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6-hydroxycoumarin
2H-1-benzopyran-2-one, 6-hydroxy-

Supplier Sponsors

Name:6-hydroxychromen-2-one
CAS Number: 6093-68-1Picture of molecule3D/inchi
FDA UNII: Search
Nikkaji Web:J419.093I
MDL:MFCD00630040
XlogP3:1.00 (est)
Molecular Weight:162.14442000
Formula:C9 H6 O3
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 398.20 °C. @ 760.00 mm Hg (est)
Flash Point: 373.00 °F. TCC ( 189.60 °C. ) (est)
logP (o/w): 0.650 (est)
Soluble in:
 water, 3.339e+004 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
6-Hydroxy Coumarin >98%
ExtraSynthese
For experimental / research use only.
6-Hydroxycoumarin (HPLC) ≥90%
Santa Cruz Biotechnology
For experimental / research use only.
6-Hydroxycoumarin ≥99%
Sigma-Aldrich: Aldrich
For experimental / research use only.
6-Hydroxycoumarin 96%
sds
TCI AMERICA
For experimental / research use only.
6-Hydroxycoumarin >98.0%(GC)(T)
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for 6-hydroxycoumarin usage levels up to:
 not for fragrance use.
 
Recommendation for 6-hydroxycoumarin flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :99477
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
6-hydroxychromen-2-one
Chemidplus:0006093681
 
References:
 6-hydroxychromen-2-one
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):99477
Pubchem (sid):135056463
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEMBL:View
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2932.20.4500
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 found in nature
 
Synonyms:
2H-1-benzopyran-2-one, 6-hydroxy-
6-hydroxy-2H-1-benzopyran-2-one
6-hydroxychromen-2-one
 

Articles:

PubMed:Isolation, Cytotoxicity Evaluation and HPLC-Quantification of the Chemical Constituents from Prangos pabularia.
PubMed:Synthesis and biological evaluation of novel isoxazoles and triazoles linked 6-hydroxycoumarin as potent cytotoxic agents.
PubMed:RETRACTED: A study of the role of apoptotic cell death and cell cycle events mediating the mechanism of action of 6-hydroxycoumarin-3-carboxylatosilver in human malignant hepatic cells.
PubMed:Inhibitory effects of 6-alkoxycoumarin and 7-alkoxycoumarin derivatives on lipopolysaccharide/interferon γ-stimulated nitric oxide production in RAW264 cells.
PubMed:[Coumarins of Anemone raddeana Regel and their biological activity].
PubMed:Quinolizidinyl derivatives of bi- and tricyclic systems as potent inhibitors of acetyl- and butyrylcholinesterase with potential in Alzheimer's disease.
PubMed:[Chemical constituents of an endophytic fungus from Annona muricata].
PubMed:Coumarins incorporating hydroxy- and chloro-moieties selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II.
PubMed:Antitermite activities of coumarin derivatives and scopoletin from Protium javanicum Burm. f.
PubMed:Antioxidant constituents from Cotoneaster racemiflora.
PubMed:Mechanism of action of coumarin and silver(I)-coumarin complexes against the pathogenic yeast Candida albicans.
PubMed:A study of the role of apoptotic cell death and cell cycle events mediating the mechanism of action of 6-hydroxycoumarin-3-carboxylatosilver in human malignant hepatic cells.
PubMed:In vitro anti-tumour and cyto-selective effects of coumarin-3-carboxylic acid and three of its hydroxylated derivatives, along with their silver-based complexes, using human epithelial carcinoma cell lines.
PubMed:Cytotoxic and antimicrobial constituents of the bark of Diospyros maritima collected in two geographical locations in Indonesia.
PubMed:Coumarins from the heartwoods of Mansonia gagei Drumm.
PubMed:Cytostatic activity of coumarin metabolites and derivatives in the B16-F10 murine melanoma cell line.
 
Notes:
None found
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