flavokawain C, 56798-34-6

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Name:	(E)-1-(2-hydroxy-4,6-dimethoxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one
CAS Number:	56798-34-6	3D/inchi
FDA UNII:	Search
Nikkaji Web:	J647.134J
MDL:	MFCD00016489
XlogP3-AA:	3.50 (est)
Molecular Weight:	300.31052000
Formula:	C17 H16 O5
BioActivity Summary:	listing
NMR Predictor:	Predict (works with chrome, Edge or firefox)

Category:natural substances and extractives

US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:

Google Scholar:	Search
Google Books:	Search
Google Scholar: with word "volatile"	Search
Google Scholar: with word "flavor"	Search
Google Scholar: with word "odor"	Search
Google Patents:	Search
US Patents:	Search
EU Patents:	Search
Pubchem Patents:	Search

Physical Properties:

Assay:	95.00 to 100.00
Food Chemicals Codex Listed:	No
Boiling Point:	556.00 °C. @ 760.00 mm Hg (est)
Flash Point:	405.00 °F. TCC ( 207.30 °C. ) (est)
logP (o/w):	3.480 (est)
Soluble in:
	water, 36.49 mg/L @ 25 °C (est)

Organoleptic Properties:

Odor and/or flavor descriptions from others (if found).

Cosmetic Information:

None found

Suppliers:

ExtraSynthese

For experimental / research use only.

Flavokawain C (HPLC) ≥90%

Safety Information:


Hazards identification

Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements

Pictogram

Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in Use Information:

Category:
natural substances and extractives
Recommendation for flavokawain C usage levels up to:
	not for fragrance use.

Recommendation for flavokawain C flavor usage levels up to:
	not for flavor use.

Safety References:

EPI System: View

EPA ACToR:Toxicology Data

EPA Substance Registry Services (SRS):Registry

Laboratory Chemical Safety Summary :6293081

National Institute of Allergy and Infectious Diseases:Data

(E)-1-(2-hydroxy-4,6-dimethoxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one

References:

	(E)-1-(2-hydroxy-4,6-dimethoxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one
NIST Chemistry WebBook:	Search Inchi
Pubchem (cid):	6293081
Pubchem (cas):	56798-34-6

Other Information:

(IUPAC):	Atomic Weights of the Elements 2011 (pdf)
Videos:	The Periodic Table of Videos
tgsc:	Atomic Weights use for this web site
(IUPAC):	Periodic Table of the Elements
CHEMBL:	View
HMDB (The Human Metabolome Database):	HMDB30875
FooDB:	FDB002836
VCF-Online:	VCF Volatile Compounds in Food
ChemSpider:	View

Potential Blenders and core components note

None Found

Potential Uses:

None Found

Occurrence (nature, food, other):note

kava
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Synonyms:

2',4-	dihydroxy-4',6'-dimethoxychalcone
	flavokavain C
(2E)-1-(2-	hydroxy-4,6-dimethoxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one
(E)-1-(2-	hydroxy-4,6-dimethoxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one
2-	propen-1-one, 1-(2-hydroxy-4,6-dimethoxyphenyl)-3-(4-hydroxyphenyl)-, (2E)-

Articles:

PubMed:Induction of Apoptosis and Cell Cycle Arrest by Flavokawain C on HT-29 Human Colon Adenocarcinoma via Enhancement of Reactive Oxygen Species Generation, Upregulation of p21, p27, and GADD153, and Inactivation of Inhibitor of Apoptosis Proteins.

PubMed:Flavokawain C Inhibits Cell Cycle and Promotes Apoptosis, Associated with Endoplasmic Reticulum Stress and Regulation of MAPKs and Akt Signaling Pathways in HCT 116 Human Colon Carcinoma Cells.

PubMed:Phenols displaying tyrosinase inhibition from Humulus lupulus.

PubMed:Comparative evaluation of cytotoxicity and antioxidative activity of 20 flavonoids.

Notes:

Found in kava (Piper methysticum). FDA advises against use of kava in food due to potential risk of severe liver damage (2002)

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flavokawain C 2',4-dihydroxy-4',6'-dimethoxychalcone

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Articles:

flavokawain C
2',4-dihydroxy-4',6'-dimethoxychalcone