EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

flavokawain A
2'-hydroxy-4,4',6'-trimethoxychalcone

Supplier Sponsors

Name:(E)-1-(2-hydroxy-4,6-dimethoxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one
CAS Number: 3420-72-2Picture of molecule3D/inchi
FDA UNII: Search
Nikkaji Web:J107.409A
Beilstein Number:2224776
MDL:MFCD00017174
XlogP3-AA:3.80 (est)
Molecular Weight:314.33746000
Formula:C18 H18 O5
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Flash Point: 32.00 °F. TCC ( 0.00 °C. ) (est)
Soluble in:
 water, 10.02 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
Flavokawain A > 95%
Odor: characteristic
Use: Flavokawain A isolated from the roots of Piper methysticum. anti-tumor activity; anti-inflammatory
Carbosynth
For experimental / research use only.
2'-Hydroxy-4,4',6'-trimethoxychalcone
ExtraSynthese
For experimental / research use only.
Flavokawain A (HPLC) ≥95%
Santa Cruz Biotechnology
For experimental / research use only.
2'-Hydroxy-4,4',6'-trimethoxychalcone
Sigma-Aldrich: Aldrich
For experimental / research use only.
2'-Hydroxy-4,4',6'-trimethoxychalcone 98%
sds
TCI AMERICA
For experimental / research use only.
2'-Hydroxy-4,4',6'-trimethoxychalcone >98.0%(GC)
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for flavokawain A usage levels up to:
 not for fragrance use.
 
Recommendation for flavokawain A flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :5355469
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
(E)-1-(2-hydroxy-4,6-dimethoxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one
 
References:
 (E)-1-(2-hydroxy-4,6-dimethoxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):5355469
Pubchem (sid):39380957
Flavornet:3420-72-2
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEMBL:View
HMDB (The Human Metabolome Database):HMDB33586
FooDB:FDB011662
Export Tariff Code:2914.50.3000
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 kava
Search Trop Picture
 
Synonyms:
 flavokavain A
2'-hydroxy-4,4',6'-trimethoxychalcone
(2E)-1-(2-hydroxy-4,6-dimethoxyphenyl)-3-(4-methoxyphenyl)-2-propen-1-one
(E)-1-(2-hydroxy-4,6-dimethoxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one
 

Articles:

PubMed:Dietary feeding of Flavokawain A, a Kava chalcone, exhibits a satisfactory safety profile and its association with enhancement of phase II enzymes in mice.
PubMed:Flavokawain A Induces Apoptosis in MCF-7 and MDA-MB231 and Inhibits the Metastatic Process In Vitro.
PubMed:The flavokawains: uprising medicinal chalcones.
PubMed:Kava chalcone, flavokawain A, inhibits urothelial tumorigenesis in the UPII-SV40T transgenic mouse model.
PubMed:Suppression of iNOS and COX-2 expression by flavokawain A via blockade of NF-κB and AP-1 activation in RAW 264.7 macrophages.
PubMed:Effects of the kava chalcone flavokawain A differ in bladder cancer cells with wild-type versus mutant p53.
PubMed:HPLC analysis of flavokavins and kavapyrones from Piper methysticum Forst.
PubMed:Flavokawain A, a novel chalcone from kava extract, induces apoptosis in bladder cancer cells by involvement of Bax protein-dependent and mitochondria-dependent apoptotic pathway and suppresses tumor growth in mice.
PubMed:Cyclooxygenase enzyme inhibitory compounds with antioxidant activities from Piper methysticum (kava kava) roots.
PubMed:(Rel)-1beta,2alpha-di-(2,4-dihydroxy-6-methoxybenzoyl)-3beta, 4alpha-di-(4-methoxyphenyl)-cyclobutane and other flavonoids from the aerial parts of Goniothalamus gardneri and Goniothalamus thwaitesii.
 
Notes:
Found in kava (Piper methysticum). FDA advises against use of kava in food due to potential risk of severe liver damage (2002)
Please share your Comments.
Email Address:
Top of Page Home
Copyright © 1980-2021 The Good Scents Company (tgsc) ™ Disclaimer Privacy Policy