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ginsenoside Rb2
beta-D-glucopyranoside, (3-beta,12-beta)-20-((6-o-alpha-l-arabinopyranosyl-beta-d-glucopyranosyl)oxy)-12-hydroxydammar-24-en-3-yl 2-o-beta-d-glucopyranosyl-

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CAS Number: 11021-13-9Picture of molecule3D/inchi
Other(deleted CASRN):52351-30-1
ECHA EINECS - REACH Pre-Reg:234-251-4
FDA UNII: N219O0L31C
MDL:MFCD00221755
XlogP3-AA:0.30 (est)
Molecular Weight:1079.28270000
Formula:C53 H90 O22
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point:1117.10 °C. @ 760.00 mm Hg (est)
Flash Point:1165.00 °F. TCC ( 629.40 °C. ) (est)
logP (o/w): 4.730 (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
Ginsenoside Rb2 98%
BOC Sciences
For experimental / research use only.
Ginsenoside Rb2
Carbosynth
For experimental / research use only.
Ginsenoside Rb2
ExtraSynthese
For experimental / research use only.
Ginsenoside Rb2 (HPLC) ≥97%
Santa Cruz Biotechnology
For experimental / research use only.
Ginsenoside Rb2 ≥98%
Sigma-Aldrich
For experimental / research use only.
Ginsenoside Rb2
analytical standard
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD50 305 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 343, 1975.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for ginsenoside Rb2 usage levels up to:
 not for fragrance use.
 
Recommendation for ginsenoside Rb2 flavor usage levels up to:
 not for flavor use.
 
Safety References:
ClinicalTrials.gov:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :73598
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
Chemidplus:0011021139
RTECS:LZ5779240 for cas# 11021-13-9
 
References:
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):73598
Pubchem (sid):135031817
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):Search
FooDB:FDB013599
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 ginseng
Search Trop Picture
 
Synonyms:
20-((6-O-alpha-L-arabinopyranosyl-beta-D-glucopyranosyl)oxy)-12beta-hydroxydammar-24-en-3beta-yl 2-O-beta-D-glucopyranosyl-beta-D-glucopyranoside
 cinsenoside C
 ginsenoside RB2
beta-D-glucopyranoside, (3-beta,12-beta)-20-((6-o-alpha-l-arabinopyranosyl-beta-d-glucopyranosyl)oxy)-12-hydroxydammar-24-en-3-yl 2-o-beta-d-glucopyranosyl-
 

Articles:

