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ginsenoside Rc
20-((6-O-alpha-L-arabinofuranosyl-beta-D-glucopyranosyl)oxy)-12beta-hydroxydammar-24-en-3beta-yl 2-O-beta-D-glucopyranosyl-beta-D-glucopyranoside

Supplier Sponsors

CAS Number: 11021-14-0Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:234-253-5
FDA UNII: 0K83B0L786
Beilstein Number:1677618
MDL:MFCD00133368
XlogP3-AA:0.90 (est)
Molecular Weight:1079.28270000
Formula:C53 H90 O22
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point:1128.30 °C. @ 760.00 mm Hg (est)
Flash Point:1177.00 °F. TCC ( 636.20 °C. ) (est)
logP (o/w): 5.100 (est)
Soluble in:
 water, 0.3637 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
Ginsenoside Rc 98%
BOC Sciences
For experimental / research use only.
Ginsenoside Rc
ExtraSynthese
For experimental / research use only.
Ginsenoside Rc (HPLC) ≥98%
Santa Cruz Biotechnology
For experimental / research use only.
Ginsenoside Rc ≥98%
Sigma-Aldrich: Sigma
For experimental / research use only.
Ginsenoside-Rc
sds
from Panax ginseng (Korean ginseng) root triterpenoid saponin, ≥98% (HPLC)
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD50 410 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 539, 1975.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for ginsenoside Rc usage levels up to:
 not for fragrance use.
 
Recommendation for ginsenoside Rc flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :100018
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
Chemidplus:0011021140
RTECS:LY9536300 for cas# 11021-14-0
 
References:
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):100018
Pubchem (sid):135056492
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):HMDB34995
FooDB:FDB013598
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
EFSA Update of results on the monitoring of furan levels in food:Read Report
EFSA Previous report: Results on the monitoring of furan levels in food:Read Report
EFSA Report of the CONTAM Panel on provisional findings on furan in food:Read Report
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 ginseng
Search Trop Picture
 
Synonyms:
20-((6-O-alpha-L-arabinofuranosyl-beta-D-glucopyranosyl)oxy)-12beta-hydroxydammar-24-en-3beta-yl 2-O-beta-D-glucopyranosyl-beta-D-glucopyranoside
 ginsenoside RC
 panaxoside Rc
 panaxoside RC
 

Articles:

