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ginsenoside Rg1
(3beta,6alpha,12beta)-3,12-dihydroxydammar-24-ene-6,20-diyl bis-beta-D-Glucopyranoside

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CAS Number: 22427-39-0Picture of molecule3D/inchi
Other(deleted CASRN):11054-31-2
ECHA EINECS - REACH Pre-Reg:244-989-9
FDA UNII: PJ788634QY
MDL:MFCD00210293
XlogP3-AA:2.70 (est)
Molecular Weight:801.02464000
Formula:C42 H72 O14
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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US Patents:Search
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Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 902.70 °C. @ 760.00 mm Hg (est)
Flash Point: 931.00 °F. TCC ( 499.70 °C. ) (est)
logP (o/w): 1.670 (est)
Soluble in:
 water, 0.5742 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
Ginsenoside Rg1 98%
BOC Sciences
For experimental / research use only.
Ginsenoside Rg1
Carbosynth
For experimental / research use only.
Ginsenoside Rg1
ExtraSynthese
For experimental / research use only.
Ginsenoside Rg1 (HPLC) ≥98%
Santa Cruz Biotechnology
For experimental / research use only.
Ginsenoside Rg1 ≥98%
Sigma-Aldrich
For experimental / research use only.
Ginsenoside Rg1
analytical standard
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD50 405 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 343, 1975.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for ginsenoside Rg1 usage levels up to:
 not for fragrance use.
 
Recommendation for ginsenoside Rg1 flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :90781
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
Chemidplus:0022427390
RTECS:LY9537200 for cas# 22427-39-0
 
References:
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:22427-39-0
Pubchem (cid):90781
Pubchem (sid):135049248
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
KEGG (GenomeNet):C08946
HMDB (The Human Metabolome Database):HMDB35857
FooDB:FDB014636
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 ginseng
Search Trop Picture
 
Synonyms:
(3beta,6alpha,12beta)-3,12-dihydroxydammar-24-ene-6,20-diyl bis-beta-D-Glucopyranoside
(3beta,6alpha,12beta)-3,12-dihydroxydammar-24-ene-6,20-diylbis(beta-D-glucopyranoside)
 ginsenoside A2
 ginsenoside RG1
beta-D-glucopyranoside, (3beta,6alpha,12beta)-3,12-dihydroxy dammar-24-ene-6,20-diylbis-
beta-D-glucopyranoside, (3beta,6alpha,12beta)-3,12-dihydroxydammar-24-ene-6,20-diyl bis-
(6)-beta-D-glucopyranosyl-(20)-beta-D-glucopyranosyl-20S-protopanaxatriol
 panaxoside A
 panaxoside Rg1
 sanchinoside C1
 sanchinoside Rg1
 

Articles:

PubMed:Bioconversion of ginsenosides in the american ginseng ( xī yáng shēn) extraction residue by fermentation with lingzhi ( líng zhī, ganoderma lucidum).
PubMed:Subacute oral toxicity study of korean red ginseng extract in sprague-dawley rats.
PubMed:Efficacy comparison of Korean ginseng and American ginseng on body temperature and metabolic parameters.
PubMed:Peripheral immunomodulation with ginsenoside Rg1 ameliorates neuroinflammation-induced behavioral deficits in rats.
PubMed:Biotransformation of ginsenoside Rd in the ginseng extraction residue by fermentation with lingzhi (Ganoderma lucidum).
PubMed:Reduction of hepatitis A virus on FRhK-4 cells treated with Korean red ginseng extract and ginsenosides.
PubMed:A novel strategy with standardized reference extract qualification and single compound quantitative evaluation for quality control of Panax notoginseng used as a functional food.
PubMed:The effect of extrusion conditions on the acidic polysaccharide, ginsenoside contents and antioxidant properties of extruded Korean red ginseng.
PubMed:[Effect of inorganic fertilizer on quality of Panax ginseng].
PubMed:Metabolite profiling of ginsenoside Re in rat urine and faeces after oral administration.
PubMed:Protective effects of astragalosides on dexamethasone and Aβ25-35 induced learning and memory impairments due to decrease amyloid precursor protein expression in 12-month male rats.
PubMed:Antioxidant, antiproliferative, and pro-apoptotic activities of a saponin extract derived from the roots of Panax notoginseng (Burk.) F.H. Chen.
PubMed:Porosity changes and retention of ginsenosides in North American ginseng root using different dehydration processes.
PubMed:Study on the interactions between ginsenosides and lysozyme under acidic condition by ESI-MS and molecular docking.
PubMed:Effect and mechanism of ginsenosides CK and Rg1 on stimulation of glucose uptake in 3T3-L1 adipocytes.
PubMed:[Microorganisms of special herb-glycosidases and their fermentation, enzyme properties].
PubMed:Improvement of memory in mice and increase of hippocampal excitability in rats by ginsenoside Rg1's metabolites ginsenoside Rh1 and protopanaxatriol.
PubMed:Ginsenosides Rb1 and Rg1 suppress triglyceride accumulation in 3T3-L1 adipocytes and enhance beta-cell insulin secretion and viability in Min6 cells via PKA-dependent pathways.
PubMed:Effect of ginsenosides on glucose uptake in human Caco-2 cells is mediated through altered Na+/glucose cotransporter 1 expression.
PubMed:Effects of ginsenoside Rg1 on postimplantation rat and mouse embryos cultured in vitro.
PubMed:Isolation of dammarane saponins from Panax notoginseng by high-speed counter-current chromatography.
PubMed:Hypothalamic neuronal histamine modulates adaptive behavior and thermogenesis in response to endogenous pyrogen.
PubMed:Ginsenoside Rg1 modulates ingestive behavior and thermal response induced by interleukin-1 beta in rats.
PubMed:[Study on the nootropic mechanism of ginsenoside Rb1 and Rg1--influence on mouse brain development].
PubMed:Ginsenoside Rg1 prevents histaminergic modulation of rat adaptive behavior from elevation of ambient temperature.
PubMed:Attenuation of anorexia induced by heat or surgery during sustained administration of ginsenoside Rg1 into rat third ventricle.
 
Notes:
Constit. of Panax ginseng (ginseng)
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