PubMed:Inhibitory effects of ginsenoside-rb2 on nicotinic stimulation-evoked catecholamine secretion.
PubMed:Ginsenoside-Rb2 inhibits dexamethasone-induced apoptosis through promotion of GPR120 induction in bone marrow-derived mesenchymal stem cells.
PubMed:Quantitative comparison and metabolite profiling of saponins in different parts of the root of Panax notoginseng.
PubMed:[Screening active components in compound danshen based on PXR-CYP3A4: an experimental study].
PubMed:Ginsenoside-Rb2 displays anti-osteoporosis effects through reducing oxidative damage and bone-resorbing cytokines during osteogenesis.
PubMed:Pharmacokinetic compatibility of ginsenosides and Schisandra Lignans in Shengmai-san: from the perspective of p-glycoprotein.
PubMed:[Chemical constituents from processed rhizomes of Panax notoginseng].
PubMed:Efficacy comparison of Korean ginseng and American ginseng on body temperature and metabolic parameters.
PubMed:[Chemical constituents from roots and rhizomes of Panax ginseng cultivated in Jilin province].
PubMed:Hydrophilic interaction chromatography for selective separation of isomeric saponins.
PubMed:Benefit of neuroprotection in acute ischaemic stroke, shall we dare to hope?
PubMed:Complete conversion of major protopanaxadiol ginsenosides to compound K by the combined use of α-L-arabinofuranosidase and β-galactosidase from Caldicellulosiruptor saccharolyticus and β-glucosidase from Sulfolobus acidocaldarius.
PubMed:Protective effect of ginsenoside-Rb2 from Korean red ginseng on the lethal infection of haemagglutinating virus of Japan in mice.
PubMed:Isolation and characterization of novel ginsenoside-hydrolyzing glycosidase from Microbacterium esteraromaticum that transforms ginsenoside Rb2 to rare ginsenoside 20(S)-Rg3.
PubMed:Diversity of endophytic fungi from roots of Panax ginseng and their saponin yield capacities.
PubMed:[High-resolution THz spectra of six biological and pharmaceutical materials].
PubMed:Lactobacillus ginsenosidimutans sp. nov., isolated from kimchi with the ability to transform ginsenosides.
PubMed:Silver (Ι)-assisted enantiomeric analysis of ginsenosides using electrospray ionization tandem mass spectrometry.
PubMed:Enzymatic transformation of the major ginsenoside Rb2 to minor compound Y and compound K by a ginsenoside-hydrolyzing β-glycosidase from Microbacterium esteraromaticum.
PubMed:Cloning and characterization of ginsenoside Ra1-hydrolyzing beta-D-xylosidase from Bifidobacterium breve K-110.
PubMed:Determination of ginsenosides Rb1, Rb2, and Rb3 in rat plasma by a rapid and sensitive liquid chromatography tandem mass spectrometry method: Application in a pharmacokinetic study.
PubMed:Antioxidant, antiproliferative, and pro-apoptotic activities of a saponin extract derived from the roots of Panax notoginseng (Burk.) F.H. Chen.
PubMed:[Determination of astragaloside IV of eight area in Astragali Radix is by HPLC-ELSD internal standard method].
PubMed:Cloning and characterization of α-L-arabinofuranosidase and bifunctional α-L-arabinopyranosidase/β-D-galactopyranosidase from Bifidobacterium longum H-1.
PubMed:The antidiabetic effect of ginsenoside Rb2 via activation of AMPK.
PubMed:AMP-activated protein kinase: a potential target for ginsenosides?
PubMed:Effect of protopanaxadiol derivatives in high glucose-induced fibronectin expression in primary cultured rat mesangial cells: role of mitogen-activated protein kinases and Akt.
PubMed:[Absorption characteristics of ginsenoside Rb2 in Caco-2 cell monolayer].
PubMed:On-line concentration of neutral analytes by complexation and acetonitrile sweeping in nonionic microemulsion electrokinetic chromatography with direct ultraviolet detection.
PubMed:The ginsenoside-Rb2 lowers cholesterol and triacylglycerol levels in 3T3-L1 adipocytes cultured under high cholesterol or fatty acids conditions.
PubMed:[A quantitative method using one marker for simultaneous assay of ginsenosides in Panax ginseng and P. notoginseng].
PubMed:Method development for gypenosides fingerprint by high performance liquid chromatography with diode-array detection and the addition of internal standard.
PubMed:Study on the hydroxyl radical scavenging activity changes of ginseng and ginsenoside-Rb2 by heat processing.
PubMed:Study on the noncovalent complexes of ginsenoside and cytochrome c by electrospray ionization mass spectrometry.
PubMed:Differential effects of ginsenosides on NO and TNF-alpha production by LPS-activated N9 microglia.
PubMed:A ginsenoside metabolite, 20-O-beta-D-glucopyranosyl-20(S)-protopanaxadiol, triggers apoptosis in activated rat hepatic stellate cells via caspase-3 activation.
PubMed:Effects of individual ginsenosides, ginkgolides and flavonoids on CYP2C19 and CYP2D6 activity in human liver microsomes.
PubMed:Transformation of ginsenosides Rb2 and Rc from Panax ginseng by food microorganisms.
PubMed:Protective effect of fermented red ginseng on a transient focal ischemic rats.
PubMed:Simultaneous determination of ginsenoside Rb(1) and Rg(1) in human plasma by liquid chromatography-mass spectrometry.
PubMed:Purification and characterization of alpha-L-arabinopyranosidase and alpha-L-arabinofuranosidase from Bifidobacterium breve K-110, a human intestinal anaerobic bacterium metabolizing ginsenoside Rb2 and Rc.
