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ginsenoside Rg2
beta-D-glucopyranoside, (3-beta,6-alpha,12-beta)-3,12,20-trihydroxydammar-24-en-6-yl-2-o-(6-deoxy-alpha-l-mannopyranosyl)-

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CAS Number: 52286-74-5Picture of molecule3D/inchi
FDA UNII: 5R89LAS235
Beilstein Number:6627213
MDL:MFCD00210511
XlogP3-AA:3.20 (est)
Molecular Weight:785.02544000
Formula:C42 H72 O13
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 889.60 °C. @ 760.00 mm Hg (est)
Flash Point: 917.00 °F. TCC ( 491.80 °C. ) (est)
logP (o/w): 6.830 (est)
Soluble in:
 water, 0.06564 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
Ginsenoside Rg2 98%
BOC Sciences
For experimental / research use only.
Ginsenoside Rg2
ExtraSynthese
For experimental / research use only.
Ginsenoside Rg2 (HPLC) ≥97%
Santa Cruz Biotechnology
For experimental / research use only.
Ginsenoside Rg2 ≥98%
Sigma-Aldrich
For experimental / research use only.
Ginsenoside Rg2
analytical standard
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD50 1340 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 343, 1975.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for ginsenoside Rg2 usage levels up to:
 not for fragrance use.
 
Recommendation for ginsenoside Rg2 flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :6441009
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
Chemidplus:0052286745
RTECS:LZ6430000 for cas# 52286-74-5
 
References:
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):6441009
Pubchem (sid):135117970
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):HMDB35395
FooDB:FDB014070
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 ginseng
Search Trop Picture
 
Synonyms:
 chikusetsusaponin I
beta-D-glucopyranoside, (3-beta,6-alpha,12-beta)-3,12,20-trihydroxydammar-24-en-6-yl-2-o-(6-deoxy-alpha-l-mannopyranosyl)-
 prosapogenin C2
(6)-(alpha-L-rhamnopyranosyl(1-rham-2-glu)-beta-D-glucopyranosyl)-20S-protopanaxatriol
 

Articles:

