EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

ginsenoside Rh1
beta-D-glucopyranoside, (3beta,6alpha,12beta)-3,12,20-trihydroxydammar-24-en-6-yl

Supplier Sponsors

CAS Number: 63223-86-9Picture of molecule3D/inchi
FDA UNII: XBR6F7G8FU
MDL:MFCD09951797
XlogP3-AA:4.30 (est)
Molecular Weight:638.88294000
Formula:C36 H62 O9
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 755.10 °C. @ 760.00 mm Hg (est)
Flash Point: 771.00 °F. TCC ( 410.50 °C. ) (est)
logP (o/w): 3.740 (est)
Soluble in:
 water, 0.07331 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
Ginsenoside Rh1; 20(s)-Ginsenoside Rh1 98%
BOC Sciences
For experimental / research use only.
Ginsenoside Rh1
ExtraSynthese
For experimental / research use only.
Ginsenoside Rh1 (HPLC) ≥98%
Glentham Life Sciences
Ginsenoside Rh1
Santa Cruz Biotechnology
For experimental / research use only.
Ginsenoside Rh1 ≥97%
Sigma-Aldrich
For experimental / research use only.
Ginsenoside Rh1
analytical standard
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for ginsenoside Rh1 usage levels up to:
 not for fragrance use.
 
Recommendation for ginsenoside Rh1 flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :3085260
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
Chemidplus:0063223869
RTECS:LZ6428000 for cas# 63223-86-9
 
References:
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):3085260
Pubchem (sid):135234707
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):HMDB39554
FooDB:FDB019175
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 found in nature
 
Synonyms:
 ginsenoside RH1
beta-D-glucopyranoside, (3beta,6alpha,12beta)-3,12,20-trihydroxydammar-24-en-6-yl
 

Articles:

