| PubMed:Detoxifying effect of fermented black ginseng on H2O2-induced oxidative stress in HepG2 cells. |
| PubMed:[Regulatory effect of ginsenoside Rh2 on HDAC1/2 activity and cyclin in human erythroleukemia K562 cells]. |
| PubMed:Synthesis and anti-cancer cell activity of pseudo-ginsenoside Rh2. |
| PubMed:20(S)-Ginsenoside Rh2 as aldose reductase inhibitor from Panax ginseng. |
| PubMed:Skin anti-photoaging properties of ginsenoside Rh2 epimers in UV-B-irradiated human keratinocyte cells. |
| PubMed:Effect of ginsenoside Rh2 on the migratory ability of HepG2 liver carcinoma cells: recruiting histone deacetylase and inhibiting activator protein 1 transcription factors. |
| PubMed:Treatment of stress urinary incontinence by ginsenoside Rh2. |
| PubMed:Pharmacokinetics and tissue distribution of ginsenoside Rh2 and Rg3 epimers after oral administration of BST204, a purified ginseng dry extract, in rats. |
| PubMed:[Ginsenoside Rh2 inhibits proliferation and promotes apoptosis of leukemia KG1-α cells]. |
| PubMed:Ginsenoside Rh2 alleviates dextran sulfate sodium-induced colitis via augmenting TGFβ signaling. |
| PubMed:Ginsenoside Rh2 promotes nonamyloidgenic cleavage of amyloid precursor protein via a cholesterol-dependent pathway. |
| PubMed:Novel multicore niosomes based on double pH-sensitive mixed micelles for Ginsenoside Rh2 delivery. |
| PubMed:p53-dependent Fas expression is critical for Ginsenoside Rh2 triggered caspase-8 activation in HeLa cells. |
| PubMed:Down-regulation of phosphoglucose isomerase/autocrine motility factor enhances gensenoside Rh2 pharmacological action on leukemia KG1α cells. |
| PubMed:AMP-activated protein kinase determines apoptotic sensitivity of cancer cells to ginsenoside-Rh2. |
| PubMed:EGFR signaling-dependent inhibition of glioblastoma growth by ginsenoside Rh2. |
| PubMed:Esterification enhanced intestinal absorption of ginsenoside Rh2 in Caco-2 cells without impacts on its protective effects against H₂O₂-induced cell injury in human umbilical vein endothelial cells (HUVECs). |
| PubMed:20S-Ginsenoside Rh2 induces apoptosis in human Leukaemia Reh cells through mitochondrial signaling pathways. |
| PubMed:Ginsenoside Rh2-B1 stimulates cell proliferation and IFN-γ production by activating the p38 MAPK and ERK-dependent signaling pathways in CTLL-2 cells. |
| PubMed:Biotransformation of ginsenoside Rb1 via the gypenoside pathway by human gut bacteria. |
| PubMed:Ginsenoside Rb1 is transformed into Rd and Rh2 by Microbacterium trichothecenolyticum. |
| PubMed:Ginsenoside Rh2 improves learning and memory in mice. |
| PubMed:Pharmacokinetic interactions between 20(S)-ginsenoside Rh2 and the HIV protease inhibitor ritonavir in vitro and in vivo. |
| PubMed:Inhibitory effects of sulfated 20(S)-ginsenoside Rh2 on the release of pro-inflammatory mediators in LPS-induced RAW 264.7 cells. |
| PubMed:Stereoselective determination of ginsenosides Rg3 and Rh2 epimers in rat plasma by LC-MS/MS: application to a pharmacokinetic study. |
| PubMed:Effects of ginsenoside Rh2 on growth and migration of pancreatic cancer cells. |
| PubMed:Ginsenoside Rh2 Downregulates LPS-Induced NF- κ B Activation through Inhibition of TAK1 Phosphorylation in RAW 264.7 Murine Macrophage. |
| PubMed:Ginsenoside Rh2 induces human hepatoma cell apoptosisvia bax/bak triggered cytochrome C release and caspase-9/caspase-8 activation. |
| PubMed:Ginsenoside Rh1 ameliorates high fat diet-induced obesity in mice by inhibiting adipocyte differentiation. |
| PubMed:Anti-inflammatory, antioxidative and matrix metalloproteinase inhibitory properties of 20(R)-ginsenoside Rh2 in cultured macrophages and keratinocytes. |