PubMed:Antiviral activity of ginsenosides against coxsackievirus B3, enterovirus 71, and human rhinovirus 3.
PubMed:Detoxifying effect of fermented black ginseng on H2O2-induced oxidative stress in HepG2 cells.
PubMed:Simultaneous determination of timosaponin B-II and A-III in rat plasma by LC-MS/MS and its application to pharmacokinetic study.
PubMed:Identification and characterization of a ginsenoside-transforming β-glucosidase from Pseudonocardia sp. Gsoil 1536 and its application for enhanced production of minor ginsenoside Rg2(S).
PubMed:[Chemical constituents from processed rhizomes of Panax notoginseng].
PubMed:[Chemical constituents from roots and rhizomes of Panax ginseng cultivated in Jilin province].
PubMed:Changes in ginsenoside composition of ginseng berry extracts after a microwave and vinegar process.
PubMed:[Quality variation and ecotype division of Panax quinquefolium in China].
PubMed:A comparative study on anticoagulant activities of three Chinese herbal medicines from the genus Panax and anticoagulant activities of ginsenosides Rg1 and Rg2.
PubMed:Ginsenoside rg2 inhibits lipopolysaccharide-induced adhesion molecule expression in human umbilical vein endothelial cell.
PubMed:[Screening of pregnane X receptor activation from ginsenosides].
PubMed:Saponins composition of rhizomes, taproots, and lateral roots of Satsuma-ninjin (Panax japonicus).
PubMed:State-of-the-art separation of ginsenosides from Korean white and red ginseng by countercurrent chromatography.
PubMed:Metabolite profiling of ginsenoside Re in rat urine and faeces after oral administration.
PubMed:Biotransformation of ginsenosides Re and Rg1 into ginsenosides Rg2 and Rh1 by recombinant β-glucosidase.
PubMed:Changes in the Contents of Prosapogenin in the Red Ginseng (Panax ginseng) Depending on Steaming Batches.
PubMed:Protective effects of Rg2 on hypoxia-induced neuronal damage in hippocampal neurons.
PubMed:Ginsenoside Rg2 induces orphan nuclear receptor SHP gene expression and inactivates GSK3β via AMP-activated protein kinase to inhibit hepatic glucose production in HepG2 cells.
PubMed:[Chemical constituents of Chinese red ginseng].
PubMed:Effects of ginsenoside Rg2 on the ultraviolet B-induced DNA damage responses in HaCaT cells.
PubMed:Panajaponin, a new glycosphingolipid from Panax japonicus.
PubMed:Dammarane-type glycosides and long chain sesquiterpene glycosides from Gynostemma yixingense.
PubMed:[Metabolic study of ginsenoside Re in rats].
PubMed:[Study on excretion of ginsenoside Rg2 in rats].
PubMed:Simultaneous determination of nucleobases, nucleosides and saponins in Panax notoginseng using multiple columns high performance liquid chromatography.
PubMed:[Effects of 3 genosides on bio-thermodynamic expression of splenic lymphocyte in mice].
PubMed:Panax ginseng ginsenoside-Rg2 protects memory impairment via anti-apoptosis in a rat model with vascular dementia.
PubMed:Microbial transformation of 20(S)-protopanaxatriol-type saponins by Absidia coerulea.
PubMed:Effects of mRg2, a mixture of ginsenosides containing 60% Rg2, on the ultraviolet B-induced DNA repair synthesis and apoptosis in NIH3T3 cells.
PubMed:Protective effects of ginsenoside Rg2 against glutamate-induced neurotoxicity in PC12 cells.
PubMed:Simultaneous enantiomer determination of 20 (R)- and 20 (S)-ginsenoside-Rg2 in rat plasma after intravenous administration using HPLC method.
PubMed:Extraction of 20(S)-ginsenoside Rg2 from cultured Panax notoginseng cells in vitro stimulates human umbilical cord vein endothelial cell proliferation.
PubMed:[Effect of ginsenoside Rg2 on chemical myocardial ischemia in rats].
PubMed:Differential effect of ginsenoside metabolites on the 5-HT3A receptor-mediated ion current in Xenopus oocytes.
PubMed:[Study on the chemical constituents of the roots of commercial ginseng].
PubMed:Differential effect of bovine serum albumin on ginsenoside metabolite-induced inhibition of alpha3beta4 nicotinic acetylcholine receptor expressed in Xenopus oocytes.
PubMed:[Effect of Rg2 on hemodynamics of hemorrhagic shock and its antioxidation in dogs].
PubMed:Enzymatic preparation of ginsenosides Rg2, Rh1, and F1 from protopanaxatriol-type ginseng saponin mixture.
PubMed:Enzymatic preparation of ginsenosides Rg2, Rh1, and F1.
PubMed:Effects of ginsenoside Rg2 on the 5-HT3A receptor-mediated ion current in Xenopus oocytes.
PubMed:[Practical optimization of the two-dimensional thin-layer chromatographic separation of ginsenosides].
PubMed:Effects of ginsenoside Rg2 on human neuronal nicotinic acetylcholine receptors.
PubMed:Effects of ginsenosides, active components of ginseng, on nicotinic acetylcholine receptors expressed in Xenopus oocytes.
PubMed:Purification and characterization of ginsenoside-alpha-L-rhamnosidase.
PubMed:Characterization of ginseng saponin ginsenoside-Rg(3) inhibition of catecholamine secretion in bovine adrenal chromaffin cells.
PubMed:Effects of ginsenosides from Panax ginseng on cell-to-cell communication function mediated by gap junctions.
PubMed:Enzymatic synthesis of two ginsenoside Re-beta-xylosides.
PubMed:Enzymatic preparation of genuine prosapogenin, 20(S)-ginsenoside Rh1, from ginsenosides Re and Rg1.
PubMed:Preparation of monoclonal antibody against ginsenoside Rf and its enzyme immunoassay.
PubMed:Effects of ginseng saponins on responses induced by various receptor stimuli.
PubMed:Determination of ginsenoside Rf and Rg2 from Panax ginseng using enzyme immunoassay.
PubMed:Properties of ginseng saponin inhibition of catecholamine secretion in bovine adrenal chromaffin cells.
PubMed:Inhibition of in vitro tumor cell invasion by ginsenoside Rg3.
PubMed:Ginseng saponins reduce acetylcholine-evoked Na+ influx and catecholamine secretion in bovine adrenal chromaffin cells.
PubMed:Effect of 20(S)-ginsenoside-Rg2 and cyproheptadine on two-way active avoidance learning and memory in rats.
PubMed:[Separation of 20(S)-ginsenoside-Rg2 and its 20(R) epimer by reversed phase low pressure column (Rp-18) chromatography].
PubMed:[Dammarane-type saponins in leaves of Panax collected in Sichuan].
PubMed:Antiplatelet actions of panaxynol and ginsenosides isolated from ginseng.
PubMed:[Isolation and identification of saponin IV, V, VI and VII in ginseng stems].
PubMed:[Rhizoma ginseng (III)--Isolation and identification of saponins E1 and E2].
PubMed:Stimulation of the lipogenic pathway in ginsenoside-Rb2 treated rats.
PubMed:Isolation and characterization of ginsenoside-Rg2, 20R-prosapogenin, 20S-prosapogenin and delta 20-prosapogenin. Chemical studies on saponins of Panax ginseng C. A. Meyer, Third report.
 
Notes:
Constit. of Panax ginseng (ginseng)
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