PubMed:Effects of ginsenosides on carbachol-stimulated formation of inositol phosphates in rat cortical cell cultures.
PubMed:Enhancement of fibrinolytic activity of bovine aortic endothelial cells by ginsenoside Rb2.
PubMed:[Determination of six ginsenosides in Panax species by high performance liquid chromatography].
PubMed:Ginsenosides from Panax ginseng differentially regulate lymphocyte proliferation.
PubMed:Fecal metabolic activities of herbal components to bioactive compounds.
PubMed:Transcriptional regulation and environmental induction of gene encoding copper- and zinc-containing superoxide dismutase.
PubMed:Epidermis proliferative effect of the Panax ginseng ginsenoside Rb2.
PubMed:Inhibitory effect of ginsenoside-Rb2 on invasiveness of uterine endometrial cancer cells to the basement membrane.
PubMed:Effects of ginsenosides from Panax ginseng on cell-to-cell communication function mediated by gap junctions.
PubMed:In vitro inhibitory effect of protopanaxadiol ginsenosides on tumor necrosis factor (TNF)-alpha production and its modulation by known TNF-alpha antagonists.
PubMed:Effects of Ginsenoside Rb2 and Rc on inferior human sperm motility in vitro.
PubMed:Constitutive beta-glucosidases hydrolyzing ginsenoside Rb1 and Rb2 from human intestinal bacteria.
PubMed:Preventive effect of epicatechin and ginsenoside Rb(2) on the inhibition of gap junctional intercellular communication by TPA and H(2)O(2).
PubMed:Role of human intestinal Prevotella oris in hydrolyzing ginseng saponins.
PubMed:[Active constituents reducing side-effects of prednisone acetate in leaves of Panax ginseng C.A.Mey].
PubMed:Ginsenosides increase secretion of lipoprotein lipase by 3T3-L1 adipocytes.
PubMed:Transcriptional activation of the Cu,Zn-superoxide dismutase gene through the AP2 site by ginsenoside Rb2 extracted from a medicinal plant, Panax ginseng.
PubMed:Molecular biological analysis of the effects of ginsenoside-Rb2 on albumin mRNA in streptozotocin-induced diabetic rats.
PubMed:Inhibitory effect of tumor metastasis in mice by saponins, ginsenoside-Rb2, 20(R)- and 20(S)-ginsenoside-Rg3, of red ginseng.
PubMed:Suppression of the formation of sister chromatid exchanges by low concentrations of ginsenoside Rh2 in human blood lymphocytes.
PubMed:[Single calcium channel analysis and electron spin resonance (ESR) spectral study on the myocardial effects of ginsenoside Rb2].
PubMed:[Protective effects of ginsenoside on myocardiac ischemic and reperfusion injuries].
PubMed:[Studies on the pharmacodynamics of ginsenoside-Rg1, -Rb1 and -Rb2 in rats].
PubMed:Inhibition of tumor angiogenesis and metastasis by a saponin of Panax ginseng, ginsenoside-Rb2.
PubMed:Studies on absorption, distribution, excretion and metabolism of ginseng saponins. VIII. Isotope labeling of ginsenoside Rb2.
PubMed:Influences of ginsenosides Rb1, Rb2, and Rb3 on electric and contractile activities of normal and damaged cultured myocardiocytes.
PubMed:Studies on the enzyme immunoassay of bio-active constituents in oriental medicinal drugs. VI. Enzyme immunoassay of ginsenoside Rb1 from Panax ginseng.
PubMed:Inhibitory effect of ginsenosides on migration of arterial smooth muscle cells.
PubMed:Studies on absorption, distribution, excretion and metabolism of ginseng saponins. VII. Comparison of the decomposition modes of ginsenoside-Rb1 and -Rb2 in the digestive tract of rats.
PubMed:[Effects of panaxadiol and panaxatriol saponins on action potentials of normal and xanthine-xanthine oxidase damaged cultured myocardial cells].
PubMed:Effects of ginsenoside-Rb2 on adenine nucleotide content of rat hepatic tissue.
PubMed:Studies on absorption, distribution, excretion and metabolism of ginseng saponins. VI. The decomposition products of ginsenoside Rb2 in the stomach of rats.
PubMed:Facilitation of protein biosynthesis by ginsenoside-Rb2 administration in diabetic rats.
PubMed:Studies on absorption, distribution, excretion and metabolism of ginseng saponins. V. The decomposition products of ginsenoside Rb2 in the large intestine of rats.
PubMed:The effect of ginsenoside-Rb2 on nitrogen balance.
PubMed:Effect of serial administration of ginsenoside-Rb2 in diabetic rats: in terms of carbohydrate and lipid metabolites.
PubMed:Effect of ginsenoside-Rb2 on nitrogen compounds in streptozotocin-diabetic rats.
PubMed:Specific interaction of arabinose residue in ginsenoside with egg phosphatidylcholine vesicles.
PubMed:Effect of ginsenosides Rg1, Rc and Rb2 on hormone-induced lipolysis and lipogenesis in rat epididymal fat cells.
PubMed:Hyperlipemia-improving effects of ginsenoside-Rb2 in streptozotocin-diabetic rats.
PubMed:Studies on the mechanism of the hypoglycemic activity of ginsenoside-Rb2 in streptozotocin-diabetic rats.
PubMed:Hyperlipemia-improving effects of ginsenoside-Rb2 in cholesterol-fed rats.
PubMed:Stimulation of the lipogenic pathway in ginsenoside-Rb2 treated rats.
PubMed:Stimulation of lipid and sugar metabolism in ginsenoside-Rb2 treated rats.
PubMed:Studies on the biochemical action of ginseng saponin. I. Purification from ginseng extract of the active component stimulating serum protein biosynthesis.
 
Notes:
from ginseng; inhibits tumor metastasis of b16-bl6. Constit. of Panax ginseng (ginseng)
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