EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

4',7-dihydroxyflavone
4H-1-benzopyran-4-one, 7-hydroxy-2-(4-hydroxyphenyl)-

Supplier Sponsors

Name:7-hydroxy-2-(4-hydroxyphenyl)chromen-4-one
CAS Number: 2196-14-7Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:207-635-4
FDA UNII: 53ZZF57X0U
Nikkaji Web:J78.045F
Beilstein Number:0224356
XlogP3:3.30 (est)
Molecular Weight:254.24150000
Formula:C15 H10 O4
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:pharmaceuticals / chemical synthisis
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 512.80 °C. @ 760.00 mm Hg (est)
Flash Point: 394.00 °F. TCC ( 201.20 °C. ) (est)
logP (o/w): 2.540 (est)
Soluble in:
 water, 568.4 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
7,4'-Dihydroxyflavone 98%
BOC Sciences
For experimental / research use only.
7,4'-Dihydroxyflavone >98%
Odor: characteristic
Use: 7,4'-Dihydroxyflavone also called as 4',7-Dihydroxyflavone is a natural flavonoid compound found in several plants. 7,4'-Dihydroxyflavone can induce transcription of nodulation (nod) genes in Rhizobium meliloti.
ExtraSynthese
For experimental / research use only.
4',7-Dihydroxyflavone (HPLC) ≥95%
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD > 1000 mg/kg
Farmaco, Edizione Scientifica. Vol. 38, Pg. 67, 1983.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
pharmaceuticals / chemical synthisis
Recommendation for 4',7-dihydroxyflavone usage levels up to:
 not for fragrance use.
 
Recommendation for 4',7-dihydroxyflavone flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :5282073
National Institute of Allergy and Infectious Diseases:Data
7-hydroxy-2-(4-hydroxyphenyl)chromen-4-one
Chemidplus:0002196147
 
References:
 7-hydroxy-2-(4-hydroxyphenyl)chromen-4-one
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):5282073
Pubchem (sid):134982200
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C12123
HMDB (The Human Metabolome Database):Search
FooDB:FDB001536
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 alfalfa
Search Trop Picture
 bean fava bean
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 fenugreek
Search Trop Picture
 not found in nature
 
Synonyms:
4H-1-benzopyran-4-one, 7-hydroxy-2-(4-hydroxyphenyl)-
7,4'-dihydroxyflavanone
7,4'-dihydroxyflavone
 flavone, 4',7-dihydroxy-
7-hydroxy-2-(4-hydroxyphenyl)chromen-4-one
 

Articles:

PubMed:Inducible De Novo Biosynthesis of Isoflavonoids in Soybean Leaves by Spodoptera litura Derived Elicitors: Tracer Techniques Aided by High Resolution LCMS.
PubMed:Carboxymethyl flavonoids and a chromone with antimicrobial activity from Selaginella moellendorffii Hieron.
PubMed:The Flavonoid 7,4'-Dihydroxyflavone Inhibits MUC5AC Gene Expression, Production, and Secretion via Regulation of NF-κB, STAT6, and HDAC2.
PubMed:Inhibitory constituents of Sophora tonkinensis on nitric oxide production in RAW 264.7 macrophages.
PubMed:Glycyrrhiza uralensis flavonoids present in anti-asthma formula, ASHMI™, inhibit memory Th2 responses in vitro and in vivo.
PubMed:Synthesis, biological evaluation of 5-carbomethoxymethyl-7-hydroxy-2-pentylchromone, 5-carboethoxymethyl-4',7-dihydroxyflavone and their analogues.
PubMed:Carboxymethyl flavonoids and a monoterpene glucoside from Selaginella moellendorffii.
PubMed:Bioactive flavones and biflavones from Selaginella moellendorffii Hieron.
PubMed:Intestinal first-pass glucuronidation activities of selected dihydroxyflavones.
PubMed:Isolation and characterization of phenolic compounds from the leaves of Salix matsudana.
PubMed:Flavones and flavonols play distinct critical roles during nodulation of Medicago truncatula by Sinorhizobium meliloti.
PubMed:Microbial metabolism. Part 6. Metabolites of 3- and 7-hydroxyflavones.
PubMed:Flavonoids of Crotalaria sessiliflora.
PubMed:Flavonoid-related regulation of auxin accumulation in Agrobacterium tumefaciens-induced plant tumors.
PubMed:New Rhizobium leguminosarum flavonoid-induced proteins revealed by proteome analysis of differentially displayed proteins.
PubMed:[Flavone constituents in the seeds of Sophora vicii folia Hance].
PubMed:[Chemical components of decoction of radix Paeoniae and radix Glycyrrhizae].
PubMed:[Constituents of the petroleum ether and ethyl acetate extract fractions from Dracaena cochinensis (Lour.) S.C. Chen].
PubMed:Structurally diverse chitolipooligosaccharide nod factors accumulate primarily in membranes of wild type Rhizobium leguminosarum biovar trifolii.
PubMed:Flavone-enhanced accumulation and symbiosis-related biological activity of a diglycosyl diacylglycerol membrane glycolipid from Rhizobium leguminosarum biovar trifolii.
PubMed:Phospholipid and fatty acid compositions of Rhizobium leguminosarum biovar trifolii ANU843 in relation to flavone-activated pSym nod gene expression.
PubMed:Chemotaxis of Rhizobium meliloti towards Nodulation Gene-Inducing Compounds from Alfalfa Roots.
PubMed:Flavonoids released naturally from alfalfa promote development of symbiotic glomus spores in vitro.
PubMed:Concurrent Synthesis and Release of nod-Gene-Inducing Flavonoids from Alfalfa Roots.
PubMed:Chrysoeriol and Luteolin Released from Alfalfa Seeds Induce nod Genes in Rhizobium meliloti.
PubMed:[HPLC analysis of flavonoids in the root of six Glycyrrhiza species].
PubMed:A Chalcone and Two Related Flavonoids Released from Alfalfa Roots Induce nod Genes of Rhizobium meliloti.
PubMed:Interactions among Flavonoid nod Gene Inducers Released from Alfalfa Seeds and Roots.
PubMed:Metabolism of apigenin and related compounds in the rat. Metabolite formation in vivo and by the intestinal microflora in vitro.
 
Notes:
inducer of nod gene.
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