PubMed:[Screening active components in compound danshen based on PXR-CYP3A4: an experimental study].
PubMed:Characterization of a ginsenoside-transforming β-glucosidase from Paenibacillus mucilaginosus and its application for enhanced production of minor ginsenoside F₂.
PubMed:Efficacy comparison of Korean ginseng and American ginseng on body temperature and metabolic parameters.
PubMed:Ginsenosides from Korean red ginseng inhibit matrix metalloproteinase-13 expression in articular chondrocytes and prevent cartilage degradation.
PubMed:[Chemical constituents from roots and rhizomes of Panax ginseng cultivated in Jilin province].
PubMed:Hydrophilic interaction chromatography for selective separation of isomeric saponins.
PubMed:Pharmacokinetic study of ginsenoside Rc and simultaneous determination of its metabolites in rats using RRLC-Q-TOF-MS.
PubMed:Ginsenoside Rc modulates Akt/FoxO1 pathways and suppresses oxidative stress.
PubMed:Mass production of the ginsenoside Rg3(S) through the combinative use of two glycoside hydrolases.
PubMed:Complete conversion of major protopanaxadiol ginsenosides to compound K by the combined use of α-L-arabinofuranosidase and β-galactosidase from Caldicellulosiruptor saccharolyticus and β-glucosidase from Sulfolobus acidocaldarius.
PubMed:Production of ginsenoside Rd from ginsenoside Rc by α-L-arabinofuranosidase from Caldicellulosiruptor saccharolyticus.
PubMed:Diversity of endophytic fungi from roots of Panax ginseng and their saponin yield capacities.
PubMed:Determination of ginsenoside Rc in rat plasma by LC-MS/MS and its application to a pharmacokinetic study.
PubMed:Saponins composition of rhizomes, taproots, and lateral roots of Satsuma-ninjin (Panax japonicus).
PubMed:Lactobacillus ginsenosidimutans sp. nov., isolated from kimchi with the ability to transform ginsenosides.
PubMed:Four new triterpenoid saponins from the leaves of Panax japonicus grown in southern Miyazaki Prefecture (4).
PubMed:Bioconversion of ginsenoside Rc into Rd by a novel α-L-arabinofuranosidase, Abf22-3 from Leuconostoc sp. 22-3: cloning, expression, and enzyme characterization.
PubMed:[Identification of major components of traditional Chinese medicine Naodesheng tablet by HPLC-DAD-MS(n)].
PubMed:New triterpenoid saponins from fruits specimens of Panax japonicus collected in Kumamoto and Miyazaki prefectures (1).
PubMed:Effects of Ginsenoside Metabolites on GABAA Receptor-Mediated Ion Currents.
PubMed:Characterization of a novel ginsenoside-hydrolyzing α-L-arabinofuranosidase, AbfA, from Rhodanobacter ginsenosidimutans Gsoil 3054T.
PubMed:Effects of natural products on the function of human organic anion transporting polypeptide 1B1.
PubMed:Effects of Minor Ginsenosides, Ginsenoside Metabolites, and Ginsenoside Epimers on the Growth of Caenorhabditis elegans.
PubMed:Cloning and characterization of α-L-arabinofuranosidase and bifunctional α-L-arabinopyranosidase/β-D-galactopyranosidase from Bifidobacterium longum H-1.
PubMed:Differentiation of Panax quinquefolius grown in the USA and China using LC/MS-based chromatographic fingerprinting and chemometric approaches.
PubMed:Microbial transformation of ginsenosides Rb1, Rb3 and Rc by Fusarium sacchari.
PubMed:Effect of protopanaxadiol derivatives in high glucose-induced fibronectin expression in primary cultured rat mesangial cells: role of mitogen-activated protein kinases and Akt.
PubMed:Ginsenoside Rc, an active component of Panax ginseng, stimulates glucose uptake in C2C12 myotubes through an AMPK-dependent mechanism.
PubMed:Dammarane-type glycosides and long chain sesquiterpene glycosides from Gynostemma yixingense.
PubMed:[Comparative studies on the amount of ginsenosides between the crown galls and Chinese medicinal materials of Panax quinquefolium].
PubMed:Saponins from the processed rhizomes of Polygonatum kingianum.
PubMed:[A quantitative method using one marker for simultaneous assay of ginsenosides in Panax ginseng and P. notoginseng].
PubMed:Effects of extrusion process variables on extractable ginsenosides in wheat-ginseng extrudates.
PubMed:Ginsenoside compound K production from ginseng root extract by a thermostable beta-glycosidase from Sulfolobus solfataricus.
PubMed:Effects of ginsenosides, active ingredients of Panax ginseng, on development, growth, and life span of Caenorhabditis elegans.
PubMed:Chemical characteristics for different parts of Panax notoginseng using pressurized liquid extraction and HPLC-ELSD.
PubMed:Identification and differentiation of Panax species using ELISA, RAPD and eastern blotting.
PubMed:Ginsenoside extraction from Panax quinquefolium L. (American ginseng) root by using ultrahigh pressure.
PubMed:Transformation of ginsenosides Rb2 and Rc from Panax ginseng by food microorganisms.
PubMed:[The effect of preparation method on the quality of shen-mai injection].
PubMed:Chromatographic resolution of glucosidic compounds, ginsenosides on polyethersulphone membrane, and its application to the quantitative immunoassay for ginseng saponins.
PubMed:Embryotoxicity study of ginsenoside Rc and Re in in vitro rat whole embryo culture.
PubMed:Determination of ginsenosides Rb1, Rc, and Re in different dosage forms of ginseng by negative ion electrospray liquid chromatography-mass spectrometry.
PubMed:Purification and characterization of alpha-L-arabinopyranosidase and alpha-L-arabinofuranosidase from Bifidobacterium breve K-110, a human intestinal anaerobic bacterium metabolizing ginsenoside Rb2 and Rc.
PubMed:Modulation of G protein alpha-subunit mRNA levels in discrete rat brain regions by cerebroventricular infusion of ginsenoside Rc and Rg1.
PubMed:Ginsenoside Rc and Re stimulate c-fos expression in MCF-7 human breast carcinoma cells.
PubMed:Effects of ginsenosides on GABA(A) receptor channels expressed in Xenopus oocytes.
PubMed:Metabolism of ginsenoside R(c) by human intestinal bacteria and its related antiallergic activity.
PubMed:Effects of ginsenosides on vanilloid receptor (VR1) channels expressed in Xenopus oocytes.
PubMed:Effects of ginsenosides from Panax ginseng on cell-to-cell communication function mediated by gap junctions.
PubMed:Changes of [3H]MK-801, [3H]muscimol and [3H]flunitrazepam binding in rat brain by the prolonged ventricular infusion of ginsenoside Rc and Rg1.
PubMed:In vitro inhibitory effect of protopanaxadiol ginsenosides on tumor necrosis factor (TNF)-alpha production and its modulation by known TNF-alpha antagonists.
PubMed:Effects of Ginsenoside Rb2 and Rc on inferior human sperm motility in vitro.
PubMed:Effects of naturally occurring glucosides, solasodine glucosides, ginsenosides and parishin derivatives on multidrug resistance of lymphoma cells and leukocyte functions.
PubMed:Ginsenoside Rc and Rg1 differentially modulate NMDA receptor subunit mRNA levels after intracerebroventricular infusion in rats.
PubMed:High production of ginsenosides by transformed root cultures of Panax ginseng: effect of basal medium and Agrobacterium rhizogenes strains.
PubMed:Effects of ginseng components on c-DNA-expressed cytochrome P450 enzyme catalytic activity.
PubMed:Ginsenosides that produce differential antinociception in mice.
PubMed:Formation of monoclonal antibody against a major ginseng component, ginsenoside Rb1 and its characterization.
PubMed:Role of human intestinal Prevotella oris in hydrolyzing ginseng saponins.
PubMed:Saponins from Vietnamese Ginseng, Panax vietnamensis HA et Grushv. Collected in central Vietnam. II.
PubMed:Interactions of ginsenosides with ligand-bindings of GABA(A) and GABA(B) receptors.
PubMed:[Saponins in fruits pedicels of Panax notoginseng (Burk.). F.H. Chen].
PubMed:Specific interaction of arabinose residue in ginsenoside with egg phosphatidylcholine vesicles.
PubMed:Effect of ginsenosides Rg1, Rc and Rb2 on hormone-induced lipolysis and lipogenesis in rat epididymal fat cells.
PubMed:Saponins can cause the agglutination of phospholipid vesicles.
PubMed:[Chemical constituents of flower-buds of Panax ginseng--isolation and identification of ginsenoside-Rb3 and ginsenoside-Rc].
 
Notes:
Constit. of Panax ginseng (ginseng)
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