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ginkgolide J
7beta-hydroxyginkgolide A

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CAS Number: 107438-79-9Picture of molecule3D/inchi
FDA UNII: M5297RI2UE
XlogP3-AA:-0.40 (est)
Molecular Weight:424.40328000
Formula:C20 H24 O10
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 760.40 °C. @ 760.00 mm Hg (est)
Flash Point: 524.00 °F. TCC ( 273.60 °C. ) (est)
logP (o/w): -0.680 (est)
Soluble in:
 water, 1.838e+005 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
Ginkgolide J 98%
BOC Sciences
For experimental / research use only.
Ginkgolide J >98%
Odor: characteristic
Use: Ginkgolide J is extracted from the seed of Ginkgo biloba L. It reduces apoptotic damage in cultured chick embryonic neurons. It contributes to the antioxidant properties of G. biloba. It has the superoxide scavenging effect and neuroprotective effect.
ExtraSynthese
For experimental / research use only.
Ginkgolide J (HPLC) ≥98%
Santa Cruz Biotechnology
For experimental / research use only.
Ginkgolide J ≥90%
Sigma-Aldrich
For experimental / research use only.
Ginkgolide J
analytical standard
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for ginkgolide J usage levels up to:
 not for fragrance use.
 
Recommendation for ginkgolide J flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :163776
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
Chemidplus:0107438799
 
References:
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):163776
Pubchem (sid):135119946
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
KEGG (GenomeNet):C07604
HMDB (The Human Metabolome Database):HMDB29605
FooDB:FDB000771
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 ginkgo biloba
Search Trop Picture
 
Synonyms:
 ginkgolide A, 7-hydroxy-, (7beta)-
7beta-hydroxyginkgolide A
 

Articles:

PubMed:Transport of ginkgolides with different lipophilicities based on an hCMEC/D3 cell monolayer as a blood-brain barrier cell model.
PubMed:Urinary excretion of ginkgolide terpene lactones following acute consumption of Ginkgo biloba extract.
PubMed:Evaluation of Ginkgo biloba extract as an activator of human glucocorticoid receptor.
PubMed:Complete 1H NMR spectral analysis of ten chemical markers of Ginkgo biloba.
PubMed:Selective agonism of human pregnane X receptor by individual ginkgolides.
PubMed:Isoform-selective activation of human constitutive androstane receptor by Ginkgo biloba extract: functional analysis of the SV23, SV24, and SV25 splice variants.
PubMed:Human pregnane X receptor agonism by Ginkgo biloba extract: assessment of the role of individual ginkgolides.
PubMed:Development of an alternative method for determination of terpene lactones in ginkgo dry extract.
PubMed:Optimization of extraction technique and validation of developed RP-HPLC-ELSD method for determination of terpene trilactones in Ginkgo biloba leaves.
PubMed:Column liquid chromatography/electrospray ionization-time of flight-mass spectrometry and ultraperformance column liquid chromatography/mass spectrometry methods for the determination of ginkgolides and bilobalide in the leaves of Ginkgo biloba and dietary supplements.
PubMed:Effect of Ginkgo biloba extract on oxidative metabolism of valproic acid in hepatic microsomes from donors with the CYP2C9*1/*1 genotype.
PubMed:Protection against beta-amyloid induced abnormal synaptic function and cell death by Ginkgolide J.
PubMed:Single-laboratory validation for the determination of terpene lactones in Ginkgo biloba dietary supplement crude materials and finished products by high-performance liquid chromatography with evaporative light-scattering detection.
PubMed:Ginkgolide A contributes to the potentiation of acetaminophen toxicity by Ginkgo biloba extract in primary cultures of rat hepatocytes.
PubMed:Ginkgo biloba leaf extract reverses amyloid beta-peptide-induced isoprostane production in rat brain in vitro.
PubMed:Distinct role of bilobalide and ginkgolide A in the modulation of rat CYP2B1 and CYP3A23 gene expression by Ginkgo biloba extract in cultured hepatocytes.
PubMed:Isolation of ginkgolides A, B, C, J and bilobalide from G. biloba extracts.
PubMed:A method for extraction and quantification of Ginkgo terpene trilactones.
PubMed:Inhibition of hippocampal LTP by ginkgolide B is mediated by its blocking action on PAF rather than glycine receptors.
PubMed:Pharmacological studies supporting the therapeutic use of Ginkgo biloba extract for Alzheimer's disease.
PubMed:Rapid analysis of terpene lactones in extract of Ginkgo biloba L. by high performance liquid chromatography.
PubMed:Simultaneous determination of terpene lactones and flavonoid aglycones in Ginkgo biloba by high-performance liquid chromatography with evaporative light scattering detection.
PubMed:Ginkgolides: selective acetylations, translactonization, and biological evaluation.
PubMed:Liquid chromatography-atmospheric pressure chemical ionisation/mass spectrometry: a rapid and selective method for the quantitative determination of ginkgolides and bilobalide in ginkgo leaf extracts and phytopharmaceuticals.
PubMed:Three ginkgolide hydrates from Ginkgo biloba L.: ginkgolide A monohydrate, ginkgolide C sesquihydrate and ginkgolide J dihydrate, all determined at 120 K.
PubMed:Inhibition of serum deprivation- and staurosporine-induced neuronal apoptosis by Ginkgo biloba extract and some of its constituents.
PubMed:Antioxidative activity of ginkgolides against superoxide in an aprotic environment.
PubMed:Effect of ischaemia and role of eicosanoids in release of atrial natriuretic factor from rat heart.
PubMed:Separate induction of human blood platelet aggregation or cytotoxicity by different concentrations of PAF-acether and thrombin.
PubMed:Effects of PAF antagonists on renal vascular escape and tachyphylaxis in perfused rabbit kidney.
PubMed:The effect of the platelet-activating factor antagonist, BN 52021, on human natural killer cell-mediated cytotoxicity.
 
Notes:
a naturally occurring ginkgolide from ginkgo. Isol. from Ginkgo biloba (ginkgo)
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