| PubMed:Sulfated derivatives of 20(S)-ginsenoside Rh2 and their inhibitory effects on LPS-induced inflammatory cytokines and mediators. |
| PubMed:Ginsenoside Rh2 mediates changes in the microRNA expression profile of human non-small cell lung cancer A549 cells. |
| PubMed:Cardioprotective Effects of 20(S)-Ginsenoside Rh2 against Doxorubicin-Induced Cardiotoxicity In Vitro and In Vivo. |
| PubMed:Ginsenoside Rh2 induces cell cycle arrest and differentiation in human leukemia cells by upregulating TGF-β expression. |
| PubMed:Inhibition of Na(+)/K(+) -ATPase by antcins, unique steroid-like compounds in Antrodia camphorate. |
| PubMed:In vitro studies on the oxidative metabolism of 20(s)-ginsenoside Rh2 in human, monkey, dog, rat, and mouse liver microsomes, and human liver s9. |
| PubMed:Microbial transformation of ginsenoside Rg3 to ginsenoside Rh2 by Esteya vermicola CNU 120806. |
| PubMed:Key role of nuclear factor-κB in the cellular pharmacokinetics of adriamycin in MCF-7/Adr cells: the potential mechanism for synergy with 20(S)-ginsenoside Rh2. |
| PubMed:Reactive oxygen species mediated ginsenoside Rg3- and Rh2-induced apoptosis in hepatoma cells through mitochondrial signaling pathways. |
| PubMed:Sulfated derivative of 20(S)-ginsenoside Rh2 inhibits inflammatory cytokines through MAPKs and NF-kappa B pathways in LPS-induced RAW264.7 macrophages. |
| PubMed:Induction of apoptosis by ginsenoside Rk1 in SK-MEL-2-human melanoma. |
| PubMed:Stereoselective regulations of P-glycoprotein by ginsenoside Rh2 epimers and the potential mechanisms from the view of pharmacokinetics. |
| PubMed:Ginsenoside Rh2 inhibits osteoclastogenesis through down-regulation of NF-κB, NFATc1 and c-Fos. |
| PubMed:Pharmacokinetics-pharmacology disconnection of herbal medicines and its potential solutions with cellular pharmacokinetic-pharmacodynamic strategy. |
| PubMed:A dynamic study on reversal of multidrug resistance by ginsenoside Rh₂ in adriamycin-resistant human breast cancer MCF-7 cells. |
| PubMed:Antihyperglycemic effect of ginsenoside Rh2 by inducing islet β-cell regeneration in mice. |
| PubMed:Structural modification of ginsenoside Rh(2) by fatty acid esterification and its detoxification property in antitumor. |
| PubMed:Ginsenoside Rh2(S) induces the differentiation and mineralization of osteoblastic MC3T3-E1 cells through activation of PKD and p38 MAPK pathways. |
| PubMed:[Effects of 20 (S) -ginsenoside Rh2 and 20 (R) -ginsenoside Rh2 on proliferation and apoptosis of human lung adenocarcinoma A549 cells]. |
| PubMed:pseudo-G-Rh2 induces mitochondrial-mediated apoptosis in SGC-7901 human gastric cancer cells. |
| PubMed:Effects of Minor Ginsenosides, Ginsenoside Metabolites, and Ginsenoside Epimers on the Growth of Caenorhabditis elegans. |
| PubMed:Ginsenoside Rh2(S) induces differentiation and mineralization of MC3T3-E1 cells through activation of the PKD/AMPK signaling pathways. |
| PubMed:Enhancement of oral bioavailability of 20(S)-ginsenoside Rh2 through improved understanding of its absorption and efflux mechanisms. |
| PubMed:Co-treatment with ginsenoside Rh2 and betulinic acid synergistically induces apoptosis in human cancer cells in association with enhanced capsase-8 activation, bax translocation, and cytochrome c release. |
| PubMed:Cellular pharmacokinetic mechanisms of adriamycin resistance and its modulation by 20(S)-ginsenoside Rh2 in MCF-7/Adr cells. |
| PubMed:Ginsenoside Rh2 inhibits glioma cell proliferation by targeting microRNA-128. |
| PubMed:Anti-proliferative effects of raw and steamed extracts of Panax notoginseng and its ginsenoside constituents on human liver cancer cells. |