PubMed:Cloning and heterologous expression of UDP-glycosyltransferase genes from Bacillus subtilis and its application in the glycosylation of ginsenoside Rh1.
PubMed:Detoxifying effect of fermented black ginseng on H2O2-induced oxidative stress in HepG2 cells.
PubMed:Ginsenoside Rh1 induces mouse osteoblast growth and differentiation through the bone morphogenetic protein 2/runt-related gene 2 signalling pathway.
PubMed:Characterization of β-xylosidase from Thermoanaerobacterium thermosaccharolyticum and its application to the production of ginsenosides Rg1 and Rh 1 from notoginsenosides R 1 and R 2.
PubMed:Ginsenoside Rb1 eliminates HIV-1 (D3)-transduced cytoprotective human macrophages by inhibiting the AKT pathway.
PubMed:Ginsenoside Rh1 potentiates dexamethasone's anti-inflammatory effects for chronic inflammatory disease by reversing dexamethasone-induced resistance.
PubMed:[Chemical constituents from processed rhizomes of Panax notoginseng].
PubMed:Quality characteristics and ginsenosides composition of ginseng-yakju according to the particle size of ginseng powder.
PubMed:Long-term administration of ginsenoside Rh1 enhances learning and memory by promoting cell survival in the mouse hippocampus.
PubMed:Ginsenoside Rh1 eliminates the cytoprotective phenotype of human immunodeficiency virus type 1-transduced human macrophages by inhibiting the phosphorylation of pyruvate dehydrogenase lipoamide kinase isozyme 1.
PubMed:Protopanaxatriol ginsenoside Rh1 inhibits the expression of matrix metalloproteinases and the in vitro invasion/migration of human astroglioma cells.
PubMed:Comparative pharmacokinetics of timosaponin B-II and timosaponin A-III after oral administration of Zhimu-Baihe herb-pair, Zhimu extract, free timosaponin B-II and free timosaponin A-III to rats.
PubMed:Ginsenoside Rh1 ameliorates high fat diet-induced obesity in mice by inhibiting adipocyte differentiation.
PubMed:Saponins composition of rhizomes, taproots, and lateral roots of Satsuma-ninjin (Panax japonicus).
PubMed:Antibiotics attenuate anti-scratching behavioral effect of ginsenoside Re in mice.
PubMed:Effect of ginsenoside Rh1 on myocardial injury and heart function in isoproterenol-induced cardiotoxicity in rats.
PubMed:Ginsenoside Rh1 suppresses matrix metalloproteinase-1 expression through inhibition of activator protein-1 and mitogen-activated protein kinase signaling pathway in human hepatocellular carcinoma cells.
PubMed:Biotransformation of ginsenosides Re and Rg1 into ginsenosides Rg2 and Rh1 by recombinant β-glucosidase.
PubMed:Chemical Diversity of Panax ginseng, Panax quinquifolium, and Panax notoginseng.
PubMed:Effects of Minor Ginsenosides, Ginsenoside Metabolites, and Ginsenoside Epimers on the Growth of Caenorhabditis elegans.
PubMed:Ginsenoside Rh1 inhibits the invasion and migration of THP-1 acute monocytic leukemia cells via inactivation of the MAPK signaling pathway.
PubMed:[Chemical constituents of Chinese red ginseng].
PubMed:Oral administration of ginsenoside Rh1 inhibits the development of atopic dermatitis-like skin lesions induced by oxazolone in hairless mice.
PubMed:[Raman spectroscopy study on the interaction of ginsenoside Rb1 with DPPC bilayers].
PubMed:Post-exposure treatment with ginsenoside compound K ameliorates auditory functional injury associated with noise-induced hearing loss in mice.
PubMed:Anti-inflammatory mechanism of ginsenoside Rh1 in lipopolysaccharide-stimulated microglia: critical role of the protein kinase A pathway and hemeoxygenase-1 expression.
PubMed:[Pharmacokinetics of ginsenosides Rg1 and its metabolites in rats].
PubMed:Microsomal cytochrome p450-mediated metabolism of protopanaxatriol ginsenosides: metabolite profile, reaction phenotyping, and structure-metabolism relationship.
PubMed:Ginsenoside Rh1 suppresses inducible nitric oxide synthase gene expression in IFN-gamma-stimulated microglia via modulation of JAK/STAT and ERK signaling pathways.
PubMed:[Determination and enzymolysis preparation of ginsenoside Rh1].
PubMed:Dammarane-type glycosides and long chain sesquiterpene glycosides from Gynostemma yixingense.
PubMed:[Metabolic study of ginsenoside Re in rats].
PubMed:Biotransformation of ginsenoside Rf to Rh1 by recombinant beta-glucosidase.
PubMed:Improvement of memory in mice and increase of hippocampal excitability in rats by ginsenoside Rg1's metabolites ginsenoside Rh1 and protopanaxatriol.
PubMed:Characterization of pharmacokinetic profiles and metabolic pathways of 20(S)-ginsenoside Rh1 in vivo and in vitro.
PubMed:[A quantitative method using one marker for simultaneous assay of ginsenosides in Panax ginseng and P. notoginseng].
PubMed:Determination of 20(S)-ginsenoside Rh1 and its aglycone 20(S)-protopanaxatriol in rat plasma by sensitive LC-APCI-MS method and its application to pharmacokinetic study.
PubMed:Protective effect of ginsenosides Rg(2) and Rh(1) on oxidation-induced impairment of erythrocyte membrane properties.
PubMed:Simultaneous determination of nucleobases, nucleosides and saponins in Panax notoginseng using multiple columns high performance liquid chromatography.
PubMed:Biotransformation of ginsenoside Rb1, crocin, amygdalin, geniposide, puerarin, ginsenoside Re, hesperidin, poncirin, glycyrrhizin, and baicalin by human fecal microflora and its relation to cytotoxicity against tumor cells.
PubMed:Screening of anti-platelet aggregation agents from Panax notoginseng using human platelet extraction and HPLC-DAD-ESI-MS/MS.
PubMed:[Studies on chemical constituents from rhizomes of Panax notoginseng].
PubMed:Microbial transformation of 20(S)-protopanaxatriol-type saponins by Absidia coerulea.
PubMed:An in vitro evaluation of cytochrome P450 inhibition and P-glycoprotein interaction with goldenseal, Ginkgo biloba, grape seed, milk thistle, and ginseng extracts and their constituents.
PubMed:The effects of ginsenoside Re and its metabolite, ginsenoside Rh1, on 12-O-tetradecanoylphorbol 13-acetate- and oxazolone-induced mouse dermatitis models.
PubMed:Influence of ginsenoside Rh1 and F1 on human cytochrome p450 enzymes.
PubMed:Metabolism of ginsenoside Re by human intestinal microflora and its estrogenic effect.
PubMed:Simultaneous rapid quantification of ginsenoside Rg1 and its secondary glycoside Rh1 and aglycone protopanaxatriol in rat plasma by liquid chromatography-mass spectrometry after solid-phase extraction.
PubMed:[Isolation and identification of minor bioactive saponins from the leaves of Panax notoginseng].
PubMed:Ginsenoside Rh1 possesses antiallergic and anti-inflammatory activities.
PubMed:Degradation of ginsenosides in humans after oral administration.
PubMed:A ginsenoside-Rh1, a component of ginseng saponin, activates estrogen receptor in human breast carcinoma MCF-7 cells.
PubMed:Enzymatic preparation of ginsenosides Rg2, Rh1, and F1 from protopanaxatriol-type ginseng saponin mixture.
PubMed:Enzymatic preparation of ginsenosides Rg2, Rh1, and F1.
PubMed:[Saponins with low sugar chain from the leaves of Panax notoginseng (Burk) F. H. Chen].
PubMed:Purification and characterization of ginsenoside-alpha-L-rhamnosidase.
PubMed:Anticarcinogenic effect of Panax ginseng C.A. Meyer and identification of active compounds.
PubMed:In vitro anti-Helicobacter pylori activity of panaxytriol isolated from ginseng.
PubMed:Metabolism of ginsenoside Rg1 by intestinal bacteria. II. Immunological activity of ginsenoside Rg1 and Rh1.
PubMed:Effects of ginsenosides from Panax ginseng on cell-to-cell communication function mediated by gap junctions.
PubMed:Enzymatic preparation of genuine prosapogenin, 20(S)-ginsenoside Rh1, from ginsenosides Re and Rg1.
PubMed:Ginsenoside Rh2 and Rh3 induce differentiation of HL-60 cells into granulocytes: modulation of protein kinase C isoforms during differentiation by ginsenoside Rh2.
PubMed:Modulation of protein kinase C activity in NIH 3T3 cells by plant glycosides from Panax ginseng.
PubMed:Ginsenosides increase secretion of lipoprotein lipase by 3T3-L1 adipocytes.
PubMed:Ginsenoside-Rh1 and Rh2 inhibit the induction of nitric oxide synthesis in murine peritoneal macrophages.
PubMed:Determination of aglycones of ginsenosides in ginseng preparations sold in Sweden and in urine samples from Swedish athletes consuming ginseng.
PubMed:Saponins from Vietnamese ginseng, Panax vietnamensis Ha et Grushv. Collected in central Vietnam. I.
PubMed:Control of phenotypic expression of cultured B16 melanoma cells by plant glycosides.
 
Notes:
Isol. from Panax spp.
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