
inhibitors of arachidonic acid peroxidation.
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