| PubMed:Ginsenoside Rh2 induces apoptosis and paraptosis-like cell death in colorectal cancer cells through activation of p53. |
| PubMed:Ginsenoside Rh2 induces Bcl-2 family proteins-mediated apoptosis in vitro and in xenografts in vivo models. |
| PubMed:Cholesterol-dependent induction of dendrite formation by ginsenoside Rh2 in cultured melanoma cells. |
| PubMed:20(S)-ginsenoside Rh2 noncompetitively inhibits P-glycoprotein in vitro and in vivo: a case for herb-drug interactions. |
| PubMed:Rh2 or its aglycone aPPD in combination with docetaxel for treatment of prostate cancer. |
| PubMed:Intestinal absorption mechanisms of ginsenoside Rh2: stereoselectivity and involvement of ABC transporters. |
| PubMed:Induction of apoptosis by the ginsenoside Rh2 by internalization of lipid rafts and caveolae and inactivation of Akt. |
| PubMed:Stereospecificity of hydroxyl group at C-20 in antiproliferative action of ginsenoside Rh2 on prostate cancer cells. |
| PubMed:Steroid-like compounds in Chinese medicines promote blood circulation via inhibition of Na+/K+ -ATPase. |
| PubMed:[Effect of ginsenoside Rh2 on the development of transferred tumors and chemotherapy efficiency]. |
| PubMed:[Research on the mechanism of ginsenoside Rh2 reversing the resistance of lung adenocarcinoma cells to cisplatin]. |
| PubMed:Ginsenoside Rh2 ameliorates scopolamine-induced learning deficit in mice. |
| PubMed:Ginsenoside Rh2-mediated G1 phase cell cycle arrest in human breast cancer cells is caused by p15 Ink4B and p27 Kip1-dependent inhibition of cyclin-dependent kinases. |
| PubMed:Pharmacokinetic characterization of ginsenoside Rh2, an anticancer nutrient from ginseng, in rats and dogs. |
| PubMed:Ginsenoside Rh2 induces ligand-independent Fas activation via lipid raft disruption. |
| PubMed:20(R)-ginsenoside Rh2, not 20(S), is a selective osteoclastgenesis inhibitor without any cytotoxicity. |
| PubMed:Pre-clinical evaluation of Rh2 in PC-3 human xenograft model for prostate cancer in vivo: formulation, pharmacokinetics, biodistribution and efficacy. |
| PubMed:Anxiolytic-like effects of ginsenosides Rg3 and Rh2 from red ginseng in the elevated plus-maze model. |
| PubMed:Improving enzymatic production of ginsenoside Rh2 from Rg3 by using nonionic surfactant. |
| PubMed:[Effect of ginsenoside Rh2 on transplanted-tumor and expression of JAM in mice]. |
| PubMed:[Fungal biotransformation of ginsenoside Rg3]. |
| PubMed:Increase of adipogenesis by ginsenoside (Rh2) in 3T3-L1 cell via an activation of glucocorticoid receptor. |
| PubMed:Determination of two C21 steroidal glycosides of Baishouwu and their metabolites in mice plasma and tumor homogenate by liquid chromatography-tandem mass spectrometry. |
| PubMed:A new triterpenoid from Panax ginseng exhibits cytotoxicity through p53 and the caspase signaling pathway in the HepG2 cell line. |
| PubMed:Role of pituitary adenylate cyclase-activating polypeptide (PACAP) in the action of ginsenoside Rh2 against beta-amyloid-induced inhibition of rat brain astrocytes. |
| PubMed:20(S)-protopanaxadiol and the ginsenoside Rh2 inhibit Na+ channel-activated depolarization and Na+ channel-dependent amino acid neurotransmitter release in synaptic fractions isolated from mammalian brain. |
| PubMed:20(S)-25-methoxyl-dammarane-3beta, 12beta, 20-triol, a novel natural product for prostate cancer therapy: activity in vitro and in vivo and mechanisms of action. |
| PubMed:Induced differentiation of hepatocellular carcinoma by natural products. |
| PubMed:Characterizing the mechanism for ginsenoside-induced cytotoxicity in cultured leukemia (THP-1) cells. |
