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gossypetin
3,5,7,8,3',4'-hexahydroxyflavone

Supplier Sponsors

Name:2-(3,4-dihydroxyphenyl)-3,5,7,8-tetrahydroxychromen-4-one
CAS Number: 489-35-0Picture of molecule3D/inchi
FDA UNII: SET4M23ZTM
Nikkaji Web:J94.551J
MDL:MFCD00017680
XlogP3-AA:1.80 (est)
Molecular Weight:318.23830000
Formula:C15 H10 O8
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 679.30 °C. @ 760.00 mm Hg (est)
Flash Point: 501.00 °F. TCC ( 260.60 °C. ) (est)
logP (o/w): 1.160 (est)
Soluble in:
 water, 5119 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
Equisporol 98%
BOC Sciences
For experimental / research use only.
Gossypetin
Carbosynth
For experimental / research use only.
3,5,7,8,3',4'-Hexahydroxyflavone
ExtraSynthese
For experimental / research use only.
Gossypetin (HPLC) ≥90%
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for gossypetin usage levels up to:
 not for fragrance use.
 
Recommendation for gossypetin flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :5280647
National Institute of Allergy and Infectious Diseases:Data
2-(3,4-dihydroxyphenyl)-3,5,7,8-tetrahydroxychromen-4-one
Chemidplus:0000489350
 
References:
 2-(3,4-dihydroxyphenyl)-3,5,7,8-tetrahydroxychromen-4-one
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):5280647
Pubchem (sid):135227191
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C04109
HMDB (The Human Metabolome Database):Search
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 found in nature
 
Synonyms:
 articulatidin
4H-1-benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-3,5,7,8-tetrahydroxy-
2-(3,4-dihydroxyphenyl)-3,5,7,8-tetrahydroxychromen-4-one
 equisporol
3,5,7,8,3',4'-hexahydroxyflavone
 

Articles:

PubMed:Protective effect of Urtica dioica methanol extract against experimentally induced urinary calculi in rats.
PubMed:Discovery of lesser known flavones as inhibitors of NF-κB signaling in MDA-MB-231 breast cancer cells--A SAR study.
PubMed:Antiartherosclerotic effects of plant flavonoids.
PubMed:[Chemical constituents of leaves of Psidium guajava].
PubMed:Anti-atherosclerotic potential of gossypetin via inhibiting LDL oxidation and foam cell formation.
PubMed:LC-NMR, NMR, and LC-MS identification and LC-DAD quantification of flavonoids and ellagic acid derivatives in Drosera peltata.
PubMed:Gossypetin, a naturally occurring hexahydroxy flavone, ameliorates gamma radiation-mediated DNA damage.
PubMed:A critical evaluation on the reliability of two aluminum chloride chelation methods for quantification of flavonoids.
PubMed:[Study on chemical constituents of Drosera peltata var. multisepala].
PubMed:Flavonoid constituents and free radical scavenging activity of Alchemilla mollis.
PubMed:[Metabolites in rat urine after orally administrating gossypetin-8-O-beta-D-glucuronide].
PubMed:Semisynthesis of natural flavones inhibiting tubulin polymerization, from hesperidin.
PubMed:Characterization of inhibitor-bound alpha-synuclein dimer: role of alpha-synuclein N-terminal region in dimerization and inhibitor binding.
PubMed:Neuraminidase inhibitory activities of flavonols isolated from Rhodiola rosea roots and their in vitro anti-influenza viral activities.
PubMed:Comparative analysis of flavonoid profile, antioxidant and antimicrobial activity of the berries of Juniperus communis L. var. communis and Juniperus communis L. var. saxatilis Pall. from Turkey.
PubMed:Metabolism of hibifolin by human intestinal bacteria.
PubMed:Chemodiversity of exudate flavonoids in Cassinia and Ozothamnus (Asteraceae, Gnaphalieae).
PubMed:Screening of herbal constituents for aromatase inhibitory activity.
PubMed:Dietary flavones and flavonoles are inhibitors of poly(ADP-ribose)polymerase-1 in pulmonary epithelial cells.
PubMed:Metabolic profiling of flavonoids in Lotus japonicus using liquid chromatography Fourier transform ion cyclotron resonance mass spectrometry.
PubMed:Anti-oxidant constituents from Sedum takesimense.
PubMed:Gossypin, a pentahydroxy glucosyl flavone, inhibits the transforming growth factor beta-activated kinase-1-mediated NF-kappaB activation pathway, leading to potentiation of apoptosis, suppression of invasion, and abrogation of osteoclastogenesis.
PubMed:Bioactive compounds from Rhodiola rosea (Crassulaceae).
PubMed:Antioxidant phenolic constituents from Fagopyrum dibotrys.
PubMed:Inhibition of heparin-induced tau filament formation by phenothiazines, polyphenols, and porphyrins.
PubMed:Polyoxygenated flavonoids from Eugenia edulis.
PubMed:Electrospray mass spectrometric decomposition of some glucuronic acid-containing flavonoid diglycosides.
PubMed:Chemical constituents of Pyrrosia petiolosa.
PubMed:New erythroxane-type diterpenoids from Fagonia boveana (Hadidi) Hadidi & Graf.
PubMed:A novel flavonol lyxoside of Orostachys japonicus herb.
PubMed:UDP-glucose: flavonol 7-O-glucosyltransferase activity in flower extracts of Chrysanthemum segetum.
PubMed:Bioactive constituents of Chinese natural medicines. II. Rhodiolae radix. (1). Chemical structures and antiallergic activity of rhodiocyanosides A and B from the underground part of Rhodiola quadrifida (Pall.) Fisch. et Mey. (Crassulaceae).
PubMed:Rhodiocyanosides A and B, new antiallergic cyanoglycosides from Chinese natural medicine "si lie hong jing tian", the underground part of Rhodiola quadrifida (Pall.) Fisch. et Mey.
PubMed:Dietary flavonoids in atherosclerosis prevention.
PubMed:The modification of low density lipoprotein by the flavonoids myricetin and gossypetin.
PubMed:Evaluation of flavonoids inGossypium arboreum (L.) cottons as potential source of resistance to tobacco budworm.
PubMed:Anti-inflammatory activity and inhibition of arachidonic acid metabolism by flavonoids.
PubMed:Flavonoids inhibit the oxidative modification of low density lipoproteins by macrophages.
PubMed:Inhibition of sheep platelet arachidonate metabolism by flavonoids from Spanish and Indian medicinal herbs.
PubMed:Modulating effect of plant flavonoids on the mutagenicity of N-methyl-N'-nitro-N-nitrosoguanidine.
PubMed:Loss of plasmid linked antibiotic resistance in Escherichia coli on treatment with some phenolic compounds.
PubMed:C18 solid-phase isolation and high-performance liquid chromatography/ultraviolet diode array determination of fully methoxylated flavones in citrus juices.
PubMed:Flavonoids from Picnomon acarna.
 
Notes:
inhibits activity of penicillinase enzyme in e coli.
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