| PubMed:Bifidus fermentation increases hypolipidemic and hypoglycemic effects of red ginseng. |
| PubMed:[Effect of ginsenoside Rh2 on immunocompetence of alveolar macrophages in patients with non-small cell lung cancer]. |
| PubMed:Anti-obesity effects of ginsenoside Rh2 are associated with the activation of AMPK signaling pathway in 3T3-L1 adipocyte. |
| PubMed:Repression of matrix metalloproteinase gene expression by ginsenoside Rh2 in human astroglioma cells. |
| PubMed:Determination of 25-OH-PPD in rat plasma by high-performance liquid chromatography-mass spectrometry and its application in rat pharmacokinetic studies. |
| PubMed:Ginsenosides compound K and Rh(2) inhibit tumor necrosis factor-alpha-induced activation of the NF-kappaB and JNK pathways in human astroglial cells. |
| PubMed:Ginsenoside Rh2 is one of the active principles of Panax ginseng root to improve insulin sensitivity in fructose-rich chow-fed rats. |
| PubMed:Quantitative determination of ginsenoside Rh2 in rat biosamples by liquid chromatography electrospray ionization mass spectrometry. |
| PubMed:[Determination of ginsenoside Rd and its metabolites in rat urine by LC-MS]. |
| PubMed:Ginsenoside-Rh2-induced mitochondrial depolarization and apoptosis are associated with reactive oxygen species- and Ca2+-mediated c-Jun NH2-terminal kinase 1 activation in HeLa cells. |
| PubMed:Estrogenic activity of triterpene glycosides in yeast two-hybrid assay. |
| PubMed:Inhibitory effects of Korean red ginseng and its genuine constituents ginsenosides Rg3, Rf, and Rh2 in mouse passive cutaneous anaphylaxis reaction and contact dermatitis models. |
| PubMed:[Determination of 20 (S)-ginsengnoside Rh2 in the alkali-hydrolysis product of saponins from leaves of Panax qinquefolium by RP-HPLC]. |
| PubMed:Ginsenosides Rg3 and Rh2 inhibit the activation of AP-1 and protein kinase A pathway in lipopolysaccharide/interferon-gamma-stimulated BV-2 microglial cells. |
| PubMed:In vitro assessment of plasma protein binding of 20(R)-ginsenoside Rh2 by equilibrium dialysis and LC-MS analysis: a case of species differences. |
| PubMed:Ginsenoside Rh(2) enhances antitumour activity and decreases genotoxic effect of cyclophosphamide. |
| PubMed:Rh2 synergistically enhances paclitaxel or mitoxantrone in prostate cancer models. |
| PubMed:20(S)-ginsenoside Rh2, a newly identified active ingredient of ginseng, inhibits NMDA receptors in cultured rat hippocampal neurons. |
| PubMed:Mediation of beta-endorphin by ginsenoside Rh2 to lower plasma glucose in streptozotocin-induced diabetic rats. |
| PubMed:Increase of insulin secretion by ginsenoside Rh2 to lower plasma glucose in Wistar rats. |
| PubMed:[Effects of ginsenoside Rh2(GS-Rh2) on cell cycle of Eca-109 esophageal carcinoma cell line]. |
| PubMed:Natural products from ginseng inhibit [3H]batrachotoxinin A 20-alpha-benzoate binding to Na+ channels in mammalian brain. |
| PubMed:Caspase-3-dependent protein kinase C delta activity is required for the progression of Ginsenoside-Rh2-induced apoptosis in SK-HEP-1 cells. |
| PubMed:Transformation of ginsenosides Rb2 and Rc from Panax ginseng by food microorganisms. |
| PubMed:Liquid chromatography/mass spectrometric analysis of rat samples for in vivo metabolism and pharmacokinetic studies of ginsenoside Rh2. |
| PubMed:Hepatoprotective effect of 20(S)-ginsenosides Rg3 and its metabolite 20(S)-ginsenoside Rh2 on tert-butyl hydroperoxide-induced liver injury. |
| PubMed:[Examination of resistance of lung adenocarcinoma cells to cisplatin by technetium-99m methoxyisobutyl isonitrile]. |
| PubMed:Development of a HPLC-MS assay for ginsenoside Rh2, a new anti-tumor substance from natural product and its pharacokinetic study in dogs. |
| PubMed:Molecular mechanisms of ginsenoside Rh2-mediated G1 growth arrest and apoptosis in human lung adenocarcinoma A549 cells. |
| PubMed:High performance liquid chromatographic-mass spectrometric determination of ginsenoside Rg3 and its metabolites in rat plasma using solid-phase extraction for pharmacokinetic studies. |
| PubMed:Liquid chromatography/tandem mass spectrometry for pharmacokinetic studies of 20(R)-ginsenoside Rg3 in dog. |
| PubMed:Determination of dioscin in rat plasma by liquid chromatography-tandem mass spectrometry. |
| PubMed:Uptake and metabolism of ginsenoside Rh2 and its aglycon protopanaxadiol by Caco-2 cells. |
| PubMed:Changes of [3H]MK-801, [3H]muscimol and [3H]flunitrazepam binding in rat brain by the prolonged ventricular infusion of transformed ginsenosides. |
| PubMed:[Effect of telomerase on ginsenoside Rh2-induced differentiation of hepatocarcinoma cell line SMMC-7721]. |
| PubMed:Protective effect of fermented red ginseng on a transient focal ischemic rats. |
| PubMed:Ginsenoside Rh2 induces apoptosis via activation of caspase-1 and -3 and up-regulation of Bax in human neuroblastoma. |
| PubMed:Rh2, a compound extracted from ginseng, hypersensitizes multidrug-resistant tumor cells to chemotherapy. |
| PubMed:[Effects of ginsenoside Rh2 on signal transduction in hepatocarcinoma SMMC-7721 cells]. |
| PubMed:[Induction of differentiation by ginsenoside Rh2 in hepatocarcinoma cell SMMC-7721]. |
| PubMed:Mechanistic studies on protopanaxadiol, Rh2, and ginseng (Panax quinquefolius) extract induced cytotoxicity in intestinal Caco-2 cells. |
| PubMed:Effects of ginsenosides Rg3 and Rh2 on the proliferation of prostate cancer cells. |
| PubMed:Ginsenosides 20(S)-protopanaxadiol and Rh2 reduce cell proliferation and increase sub-G1 cells in two cultured intestinal cell lines, Int-407 and Caco-2. |
| PubMed:Ginsenoside Rh2 reduces ischemic brain injury in rats. |
| PubMed:Transformation of ginseng saponins to ginsenoside Rh2 by acids and human intestinal bacteria and biological activities of their transformants. |
| PubMed:In vitro induction of differentiation by ginsenoside Rh2 in SMMC-7721 hepatocarcinoma cell line. |
| PubMed:Antiallergic activity of ginsenoside Rh2. |
| PubMed:Caspase-3-mediated cleavage of Cdc6 induces nuclear localization of p49-truncated Cdc6 and apoptosis. |
| PubMed:The c-Jun N-terminal kinase 1 activity is differentially regulated by specific mechanisms during apoptosis. |
| PubMed:SEK1-dependent JNK1 activation prolongs cell survival during G-Rh2-induced apoptosis. |
| PubMed:[Saponins with low sugar chain from the leaves of Panax notoginseng (Burk) F. H. Chen]. |
| PubMed:Activity of drugs from traditional Chinese medicine toward sensitive and MDR1- or MRP1-overexpressing multidrug-resistant human CCRF-CEM leukemia cells. |
| PubMed:Apoptotic effects of ginsenoside Rh2 on human malignant melanoma A375-S2 cells. |
| PubMed:Metabolism of 20(S)- and 20(R)-ginsenoside Rg3 by human intestinal bacteria and its relation to in vitro biological activities. |
| PubMed:The antimetastatic and immunomodulating activities of ginseng minor glycosides. |
| PubMed:Anticarcinogenic effect and enhancement of metastatic potential of BALB/c 3T3 cells by ginsenoside Rh(2). |
| PubMed:Effects of ginsenosides from Panax ginseng on cell-to-cell communication function mediated by gap junctions. |
| PubMed:Purification and characterization of ginsenoside-beta-glucosidase from ginseng. |
| PubMed:Differential expression of protein kinase C subtypes during ginsenoside Rh2-lnduced apoptosis in SK-N-BE(2) and C6Bu-1 cells. |
| PubMed:Caspase 3-mediated cleavage of p21WAF1/CIP1 associated with the cyclin A-cyclin-dependent kinase 2 complex is a prerequisite for apoptosis in SK-HEP-1 cells. |
| PubMed:Ginsenoside Rh2 induces apoptosis independently of Bcl-2, Bcl-xL, or Bax in C6Bu-1 cells. |
| PubMed:Ginsenoside RH-2 induces apoptotic cell death in rat C6 glioma via a reactive oxygen- and caspase-dependent but Bcl-X(L)-independent pathway. |
| PubMed:Anti-proliferating effects of ginsenoside Rh2 on MCF-7 human breast cancer cells. |
| PubMed:Caspase 3 specifically cleaves p21WAF1/CIP1 in the earlier stage of apoptosis in SK-HEP-1 human hepatoma cells. |
| PubMed:Inhibitory effects of ginsenoside Rh2 on tumor growth in nude mice bearing human ovarian cancer cells. |
| PubMed:Ginsenoside Rh2 and Rh3 induce differentiation of HL-60 cells into granulocytes: modulation of protein kinase C isoforms during differentiation by ginsenoside Rh2. |
| PubMed:Properties of ginseng saponin inhibition of catecholamine secretion in bovine adrenal chromaffin cells. |
| PubMed:Activation of caspase-3 protease via a Bcl-2-insensitive pathway during the process of ginsenoside Rh2-induced apoptosis. |
| PubMed:Modulation of protein kinase C activity in NIH 3T3 cells by plant glycosides from Panax ginseng. |
| PubMed:G1 phase-specific suppression of the Cdk2 activity by ginsenoside Rh2 in cultured murine cells. |
| PubMed:Ginsenoside-Rh2 blocks the cell cycle of SK-HEP-1 cells at the G1/S boundary by selectively inducing the protein expression of p27kip1. |
| PubMed:Ginsenoside-Rh1 and Rh2 inhibit the induction of nitric oxide synthesis in murine peritoneal macrophages. |
| PubMed:[Differentiation of B16 melanoma cells induced by ginsenoside RH2]. |
| PubMed:Reversal of daunomycin and vinblastine resistance in multidrug-resistant P388 leukemia in vitro through enhanced cytotoxicity by triterpenoids. |
| PubMed:Suppression of the formation of sister chromatid exchanges by low concentrations of ginsenoside Rh2 in human blood lymphocytes. |
| PubMed:Highlight on the studies of anticancer drugs derived from plants in China. |
| PubMed:[Inhibitory effects of oral administration of ginsenoside Rh2 on tumor growth in nude mice bearing serous cyst adenocarcinoma of the human ovary]. |
| PubMed:Inhibitory effects by oral administration of ginsenoside Rh2 on the growth of human ovarian cancer cells in nude mice. |
| PubMed:Involvement of peanut agglutinin-binding sugar chains in experimental metastasis of B16 melanoma cells. |
| PubMed:[Pharmacological study on Panax ginseng C. A. Meyer. XV. Effects of 70% methanolic extract from red and white ginseng on the antitumor activity of mitomycin C]. |
| PubMed:[In vitro and in vivo effects of ginsenoside Rh2 on the proliferation of serous cystadenocarcinoma of the human ovary]. |
| PubMed:Mechanism of action of ginsenoside Rh2: uptake and metabolism of ginsenoside Rh2 by cultured B16 melanoma cells. |
| PubMed:[Isolation and identification of 20(R)-ginsenoside-Rh2 (an anti-cancer constituent) from the fruits of Panax ginseng. C.A. Meyer]. |
| PubMed:Inhibition of human ovarian cancer cell proliferation in vitro by ginsenoside Rh2 and adjuvant effects to cisplatin in vivo. |
| PubMed:[Induction of phenotypic reverse transformation by plant glycosides in cultured cancer cells]. |
| PubMed:[Isolation and identification of the anti-tumor constituent, ginsenoside-Rh2]. |
| PubMed:[Studies on new minor saponins isolated from leaves of Panax ginseng C. A. Meyer]. |
| PubMed:Control of phenotypic expression of cultured B16 melanoma cells by plant glycosides. |
3D/inchi